JP2022191962A - Blister container film for hiding content - Google Patents

Abstract

To provide a blister container film designed to enable manufacturing of a blister container which inhibits viewing of a stored pharmaceutical (oral medicine) but allows viewing of character information printed on a lid material in order to prevent an accident of the pharmaceutical accidentally swallowed together with the blister container.SOLUTION: A blister container film for hiding its contents is for manufacturing a blister container provided with a pocket part. The blister container film comprises a whitening layer. When the pocket part is formed in the blister container film, the whitening layer of the pocket part is whitened, the contents to be stored in the pocket part are at least partially hidden, while the parts other than the pocket part are not whitened.SELECTED DRAWING: Figure 1

Description

The present invention relates to a blister container film for concealing contents.

Orally administered pharmaceutical preparations (oral pharmaceuticals) such as tablets and capsules are often provided to patients while being packaged in blister containers. The blister container is formed by forming a pocket portion that is recessed on one side and protrudes on the opposite side in a blister container film made of a resin sheet, and after storing the contents (formulation) in the recessed portion of the pocket portion, the lid is attached. It is manufactured by joining materials.

As one aspect of such a blister container, a PTP (Press Through Package) is known, in which the contents can be taken out by piercing the lid material by crushing the pocket portion from the protruding side.

Many of the blister containers have a transparent blister container film, and even when the container is unopened, the text information printed on the contents and the lid can be seen visually. information can be notified.

However, in actual clinical practice, there have been reports of patients such as the elderly and infants swallowing the prescribed preparation together with the blister container. This is an accident that tends to occur, for example, when the blister container is separated into individual tablets and taken.

Since the blister container is transparent to X-rays, it is difficult to detect by X-ray inspection when the blister container is accidentally swallowed.

Under the circumstances as described above, techniques for preventing accidental ingestion of blister containers have been proposed.

For example, Patent Literature 1 describes a technique that makes it difficult to swallow by increasing the size of the blank portion from the pocket portion to the edge of the blister container.

Further, Patent Document 2 proposes a technique of double packaging a blister container with a card case made of paper, and explains that this prevents accidental ingestion.

Furthermore, in Non-Patent Document 1, when the formulation is housed in an aluminum blister container, the formulation cannot be visually recognized before opening, which reduces children's interest, thereby preventing accidental ingestion.

Registered Utility Model No. 3210345 JP 2015-009855 A

“Minutes of the 27th Pharmaceutical and Medical Device Countermeasures Subcommittee”, [online], May 12, 2015, Ministry of Health, Labor and Welfare, [searched on May 12, 2011], Internet <URL: https:// www.mhlw.go.jp/stf/shingi2/0000088865.html>

If the margin size of the blister container is increased, the amount of resin used will increase, and there is concern that the environmental load will increase.

Double packaging the blister container with a paper card case requires the use of different materials, which increases the cost and process load of manufacturing the blister container, and also increases the weight and bulk of the container. , and the burden of disposal increases.

Furthermore, in the aluminum blister container, text information printed on the cover material is hidden by the aluminum foil, which impairs the notification of the formulation information to the formulation user.

The present invention has been made in view of the above circumstances, and an object of the present invention is to prevent accidental ingestion of a formulation (oral drug) together with a blister container by concealing the formulation to be stored and providing a lid material. To provide a blister container film for concealing contents, capable of manufacturing a blister container in which character information printed on the film is visible.

The present invention is as follows.

<<Aspect 1>>
A blister container film for manufacturing a blister container with a pocket, comprising:
the blister container film comprises a whitening layer;
When the pocket portion is formed in the blister container film,
the whitening layer of the pocket portion whitens to at least partially conceal contents contained in the pocket; and
Parts other than the pocket part do not whiten,
Blister container film for concealing contents.
<<Aspect 2>>
A blister container film according to aspect 1, which is transparent or translucent.
<<Aspect 3>>
3. The blister container film according to aspect 1 or 2, wherein the whitening layer contains a resin having a sea-island microphase-separated structure composed of a continuous phase containing hard segments and a dispersed phase containing soft segments.
<<Aspect 4>>
the hard segment comprises a crystalline polyolefin, and the soft segment comprises an amorphous polyolefin;
A blister container film according to aspect 3.
<<Aspect 5>>
The blister container film according to aspect 3 or 4, wherein the resin having a sea-island microphase separation structure is block copolymer type polypropylene.
<<Aspect 6>>
The whitening layer according to any one of aspects 3 to 5, wherein the content of the resin having the sea-island microphase separation structure in the whitening layer is 80% by mass or more based on the total mass of the whitening layer. Blister container film.
<<Aspect 7>>
The blister container film according to any one of aspects 1 to 6, wherein the whitening layer has a thickness of 20 μm or more.
<<Aspect 8>>
The blister container film according to any one of aspects 1-7, further comprising a substrate layer.
<<Aspect 9>>
The base material layer is PVC (polyvinyl chloride), CPP (unstretched polypropylene), COC (norbornene-ethylene copolymer), PVC/PVDC (polyvinyl chloride/polyvinylidene chloride composite sheet), or PVC/PCTFE ( 9. A blister container film according to aspect 8, which is a layer of polyvinyl chloride/polychlorotrifluoroethylene composite sheet).
<<Aspect 10>>
The blister container film according to any one of aspects 1-9, further comprising a sealant layer.
<<Aspect 11>>
The blister container film according to any one of aspects 1-10, further comprising a functional layer selected from a moisture absorbing layer, an odor absorbing layer and an oxygen absorbing layer.
<<Aspect 12>>
A blister container formed from the blister container film of any one of aspects 1-11;
A content-filled blister container, comprising a content stored in the pocket portion of the blister container, and a lid adhered to the blister container.
<<Aspect 13>>
13. The filled blister container of aspect 12, wherein said content is an oral pharmaceutical product.

According to the present invention, in order to prevent accidental ingestion of a formulation (oral drug) together with the blister container, a blister container is manufactured in which the formulation contained therein is invisible and the character information printed on the lid material is visible. A blister container film for concealing contents is provided.

