JP2022511122A - 治療用組成物 - Google Patents
治療用組成物 Download PDFInfo
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- JP2022511122A JP2022511122A JP2021542081A JP2021542081A JP2022511122A JP 2022511122 A JP2022511122 A JP 2022511122A JP 2021542081 A JP2021542081 A JP 2021542081A JP 2021542081 A JP2021542081 A JP 2021542081A JP 2022511122 A JP2022511122 A JP 2022511122A
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Abstract
Description
本出願は、2018年10月1日出願の「抗病原性治療用組成物(ANTI-PATHOGENIC THERAPEUTIC COMPOSITIONS)」と表題が付けられた米国特許仮出願第62/739,844号、2019年5月9日出願の「治療用組成物(THERAPEUTIC COMPOSITIONS)」と表題が付けられた米国特許仮出願第62/845,858号、及び2019年5月9日出願の「治療用組成物(THERAPEUTIC COMPOSITIONS)」と表題が付けられた米国特許仮出願第62/845,859号の各々の優先権を主張するものである。これらの出願の各々は、その全体が参照により本明細書に組み込まれる。
本明細書において言及される全ての刊行物及び特許出願は、その全体が、各個々の刊行物若しくは特許出願が具体的に及び独立に参照により組み込まれることが示されたのと同様の程度まで、参照により本明細書に組み込まれる。
本明細書に記載された組成物及び療法は、病原体及び/若しくは癌を効果的に死滅させる及び/若しくは阻止する為に使用されてよい。具体的には、前記組成物は細菌生育を死滅させる若しくは阻止し得、及び同時に、創傷治癒が挙げられる(がそれに限定されない)治癒を補助し得る。本明細書に記載される組成物(抗病原性組成物)は、治療上効果的な量の1以上のアミノ酸及び1以上の脂肪酸(例えば、UCA及びLARG、デカン酸及びLARG等)を含有し得る。指定された比率範囲内のこれらの化合物の組み合わせは、例えば、病原体の生育を阻止し及び/若しくは病原体の死滅(排除)を増強することによって、感染を防ぎ及び治癒を補助し得る作用の、付加的ではなく相乗的な生物機構を発揮し得る。更に、本明細書に記載される組成物は、処置される患者(例えば、ヒト)に対して、その代替化合物(the substituent compounds)の逐次投与よりも大きな治療利益を与え得る。更に、これらの組成物は、癌細胞(腫瘍を包含する)の生育及び/若しくは広がりを阻止することが挙げられるがそれに限定されない、抗癌治療効果を有することが実証された。
一般に、本明細書に記載される治療用組成物のいずれかは、脂肪酸及びアミノ酸として働き得る若しくはその活性を増強し得る1以上の追加的な成分を含んでよい。例えば、本明細書に記載される治療用組成物のいずれかは、増強された有効性等の、異なる若しくは増強された特性を提供する為に1以上追加的な活性成分と組み合わされてよい。
齧歯類からの全身安全性の研究によって、本明細書に記載される治療用組成物(例えば、脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の治療用組成物)は、比較的高い濃度であっても安全であるということが示された。故に、これらの組成物は、(例えば、抗病原性理由及び/若しくは抗癌性処置の為に)それを必要とする患者を処置する為に局所的に及び/若しくは全身的に与えられ得る。例えば一研究において、1つの例示的組成物(例えば、GS-1)を単回用量において皮下注射により最大効力において1.25mL/kgの用量レベル(381mg/kgのAPIに相当)で投与した。副作用は観察されなかった。
上述したように、本明細書に記載される組成物は、例えば、ペイン(pain)、プラスチック等に対する)材料添加剤を包含する、コーティング及び/若しくは添加剤の為に使用されてよい。例えば、GS-1を、中心静脈カテーテルをコーティングしてグラム陽性(MRSA)及びグラム陰性(大腸菌)細菌に対する抗微生物性活性を与える為に使用した。実薬対照試験においてGS-1は、市場において既に使用されているクロルヘキシジンコーティング及び銀コーティングと同等の若しくはより優れた性能を提供した。コーティングは、噴霧する、浸漬する等によって適用されてよい。コーティングは、封入されても、部分的に封入されても、及び/若しくは封入されなくてもよい。
一般に、本明細書に記載されるような処置の一部として任意の適切な用量を使用してよい。本明細書に記載される組成物は、非常に低い濃度(例えば、0.1%w/w未満)で効果的であり得る用量範囲で提供され得るが、より高い濃度でも、副作用は有るとしてもほとんど無いに等しい状態で効果的であり得るということが、予備的研究により示唆されている。例えば、本明細書に記載される方法のいずれかは、約30%w/w~約0.001%w/wの範囲内で被験者を処置する為に使用されてよい。幾つかの変形形態では、患者は約15%w/w~約0.01%w/wの間の用量を与えられてよい。患者は約10%~約0.01%w/wの間の用量を用いて処置されてよい。患者は約5%~約0.01%w/wの間の用量を用いて処置されてよい。幾つかの変形形態では、患者は約2.5%~約0.01%w/wの間の用量を用いて処置されてよい。幾つかの変形形態では、前記患者は約1%~約0.01%w/wの間の用量を用いて処置されてよい。幾つかの変形形態では、前記患者は約0.5%~約0.001%w/wの間の用量を用いて処置されてよい。幾つかの変形形態では、前記患者は約0.25%~約0.001%w/wの間の用量を用いて処置されてよい。幾つかの変形形態では、前記患者は約0.25%~約0.01%w/wの間の用量を用いて処置されてよい。
