JP2022176109A - Hyaluronic acid production promoter, cosmetic and method for producing hyaluronic acid production promoter - Google Patents
Hyaluronic acid production promoter, cosmetic and method for producing hyaluronic acid production promoter Download PDFInfo
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- JP2022176109A JP2022176109A JP2022070640A JP2022070640A JP2022176109A JP 2022176109 A JP2022176109 A JP 2022176109A JP 2022070640 A JP2022070640 A JP 2022070640A JP 2022070640 A JP2022070640 A JP 2022070640A JP 2022176109 A JP2022176109 A JP 2022176109A
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- JP
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- Prior art keywords
- extract
- hyaluronic acid
- fullerene
- acid
- retinol
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- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 104
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 103
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 103
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
Description
本発明は、ヒアルロン酸の産生を促進する技術に関する。 TECHNICAL FIELD The present invention relates to techniques for promoting the production of hyaluronic acid.
ヒアルロン酸は、N-アセチルグルコサミンとD-グルクロン酸が交互に結合した直鎖状の高分子多糖であり、生体内に広く分布するグリコサミノグリカンの一種である。そして、ヒアルロン酸は、主に皮膚の水分を保持する機能を有することから、皮膚の状態に重要な役割を果たしていることが知られている。しかし、皮膚のヒアルロン酸は、内的要因(例えば加齢)および外的要因(例えば紫外線や乾燥)により減少する。そして、ヒアルロン酸が減少すると潤いが低下し、その結果、乾燥、しわ、たるみ等の様々な問題を引き起こす。以上の通り、ヒアルロン酸の産生量は皮膚の状態に大きく影響する。 Hyaluronic acid is a linear high-molecular-weight polysaccharide in which N-acetylglucosamine and D-glucuronic acid are alternately bound, and is a kind of glycosaminoglycan widely distributed in vivo. Hyaluronic acid is known to play an important role in skin conditions, mainly because it has a function of retaining moisture in the skin. However, hyaluronic acid in the skin decreases due to internal factors (such as aging) and external factors (such as UV rays and dryness). A decrease in hyaluronic acid leads to a decrease in moisture, resulting in various problems such as dryness, wrinkles, and sagging. As described above, the amount of hyaluronic acid produced greatly affects the skin condition.
ここで、フラーレンは、高い抗酸化力(活性酸素の発生および活性酸素の働きを抑制することで酸化を抑制する能力)、および、抗炎症作用をもつことが知られている。そこで、フラーレンが配合された各種の化粧料(例えば特許文献1)が従来から提案されている。 Here, fullerene is known to have high antioxidant power (the ability to suppress oxidation by suppressing the generation of active oxygen and the action of active oxygen) and anti-inflammatory action. Therefore, various cosmetics containing fullerenes (for example, Patent Document 1) have been conventionally proposed.
しかし、フラーレンがヒアルロン酸の産生を促進する効果については知られていなかった。以上の事情を考慮して、本発明では、新規なヒアルロン酸産生促進剤を提供することを課題とする。 However, the effect of fullerene to promote the production of hyaluronic acid has not been known. In consideration of the above circumstances, an object of the present invention is to provide a novel hyaluronic acid production promoter.
上記の課題を解決するため、本発明に係るヒアルロン酸産生促進剤は、フラーレンを有効成分として含む。 In order to solve the above problems, the hyaluronic acid production promoter according to the present invention contains fullerene as an active ingredient.
本発明に係るヒアルロン酸産生促進剤は、フラーレンを有効成分として含む新規なヒアルロン酸産生促進剤を提供する。具体的には、本発明に係るヒアルロン酸産生促進剤は、高い抗酸化力および抗炎症作用を有するとともに、ヒアルロン酸の産生を促進することが可能である。 The hyaluronic acid production promoter according to the present invention provides a novel hyaluronic acid production promoter containing fullerene as an active ingredient. Specifically, the hyaluronic acid production promoter according to the present invention has high antioxidant power and anti-inflammatory action, and can promote the production of hyaluronic acid.