FIG. 1 is a photograph showing the appearance of pellets stored in the pocket of the blister container film obtained in Example 1-1. FIG. 2 is a photograph showing the appearance of pellets stored in the pocket of the blister container film obtained in Example 1-4. FIG. 3 is a photograph showing the appearance of pellets stored in the pocket portion of the blister container film obtained in Comparative Example 1-1.

《Blister Container Film》
The blister container film of the present invention is
A blister container film for manufacturing a blister container with a pocket, comprising:
The blister container film includes a whitening layer,
When the pocket portion is formed in the blister container film,
the whitening layer of the pocket portion whitens to at least partially conceal contents contained in the pocket; and
Parts other than the pocket part do not whiten,
It is a blister container film for concealing contents.

The blister container film of the present invention may further contain a substrate layer, a sealant layer, a functional layer, etc., in addition to the whitening layer.

<Whitening layer>
The whitening layer in the blister container film of the present invention is a layer having a whitening property such that when pocket portions are formed in the blister container film, the pocket portions formed are whitened, but portions other than the pocket portions are not whitened. be. The formation of pockets in the blister container film may be performed by a method commonly referred to as "pocketing". This "pocket forming" is a concept including "draw forming", "pneumatic forming", "pneumatic plug assist forming" and the like.

The whitening of the pockets of the blister container film visually blocks at least a portion, preferably all, of the contents contained in the pockets. This makes it difficult or impossible to see the contents through the blister container film when the blister container is unopened. As a result, it can be expected to prevent cases in which the contents of the blister container are mistakenly ingested, and cases in which a person other than the patient takes an interest in the preparation and takes it.

In order to whiten the whitening layer of the pocket portion to at least partially conceal the contents housed in the pocket, the whitened blister container film should conform to JIS K7362-1:1999 (all rays) and JIS K7136:2000. (Haze) may be 95% or more, 96% or more, 97% or more, 98% or more, 99% or more, or about 100%.

On the other hand, since the portion other than the pocket portion of the blister container film does not whiten, the character information printed on the lid material can be visually recognized through the blister container film, and the user can obtain information on the drug product that is the content. be able to.

The blister container film may be transparent or translucent in order to ensure visibility of portions other than the pocket portion. The blister container film being "transparent or translucent" means that the haze value measured in accordance with JIS K7361 (total light) and JIS K7136 (haze) is less than 95%, 94% or less, 93% or less, 92% or less, 91% or less, 90% or less, 89% or less, or 88% or less.

The whitening layer in the blister container film of the present invention may be a layer containing a resin or a layer composed of a resin.

The whitening property in which the pockets of the whitening layer whiten when the pockets are formed in the blister container film is considered to be due to the phenomenon of whitening when the resin is plastically deformed. Without wishing to be bound by theory, it is believed that the whitening associated with plastic deformation of the resin is due to the formation of craze structures in the resin.

The resin may form a craze structure, for example, when it is bent and plastically deformed. The craze structure is a structure composed of oriented chains that are oriented by stretching the resin molecular chains in the principal stress direction during plastic deformation, and minute voids that are generated along with the orientation of the molecular chains. The portion where the craze structure is formed appears white because it scatters light.

Even when a layered resin is subjected to pocket molding, a craze structure consisting of oriented chains and minute voids can be formed by stretching the molecular chains with the deformation direction for pocket formation as the principal stress direction. .

Due to such a mechanism, when the pocket portion is formed in the blister container film, the whitening layer contained in the blister container film in the pocket portion forms a craze structure and is presumed to be whitened.

The structure of the whitening layer is arbitrary as long as it has the whitening properties as described above. However, the whitening layer may contain, for example, a thermoplastic resin, and in particular, a resin having a sea-island microphase separation structure composed of a continuous phase containing hard segments and a dispersed phase containing soft segments (hereinafter referred to as Also referred to as "sea-island type whitening resin").

The whitening layer may consist only of the sea-island type whitening resin as described above, or may contain other optional components. The optional component may be, for example, a resin other than the sea-island type whitening resin, a filler, and the like.

In addition to the above, the whitening layer may further contain additives commonly used in resins, such as colorants, antioxidants, clarifying agents, plasticizers and antistatic agents.

Also, the whitening layer may have a reinforcing layer on one side or both sides.

(Sea-island whitening resin)
The sea-island whitening resin contained in the whitening layer of the blister container film of the present invention is a resin having a sea-island microphase-separated structure composed of a continuous phase containing hard segments and a dispersed phase containing soft segments.

The hard segment may comprise a crystalline polyolefin. Crystalline polyolefins may be, for example, polypropylene, high density polyethylene, and the like.

Soft segments may include, for example, amorphous polyolefins. Amorphous polyolefins may be, for example, low density polyethylene, linear low density polyethylene, ethylene-propylene rubber, ethylene-propylene-diene rubber, hydrogenated butadiene rubber, hydrogenated isoprene rubber, and the like.

The islands-in-the-sea whitening resin may be a copolymer in which the hard and soft segments are covalently bonded, or a blend in which the hard and soft segments are present as separate polymeric molecules. can be In addition, a compatibilizer may be further included for controlling the interfacial tension between the continuous phase containing hard segments and the dispersed phase containing soft segments to adjust the particle size of the dispersed phase. The compatibilizer is, for example, a block copolymer composed of a block having a polymer chain of the same type as the resin constituting the hard segment and a block having a polymer chain of the same type as the resin constituting the soft segment. , graft copolymers, and the like.

The islands-in-the-sea type whitening resin may specifically be, for example, a block copolymer type polypropylene (block PP).

Block PP has a structure having a dispersed phase containing polyethylene as a soft segment in a continuous phase containing polypropylene as a hard segment, and an ethylene-propylene rubber as a compatibilizer at the interface between the continuous phase and the dispersed phase. can be

Block PP is easy to form and mold, has the advantage of high heat resistance, and has a high affinity with unstretched polypropylene (CPP) used as a general-purpose PTP sheet (base material). Also, when block PP and CPP base materials are used in combination, they can be used as monomaterials in consideration of recyclability.