一般に、本明細書に記載される治療用組成物は、貯蔵に安定である脂肪酸(例えば、ウンデシレン酸)とアミノ酸(例えば、L-アルギニン)との比率を含んでよい。例えば、UCAとLARGとの、例えば、約1:0.6~約1:1.6(特に約1:0.65~1:1.4、例えば、約1:0.65~1:1.3、約1:0.65~1:1等)の間のUCAとLARGとのモル比(UCA:LARG)を有する組成物は、0℃を上回る温度において数日、数週、若しくは数ヶ月間安定であり得る。更に幾つかの変形形態では、本明細書に記載される組成物(例えば、UCAとLARGとの組成物)は、更に低い温度、特に-20℃等の温度において、延長された期間、例えば、24時間超(2日間、3日間、4日間、7日間、10日間、14日間、21日間、30日間、60日間、120日間、6ヶ月間、1年間等)に渡り安定であり得る。
Claims (175)
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記脂肪酸はC4~C40脂肪酸である、治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記脂肪酸はC4~C20脂肪酸である、治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記脂肪酸はC4~C40脂肪酸であり及び前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記脂肪酸はC4~C20脂肪酸であり及び前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、治療用組成物。
- 脂肪酸:アミノ酸の前記モル比は1:0.6~約1:1の間である、請求項1~6のいずれかに記載の組成物。
- 脂肪酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項1~6のいずれかに記載の組成物。
- 脂肪酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項1~6のいずれかに記載の組成物。
- 前記組成物は水性の組成物である、請求項1~9のいずれかに記載の組成物。
- pHが6~10の間である、請求項1~10のいずれかに記載の組成物。
- pHが6.9~7.8の間である、請求項1~10のいずれかに記載の組成物。
- 賦形剤、希釈剤、若しくは担体を更に含む、請求項1~12のいずれかに記載の組成物
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項13に記載の組成物。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項13に記載の組成物。
- 冷却若しくは加熱添加剤を更に含む、請求項1~15のいずれかに記載の組成物。
- 前記組成物はヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項1~16のいずれかに記載の組成物。
- 前記組成物は、経口、非経口、腹腔内、経粘膜、経皮、直腸、吸入可能、及び局所投与のうちの1以上の為に構成される、請求項1~16のいずれかに記載の組成物。
- 前記組成物は医療デバイスをコーティングする為に構成される、請求項1~16のいずれかに記載の組成物。
- 病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の抗病原性組成物を投与することを含み、前記抗病原性組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C40脂肪酸である、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C20脂肪酸である、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C40脂肪酸であり、及び前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C20脂肪酸であり、及び前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項20~25のいずれかに記載の方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項20~25のいずれかに記載の方法。
- 前記抗病原性組成物は水性の組成物である、請求項20~27のいずれかに記載の方法。
- 前記抗病原性組成物のpHは6~10の間である、請求項20~28のいずれかに記載の方法。
- 前記抗病原性組成物のPHは6.9~7.8の間である、請求項20~28のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者の皮膚に適用することを含む、請求項20~30のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者の創傷に適用することを含む、請求項20~30のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者に全身的に適用することを含む、請求項20~30のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者に噴霧することを含む、請求項20~30のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を医療デバイスから放出させることを含む、請求項20~30のいずれかに記載の方法。
