JP2022507830A - 治療薬を発現する改変細胞とその使用 - Google Patents

治療薬を発現する改変細胞とその使用 Download PDF

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JP2022507830A
JP2022507830A JP2021527959A JP2021527959A JP2022507830A JP 2022507830 A JP2022507830 A JP 2022507830A JP 2021527959 A JP2021527959 A JP 2021527959A JP 2021527959 A JP2021527959 A JP 2021527959A JP 2022507830 A JP2022507830 A JP 2022507830A
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cell
cells
car
antigen
modified
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JPWO2020106843A5 (https=
JP2022507830A5 (https=
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シャオ，レイ
カオ，ジーユアン
プー，チェンフェイ
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Innovative Cellular Therapeutics Holdings Ltd Grand Cayman
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Innovative Cellular Therapeutics Holdings Ltd Grand Cayman
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Priority claimed from US16/445,965 external-priority patent/US10918667B2/en
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Publication of JPWO2020106843A5 publication Critical patent/JPWO2020106843A5/ja
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/20—Interleukins [IL]
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    • A61K38/21—Interferons [IFN]
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0634—Cells from the blood or the immune system
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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JP2021527959A 2018-11-20 2019-11-20 治療薬を発現する改変細胞とその使用 Pending JP2022507830A (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201862769987P 2018-11-20 2018-11-20
US62/769,987 2018-11-20
US201862774595P 2018-12-03 2018-12-03
US62/774,595 2018-12-03
US201962795810P 2019-01-23 2019-01-23
US62/795,810 2019-01-23
US201962828770P 2019-04-03 2019-04-03
US62/828,770 2019-04-03
US201962846563P 2019-05-10 2019-05-10
US62/846,563 2019-05-10
US201962848961P 2019-05-16 2019-05-16
US62/848,961 2019-05-16
US16/445,965 US10918667B2 (en) 2018-11-20 2019-06-19 Modified cell expressing therapeutic agent and uses thereof
US16/445,965 2019-06-19
US201962889926P 2019-08-21 2019-08-21
US62/889,926 2019-08-21
US201962902766P 2019-09-19 2019-09-19
US62/902,766 2019-09-19
PCT/US2019/062417 WO2020106843A1 (en) 2018-11-20 2019-11-20 Modified cell expressing therapeutic agent and uses thereof

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JP2022507830A true JP2022507830A (ja) 2022-01-18
JPWO2020106843A5 JPWO2020106843A5 (https=) 2022-11-29
JP2022507830A5 JP2022507830A5 (https=) 2022-11-29