For the above reasons, block PP is considered to be particularly suitable as the islands-in-the-sea type whitening resin in the present invention.

The content of the sea-island type whitening resin in the whitening layer of the blister container film of the present invention is 60% by mass or more, 70% by mass or more, 80% by mass or more, 82% by mass or more, 85% by mass or more, relative to the total mass of the whitening layer. It may be at least 90% by mass, at least 90% by mass, at least 98% by mass, at least 99% by mass, or at least 100% by mass. When the whitening layer contains the sea-island type whitening resin in such a ratio, the whitening property of the whitening layer is favorably expressed.

(Resins other than sea-island whitening resins)
The whitening layer of the blister container film of the present invention may contain a resin other than the sea-island type whitening resin.

The resin other than the islands-in-the-sea whitening resin may be a thermoplastic resin, such as low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene, high density polyethylene (HDPE), metallocene catalyzed Polyethylene, propylene homopolymer, propylene-ethylene block copolymer, propylene-ethylene random copolymer, metallocene-catalyzed polypropylene, chlorinated polypropylene, polymethylpentene, saturated polyester, ethylene-acrylic acid copolymer (EAA), ethylene - methacrylic acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMAC), ethylene-vinyl acetate copolymer (EVA), ionomer, carboxylic acid-modified polyethylene, Carboxylic acid-modified polypropylene, carboxylic acid-modified EVA, polyvinyl chloride (PVC), polystyrene, polycarbonate, polyamide, thermoplastic elastomer and the like can be mentioned, and one or a combination of two or more selected from these can be used. good.

The content ratio of the resin other than the sea-island type whitening resin in the whitening layer of the blister container film of the present invention is 20% by mass or less, 18% by mass or less, 15% by mass or less, and 13% by mass with respect to the total mass of the whitening layer. 10% by mass or less, 8% by mass or less, 5% by mass or less, 2% by mass or less, or 1% by mass or less, or 0% by mass or less.

(filler)
The whitening layer of the blister container film of the present invention may contain fillers.

The filler may not impair the transparency or translucency of the blister container film in areas other than the pockets. Specific examples of the filler include molecular sieves (hydrophilic zeolites) 3A, 4A, 5A, 13X, silica, porous silica, zeolite, calcium oxide, cerium oxide, etc., and selected from these. It may be one type or a combination of two or more types.

The content of the filler in the whitening layer of the blister container film of the present invention is 10% by mass or less, 5% by mass or less, 3% by mass or less, 1% by mass or less, and 0.5% by mass with respect to the total mass of the whitening layer. % or less, 0.1 mass % or less, 0.05 mass % or less, or 0.01 mass % or less, or 0 mass %.

(Optional function of whitening layer)
As described above, the whitening layer is a layer having a whitening property such that when pocket portions are formed in the blister container film, the pockets formed by extrusion are whitened, but portions other than the pocket portions are not whitened. be.

However, the islands-in-the-sea type whitening resin contained in the whitening layer preferably exhibits thermoplasticity, and the hard segment imparts moderate hardness at room temperature. Therefore, the whitening layer can have the function of exhibiting the whitening properties described above and also the function of a base layer that imparts pocket formability to the blister container film. A base material layer is mentioned later.

Further, the islands-in-the-sea type whitening resin contained in the whitening layer preferably exhibits thermoplasticity. Therefore, the whitening layer can function as a sealant layer for heat-sealing the blister container film to the lid material in addition to the function of exhibiting the whitening properties described above. The sealant layer will be described later.

(Layer structure of whitening layer)
The whitening layer may have a single layer structure composed of one layer containing the resin as described above, or may have a multilayer structure composed of two or more layers each containing the resin as described above. When the whitening layer is of multilayer construction, the thickness of the whitening layer described below should be understood as the total thickness of the multiple layers.
(Thickness of whitening layer)

The thickness of the whitening layer of the blister container film of the present invention may be 10 μm or more. When the thickness of the whitening layer is 10 μm or more, whitening properties are favorably expressed. The thickness of the whitening layer may be 20 μm or more, 30 μm or more, 40 μm or more, 50 μm or more, 60 μm or more, or 70 μm or more, and may be 300 μm or less, 280 μm or less, 260 μm or less, 240 μm or less, 220 μm or less, or 200 μm or less. you can

When the blister container film of the present invention has a sealant layer in addition to the whitening layer, it is convenient to consider it in two ways depending on whether the blister container film further has a substrate layer.

When the blister container film of the present invention has a sealant layer and a base layer, which will be described later, the whitening layer does not need to function as a base layer. In this case, the thickness of the whitening layer may be 20 μm or more, 30 μm or more, 40 μm or more, 50 μm or more, 60 μm or more, or 70 μm or more, 100 μm or less, 90 μm or less, 80 μm or less, 70 μm or less, 60 μm or less, 50 μm or less Alternatively, it may be 40 μm or less.

On the other hand, when the blister container film of the present invention has a sealant layer but does not have a base layer, it is necessary for the whitening layer to exhibit the function of the base layer. In this case, the thickness of the whitening layer may be 100 μm or more, 120 μm or more, 140 μm or more, 160 μm or more, or 180 μm or more, and may be 300 μm or less, 280 μm or less, 260 μm or less, 240 μm or less, 220 μm or less, or 200 μm or less. good.

Next, when the blister container film of the present invention does not have a sealant layer, whether or not the blister container film further has a base layer, and whether or not the whitening layer needs to exhibit the function of the sealant layer. It is convenient to divide into the following three categories according to .
(1) When the blister container film does not have a sealant layer and has a base layer, and the whitening layer does not need to exhibit the function of the sealant layer (2) When the blister container film has a sealant layer (3) When the blister container film does not have a base layer

When the blister container film of the present invention does not have a sealant layer and the whitening layer does not exhibit the function of the sealant layer, the bonding with the lid material during the manufacture of the blister container is If so, it can be by heat sealing, or it could be by using an adhesive.

