JP2022507533A - 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法 - Google Patents

肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法 Download PDF

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JP2022507533A
JP2022507533A JP2021526561A JP2021526561A JP2022507533A JP 2022507533 A JP2022507533 A JP 2022507533A JP 2021526561 A JP2021526561 A JP 2021526561A JP 2021526561 A JP2021526561 A JP 2021526561A JP 2022507533 A JP2022507533 A JP 2022507533A
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pharmaceutically acceptable
compound
acceptable salt
decane
biphenyl
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JP2022507533A5 (https=
Inventor
スティーブ リング，
マグダレーナ アロンソ－ガリシア，
トーマス パック，
ジュリー ルーカ，
デイビッド カーペンター，
メリッサ ローズ，
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Altavant Sciences GmbH
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Altavant Sciences GmbH
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Publication of JP2022507533A publication Critical patent/JP2022507533A/ja
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Priority to JP2023217954A priority Critical patent/JP2024019691A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021526561A 2018-11-16 2019-11-15 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法 Pending JP2022507533A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023217954A JP2024019691A (ja) 2018-11-16 2023-12-25 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862768575P 2018-11-16 2018-11-16
US62/768,575 2018-11-16
PCT/IB2019/001224 WO2020099926A1 (en) 2018-11-16 2019-11-15 A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension

Related Child Applications (1)

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JP2023217954A Division JP2024019691A (ja) 2018-11-16 2023-12-25 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法

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JP2022507533A true JP2022507533A (ja) 2022-01-18
JP2022507533A5 JP2022507533A5 (https=) 2022-10-05

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JP2021526561A Pending JP2022507533A (ja) 2018-11-16 2019-11-15 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法
JP2023217954A Pending JP2024019691A (ja) 2018-11-16 2023-12-25 肺動脈性高血圧症および他疾患に関連する肺動脈性肺高血圧症の治療法

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US (2) US11413287B2 (https=)
EP (1) EP3880203A1 (https=)
JP (2) JP2022507533A (https=)
KR (1) KR20210105343A (https=)
CN (1) CN113242736A (https=)
AU (1) AU2019382168A1 (https=)
CA (1) CA3119909A1 (https=)
WO (1) WO2020099926A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11413287B2 (en) 2018-11-16 2022-08-16 Altavant Sciences Gmbh Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension
WO2020128614A1 (en) * 2018-12-17 2020-06-25 Altavant Sciences Gmbh Method for treating interstital lung disease
MX2021009055A (es) 2019-01-30 2021-10-22 Altavant Sciences Gmbh Pauta posológica y método para tratar la hipertensión arterial pulmonar con rodatristat etilo.
AU2020244278A1 (en) * 2019-03-15 2021-09-30 Altavant Sciences Gmbh A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing
WO2023062595A1 (en) * 2021-10-14 2023-04-20 Altavant Sciences Gmbh Treatment of subjects having pulmonary arterial hypertension with rodatristat ethyl

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875622B2 (en) 2007-07-11 2011-01-25 Lexicon Pharmaceuticals, Inc. Methods and compositions for treating pulmonary hypertension and related diseases and disorders
TW201245183A (en) * 2010-11-05 2012-11-16 Lexicon Pharmaceuticals Inc Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid
UA119247C2 (uk) * 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Спіроциклічні сполуки як інгібітори триптофангідроксилази
US9399741B2 (en) 2013-10-09 2016-07-26 Uop Llc Methods and apparatuses for desulfurizing hydrocarbon streams
CA3119912A1 (en) * 2018-11-14 2020-05-22 Altavant Sciences Gmbh A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (tph1) for treating diseases or disorders associated with peripheral serotonin
US11413287B2 (en) 2018-11-16 2022-08-16 Altavant Sciences Gmbh Method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension
WO2020128614A1 (en) * 2018-12-17 2020-06-25 Altavant Sciences Gmbh Method for treating interstital lung disease
WO2020128608A1 (en) 2018-12-17 2020-06-25 Altavant Sciences Gmbh Compound for use in a method for treating sarcoidosis-associated pulmonary hypertension
MX2021009055A (es) * 2019-01-30 2021-10-22 Altavant Sciences Gmbh Pauta posológica y método para tratar la hipertensión arterial pulmonar con rodatristat etilo.
AU2020244278A1 (en) 2019-03-15 2021-09-30 Altavant Sciences Gmbh A method for treating pulmonary arterial hypertension and associated pulmonary arterial hypertension and daily dosing
CN115379825A (zh) 2020-01-31 2022-11-22 阿尔塔万特科学公司 用rodatristat治疗肺动脉高压的剂量和方法
US11937070B2 (en) 2021-07-01 2024-03-19 Tencent America LLC Layered description of space of interest
WO2023079486A1 (en) 2021-11-03 2023-05-11 Altavant Sciences Gmbh Treatment of pulmonary arterial hypertension with rodatristat and ambrisentan

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROBERT J. AIELLO ET AL., JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. Vl.360, No.2, JPN6023025720, 2017, pages 269 - 289, ISSN: 0005273645 *

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Publication number Publication date
US11911382B2 (en) 2024-02-27
US20230000866A1 (en) 2023-01-05
AU2019382168A1 (en) 2021-06-03
CN113242736A (zh) 2021-08-10
US11413287B2 (en) 2022-08-16
KR20210105343A (ko) 2021-08-26
WO2020099926A1 (en) 2020-05-22
CA3119909A1 (en) 2020-05-22
JP2024019691A (ja) 2024-02-09
US20200155552A1 (en) 2020-05-21
EP3880203A1 (en) 2021-09-22

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