JP2022503792A - メニン阻害剤を用いた血液悪性腫瘍の処置 - Google Patents

メニン阻害剤を用いた血液悪性腫瘍の処置 Download PDF

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JP2022503792A
JP2022503792A JP2021516496A JP2021516496A JP2022503792A JP 2022503792 A JP2022503792 A JP 2022503792A JP 2021516496 A JP2021516496 A JP 2021516496A JP 2021516496 A JP2021516496 A JP 2021516496A JP 2022503792 A JP2022503792 A JP 2022503792A
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gene
mutation
alkyl
mutations
optionally substituted
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JP2022503792A5 (https=
JPWO2020069027A5 (https=
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バローズ，フランシス
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Kura Oncology Inc
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Kura Oncology Inc
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2021516496A 2018-09-26 2019-09-25 メニン阻害剤を用いた血液悪性腫瘍の処置 Pending JP2022503792A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862736974P 2018-09-26 2018-09-26
US62/736,974 2018-09-26
PCT/US2019/053015 WO2020069027A1 (en) 2018-09-26 2019-09-25 Treatment of hematological malignancies with inhibitors of menin

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JP2022503792A true JP2022503792A (ja) 2022-01-12
JP2022503792A5 JP2022503792A5 (https=) 2022-10-04
JPWO2020069027A5 JPWO2020069027A5 (https=) 2022-10-04

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US (1) US20230095934A1 (https=)
EP (1) EP3856173A4 (https=)
JP (1) JP2022503792A (https=)
CN (1) CN113164443A (https=)
WO (1) WO2020069027A1 (https=)

Cited By (1)

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JP2023506530A (ja) * 2019-12-19 2023-02-16 ヤンセン ファーマシューティカ エヌ．ベー． 置換直鎖スピロ誘導体

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CA3058448A1 (en) 2017-03-31 2018-10-04 The Regents Of The University Of Michigan Piperidines as covalent menin inhibitors
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WO2019222677A1 (en) 2018-05-18 2019-11-21 Incyte Corporation Fused pyrimidine derivatives as a2a / a2b inhibitors
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TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
MX2022012471A (es) 2020-04-07 2022-11-30 Syndax Pharmaceuticals Inc Combinaciones de inhibidores de menina e inhibidores de cyp3a4 y métodos de uso de las mismas.
CN114478568A (zh) * 2020-10-27 2022-05-13 苏州优理生物医药科技有限公司 一种噻吩并嘧啶类化合物、包含其药物组合物及其应用
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EP4334320A1 (en) * 2021-05-08 2024-03-13 JANSSEN Pharmaceutica NV Substituted spiro derivatives
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WO2022257047A1 (en) * 2021-06-09 2022-12-15 Acerand Therapeutics (Hong Kong) Limited Diazaspirobicylic compounds as protein-protein interaction inhibitors and applications thereof
CA3220099A1 (en) 2021-06-17 2022-12-22 Wei Cai (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cance
MX2023015436A (es) 2021-06-26 2024-02-21 Cedilla Therapeutics Inc Inhibidores de cdk2 y metodos de uso de los mismos.
CN118234497A (zh) * 2021-12-15 2024-06-21 丹娜-法伯癌症研究所 通过破坏menin-mll表观遗传复合体靶向治疗胃肠道间质瘤(gist)
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