JP2022511786A - 新規芳香族化合物によるナチュラルキラー細胞およびilc3細胞の増殖 - Google Patents
新規芳香族化合物によるナチュラルキラー細胞およびilc3細胞の増殖 Download PDFInfo
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- JP2022511786A JP2022511786A JP2021530785A JP2021530785A JP2022511786A JP 2022511786 A JP2022511786 A JP 2022511786A JP 2021530785 A JP2021530785 A JP 2021530785A JP 2021530785 A JP2021530785 A JP 2021530785A JP 2022511786 A JP2022511786 A JP 2022511786A
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- 0 CC*(CCON(C)CCN)C(C*)NC Chemical compound CC*(CCON(C)CCN)C(C*)NC 0.000 description 23
- KLRPDFIJGRCDNF-UHFFFAOYSA-N CC(C)[n]1c(N=C(c2c[s]c3c2cccc3)N(CCC(N)=O)C2=O)c2nc1 Chemical compound CC(C)[n]1c(N=C(c2c[s]c3c2cccc3)N(CCC(N)=O)C2=O)c2nc1 KLRPDFIJGRCDNF-UHFFFAOYSA-N 0.000 description 1
- ACVWFKDOJYRVDT-UHFFFAOYSA-N CC(C)c1c[s]c2c1nc(-c1c[s]c3c1cccc3)nc2NCCc(cc1)ccc1O Chemical compound CC(C)c1c[s]c2c1nc(-c1c[s]c3c1cccc3)nc2NCCc(cc1)ccc1O ACVWFKDOJYRVDT-UHFFFAOYSA-N 0.000 description 1
- VBIMFDPTJKNRPS-UHFFFAOYSA-N CC(C)c1c[s]c2c1nc(-c1cc(F)cnc1)nc2NCCc1c[nH]c2ccccc12 Chemical compound CC(C)c1c[s]c2c1nc(-c1cc(F)cnc1)nc2NCCc1c[nH]c2ccccc12 VBIMFDPTJKNRPS-UHFFFAOYSA-N 0.000 description 1
- JZXRUFJTXOMGFJ-UHFFFAOYSA-N Cc1cc(-c(nc2NCCc3c[nH]c4ccccc34)nc3c2[o]cc3)cnc1 Chemical compound Cc1cc(-c(nc2NCCc3c[nH]c4ccccc34)nc3c2[o]cc3)cnc1 JZXRUFJTXOMGFJ-UHFFFAOYSA-N 0.000 description 1
- FWVOHSVIAYQBSR-UHFFFAOYSA-N Fc1cncc(-c2nc(cccc3)c3c(NCCc3c[nH]c4ccccc34)n2)c1 Chemical compound Fc1cncc(-c2nc(cccc3)c3c(NCCc3c[nH]c4ccccc34)n2)c1 FWVOHSVIAYQBSR-UHFFFAOYSA-N 0.000 description 1
- CVFDGHHBAWBWRT-UHFFFAOYSA-N N#Cc1cncc(-c(nc2NCCc3c[nH]c4c3cccc4)nc3c2[o]cc3)c1 Chemical compound N#Cc1cncc(-c(nc2NCCc3c[nH]c4c3cccc4)nc3c2[o]cc3)c1 CVFDGHHBAWBWRT-UHFFFAOYSA-N 0.000 description 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
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- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862774114P | 2018-11-30 | 2018-11-30 | |
| US62/774,114 | 2018-11-30 | ||
| PCT/US2019/063876 WO2020113182A1 (en) | 2018-11-30 | 2019-11-29 | Expansion of natural killer cells and ilc3 cells with novel aromatic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022511786A true JP2022511786A (ja) | 2022-02-01 |
| JP2022511786A5 JP2022511786A5 (https=) | 2023-08-03 |
| JPWO2020113182A5 JPWO2020113182A5 (https=) | 2023-08-03 |
Family
ID=69005918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021530785A Pending JP2022511786A (ja) | 2018-11-30 | 2019-11-29 | 新規芳香族化合物によるナチュラルキラー細胞およびilc3細胞の増殖 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230028680A1 (https=) |
| EP (1) | EP3887508A1 (https=) |
| JP (1) | JP2022511786A (https=) |
| KR (1) | KR20210111762A (https=) |
| CN (1) | CN113454207A (https=) |
| AU (1) | AU2019387491A1 (https=) |
| BR (1) | BR112021010245A2 (https=) |
| CA (1) | CA3119427A1 (https=) |
| EA (1) | EA202191508A1 (https=) |
| MX (1) | MX2021006398A (https=) |
| PH (1) | PH12021551241A1 (https=) |
| SG (1) | SG11202105213XA (https=) |
| WO (1) | WO2020113182A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023038037A1 (ja) * | 2021-09-08 | 2023-03-16 | 株式会社ガイアバイオメディシン | 細胞の処理方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020252464A1 (en) * | 2019-06-14 | 2020-12-17 | Celularity Inc. | Populations of natural killer cells for treating cancers |
| US20220273716A1 (en) * | 2019-07-25 | 2022-09-01 | Celularity Inc. | Populations of natural killer cells comprising a cd38 chimeric antigen receptor |
| WO2021155312A1 (en) * | 2020-01-29 | 2021-08-05 | Celularity Inc. | Placental derived natural killer cells for treatment of coronavirus infections |
| US11591381B2 (en) | 2020-11-30 | 2023-02-28 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
| WO2022144632A1 (en) | 2020-12-30 | 2022-07-07 | Crispr Therapeutics Ag | Compositions and methods for differentiating stem cells into nk cells |
| US20240082398A1 (en) * | 2021-01-15 | 2024-03-14 | City Of Hope | Methods of preparing and expanding type i innate lymphoid cells and therapeutic uses thereof |