(1) When the blister container film does not have a sealant layer but has a base layer, and the whitening layer does not need to exhibit the function of the sealant layer. 30 μm or more, 40 μm or more, 50 μm or more, 60 μm or more, or 70 μm or more, and may be 170 μm or less, 150 μm or less, 130 μm or less, 100 μm or less, 90 μm or less, 80 μm or less, 70 μm or less, or 60 μm or less. It's okay.

(2) When the blister container film does not have a sealant layer but has a base layer, and the whitening layer is required to exhibit the function of the sealant layer. It may be 140 μm or more, 160 μm or more, 180 μm or more, 200 μm or more, or 220 μm or more, and may be 300 μm or less, 280 μm or less, 260 μm or less, 240 μm or less, 220 μm or less, or 200 μm or less.

(3) When the blister container film does not have a base layer In this case, regardless of whether or not the whitening layer needs to function as a sealant layer, it is necessary for the whitening layer to function at least as a base layer. There is The thickness of the whitening layer at this time may be 120 μm or more, 140 μm or more, 160 μm or more, 180 μm or more, 200 μm or more, or 220 μm or more, and may be 300 μm or less, 280 μm or less, 260 μm or less, 240 μm or less, 220 μm or less, or 200 μm or less. can be

In addition, the whitening layer may have a reinforcing layer on one side or both sides, as described later. When the whitening layer has a reinforcing layer, the thickness of the whitening layer does not include the thickness of the reinforcing layer.

(reinforcing layer)
The whitening layer may have a reinforcing layer on one or both sides.

The reinforcing layer suppresses the formation of linear whitening marks on the whitening layer when the blister container film is scratched or bent during the production, storage, etc. of the blister container film and the container to which it is applied. It has the function to Therefore, unlike the whitening layer, the reinforcing layer may be a layer composed of a material that does not cause whitening.

Any material can be used for the reinforcing layer as long as it can exhibit the above functions. However, in order to ensure ease of processing and handling, thermoplastic resins can be used, and it is particularly preferred to use thermoplastic resins having flexibility. As described above, the reinforcing layer does not need to whiten, so the thermoplastic resin forming the reinforcing layer may be a thermoplastic resin that does not whiten due to abrasion, bending, pocket formation, or the like.

Therefore, as the thermoplastic resin constituting the reinforcing layer, it is preferable not to employ a thermoplastic resin having a sea-island microphase separation structure composed of a continuous phase containing hard segments and a dispersed phase containing soft segments.

The thermoplastic resin used as the material of the reinforcing layer may be, for example, polyethylene, polypropylene, polyester, acrylic resin, olefin-acrylic monomer copolymer, other organic polymers, and the like. The polyethylene can be, for example, linear low density polyethylene (LLDPE), low density polyethylene (LDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), and the like. The polypropylene may be, for example, random polypropylene, homopolypropylene, or the like. The polyester may be, for example, polyethylene terephthalate (PET) or the like. The acrylic resin may be, for example, polymethyl methacrylate or the like. The olefin-acrylic monomer copolymer can be, for example, ethylene-methyl acrylate copolymer (EMAC), ethylene-methyl methacrylate copolymer (EMMA), and the like. Other organic polymers may be, for example, polyvinyl chloride, ethylene-vinyl acetate copolymer (EVA), elastomers, and the like.

On the other hand, it is preferable to use polyethylene, polypropylene, polyester, or the like as the material of the reinforcing layer, because the heat resistance (heat-resistant shape retention property) of the blister container film is increased, and the film-forming properties and moldability are improved.

The thickness of the reinforcing layer may be, for example, 1 μm or more, 3 μm or more, 5 μm or more, 7 μm or more, or 10 μm or more, in order to impart appropriate workability, for example, 30 μm or less, 25 μm or less, 20 μm or less, or 15 μm. may be:

<Base material layer>
The blister container film of the present invention may have a substrate layer. The base layer has the function of imparting shape retention to the blister container film when it is made into a blister container, a function as a protective layer against impact from the outside of the container, and the function of imparting pocket formability to the blister container film. have.

The substrate layer may be a layer consisting of or including a film of thermoplastic resin to impart pocket formability to the blister container film. Thermoplastic resins include, for example, polyvinyl chloride (PVC), polypropylene (PP), polyethylene (PE), poly-4-methylpentene (PMP), norbornene-ethylene copolymer (COC), styrene-acrylonitrile copolymer (SAN), acrylonitrile-butadiene-styrene copolymer (ABS), polychlorotrifluoroethylene (PCTFE), amorphous polyethylene terephthalate (A-PET), glycol-modified polyethylene terephthalate (G-PET), and the like. .

The thermoplastic resin film constituting the substrate layer may be unstretched or stretched. However, as the thermoplastic resin film, a non-stretched film may be used because it has good moldability and excellent sealability with the lid member. Unstretched polypropylene film (CPP), unstretched A-PET, and unstretched G-PET are preferred, and unstretched CPP may be used in particular.

The substrate layer may have a barrier layer. The barrier layer has a function of suppressing permeation of oxygen, water vapor, etc., or a function of suppressing dissipation of medicinal ingredients, fragrance, etc. of the contents, thereby suppressing deterioration of the contents of the blister container.

The barrier layer may be present on one or both sides of the substrate layer, in particular on one side of the substrate layer.

The barrier layer may be, for example, a layer of polyvinylidene chloride (PVDC), polychlorotrifluoroethylene (PCTFE), norbornene-ethylene copolymer (COC), unoriented polypropylene (CPP), or the like. In addition, in the blister container film of the present invention, it is desired that character information and the like printed on the cover material can be visually recognized through a portion other than the pocket portion. Therefore, it is not preferable to use an opaque material (eg, aluminum foil, etc.) as the barrier layer of the blister container film of the present invention.

The barrier layer composed of the above materials may be coated or attached to the main body of the substrate layer.

The substrate layer is, in particular, polyvinyl chloride (PVC), unstretched polypropylene (CPP), norbornene-ethylene copolymer (COC), polyvinyl chloride/polyvinylidene chloride composite sheet (PVC/PVDC), polyvinyl chloride/ It may be a layer of polychlorotrifluoroethylene composite sheet (PVC/PCTFE).