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US (2) US20220000921A1 (https=)
EP (1) EP3883585A4 (https=)
JP (1) JP2022507830A (https=)
AU (1) AU2019384145A1 (https=)
CA (1) CA3120153A1 (https=)
SG (1) SG11202105173VA (https=)
WO (1) WO2020106843A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022531814A (ja) * 2019-03-12 2022-07-12 イノベイティブ セルラー セラピューティクス ホールディングス，エルティディ 改変細胞の増幅およびその応用
JP2023517599A (ja) * 2020-03-09 2023-04-26 四川大学華西医院 ＩＦＮ－γの抗腫瘍補助薬の調製への応用
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
EP3810640A1 (en) * 2018-06-25 2021-04-28 University of Washington De novo design of potent and selective interleukin mimetics
WO2020028275A1 (en) * 2018-07-30 2020-02-06 The Board Of Trustees Of The Leland Stanford Junior University Interferon-gamma biased agonists
JP7156653B2 (ja) 2018-08-30 2022-10-19 イノベイティブ セルラー セラピューティクス ホールディングス，エルティディ 固形腫瘍を治療するためのキメラ抗原受容体細胞
US11866494B2 (en) * 2018-08-31 2024-01-09 Innovative Cellular Therapeutics Holdings, Ltd. CAR T therapy through uses of co-stimulation
EP3883956A1 (en) 2018-11-20 2021-09-29 University of Washington Split interleukin mimetics and their use
AU2020315800A1 (en) 2019-07-19 2022-03-03 Seneca Therapeutics, Inc. Second generation seneca valley virus oncolytic therapy: compositions and methods thereof
US20210060069A1 (en) * 2019-08-23 2021-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Coupled redirected cells and uses thereof
BR112022009110A2 (pt) * 2019-11-14 2022-07-26 Werewolf Therapeutics Inc Polipeptídeos de citocina ativáveis e métodos de uso destes
EP3892720A1 (en) 2020-04-06 2021-10-13 Innovative Cellular Therapeutics Holdings, Ltd. Presenting cell and use thereof in cell therapy
KR20230040364A (ko) * 2020-07-27 2023-03-22 센터 포 엑설런스 인 몰레큘러 셀 사이언스, 차이니즈 아카데미 오브 사이언시스 키메라 항원 수용체 및 이의 용도
WO2022038264A1 (en) * 2020-08-21 2022-02-24 Julius-Maximilians-Universität Würzburg Modified lymphocytes
JP2023545126A (ja) * 2020-10-12 2023-10-26 武田薬品工業株式会社 Ｃａｒ－ｔ細胞の細胞動態及び体内分布の決定
WO2022159508A1 (en) * 2021-01-19 2022-07-28 Seneca Therapeutics, Inc. Armed seneca valley virus oncolytic therapy compositions and methods thereof
US11633427B2 (en) * 2021-02-05 2023-04-25 Innovative Cellular Therapeutics Holdings, Ltd. Vaccine and uses thereof in cell therapy
CN113046320B (zh) * 2021-02-19 2023-04-14 中国医学科学院基础医学研究所 胞外段为Vδ1(GTM)Vγ4的CAR分子及表达该分子的CAR-T细胞及其用途
CN114934071B (zh) * 2021-04-30 2023-10-17 四川大学华西医院 一种表达免疫调节因子的car载体及其应用
EP4215245A1 (en) 2022-01-19 2023-07-26 Innovative Cellular Therapeutics Holdings, Ltd. Enhanced chimeric antigen receptor cells in hypoxic tumor microenvironment
AU2024289944A1 (en) 2023-07-05 2026-01-29 Nanotein Technologies, Inc. Cell signaling complexes and uses thereof
US12473529B2 (en) 2023-07-18 2025-11-18 Nanotein Technologies, Inc. Reagents, reagent kits, and culture media for activating and expanding immune cells and uses thereof
WO2025117789A1 (en) * 2023-12-01 2025-06-05 Parker Institute For Cancer Immunotherapy Engineered immune signaling constructs
WO2025184170A1 (en) 2024-02-27 2025-09-04 Overt Bio, Inc. Methods and compositions for improving t cell function in an immunosuppressive environment
WO2025184172A1 (en) * 2024-02-27 2025-09-04 Overt Bio, Inc. Cancer reactive t cell receptors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010081738A1 (en) * 2009-01-16 2010-07-22 Agirx Limited Vaccine compositions
WO2010126766A1 (en) * 2009-04-30 2010-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inducible interleukin-12
WO2012066495A2 (en) * 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority T-cell therapy to neurodegenerative diseases
WO2017075537A1 (en) * 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
JP2018528774A (ja) * 2015-09-09 2018-10-04 シアトル チルドレンズ ホスピタル， ディービーエー シアトル チルドレンズ リサーチ インスティテュート 免疫療法のためのマクロファージの遺伝子組換え