本発明に係るヒアルロン酸産生促進剤は、皮膚におけるヒアルロン酸の産生を促進することが可能であり、フラーレン(A)を有効成分として含む。本発明で使用されるフラーレン(A)は、炭素原子から構成される球殻状の分子の総称である。フラーレン(A)としては、例えば、炭素数がC60、C70、C76、C78、C82、C84、C90、C96であるフラーレンが使用される。これらのフラーレンは単独で用いてもよいし、2種類以上を混合して用いてもよい。これらのうち、溶解性や入手のしやすさの観点から、C60、C70、または、これらの混合物が好適である。 The hyaluronic acid production promoter according to the present invention is capable of promoting hyaluronic acid production in the skin and contains fullerene (A) as an active ingredient. Fullerene (A) used in the present invention is a general term for spherical shell-shaped molecules composed of carbon atoms. As the fullerene (A), for example, fullerenes having carbon numbers of C 60 , C 70 , C 76 , C 78 , C 82 , C 84 , C 90 and C 96 are used. These fullerenes may be used alone or in combination of two or more. Among these, C 60 , C 70 , or mixtures thereof are preferred from the viewpoint of solubility and availability.
フラーレン(A)をヒアルロン酸産生促進剤に含有させる態様は任意である。上記に例示したフラーレンそのものをフラーレン(A)として含有する構成はもちろんのこと、フラーレン化合物としてフラーレン(A)を含有させてもよい。フラーレン化合物としては、例えば、フラーレン誘導体、フラーレン包接化合物、フラーレン複合体または塩などが例示される。 The mode in which the fullerene (A) is contained in the hyaluronic acid production promoter is arbitrary. The fullerene (A) may be contained as a fullerene compound as well as the configuration containing the fullerene itself as the fullerene (A) exemplified above. Examples of fullerene compounds include fullerene derivatives, fullerene inclusion compounds, fullerene complexes and salts.
フラーレン誘導体については、フラーレン骨格の炭素原子に水酸基などの修飾基が結合したものなどが例示される。フラーレンを包接または複合化する化合物としては、例えば、有機オリゴマー、有機ポリマー、包接化合物や包接錯体が形成可能なシクロデキストリン、クラウンエーテル、またはそれらの類縁化合物などが例示される。 Examples of fullerene derivatives include those in which modifying groups such as hydroxyl groups are bonded to the carbon atoms of the fullerene skeleton. Compounds that clathrate or complex fullerenes include, for example, organic oligomers, organic polymers, cyclodextrins capable of forming clathrates and clathrates, crown ethers, and analogous compounds thereof.
ヒアルロン酸産生を促進する効果をさらに向上させる観点からは、フラーレン複合体としてフラーレン(A)を含有することが好ましい。フラーレン複合体の中のも、特に、リン脂質で構成されるリポソーム内にフラーレンが包含されたリポソーム複合化フラーレンがより好ましい。 From the viewpoint of further improving the effect of promoting hyaluronic acid production, it is preferable to contain fullerene (A) as the fullerene complex. Among the fullerene complexes, liposome-complexed fullerenes in which fullerenes are encapsulated in liposomes composed of phospholipids are particularly preferred.