- 投与することは前記患者を前記抗病原性組成物を含む医療デバイスの表面と接触させることを含む、請求項20~30のいずれかに記載の方法。
- 前記病原体はグラム陰性細菌、グラム陽性細菌、真菌、マイコバクテリア、肺炎細菌、大腸細菌、ウィルスの1以上である、請求項20~25のいずれかに記載の方法。
- 前記抗病原性組成物は、セチルアルコールを除く、賦形剤、希釈剤、若しくは担体を更に含む、請求項20~25のいずれかに記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項38に記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項38に記載の方法。
- 前記抗病原性組成物は冷却若しくは加熱添加剤を更に含む、請求項20~25のいずれかに記載の方法。
- 前記抗病原性組成物はヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項20~25のいずれかに記載の方法。
- 癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の治療用組成物を投与することを含み、前記治療用組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C40脂肪酸である、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C20脂肪酸である、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C40脂肪酸であり、及び前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物は脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記脂肪酸はC4~C20脂肪酸であり、及び前記アミノ酸は荷電塩基性側鎖を有するアミノ酸である、方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項43~48のいずれかに記載の方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項43~48のいずれかに記載の方法。
- 前記治療用組成物は水性の組成物である、請求項43~50のいずれかに記載の方法。
- 前記治療用組成物のpHは6~10の間である、請求項43~51のいずれかに記載の方法。
- 前記治療用組成物のPHは6.9~7.8の間である、請求項43~51のいずれかに記載の方法。
- 投与することは前記治療用組成物を前記患者の皮膚に適用することを含む、請求項43~53のいずれかに記載の方法。
- 投与することは前記治療用組成物を前記患者に全身的に適用することを含む、請求項43~53のいずれかに記載の方法。
- 投与することは前記治療用組成物を医療デバイスから放出させることを含む、請求項43~53のいずれかに記載の方法。
- 投与することは前記患者を前記治療用組成物を含む医療デバイスの表面と接触させることを含む、請求項43~53のいずれかに記載の方法。
- 前記治療用組成物は、セチルアルコールを除く、賦形剤、希釈剤、若しくは担体を更に含む、請求項43~48のいずれかに記載の方法。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記アミノ酸はL-アルギニン、ヒスチジン、及びリジンの1以上である、治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記脂肪酸はC4~C40脂肪酸の1以上であり、及び前記アミノ酸はアルギニン、ヒスチジン、及びリジンの1以上である、治療用組成物。
- 脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記脂肪酸はC4~C20脂肪酸の1以上であり、及び前記アミノ酸はアルギニン、ヒスチジン、及びリジンの1以上である、治療用組成物。
- 前記脂肪酸はオクタン酸、ノナン酸、デカン酸、ウンデシレン酸、ラウリン酸、トリデシル酸、ミリスチン酸、リノール酸、アラキドン酸、及びアラキジン酸の1以上である、請求項59~61に記載の治療用組成物。
- 脂肪酸:アミノ酸の前記混合物は約35%~約0.001%w/wの間の合計濃度である、請求項59~61に記載の治療用組成物。
- 脂肪酸:アミノ酸の前記モル比は1:0.6~約1:1の間である、請求項59~61に記載の治療用組成物。
- 脂肪酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項59~61に記載の治療用組成物。
- 脂肪酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項59~61に記載の治療用組成物。
- 前記組成物は水性の組成物である、請求項59~61に記載の治療用組成物。
- pHが6~10の間である、請求項59~61に記載の治療用組成物。
- pHが6.9~7.8の間である、請求項59~61に記載の治療用組成物。
- 賦形剤、希釈剤、若しくは担体を更に含む、請求項59~61に記載の治療用組成物
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項70に記載の治療用組成物。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項70に記載の治療用組成物。
- 冷却若しくは加熱添加剤を更に含む、請求項59~61に記載の治療用組成物。