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ508878A (en) * 1998-05-15 2003-08-29 Genentech Inc IL-17B and IL-17Cactive variants of IL-17 which stimulates epithelial, endothelial and fibroblastic cells
SK8292002A3 (en) * 1999-11-12 2002-12-03 Maxygen Holdings Ltd A conjugate exhibiting interferon gamma activity, nucleotide sequence encoding for a polypeptide fraction of conjugate, an expression vector and a host cell containing nucleotide sequence, pharmaceutical composition comprising the same and use thereof
AUPQ755300A0 (en) * 2000-05-17 2000-06-08 Monash University Immune potentiating compositions
US7038015B2 (en) * 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US7446190B2 (en) * 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
EP1572242B1 (en) * 2002-12-13 2014-04-16 Immunomedics, Inc. Immunoconjugates with an intracellularly-cleavable linkage
AU2011239569B2 (en) * 2010-04-16 2014-07-24 Baylor College Of Medicine Method for treating solid tumors
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9402865B2 (en) * 2011-01-18 2016-08-02 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
AU2012267710A1 (en) * 2011-06-08 2014-01-23 The Regents Of The University Of California Anti-CD22 antigen binding molecules to treat lung cancer and prostate cancer
WO2013059593A1 (en) * 2011-10-20 2013-04-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd22 chimeric antigen receptors
EP3783098A1 (en) * 2013-05-14 2021-02-24 Board Of Regents, The University Of Texas System Human application of engineered chimeric antigen receptor (car) t-cells
WO2015092024A2 (en) * 2013-12-20 2015-06-25 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
US11382963B2 (en) * 2015-01-12 2022-07-12 Pieris Pharmaceuticals Gmbh Engineered T cells and uses therefor
US10493139B2 (en) * 2015-07-24 2019-12-03 Innovative Cellular Therapeutics CO., LTD. Humanized anti-CD19 antibody and use thereof with chimeric antigen receptor
AU2017225733A1 (en) * 2016-03-04 2018-09-27 Novartis Ag Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore
CN109219445B (zh) * 2016-04-01 2022-08-26 上海煦顼技术有限公司 嵌合抗原受体修饰细胞治疗癌症的应用
US11377637B2 (en) * 2016-04-15 2022-07-05 Memorial Sloan Kettering Cancer Center Transgenic T cell and chimeric antigen receptor T cell compositions and related methods
WO2017186121A1 (zh) * 2016-04-26 2017-11-02 科济生物医药（上海）有限公司 一种改善免疫应答细胞功能的方法
WO2018064921A1 (en) * 2016-10-06 2018-04-12 Innovative Cellular Therapeutics CO., LTD. Use of chimeric antigen receptor modified cells to treat cancer
WO2018136566A1 (en) * 2017-01-18 2018-07-26 F1 Oncology, Inc. Methods of transducing and expanding immune cells and uses thereof
US10561686B2 (en) * 2018-01-12 2020-02-18 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010081738A1 (en) * 2009-01-16 2010-07-22 Agirx Limited Vaccine compositions
WO2010126766A1 (en) * 2009-04-30 2010-11-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inducible interleukin-12
WO2012066495A2 (en) * 2010-11-17 2012-05-24 Ben Gurion University Of The Negev Research And Development Authority T-cell therapy to neurodegenerative diseases
JP2018528774A (ja) * 2015-09-09 2018-10-04 シアトル チルドレンズ ホスピタル， ディービーエー シアトル チルドレンズ リサーチ インスティテュート 免疫療法のためのマクロファージの遺伝子組換え
WO2017075537A1 (en) * 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CANCER RES., vol. 71, [17], JPN6023042116, 2011, pages 5697 - 5706, ISSN: 0005474238 *
PLOS ONE, vol. 6, [4], JPN6024016757, 2011, pages 18556 - 1, ISSN: 0005474239 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12240915B2 (en) 2018-08-30 2025-03-04 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
JP2022531814A (ja) * 2019-03-12 2022-07-12 イノベイティブ セルラー セラピューティクス ホールディングス，エルティディ 改変細胞の増幅およびその応用
US12076343B2 (en) 2020-02-19 2024-09-03 Innovative Cellular Therapeutics Holdings, Ltd. Engineered safety in cell therapy
JP2023517599A (ja) * 2020-03-09 2023-04-26 四川大学華西医院 ＩＦＮ－γの抗腫瘍補助薬の調製への応用
JP7780444B2 (ja) 2020-03-09 2025-12-04 成都▲至▼▲治▼生物医▲薬▼科技有限公司 ＩＦＮ－γの抗腫瘍補助薬の調製への応用
US12043654B2 (en) 2020-06-02 2024-07-23 Innovative Cellular Therapeutics Holdings, Ltd. Anti-GCC antibody and CAR thereof for treating digestive system cancer

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