| WO2023278628A1 (en) * | 2021-06-29 | 2023-01-05 | Celularity Inc. | Human placental hematopoietic stem cell derived natural killer cells in acute myeloid leukemia (aml) remission with minimal residual disease (mrd) or relapsed/refractory aml |
| AU2023249795A1 (en) | 2022-04-08 | 2024-10-17 | Shy Therapeutics, Llc | Compounds that interact with ras superfamily proteins for treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017066530A1 (en) * | 2015-10-15 | 2017-04-20 | Anthrogensis Corporation | Natural killer cells and ilc3 cells and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| EP2305795B1 (en) | 2000-12-06 | 2019-07-03 | Celularity, Inc. | Method of collecting placental stem cells |
| EP2316918B1 (en) | 2001-02-14 | 2015-07-01 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP2005089352A (ja) * | 2003-09-16 | 2005-04-07 | Kissei Pharmaceut Co Ltd | 新規なイミダゾ[1,5−a]ピラジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| US7147626B2 (en) | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| ZA200804717B (en) | 2005-12-29 | 2010-02-24 | Anthrogenesis Corp | Improved composition for collecting and preserving a placental stem cells and methods of using the composition |
| PL2471907T3 (pl) | 2005-12-29 | 2019-07-31 | Celularity, Inc. | Populacje komórek macierzystych łożyska |
| ES2421191T3 (es) * | 2006-05-03 | 2013-08-29 | Symrise Ag | Antagonistas del receptor de Ah |
| KR20220122774A (ko) | 2007-09-26 | 2022-09-02 | 셀룰래리티 인코포레이티드 | 인간 태반 관류액으로부터의 혈관형성 세포 |
| AU2013203936A1 (en) * | 2008-10-30 | 2013-05-02 | Novartis Ag | Compounds that expand hematopoietic stem cells |
| RU2013120966A (ru) * | 2010-10-08 | 2014-11-20 | Эббви Инк. | ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ |
| NZ733213A (en) * | 2014-12-31 | 2022-10-28 | Celularity Inc | Natural killer cells and uses thereof |
| TWI752155B (zh) * | 2017-02-01 | 2022-01-11 | 德商菲尼克斯製藥股份有限公司 | 芳香烴受體(AhR)調節劑化合物 |
| WO2018195397A2 (en) * | 2017-04-21 | 2018-10-25 | Kyn Therapeutics | Indole ahr inhibitors and uses thereof |
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2019
- 2019-11-29 CN CN201980090805.0A patent/CN113454207A/zh active Pending
- 2019-11-29 EP EP19827982.0A patent/EP3887508A1/en not_active Withdrawn
- 2019-11-29 WO PCT/US2019/063876 patent/WO2020113182A1/en not_active Ceased
- 2019-11-29 JP JP2021530785A patent/JP2022511786A/ja active Pending
- 2019-11-29 EA EA202191508A patent/EA202191508A1/ru unknown
- 2019-11-29 MX MX2021006398A patent/MX2021006398A/es unknown
- 2019-11-29 US US17/309,449 patent/US20230028680A1/en not_active Abandoned
- 2019-11-29 AU AU2019387491A patent/AU2019387491A1/en not_active Abandoned
- 2019-11-29 CA CA3119427A patent/CA3119427A1/en active Pending
- 2019-11-29 SG SG11202105213XA patent/SG11202105213XA/en unknown
- 2019-11-29 BR BR112021010245-0A patent/BR112021010245A2/pt not_active IP Right Cessation
- 2019-11-29 KR KR1020217020212A patent/KR20210111762A/ko not_active Ceased
-
2021
- 2021-05-28 PH PH12021551241A patent/PH12021551241A1/en unknown
Patent Citations (1)
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| WO2017066530A1 (en) * | 2015-10-15 | 2017-04-20 | Anthrogensis Corporation | Natural killer cells and ilc3 cells and uses thereof |
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| WO2023038037A1 (ja) * | 2021-09-08 | 2023-03-16 | 株式会社ガイアバイオメディシン | 細胞の処理方法 |
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| Publication number | Publication date |
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| US20230028680A1 (en) | 2023-01-26 |
| BR112021010245A2 (pt) | 2021-08-17 |
| KR20210111762A (ko) | 2021-09-13 |
| EA202191508A1 (ru) | 2021-09-21 |
| MX2021006398A (es) | 2021-07-15 |
| CA3119427A1 (en) | 2020-06-04 |
| EP3887508A1 (en) | 2021-10-06 |
| AU2019387491A1 (en) | 2021-05-27 |
| SG11202105213XA (en) | 2021-06-29 |
| PH12021551241A1 (en) | 2021-11-03 |
| WO2020113182A1 (en) | 2020-06-04 |
| CN113454207A (zh) | 2021-09-28 |
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