JP2022506113A - 睡眠時無呼吸を治療するための方法及び組成物 - Google Patents

睡眠時無呼吸を治療するための方法及び組成物 Download PDF

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JP2022506113A
JP2022506113A JP2021523282A JP2021523282A JP2022506113A JP 2022506113 A JP2022506113 A JP 2022506113A JP 2021523282 A JP2021523282 A JP 2021523282A JP 2021523282 A JP2021523282 A JP 2021523282A JP 2022506113 A JP2022506113 A JP 2022506113A
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oxybutynin
hydroxyatomoxetine
composition
subject
muscarinic receptor
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Japanese (ja)
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JP2022506113A5 (https=
JPWO2020091862A5 (https=
Inventor
ミラー，ローレンス，ジー．
ファーカス，ロナルド
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アプニメッド，インコーポレイテッド（デラウェア）
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Publication of JP2022506113A publication Critical patent/JP2022506113A/ja
Publication of JP2022506113A5 publication Critical patent/JP2022506113A5/ja
Publication of JPWO2020091862A5 publication Critical patent/JPWO2020091862A5/ja
Priority to JP2024062027A priority Critical patent/JP2024088740A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021523282A 2018-10-31 2019-07-23 睡眠時無呼吸を治療するための方法及び組成物 Pending JP2022506113A (ja)

Priority Applications (1)

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JP2024062027A JP2024088740A (ja) 2018-10-31 2024-04-08 睡眠時無呼吸を治療するための方法及び組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862753420P 2018-10-31 2018-10-31
US62/753,420 2018-10-31
PCT/US2019/043065 WO2020091862A1 (en) 2018-10-31 2019-07-23 Methods and compositions for treating sleep apnea

Related Child Applications (1)

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JP2024062027A Division JP2024088740A (ja) 2018-10-31 2024-04-08 睡眠時無呼吸を治療するための方法及び組成物

Publications (3)

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JP2022506113A true JP2022506113A (ja) 2022-01-17
JP2022506113A5 JP2022506113A5 (https=) 2022-07-27
JPWO2020091862A5 JPWO2020091862A5 (https=) 2022-07-27

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JP2021523282A Pending JP2022506113A (ja) 2018-10-31 2019-07-23 睡眠時無呼吸を治療するための方法及び組成物
JP2024062027A Pending JP2024088740A (ja) 2018-10-31 2024-04-08 睡眠時無呼吸を治療するための方法及び組成物

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JP2024062027A Pending JP2024088740A (ja) 2018-10-31 2024-04-08 睡眠時無呼吸を治療するための方法及び組成物

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Country Link
US (3) US20210401790A1 (https=)
EP (1) EP3873454A1 (https=)
JP (2) JP2022506113A (https=)
KR (1) KR20210084481A (https=)
CN (1) CN112930179A (https=)
AU (1) AU2019370091A1 (https=)
CA (1) CA3117766A1 (https=)
MX (2) MX2021004883A (https=)
WO (1) WO2020091862A1 (https=)

Families Citing this family (4)

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KR20240021920A (ko) * 2021-06-17 2024-02-19 애프니메드, 인코포레이티드 (델라웨어) 수면 무호흡증을 치료하기 위한 노르에피네프린 재흡수 억제제
MX2024007764A (es) * 2021-12-22 2024-07-04 Bayer Ag Combinacion de un bloqueante de canales task1/3 con un inhibidor de la recaptacion de norepinefrina para el tratamiento de la apnea del sue?o.
US20250049779A1 (en) * 2021-12-22 2025-02-13 Bayer Aktiengesellschaft Combination of an a2-adrenoceptor subtype c (alpha-2c) antagonist with a norepinephrine reuptake inhibitor for the treatment of sleep apnea
CN119789855A (zh) * 2022-09-02 2025-04-08 爱普宁公司(特拉华) 治疗睡眠呼吸暂停的方法和组合物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523382A (ja) * 2000-02-24 2003-08-05 ファルマシア・アンド・アップジョン・カンパニー 新規な薬物の組合せ
JP2004525912A (ja) * 2001-03-06 2004-08-26 イーライ・リリー・アンド・カンパニー モノアミン取込の阻害剤
JP2012176958A (ja) * 2012-04-20 2012-09-13 Watson Pharmaceuticals Inc （ｒ）−オキシブチニンおよび（ｒ）−デスエチルオキシブチニンによる平滑筋機能亢進の処置

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Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7160898B2 (en) * 2001-12-14 2007-01-09 Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
US20050176680A1 (en) * 2003-12-11 2005-08-11 Sepracor, Inc. Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression
US20080145318A1 (en) * 2006-12-13 2008-06-19 Midha Kamal K Atomoxetine formulations and associated methods
CN106714790A (zh) * 2014-07-22 2017-05-24 托马斯·P·杜利 使用β肾上腺素能受体拮抗剂和毒蕈碱受体拮抗剂组合的治疗惊恐和焦虑症状的药物组合物和方法
AU2018260666B2 (en) * 2017-04-28 2022-07-21 The Brigham And Women's Hospital, Inc. Methods and compositions for treating sleep apnea

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523382A (ja) * 2000-02-24 2003-08-05 ファルマシア・アンド・アップジョン・カンパニー 新規な薬物の組合せ
JP2004525912A (ja) * 2001-03-06 2004-08-26 イーライ・リリー・アンド・カンパニー モノアミン取込の阻害剤
JP2012176958A (ja) * 2012-04-20 2012-09-13 Watson Pharmaceuticals Inc （ｒ）−オキシブチニンおよび（ｒ）−デスエチルオキシブチニンによる平滑筋機能亢進の処置

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"Atomoxetine and Oxybutynin in Obstructive Sleep Apnea (ATOSA) / Study NCT02908529 on Date: January 1", CLINICALTRIALS.GOV ARCHIVE [ONLINE], JPN6022046544, 17 January 2018 (2018-01-17), ISSN: 0005215343 *
J CLIN PHARMACOL, vol. 42, JPN6023028340, 2002, pages 1219 - 1227, ISSN: 0005215344 *
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 256, no. 2, JPN6022046545, 1991, pages 562 - 567, ISSN: 0005215345 *

Also Published As

Publication number Publication date
MX2024013184A (es) 2024-12-06
CA3117766A1 (en) 2020-05-07
EP3873454A1 (en) 2021-09-08
US20210401790A1 (en) 2021-12-30
WO2020091862A1 (en) 2020-05-07
MX2021004883A (es) 2021-08-05
JP2024088740A (ja) 2024-07-02
US20250325510A1 (en) 2025-10-23
CN112930179A (zh) 2021-06-08
KR20210084481A (ko) 2021-07-07
US20250114321A1 (en) 2025-04-10
AU2019370091A1 (en) 2021-05-27

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