JP2022513164A - 胎盤由来同種car-t細胞およびその使用 - Google Patents
胎盤由来同種car-t細胞およびその使用 Download PDFInfo
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- JP2022513164A JP2022513164A JP2021531011A JP2021531011A JP2022513164A JP 2022513164 A JP2022513164 A JP 2022513164A JP 2021531011 A JP2021531011 A JP 2021531011A JP 2021531011 A JP2021531011 A JP 2021531011A JP 2022513164 A JP2022513164 A JP 2022513164A
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/22—Immunosuppressive or immunotolerising
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/418—Antigens related to induction of tolerance to non-self
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
- A61K40/4211—CD19 or B4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/4221—CD20
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/50—Cellular immunotherapy characterised by the use of allogeneic cells
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- C12N2510/00—Genetically modified cells
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- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
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- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862774142P | 2018-11-30 | 2018-11-30 | |
| US62/774,142 | 2018-11-30 | ||
| US201962878736P | 2019-07-25 | 2019-07-25 | |
| US62/878,736 | 2019-07-25 | ||
| PCT/US2019/064074 WO2020113234A1 (en) | 2018-11-30 | 2019-12-02 | Placenta-derived allogeneic car-t cells and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022513164A true JP2022513164A (ja) | 2022-02-07 |
| JP2022513164A5 JP2022513164A5 (https=) | 2022-12-19 |
Family
ID=69005946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021531011A Pending JP2022513164A (ja) | 2018-11-30 | 2019-12-02 | 胎盤由来同種car-t細胞およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20220118014A1 (https=) |
| EP (1) | EP3886876A1 (https=) |
| JP (1) | JP2022513164A (https=) |
| KR (1) | KR20210111244A (https=) |
| CN (1) | CN113395972A (https=) |
| AU (1) | AU2019387571A1 (https=) |
| BR (1) | BR112021010132A2 (https=) |
| CA (1) | CA3120364A1 (https=) |
| MX (1) | MX2021006402A (https=) |
| PH (1) | PH12021551246A1 (https=) |
| SG (1) | SG11202105217RA (https=) |
| WO (1) | WO2020113234A1 (https=) |
| ZA (1) | ZA202103263B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL293462A (en) * | 2019-12-04 | 2022-07-01 | Celularity Inc | Placenta-derived allogeneic car-t cells and uses thereof |
| JP7846667B2 (ja) | 2020-07-16 | 2026-04-15 | レジェンド バイオテック アイルランド リミテッド | Cd20結合分子及びその使用 |
| IL299867A (en) * | 2020-07-16 | 2023-03-01 | Nanjing Legend Biotech Co Ltd | Cd19 binding molecules and uses thereof |
| US20250290039A1 (en) * | 2023-07-10 | 2025-09-18 | Pluri Biotech Ltd. | Genetically engineered placental mucosalassociated invariant t (mait) cells and uses thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009536824A (ja) * | 2006-05-11 | 2009-10-22 | 直子 武部 | 臍帯血幹細胞の回収方法及び使用方法 |
| WO2014186469A2 (en) * | 2013-05-14 | 2014-11-20 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| WO2016094304A2 (en) * | 2014-12-12 | 2016-06-16 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| US20160237407A1 (en) * | 2015-02-17 | 2016-08-18 | Batu Biologics, Inc. | Universal donor chimeric antigen receptor cells |
| JP2016537362A (ja) * | 2013-11-15 | 2016-12-01 | アントフロゲネシス コーポレーション | ヒト胎盤灌流液細胞、その亜集団を含む組成物、およびそれらの使用 |
| WO2017015427A1 (en) * | 2015-07-21 | 2017-01-26 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| JP2018502114A (ja) * | 2014-12-31 | 2018-01-25 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 |
| WO2018115887A1 (en) * | 2016-12-21 | 2018-06-28 | Ucl Business Plc | Therapeutic cells |
| JP2018516592A (ja) * | 2015-04-17 | 2018-06-28 | デイビッド・マクスウエル・バレットDavid Maxwell BARRETT | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| JP2018527008A (ja) * | 2015-09-17 | 2018-09-20 | ノバルティス アーゲー | 有効性が増強されたcar t細胞療法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1958962A3 (en) | 1997-06-12 | 2013-05-01 | Novartis International Pharmaceutical Ltd. | Artificial antibody polypeptides |