In order to ensure the barrier function of the barrier layer, the thickness of the barrier layer may be, for example, 5 μm or more, 10 μm or more, 15 μm or more, 20 μm or more, 25 μm or more, 30 μm or more, 35 μm or more, or 40 μm or more. For example, it may be 100 μm or less, 80 μm or less, 60 μm or less, 50 μm or less, or 40 μm or less so that the thickness is not excessively thick.

From the viewpoint of ensuring shape retention, defensiveness, pocket formation, etc., the thickness of the base layer may be, for example, 150 μm or more, 160 μm or more, 180 μm or more, 200 μm or more, 220 μm or more, or 240 μm or more. On the other hand, from the viewpoint of ensuring push-through properties, reducing costs, etc., the thickness of the base material layer is, for example, 400 μm or less, 350 μm or less, 300 μm or less, 280 μm or less, or 260 μm or less so that the blister container film is not excessively thick. , or 240 μm or less.

When the substrate layer has a barrier layer, the thickness of the substrate layer includes the thickness of the barrier layer.

<Sealant layer>
The blister container film of the present invention may have a sealant layer. The sealant layer has a function of imparting sealant properties to the blister container film and enabling adhesion between the blister container film and the lid material.

The sealant layer may be a thermoplastic to allow heat sealing. Thermoplastic resins include, for example, polyethylene (PE), polypropylene (PP, especially CPP), polyvinyl chloride (PVC), ethylene-methyl methacrylate copolymer (EMMA), ethylene-methyl acrylate (EMA) copolymer ), ethylene-vinyl acetate copolymer (EVA) and the like.

The thickness of the sealant layer may be, for example, 20 μm or more, 30 μm or more, 40 μm or more, 50 μm or more, 60 μm or more, or 70 μm or more from the viewpoint of ensuring reliable sealing performance, and the thickness of the blister container film should not be excessively thick. For example, it may be 170 μm or less, 150 μm or less, 130 μm or less, 100 μm or less, 90 μm or less, 80 μm or less, 70 μm or less, or 60 μm or less.

<Function layer>
The blister container film of the present invention may have a functional layer. This functional layer may be, for example, a moisture absorbing layer, an odor absorbing layer, an oxygen absorbing layer, or the like.

The functional layer may be, for example, a layer composed of a composition containing functional particles and a matrix resin. The functional particles may be, for example, hydrophilic zeolite (hygroscopic), hydrophobic zeolite (odor absorbing), calcium oxide (hygroscopic), cerium oxide (oxygen absorbing), and the like. The matrix resin is, for example, polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), ethylene-methyl methacrylate copolymer (EMMA), ethylene-methyl acrylate (EMA) copolymer), ethylene- It may be one or more selected from vinyl acetate copolymers (EVA) and the like.

<Layer structure>
The blister container film of the present invention includes a whitening layer. The blister container film of the present invention may further have one or more layers selected from a base layer, a sealant layer, and a functional layer along with the whitening layer.

The blister container film of the present invention may consist of only the whitening layer. In this case, the whitening layer may have the functions of the base material layer and the sealant layer as well as the function of the whitening layer.

The blister container film of the present invention may consist of a whitening layer and a base layer. In this case, the whitening layer may have the function of the whitening layer as well as the function of the sealant layer. A blister container film composed of a whitening layer and a substrate layer is used so that the whitening layer is in contact with the contents.

The blister container film of the present invention may consist of a whitening layer and a sealant layer. In this case, the whitening layer may have the function of the base layer as well as the function of the whitening layer. A blister container film composed of a whitening layer and a sealant layer may be used with the sealant layer in contact with the contents.

The blister container film of the present invention may consist of a whitening layer, a substrate layer and a sealant layer. In this case, the whitening layer only needs to have a function as a whitening layer. However, it is not prohibited for the whitening layer to have other functions.

A blister container film composed of a whitening layer, a base layer, and a sealant layer is laminated in the order of the base layer, the whitening layer, and the sealant layer, or in the order of the whitening layer, the base layer, and the sealant layer. It may be a film, and is preferably a film in which a substrate layer, a whitening layer and a sealant layer are laminated in this order, or a whitening layer and a substrate layer are laminated in this order.

A blister container film composed of a whitening layer, a substrate layer, and a sealant layer may be used with the sealant layer in contact with the contents.

When the blister container film of the present invention has a base layer and a sealant layer, the base layer and the sealant layer may be made of the same material, or may be made of different materials.

When the blister container film of the present invention has a functional layer, the functional layer may be placed at any position.

However, when the blister container film has a sealant layer, the sealant layer is the outermost layer, and the functional layer is positioned so that the blister container film can be used so that the sealant layer is in contact with the contents. you can When the blister container film has a substrate layer and a sealant layer, the sealant layer may be the outermost layer, and the functional layer may be arranged so that the substrate layer is also the outermost layer.

On the other hand, when the blister container film does not have a sealant layer, the whitening layer is the outermost layer, and the functional layer is placed at a position where the blister container film can be used so that the whitening layer is in contact with the contents. can be placed.

<<Method for producing blister container film>>
(1) When the blister container film has only a whitening layer When the blister container film has only a whitening layer, the whitening layer may be produced by forming a sheet from a desired resin, This whitening layer may be used as the blister container film of the present invention. When the resin is formed into a sheet-like film, an appropriate method such as a T-die method, calendar method, casting method, press molding method, injection molding method, or the like may be employed.

(2) When the blister container film has a whitening layer and other layers When the blister container film has a whitening layer and other layers, the whitening layer material resin and the other layer material resin are used to co-extrude inflation A multi-layer blister container film may be manufactured by a method such as a co-extrusion T-die method.

Alternatively, a sheet-like whitening layer and another sheet-like layer, which are separately manufactured using the material resin of the whitening layer and the material resin of the other layer, are laminated by an appropriate method to obtain a multilayer structure. A blister container film may be produced.

The method for laminating multiple layers may be, for example, heat fusion, lamination, or the like. Heat-sealing may be carried out using an appropriate heating device such as a hot roll or hot press. Lamination may be performed, for example, by a dry lamination method, an extrusion lamination method, a hot melt method, or the like. When a multilayer blister container film is produced by lamination, the blister container film of the present invention will have a layer of laminating adhesive. There is no prohibition on the blister container film of the present invention having a layer of laminating adhesive.

