JP2022507493A - 新療法 - Google Patents

新療法 Download PDF

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Publication number
JP2022507493A
JP2022507493A JP2021526472A JP2021526472A JP2022507493A JP 2022507493 A JP2022507493 A JP 2022507493A JP 2021526472 A JP2021526472 A JP 2021526472A JP 2021526472 A JP2021526472 A JP 2021526472A JP 2022507493 A JP2022507493 A JP 2022507493A
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JP
Japan
Prior art keywords
oligonucleotide
patient
ulcerative colitis
weeks
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021526472A
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English (en)
Japanese (ja)
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JPWO2020099585A5 (https=
JP2022507493A5 (https=
Inventor
ツァルガリ、アレゾウ
サンドウォール、ペルニラ
アドマイヤー、シャルロット
ニッテル、トーマス
ゼルホウニ、ピーター
Original Assignee
インデックス・ファーマシューティカルズ・アクチエボラーグ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by インデックス・ファーマシューティカルズ・アクチエボラーグ filed Critical インデックス・ファーマシューティカルズ・アクチエボラーグ
Publication of JP2022507493A publication Critical patent/JP2022507493A/ja
Publication of JPWO2020099585A5 publication Critical patent/JPWO2020099585A5/ja
Publication of JP2022507493A5 publication Critical patent/JP2022507493A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021526472A 2018-11-14 2019-11-14 新療法 Pending JP2022507493A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1818579.3 2018-11-14
GBGB1818579.3A GB201818579D0 (en) 2018-11-14 2018-11-14 New therapy
PCT/EP2019/081377 WO2020099585A1 (en) 2018-11-14 2019-11-14 New therapy

Publications (3)

Publication Number Publication Date
JP2022507493A true JP2022507493A (ja) 2022-01-18
JPWO2020099585A5 JPWO2020099585A5 (https=) 2023-07-31
JP2022507493A5 JP2022507493A5 (https=) 2023-07-31

Family

ID=64739449

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021526472A Pending JP2022507493A (ja) 2018-11-14 2019-11-14 新療法

Country Status (10)

Country Link
US (1) US20220218736A1 (https=)
EP (1) EP3880303A1 (https=)
JP (1) JP2022507493A (https=)
KR (1) KR20210092719A (https=)
CN (1) CN113226461A (https=)
AU (1) AU2019378077A1 (https=)
BR (1) BR112021005645A2 (https=)
CA (1) CA3118899A1 (https=)
GB (1) GB201818579D0 (https=)
WO (1) WO2020099585A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4147688A1 (en) 2021-09-09 2023-03-15 InDex Pharmaceuticals AB Enema formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149797A (en) 1990-02-15 1992-09-22 The Worcester Foundation For Experimental Biology Method of site-specific alteration of rna and production of encoded polypeptides
EP2596806A1 (en) * 2011-11-25 2013-05-29 Index Pharmaceuticals AB Method for prevention of colectomy
GB201707503D0 (en) * 2017-05-10 2017-06-21 Index Pharmaceuticals Ab New Therapy 3
GB201707500D0 (en) * 2017-05-10 2017-06-21 Index Pharmaceuticals Ab New therapy
GB201707501D0 (en) * 2017-05-10 2017-06-21 Index Pharmaceuticals Ab New therapy 2

Also Published As

Publication number Publication date
GB201818579D0 (en) 2018-12-26
BR112021005645A2 (pt) 2021-06-29
KR20210092719A (ko) 2021-07-26
WO2020099585A1 (en) 2020-05-22
US20220218736A1 (en) 2022-07-14
AU2019378077A1 (en) 2021-04-22
EP3880303A1 (en) 2021-09-22
CN113226461A (zh) 2021-08-06
CA3118899A1 (en) 2020-05-22

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