ヒアルロン酸産生促進剤におけるフラーレン(A)の含有量は、特に限定されず、ヒアルロン酸産生促進剤の用途やフラーレン(A)を含有させる態様に応じて適宜に変更される。ヒアルロン酸産生促進剤中のフラーレン(A)の含有量は、例えば、0.1質量ppm以上100質量%以下である。なお、フラーレン包接化合物やフラーレン複合体としてフラーレン(A)がヒアルロン酸産生促進剤に含有される場合には、ヒアルロン酸産生促進剤におけるフラーレン(A)の含有量とは、フラーレン包接化合物およびフラーレン複合体中のフラーレンの含有量(すなわちフラーレンそのものの含有量)である。 The content of fullerene (A) in the hyaluronic acid production promoter is not particularly limited, and is appropriately changed according to the use of the hyaluronic acid production promoter and the mode of containing the fullerene (A). The content of fullerene (A) in the hyaluronic acid production promoter is, for example, 0.1 ppm by mass or more and 100% by mass or less. In addition, when the fullerene (A) is contained in the hyaluronic acid production promoter as a fullerene clathrate compound or a fullerene complex, the content of fullerene (A) in the hyaluronic acid production promoter refers to the fullerene clathrate compound and It is the content of fullerene in the fullerene complex (that is, the content of fullerene itself).
フラーレン(A)は、高い抗酸化力や抗炎症作用をもつことが知られている。したがって、フラーレン(A)が有効成分として含有される本発明のヒアルロン酸産生促進剤は、高い抗酸化力および抗炎症作用を有する。また、フラーレン(A)は、高温、光およびpHに対して高い安定性を有することも知られている。したがって、本発明に係るヒアルロン酸産生促進剤は、安定性も高いという利点がある。ひいては、安定した品質のヒアルロン酸産生促進剤を提供することが可能である。 Fullerene (A) is known to have high antioxidant power and anti-inflammatory action. Therefore, the hyaluronic acid production promoter of the present invention containing fullerene (A) as an active ingredient has high antioxidant and anti-inflammatory effects. Fullerene (A) is also known to have high stability to high temperature, light and pH. Therefore, the hyaluronic acid production promoter according to the present invention has the advantage of being highly stable. As a result, it is possible to provide a hyaluronic acid production promoter of stable quality.
なお、フラーレン(A)がヒアルロン酸の産生を促進する効果(ヒアルロン酸産生促進効果)を有することは、知られておらず、本発明の発明者らにより新しい知見として見出された。フラーレン(A)がヒアルロン酸産生促進効果を有することの詳細については、実施例において後述する。 The fact that fullerene (A) has the effect of promoting the production of hyaluronic acid (hyaluronic acid production promoting effect) has not been known, but was discovered by the inventors of the present invention as a new finding. Details of the fact that fullerene (A) has the effect of promoting hyaluronic acid production will be described later in Examples.
また、本発明に係るヒアルロン酸産生促進剤は、レチノール(B)を含有してもよい。レチノールには、シス型又はトランス型の異性体が存在する。シス型のレチノールとしては、9-cis-レチノール、11-cis-レチノール、13-cis-レチノール等が例示される。トランス型のレチノールとしては、all-trans-レチノールが例示される。本発明において使用されるレチノール(B)としては、シス型及びトランス型のいずれのレチノールであってもよく、また、これらを1種単独で含んでいてもよく、2種以上含んでいてもよい。 Moreover, the hyaluronic acid production promoter according to the present invention may contain retinol (B). Retinol exists in cis and trans isomers. Examples of cis-retinol include 9-cis-retinol, 11-cis-retinol, 13-cis-retinol and the like. Trans-retinol is exemplified by all-trans-retinol. The retinol (B) used in the present invention may be either cis-type or trans-type retinol, and may contain one of these retinols alone or two or more of them. .
レチノール(B)は、皮膚の老化防止(特にしわの改善)やニキビや乾癬等の疾患に対する有用性をもつことが知られている。したがって、ヒアルロン酸産生促進剤がレチノール(B)を含むことで、皮膚の老化防止および疾患に対する有用性が得られる。 Retinol (B) is known to be useful for preventing skin aging (especially for improving wrinkles) and treating diseases such as acne and psoriasis. Therefore, when the hyaluronic acid production promoter contains retinol (B), usefulness against skin aging prevention and diseases can be obtained.