(3) When the Blister Container Film Has a Multi-Layered Whitening Layer As described above, the whitening layer of the blister container film of the present invention may have a multi-layer structure of two or more layers. A blister container film having such a multi-layered whitening layer may be produced, for example, by a method according to the above method (2).

<< blister container >>
Further according to the present invention there is provided a blister container formed from the blister container film of the present invention.

The blister container of the present invention is
A blister container formed from the blister container film of the present invention; and a lid material adhered to the blister container.

The blister container of the present invention is particularly
a blister container formed from the blister container film of the present invention;
The blister container may be a content-filled blister container having a content housed in the pocket portion of the blister container and a lid adhered to the blister container.

In the blister container of the present invention, a pocket portion is formed in the blister container film.

When forming the pocket portions in the blister container film, a method generally called "pocketing" may be used. When pocket portions are formed in the blister container film by "pocket molding", the pocket portions turn white and develop tablet concealing properties. On the other hand, portions other than the pocket portion are not whitened, and the visibility of character information and the like printed on the cover material and the like is maintained.

The lid material may be appropriately selected and used from those known as lid materials for blister containers. The lid material may be, for example, a lid material composed of a single layer of metal foil, a lid material composed of a laminate of metal foil and a sealant layer, or the like. The metal foil in the lid may be, for example, an aluminum container.

Textual information, design, etc. regarding the contents may be printed on the surface of the lid member on the blister container film side.

Then, the blister container is obtained by attaching the cover material after the contents are stored in the pocket portion of the blister container film. Adhesion between the blister container film and the lid material may be performed, for example, by heat sealing, or may be performed by an adhesive.

The contents stored in the pocket may be a solid that can be taken out by piercing the lid material by squeezing the pocket from its projecting side.

The contents may be selected from pharmaceuticals, foods, cosmetics, sanitary products, medical devices, medical instruments, electronic components, and the like. However, the blister container of the present invention has the effect of at least partially concealing the contents by the whitened pocket portion, thereby suppressing accidental ingestion. The content may be an oral pharmaceutical product.

Materials used in the following examples and comparative examples are as follows.
《Bleached layer》
Block PP: Block polymer type polypropylene, manufactured by Japan Polypro Co., Ltd., product name "Novatec PP BC6DRF"

<<Base material layer>>
PVC: Polyvinyl chloride sheet, manufactured by Mitsubishi Chemical Corporation, product name "Vinyfoil C-0416"
CPP: unstretched polypropylene film, manufactured by Mitsubishi Chemical Corporation, product name "Super Foil E Series"
COC: norbornene-ethylene copolymer, manufactured by Polyplastics Co., Ltd., product name "TOPAS 807F-600"
PVC/PVDC: Polyvinyl chloride/polyvinylidene chloride composite sheet, manufactured by Mitsubishi Chemical Corporation, product name “Vinyfoil F Series”
PVC/PCTFE: Polyvinyl chloride/polychlorotrifluoroethylene composite sheet, manufactured by Sumitomo Bakelite Co., Ltd., product name "Sumilite FCL-1133"

《Reinforcement layer》
Homo PP: Homo polypropylene, manufactured by SunAllomer Co., Ltd., product name "SunAllomer PC412A"
LLDPE: Linear low-density polyethylene, manufactured by Prime Polymer Co., Ltd., product name "Evolue SP2520"

《Material for moisture absorption layer》
Hydrophilic zeolite: Molecular sieve 3A manufactured by Union Showa Co., Ltd.
EMAA: ethylene-methacrylic acid copolymer, manufactured by Mitsui Dow Polychemicals Co., Ltd., product name "Nucrel AN42115C"

I. Blister container film consisting of a single whitening layer «Example 1-1»
(1) Fabrication of blister container film Using a T-die-cast film forming machine, block PP was formed into a sheet having a thickness of 200 µm, which was used as a blister container film consisting of a single whitening layer.

(2) Formation of Pocket Using a blister molding machine, a pocket having a diameter of 15 mm and a depth of 3 mm was formed in the blister container film obtained above by pocket molding to prepare an evaluation sample.

(3) Evaluation A sample immediately after pocket formation and a sample after exposure to an environment at a temperature of 23°C and a relative humidity of 50% RH for 7 days after pocket formation were examined for the tablet concealability of the pocket portion and the other portion, respectively. was evaluated for printed character visibility. Specifically, the following evaluations were performed.

(Tablet concealability)
The tablet concealability of the pocket portion was evaluated by inserting an elliptical cylindrical white pellet with a major diameter of 4 mm, a minor diameter of 3 mm, and a height of 2.5 mm as a tablet substitute into the pocket portion of the blister container film, with the protruding part of the pocket facing upward. and placed it on the table. In this state, it was examined whether or not the pellets in the pockets were visually visible, and evaluation was made according to the following criteria. Table 1 shows the evaluation results. FIG. 1 shows a photograph taken from above of the pocket portion containing the pellets.

A: When the pellets were not visible at all due to the whitening of the sheet B: When the pellets were hardly visible due to the whitening of the sheet C: When the sheet was whitened but the pellets were visible D: Sheet did not bleach

<Printed Character Visibility>
The visibility of printed characters in portions other than the pocket portion was evaluated as follows. 11 point and 4 point black characters were printed on A4 size white PPC paper with standard settings. The blister container film was placed on the paper after printing the black characters so that the part other than the pocket part was on the printed characters. In this state, it was examined whether or not the printed characters could be read, and evaluation was made according to the following criteria.

A: When 11-point and 4-point printed characters are clearly visible B: When 11-point printed characters can be visually distinguished, but 4-point printed characters cannot be visually distinguished C: 11-point and 4-point printed characters When 4-point printed characters cannot be visually distinguished

<<Example 1-2>>
A single whitening layer blister container film was produced in the same manner as in Example 1-1, except that the thickness of the block PP sheet was 180 μm. Pockets were formed in the obtained blister container film in the same manner as in Example 1, and tablet concealability and visibility of printed characters were evaluated. Table 1 shows the evaluation results.