- 前記組成物はヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項59~61に記載の治療用組成物。
- 前記組成物は、経口、非経口、腹腔内、経粘膜、経皮、直腸、吸入可能、及び局所投与のうちの1以上の為に構成される、請求項59~61に記載の治療用組成物。
- 前記組成物は医療デバイスをコーティングする為に構成される、請求項59~61に記載の治療用組成物。
- 病原体を破壊する為に患者を処置する方法であって、前記方法はそれを必要とする患者に治療上効果的な量の脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む組成物を投与することを含み、前記アミノ酸はアルギニン、ヒスチジン、及びリジンの1以上である、方法。
- 病原体を破壊する為に患者を処置する方法であって、前記方法はそれを必要とする患者に治療上効果的な量の脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む組成物を投与することを含み、前記脂肪酸はC4~C20脂肪酸の1以上であり、及び前記アミノ酸はアルギニン、ヒスチジン、及びリジンの1以上である、方法。
- 前記脂肪酸はオクタン酸、ノナン酸、デカン酸、ウンデシレン酸、ラウリン酸、トリデシル酸、ミリスチン酸、リノール酸、アラキドン酸、及びアラキジン酸の1以上である、請求項77~78に記載の方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項77~78に記載の方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項77~78に記載の方法。
- 前記組成物は水性の組成物である、請求項77~78に記載の方法。
- 前記組成物のpHは6~10の間である、請求項77~78に記載の方法。
- 前記組成物のpHは6.9~7.8の間である、請求項77~78に記載の方法。
- 投与することは前記組成物を前記患者の皮膚に適用することを含む、請求項77~78に記載の方法。
- 投与することは前記組成物を前記患者の創傷に適用することを含む、請求項77~78に記載の方法。
- 投与することは前記組成物を前記患者に全身的に適用することを含む、請求項77~78に記載の方法。
- 投与することは前記組成物を前記患者に噴霧することを含む、請求項77~78に記載の方法。
- 投与することは前記組成物を医療デバイスから放出させることを含む、請求項77~78に記載の方法。
- 投与することは前記患者を前記組成物を含む医療デバイスの表面と接触させること含む、請求項77~78に記載の方法。
- 前記病原体はグラム陰性細菌、グラム陽性細菌、真菌、マイコバクテリア、肺炎細菌、大腸細菌、及びウィルスの1以上である、請求項77~78に記載の方法。
- 前記組成物は、セチルアルコールを除く、賦形剤、希釈剤、若しくは担体を更に含む、請求項77~78に記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項92に記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項92に記載の方法。
- 前記組成物は冷却若しくは加熱添加剤を更に含む、請求項77~78に記載の方法。
- 前記組成物はヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項77~78に記載の方法。
- それを必要とする患者に治療上効果的な量の脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む組成物を投与することを含む癌処置方法であって、前記アミノ酸はアルギニン、ヒスチジン、及びリジンの1以上である、方法。
- それを必要とする患者に治療上効果的な量の脂肪酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含む組成物を投与することを含む癌処置方法であって、前記脂肪酸はC4~C20脂肪酸の1以上であり、及び前記アミノ酸はアルギニン、ヒスチジン、及びリジンの1以上である、方法。
- 前記脂肪酸はオクタン酸、ノナン酸、デカン酸、ウンデシレン酸、ラウリン酸、トリデシル酸、ミリスチン酸、リノール酸、アラキドン酸、及びアラキジン酸の1以上である、請求項97~98に記載の方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項97~98に記載の方法。
- 脂肪酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項97~98に記載の方法。
- 前記組成物は水性の組成物である、請求項97~98に記載の方法。
- 前記組成物のpHは6~10の間である、請求項97~98に記載の方法。
- 前記組成物のpHは6.9~7.8の間である、請求項97~98に記載の方法。
- 投与することは前記組成物を前記患者の皮膚に適用することを含む、請求項97~98に記載の方法。
- 投与することは前記組成物を前記患者の創傷に適用することを含む、請求項97~98に記載の方法。
- 投与することは前記組成物を前記患者に全身的に適用することを含む、請求項97~98に記載の方法。
- 投与することは前記組成物を前記患者に噴霧することを含む、請求項97~98に記載の方法。
- 投与することは前記組成物を医療デバイスから放出させることを含む、請求項97~98に記載の方法。
- 投与することは前記患者を前記組成物を含む医療デバイスの表面と接触させること含む、請求項97~98に記載の方法。
- 前記病原体はグラム陰性細菌、グラム陽性細菌、真菌、マイコバクテリア、肺炎細菌、大腸細菌、及びウィルスの1以上である、請求項97~98に記載の方法。