また、本発明のヒアルロン酸産生促進剤は、フラーレン(A)に加えてレチノール(B)を含むことで、ヒアルロン酸産生促進効果が更に顕著になることが、本発明の発明者らにより新しい知見として見出された。以上の説明から理解される通り、本発明では、レチノール(B)は、フラーレン(A)が有するヒアルロン酸産生促進の効果をさらに向上させる向上剤として用いられる。フラーレン(A)に加えてレチノール(B)を含むことでヒアルロン酸産生促進効果が更に顕著になることについての詳細は、実施例において後述する。 In addition, the hyaluronic acid production promoting agent of the present invention contains retinol (B) in addition to fullerene (A), so that the effect of promoting hyaluronic acid production becomes even more remarkable. New findings by the inventors of the present invention. was found as As is understood from the above description, in the present invention, retinol (B) is used as an enhancer that further enhances the effect of fullerene (A) for promoting hyaluronic acid production. The details of the fact that the inclusion of retinol (B) in addition to fullerene (A) further enhances the hyaluronic acid production promoting effect will be described later in Examples.
レチノール(B)を含有する場合には、フラーレン(A)とレチノール(B)との配合比(質量比)「フラーレン(A):レチノール(B)」は、例えば、1:2~10:1であり、好適には4:7~9:1であり、さらに好適には4:6~8:1である。以上の配合比でフラーレン(A)とレチノール(B)とを含有させることで、ヒアルロン酸産生促進効果が更に顕著になる。 When retinol (B) is contained, the compounding ratio (mass ratio) of fullerene (A) and retinol (B) “fullerene (A): retinol (B)” is, for example, 1:2 to 10:1. , preferably 4:7 to 9:1, more preferably 4:6 to 8:1. By containing fullerene (A) and retinol (B) in the above compounding ratio, the effect of promoting hyaluronic acid production becomes more pronounced.
ヒアルロン酸産生促進剤は、フラーレン(A)およびレチノール(B)の他に、必要に応じて、水(C)や化粧料に通常使用され得る各種の成分(D)を含有してもよい。 The hyaluronic acid production promoter may contain, in addition to fullerene (A) and retinol (B), water (C) and various components (D) commonly used in cosmetics, if necessary.
水(C)としては、常水、精製水の他、硬水、軟水、天然水、海洋深層水、電解アルカリイオン水、電解酸性イオン水、イオン水、クラスター水が好ましいものとして挙げられる。 Water (C) is preferably ordinary water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.
成分(D)としては、例えば、油剤、界面活性剤、アルコール類、保湿剤、高分子・増粘・ゲル化剤、酸化防止剤、抗菌剤または防腐剤、キレート剤、pH調整剤・酸・アルカリ、粉体類、無機塩類、消炎剤・抗炎症剤、ホルモン類、植物・動物・微生物エキス類、鎮痒剤、角質剥離・溶解剤、清涼剤、収れん剤、酵素類、核酸類、香料、色素・着色剤・染料・顔料、その他の薬効剤等を本発明の効果を損なわない程度で含有していてもよい。 Examples of component (D) include oils, surfactants, alcohols, moisturizing agents, polymer/thickening/gelling agents, antioxidants, antibacterial agents or preservatives, chelating agents, pH adjusters/acids/ Alkalis, powders, inorganic salts, antiphlogistic agents/anti-inflammatory agents, hormones, plant/animal/microorganism extracts, antipruritic agents, exfoliating/dissolving agents, cooling agents, astringents, enzymes, nucleic acids, fragrances, Dyes, colorants, dyes, pigments, other medicinal agents, etc. may be contained to such an extent that the effects of the present invention are not impaired.
油剤としては、エステル油、油脂、炭化水素油、シリコーン油、ロウ類、高級脂肪酸、高級アルコール等が挙げられる。 Examples of oils include ester oils, oils, hydrocarbon oils, silicone oils, waxes, higher fatty acids, and higher alcohols.