<<Example 1-3>>
Block PP and LLDPE were dry-blended at a mass ratio of 90:10, and formed into a sheet with a thickness of 180 μm using a T die-cast film-forming machine, which was used as a whitening layer single-layer blister container film. . Pockets were formed in the obtained blister container film in the same manner as in Example 1, and tablet concealability and visibility of printed characters were evaluated. Table 1 shows the evaluation results.

<<Example 1-4, and Comparative Examples 1-1 and 1-2>>
A single whitening layer blister container film was produced and evaluated in the same manner as in Example 1-3, except that the blend ratio (mass ratio) of block PP and LLDPE was changed as shown in Table 1. Table 1 shows the evaluation results. 2 and 3 show photographs taken from above of the pockets containing the pellets of the blister container films obtained in Example 1-4 and Comparative Example 1-1, respectively.

<<Comparative Example 1-3>>
A PVC sheet with a thickness of 200 μm was used as the blister container film. Pockets were formed on this blister container film in the same manner as in Example 1-1, and the tablet concealability and visibility of printed characters were evaluated. Table 1 shows the evaluation results.

<<Comparative Examples 1-4 to 1-7>>
Evaluation was performed in the same manner as in Example 1-1, except that the sheet or composite sheet shown in Table 1 was used as the blister container film. Table 1 shows the evaluation results.

In Comparative Examples 1-4 and 1-5 using composite sheets as blister container films, pockets were formed with PVC on the outside (convex side of the pocket) and PVDC or PCTFE on the inside (concave side of the pocket).

In Comparative Examples 1-3 to 1-7, which used the materials of the prior art as the blister container film, both 11-point and 4-point printed characters on the paper were clearly visible through the portion other than the pocket portion. Although the letter visibility was "A", the pocket portion was not whitened, the pellets in the pocket were clearly visible, and the tablet concealability was "D".

In addition, in Comparative Examples 1-1 and 1-2 having a whitening layer containing block PP in the blister container film, but the content of block PP in the whitening layer was less than 80% by mass, the paper was passed through the portion other than the pocket portion. Both the upper 11 point and 4 point printed letters were clearly visible and the printed letter visibility was "A". The pocket part was slightly whitened, but the pellet in the pocket was visible, and the tablet hiding property was "C".

On the other hand, in Examples 1-1 to 1-4, in which the blister container film contains a whitening layer containing 80% by mass or more of block PP, the printed character visibility is "A" and the pocket portion was whitened and the pellets were completely or almost invisible, and the tablet hiding property was "A" or "B".

II. Evaluation of Haze Value Table 2 shows the haze values before and after pocket formation, which were measured for the blister container film obtained in Example 1-1 above. In addition, the haze value after pocket formation and the blister containers obtained in Comparative Examples 1-3 and 1-6 were measured for the blister container films obtained in Example 1-4 and Comparative Example 1-1. Table 2 also shows the haze value measured on the film before pocket formation.

The above haze values were measured according to JIS K7362-1:1999 (total light) and JIS K7136:2000 (haze).

III. Blister container film having a base layer and a whitening layer <<Example 2-1>>
(1) Production of blister container film Block PP was formed into a sheet having a thickness of 70 μm using a T die-cast film forming machine. A blister container film having a base layer and a whitening layer is obtained by laminating the obtained block PP sheet and a PVC sheet having a thickness of 200 μm as a base layer through an adhesive layer by dry lamination. used as

(2) Formation and Evaluation of Pockets Pockets were formed in the obtained blister container film in the same manner as in Example 1-1, and the tablet concealability and visibility of printed characters were evaluated. Table 3 shows the evaluation results.

<<Examples 2-2 to 2-11>>
A blister container having a base layer and a whitening layer was prepared in the same manner as in Example 2-1, except that the type and thickness of the base layer and the thickness of the block PP sheet were changed as shown in Table 3. Films were produced and evaluated. Table 3 shows the evaluation results.

In Examples 2-4 to 2-7 in which the composite sheet was used as the base material layer, PVC was used as the outermost layer, and PVDC or PCTFE was used as the whitening layer side.

<<Example 2-12>>
(1) Production of blister container film In this example, a test was conducted on a blister container film having a substrate layer and a whitening layer having reinforcing layers (homo PP layers) on both sides. By three-layer co-extrusion using an inflation film-forming machine, a three-layered film of homo PP (thickness 10 μm) / block PP (20 μm) / homo PP (thickness 10 μm) is formed, and this is used as a whitening layer. board.

A PVC sheet having a thickness of 200 μm as a base layer and the three-layered whitening layer were laminated by dry lamination via an adhesive layer to form a blister container film.

(2) Pocket Formation and Evaluation For the obtained blister container film, the same method as in Example 1-1 was used to set the base layer to the outside (convex side of the pocket) and the whitening layer to the inside (concave side of the pocket). As such, a pocket was formed to evaluate tablet concealability and visibility of printed characters. Table 3 shows the evaluation results.

<<Comparative Example 2-1>>
A blister container film having a substrate layer and a whitening layer was produced and evaluated in the same manner as in Example 2-12, except that the thickness of the block PP sheet in the three-layered whitening layer was 10 μm. Table 3 shows the evaluation results.

<<Comparative Example 2-2>>
(1) Production of Blister Container Film Using a T-die-cast film forming machine, homo-PP was formed into a sheet having a thickness of 60 μm. The obtained sheet-like block PP and a PVC sheet having a thickness of 200 μm as a base layer were adhered together by dry lamination via an adhesive layer, and used as a blister container film.

(2) Formation and Evaluation of Pockets Pockets were formed in the obtained blister container film in the same manner as in Example 1-1, and the tablet concealability and visibility of printed characters were evaluated. Table 3 shows the evaluation results.