- 前記組成物は、セチルアルコールを除く、賦形剤、希釈剤、若しくは担体を更に含む、請求項97~98に記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項112に記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項112に記載の方法。
- 前記組成物は冷却若しくは加熱添加剤を更に含む、請求項97~98に記載の方法。
- 前記組成物はヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項97~98に記載の方法。
- ウンデシレン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物。
- ウンデシレン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記治療用組成物はセチルアルコールを含まない、治療用組成物。
- ウンデシレン酸:L-アルギニンの混合物を約1:0.6~約1:1の間のモル比で約35%~約0.001%w/wの間の合計濃度で含む治療用組成物。
- デカン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物。
- デカン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む治療用組成物であって、前記治療用組成物はセチルアルコールを含まない、治療用組成物。
- デカン酸:L-アルギニンの混合物を約1:0.6~約1:1の間のモル比で約35%~約0.001%w/wの間の合計濃度で含む治療用組成物。
- ウンデシレン酸:L-アルギニンの前記モル比は1:0.6~約1:1の間である、請求項117~119のいずれかに記載の組成物。
- ウンデシレン酸:L-アルギニンの前記モル比はおよそ1:1のモル比である、請求項117~119のいずれかに記載の組成物。
- ウンデシレン酸:L-アルギニンの前記モル比はおよそ5:4のモル比である、請求項117~119のいずれかに記載の組成物。
- デカン酸:L-アルギニンの前記モル比は1:0.6~約1:1の間である、請求項120~122のいずれかに記載の組成物。
- デカン酸:L-アルギニンの前記モル比はおよそ1:1のモル比である、請求項120~122のいずれかに記載の組成物。
- デカン酸:L-アルギニンの前記モル比はおよそ5:4のモル比である、請求項120~122のいずれかに記載の組成物。
- 前記組成物は水性の組成物である、請求項117~128のいずれかに記載の組成物。
- pHが6~10の間である、請求項117~129のいずれかに記載の組成物。
- PHが6.9~7.8の間である、請求項117~130のいずれかに記載の組成物。
- 賦形剤、希釈剤、若しくは担体を更に含む、請求項117~131のいずれかに記載の組成物。
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項132に記載の組成物。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項132に記載の組成物。
- 冷却若しくは加熱添加剤を更に含む、請求項117~134のいずれかに記載の組成物。
- 前記組成物はヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項117~135のいずれかに記載の組成物。
- 前記組成物は、経口、非経口、腹腔内、経粘膜、経皮、直腸、吸入可能、及び局所投与のうちの1以上の為に構成される、請求項117~136のいずれかに記載の組成物。
- 前記組成物は医療デバイスをコーティングする為に構成される、請求項117~137のいずれかに記載の組成物。
- 病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の抗病原性組成物を投与することを含み、前記抗病原性組成物はウンデシレン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物はウンデシレン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含み、前記治療用組成物はセチルアルコールを含まない、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物はウンデシレン酸:アミノ酸の混合物を約1:0.6~約1:1.6の間のモル比で含み、前記アミノ酸はL-アルギニン、リジン、及びヒスチジンの1以上である、方法。
- 病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の抗病原性組成物を投与することを含み、前記抗病原性組成物はデカン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物はデカン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含み、前記治療用組成物はセチルアルコールを含まない、方法。
- 抗病原性組成物を用いて病原体を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記抗病原性組成物を投与することを含み、前記抗病原性組成物はデカン酸:アミノ酸の約1:0.6~約1:1.6の間のモル比の混合物を含み、前記アミノ酸はL-アルギニン、リジン、及びヒスチジンの1以上である、方法。
- ウンデシレン酸:L-アルギニン若しくはウンデシレン酸:アミノ酸又はデカン酸:L-アルギニン若しくはデカン酸:アミノ酸の前記モル比はおよそ1:1のモル比である、請求項139~144のいずれかに記載の方法。