| US10611837B2 (en) * | 2014-04-10 | 2020-04-07 | Seattle Children's Hospital | Transgene genetic tags and methods of use |
| AU2015317316A1 (en) * | 2014-09-19 | 2017-04-06 | City Of Hope | Central memory T cells for adoptive T cell therapy |
| US10201606B2 (en) * | 2014-11-26 | 2019-02-12 | Miltenyi Biotec Gmbh | Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases |
| US20160228547A1 (en) * | 2015-02-06 | 2016-08-11 | Batu Biologics, Inc. | Chimeric antigen receptor targeting of tumor endothelium |
| MX2017015147A (es) * | 2015-05-26 | 2018-03-28 | Celularity Inc | Angiogenesis usando celulas madre de placenta estimuladas. |
| CN105331585A (zh) * | 2015-11-13 | 2016-02-17 | 科济生物医药(上海)有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
| JP7123794B2 (ja) * | 2015-12-09 | 2022-08-23 | メモリアル スローン ケタリング キャンサー センター | 免疫細胞組成物及びそれを使用する方法 |
-
2019
- 2019-12-02 KR KR1020217016359A patent/KR20210111244A/ko not_active Ceased
- 2019-12-02 BR BR112021010132-2A patent/BR112021010132A2/pt not_active IP Right Cessation
- 2019-12-02 CN CN201980078364.2A patent/CN113395972A/zh active Pending
- 2019-12-02 EP EP19828010.9A patent/EP3886876A1/en not_active Withdrawn
- 2019-12-02 US US17/309,451 patent/US20220118014A1/en active Pending
- 2019-12-02 WO PCT/US2019/064074 patent/WO2020113234A1/en not_active Ceased
- 2019-12-02 MX MX2021006402A patent/MX2021006402A/es unknown
- 2019-12-02 AU AU2019387571A patent/AU2019387571A1/en not_active Abandoned
- 2019-12-02 CA CA3120364A patent/CA3120364A1/en active Pending
- 2019-12-02 SG SG11202105217RA patent/SG11202105217RA/en unknown
- 2019-12-02 JP JP2021531011A patent/JP2022513164A/ja active Pending
-
2021
- 2021-05-13 ZA ZA2021/03263A patent/ZA202103263B/en unknown
- 2021-05-28 PH PH12021551246A patent/PH12021551246A1/en unknown
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009536824A (ja) * | 2006-05-11 | 2009-10-22 | 直子 武部 | 臍帯血幹細胞の回収方法及び使用方法 |
| WO2014186469A2 (en) * | 2013-05-14 | 2014-11-20 | Board Of Regents, The University Of Texas System | Human application of engineered chimeric antigen receptor (car) t-cells |
| JP2016537362A (ja) * | 2013-11-15 | 2016-12-01 | アントフロゲネシス コーポレーション | ヒト胎盤灌流液細胞、その亜集団を含む組成物、およびそれらの使用 |
| WO2016094304A2 (en) * | 2014-12-12 | 2016-06-16 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| JP2018502114A (ja) * | 2014-12-31 | 2018-01-25 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 |
| US20160237407A1 (en) * | 2015-02-17 | 2016-08-18 | Batu Biologics, Inc. | Universal donor chimeric antigen receptor cells |
| JP2018516592A (ja) * | 2015-04-17 | 2018-06-28 | デイビッド・マクスウエル・バレットDavid Maxwell BARRETT | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
| WO2017015427A1 (en) * | 2015-07-21 | 2017-01-26 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| JP2018519842A (ja) * | 2015-07-21 | 2018-07-26 | ノバルティス アーゲー | 免疫細胞の有効性および増大を改善する方法 |
| JP2018527008A (ja) * | 2015-09-17 | 2018-09-20 | ノバルティス アーゲー | 有効性が増強されたcar t細胞療法 |
| WO2018115887A1 (en) * | 2016-12-21 | 2018-06-28 | Ucl Business Plc | Therapeutic cells |
Non-Patent Citations (2)
| Title |
|---|
| SHERIDAN, CORMAC, NATURE BIOTECHNOLOGY, vol. 36, no. 5, JPN6023044487, May 2018 (2018-05-01), pages 375 - 377, ISSN: 0005512139 * |
| 立川愛: "研究課題名(和文)加齢による免疫老化と病的免疫老化の比較解析", 科学研究費助成事業 研究成果報告書, JPN6024023993, 22 March 2018 (2018-03-22), pages 1 - 4, ISSN: 0005512140 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20210111244A (ko) | 2021-09-10 |
| ZA202103263B (en) | 2024-09-25 |
| US20220118014A1 (en) | 2022-04-21 |
| MX2021006402A (es) | 2021-08-11 |
| CN113395972A (zh) | 2021-09-14 |
| PH12021551246A1 (en) | 2021-11-03 |
| WO2020113234A1 (en) | 2020-06-04 |
| CA3120364A1 (en) | 2020-06-04 |
| SG11202105217RA (en) | 2021-06-29 |
| AU2019387571A1 (en) | 2021-06-03 |
| EP3886876A1 (en) | 2021-10-06 |
| BR112021010132A2 (pt) | 2021-08-24 |
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