In the blister container film having a base material layer and a whitening layer, in Examples 2-1 to 2-12 in which the whitening layer includes a block PP sheet having a thickness of 20 μm or more, the characters printed on the sheet are passed through a portion other than the pocket portion. It can be clearly seen with the naked eye, the visibility of the printed characters is "A", the pocket part is whitened and the pellet is completely or almost invisible, and the tablet hiding property is "A" or "B". rice field.
Met.

On the other hand, in Comparative Example 2-1, in which the whitening layer contained a block PP sheet with a thickness of less than 20 μm, the pocket part was slightly whitened, but the pellets in the pocket were visible with the naked eye. Concealability was "C".

Further, in Comparative Example 2-2 using homo PP instead of block PP for the whitening layer, even when the thickness of the homo PP sheet was increased to 60 μm, the pockets did not whiten, and the pellets in the pockets was clearly visible, and the tablet hiding property was "D".

IV. Blister container film having a substrate layer, a whitening layer, and a zeolite-containing moisture absorption layer <<Example 3-1>>
In this example, in a blister container film having a zeolite-containing moisture-absorbing layer, the ability of the whitening layer to hide the hygroscopic transparency of the moisture-absorbing layer was investigated. Specifically, a blister container film having a base layer, a whitening layer, and a zeolite-containing hygroscopic layer with reinforcing layers (LLDPE layers) on both sides was tested.

(1) Fabrication of Blister Container Film The composition of the zeolite-containing moisture-absorbing layer was 53% by mass of hydrophilic zeolite and 47% by mass of EMAA. Using a dry blend of hydrophilic zeolite and EMAA (mass ratio 53:47) and LLDPE, LLDPE (thickness 10 μm) / zeolite-containing moisture absorption layer (60 μm) by three-layer co-extrusion using an injection film-forming machine /LLDPE (thickness: 10 μm) was prepared.

A whitening layer was formed by forming a film of block PP into a sheet having a thickness of 40 μm using a T die-cast film forming machine.

A PVC/PVDC composite sheet composed of PVC with a thickness of 150 μm and PVDC with a thickness of 30 μm was used as the base layer.

A PVC/PVDC composite sheet as a base material or the like, the whitening layer obtained above, and the three-layer moisture absorbing layer obtained above were laminated in this order by dry lamination via an adhesive layer. was used as a blister container film. Here, the PVC/PVDC composite sheet used PVC as the outermost layer and PVDC as the whitening layer side.

(2) Pocket Formation and Evaluation For the obtained blister container film, the same method as in Example 1-1 was used to set the base layer to the outside (convex side of the pocket) and the whitening layer to the inside (concave side of the pocket). As such, a pocket was formed to evaluate the tablet concealability. Table 4 shows the evaluation results.

<<Example 3-2>>
A blister container film was produced and evaluated in the same manner as in Example 3-1, except that the structures of the whitening layer and the zeolite-containing moisture-absorbing layer were changed as shown in Table 4. Table 4 shows the evaluation results.

<<Comparative Example 3-1>>
A blister container film was produced and evaluated in the same manner as in Example 3-1, except that the whitening layer was not used. Table 4 shows the evaluation results.

In Comparative Example 3-1 having a zeolite-containing moisture-absorbing layer and no whitening layer, the pellets in the pockets could not be visually seen immediately after the pockets were formed, and the tablet hiding property was "A". . However, after exposure to an environment of 23° C. and 50% RH for 7 days after forming the pockets, the pellets in the pockets could be visually observed and the tablet hiding property was "D". This is probably because the zeolite in the hygroscopic layer became transparent due to moisture absorption.

However, in Examples 3-1 and 3-2, which have a whitening layer together with a zeolite-containing moisture-absorbing layer, both immediately after pocket formation and after exposure for 7 days in an environment with a temperature of 23 ° C. and a relative humidity of 50% RH , the pellet in the pocket could not be seen at all with the naked eye, and the tablet hiding property was "A". Also in these examples, it is considered that the zeolite-containing moisture-absorbing layer became transparent after being exposed for 7 days in an environment with a temperature of 23° C. and a relative humidity of 50% RH. However, the whitening layer concealed the transparency of the hygroscopic layer, and the evaluation of the tablet hiding property was maintained at "A".

Claims (13)

A blister container film for manufacturing a blister container with a pocket, comprising:
the blister container film comprises a whitening layer;
When the pocket portion is formed in the blister container film,
the whitening layer of the pocket portion whitens to at least partially conceal contents contained in the pocket; and
Parts other than the pocket part do not whiten,
Blister container film for concealing contents. 2. The blister container film of claim 1, which is transparent or translucent. The blister container film according to claim 1 or 2, wherein the whitening layer contains a resin having a sea-island microphase-separated structure composed of a continuous phase containing hard segments and a dispersed phase containing soft segments. the hard segment comprises a crystalline polyolefin, and the soft segment comprises an amorphous polyolefin;
A blister container film according to claim 3. The blister container film according to claim 3 or 4, wherein the resin having the sea-island microphase separation structure is a block copolymer type polypropylene. 6. The whitening layer according to any one of claims 3 to 5, wherein a content of the resin having the sea-island microphase separation structure in the whitening layer is 80% by mass or more based on the total mass of the whitening layer. blister container film. The blister container film according to any one of claims 1 to 6, wherein the whitening layer has a thickness of 20 µm or more. The blister container film according to any one of claims 1 to 7, further comprising a substrate layer. The base material layer is PVC (polyvinyl chloride), CPP (unstretched polypropylene), COC (norbornene-ethylene copolymer), PVC/PVDC (polyvinyl chloride/polyvinylidene chloride composite sheet), or PVC/PCTFE ( 9. A blister container film according to claim 8, which is a layer of polyvinyl chloride/polychlorotrifluoroethylene composite sheet). The blister container film according to any one of claims 1-9, further comprising a sealant layer. The blister container film according to any one of claims 1 to 10, further comprising a functional layer selected from a moisture absorbing layer, an odor absorbing layer and an oxygen absorbing layer. A blister container formed from the blister container film of any one of claims 1-11,
A content-filled blister container, comprising a content stored in the pocket portion of the blister container, and a lid adhered to the blister container. 13. The filled blister container of claim 12, wherein the contents are an oral pharmaceutical product.

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