- ウンデシレン酸:L-アルギニン若しくはウンデシレン酸:アミノ酸又はデカン酸:L-アルギニン若しくはデカン酸:アミノ酸の前記モル比はおよそ5:4のモル比である、請求項138~143のいずれかに記載の方法。
- 前記抗病原性組成物は水性の組成物である、請求項139~146のいずれかに記載の方法。
- 前記抗病原性組成物のpHは6~10の間である、請求項139~147のいずれかに記載の方法。
- 前記抗病原性組成物のpHは6.9~7.8の間である、請求項139~148のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者の皮膚に適用することを含む、請求項139~149のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者の創傷に適用することを含む、請求項139~150のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者に全身的に適用することを含む、請求項139~151のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を前記患者に噴霧することを含む、請求項139~152のいずれかに記載の方法。
- 投与することは前記抗病原性組成物を医療デバイスから放出させることを含む、請求項139~153のいずれかに記載の方法。
- 投与することは前記患者を前記抗病原性組成物を含む医療デバイスの表面と接触させることを含む、請求項139~154のいずれかに記載の方法。
- 前記病原体はグラム陰性細菌、グラム陽性細菌、真菌、マイコバクテリア、肺炎細菌、大腸細菌、及びウィルスの1以上である、請求項139~155のいずれかに記載の方法。
- 前記抗病原性組成物は、セチルアルコールを除く、賦形剤、希釈剤、若しくは担体を更に含む、請求項139~156のいずれかに記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は局所適用向けに構成される、請求項157に記載の方法。
- 前記賦形剤、希釈剤、若しくは担体は乳化剤を含む、請求項157に記載の方法。
- 前記抗病原性組成物は冷却若しくは加熱添加剤を更に含む、請求項139~159のいずれかに記載の方法。
- 前記抗病原性組成物は、ヒトへの局所投与に好適な形態の液体若しくはエマルションとして構成される、請求項139~160のいずれかに記載の方法。
- 癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の治療用組成物を投与することを含み、前記治療用組成物は、ウンデシレン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物はウンデシレン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含み、前記治療用組成物はセチルアルコールを含まない、方法。
- 癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の治療用組成物を投与することを含み、前記治療用組成物はデカン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含む、方法。
- 治療用組成物を用いて癌を破壊する為に患者を処置する方法であって、前記方法は前記患者に治療上効果的な量の前記治療用組成物を投与することを含み、前記治療用組成物はデカン酸:L-アルギニンの約1:0.6~約1:1.6の間のモル比の混合物を含み、前記治療用組成物はセチルアルコールを含まない、方法。
- ウンデシレン酸:L-アルギニン若しくはデカン酸:L-アルギニンの前記モル比はおよそ1:1のモル比である、請求項162~165のいずれかに記載の方法。
- ウンデシレン酸:L-アルギニン若しくはデカン酸:L-アルギニンの前記モル比はおよそ5:4のモル比である、請求項162~165のいずれかに記載の方法。
- 前記治療用組成物は水性の組成物である、請求項162~167のいずれかに記載の方法。
- 前記治療用組成物のpHは6~10の間である、請求項162~168のいずれかに記載の方法。
- 前記治療用組成物のpHは6.9~7.8の間である、請求項162~169のいずれかに記載の方法。
- 投与することは前記治療用組成物を前記患者の皮膚に適用することを含む、請求項162~170のいずれかに記載の方法。
- 投与することは前記治療用組成物を前記患者に全身的に適用することを含む、請求項162~171のいずれかに記載の方法。
- 投与することは前記治療用組成物を医療デバイスから放出させることを含む、請求項162~172のいずれかに記載の方法。
- 投与することは前記患者を前記治療用組成物を含む医療デバイスの表面と接触させることを含む、請求項162~173のいずれかに記載の方法。
- 前記治療用組成物は、セチルアルコールを除く、賦形剤、希釈剤、若しくは担体を更に含む、請求項162~174のいずれかに記載の方法。
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WO2022241303A1 (en) * | 2021-05-14 | 2022-11-17 | University Of South Florida | Composition and method for treating covid-19 |
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CN113583454A (zh) * | 2021-08-16 | 2021-11-02 | 河南迪怡疗护科技开发有限公司 | 抗菌型医用材料、抗菌型医疗器械 |
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