エステル油としては、ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸デシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、酢酸ラノリン、ステアリン酸イソセチル、イソステアリン酸イソセチル、ステアリン酸スクロース、オレイン酸スクロース、12-ヒドロキシステアリル酸コレステリル、ジ-2-エチルヘキシル酸エチレングリコール、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸N-アルキルグリコール、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジ-2-ヘプチルウンデカン酸グリセリン、トリ-2-エチルヘキシル酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ-2-エチルヘキシル酸ペンタンエリスリトール、トリ-2-エチルヘキシル酸グリセリン、トリイソステアリン酸トリメチロールプロパン、セチル2-エチルヘキサノエート、2-エチルヘキシルパルミテート、トリミリスチン酸グリセリン、トリ-2-ヘプチルウンデカン酸グリセライド、ヒマシ油脂肪酸メチルエステル、オレイン酸オイル、セトステアリルアルコール、アセトグリセライド、パルミチン酸2-ヘプチルウンデシル、パルミチン酸セチル、アジピン酸ジイソブチル、N-ラウロイル-L-グルタミン酸-2-オクチルドデシルエステル、アジピン酸ジ-2-ヘプチルウンデシル、エチルラウレート、セバチン酸ジ-2-エチルヘキシル、ミリスチン酸2-ヘキシルデシル、パルミチン酸2-ヘキシルデシル、アジピン酸2-ヘキシルデシル、セバチン酸ジイソプロピル、コハク酸2-エチルヘキシル、酢酸エチル、酢酸ブチル、酢酸アミル、クエン酸トリエチル等が挙げられる。 Ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, Lanolin acetate, isocetyl stearate, isocetyl isostearate, sucrose stearate, sucrose oleate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, dicaprin Neopentyl glycol acid, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, tri-2- Glyceryl ethylhexylate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptyl undecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, ceto Stearyl alcohol, acetoglyceride, 2-heptylundecyl palmitate, cetyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, Di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, citric acid triethyl and the like.
油脂としては、ツバキ油、月見草油、マカデミアナッツ油、オリーブ油、ナタネ油、トウモロコシ油、ゴマ油、ホホバ油、胚芽油、小麦胚芽油等の液体油脂を例示できる。固体油脂としては、カカオ脂、ヤシ油、馬脂、硬化ヤシ油、パーム油、牛脂、羊脂、硬化牛脂、パーム核油、豚脂、牛骨脂、モクロウ核油、硬化油、牛脚脂、モクロウ、硬化ヒマシ油等が挙げられる。 Examples of oils include liquid oils such as camellia oil, evening primrose oil, macadamia nut oil, olive oil, rapeseed oil, corn oil, sesame oil, jojoba oil, germ oil, and wheat germ oil. Solid oils and fats include cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, mutton tallow, hydrogenated beef tallow, palm kernel oil, lard, beef bone fat, Japanese wax kernel oil, hydrogenated oil, beef leg fat. , Japanese wax, hydrogenated castor oil and the like.
炭化水素油としては、流動パラフィン、オゾケライト、スクワラン、プリスタン、パラフィン、セレシン、スクワレン、ワセリン、マイクロクリスタリンワックス、ポリエチレンワックス、フィッシャートロプッシュワックス等が挙げられる。 Hydrocarbon oils include liquid paraffin, ozokerite, squalane, pristane, paraffin, ceresin, squalene, vaseline, microcrystalline wax, polyethylene wax, Fischer-Tropsch wax and the like.
シリコーン油としては、ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルハイドロジェンポリシロキサン等の鎖状ポリシロキサンや、デカメチルポリシロキサン、ドデカメチルポリシロキサン、テトラメチルテトラハイドロジェンポリシロキサンなどの環状ポリシロキサン等が挙げられる。 Examples of silicone oil include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, and cyclic polysiloxanes such as decamethylpolysiloxane, dodecamethylpolysiloxane and tetramethyltetrahydrogenpolysiloxane. is mentioned.
ロウ類としては、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、酢酸ラノリン、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、POEラノリンアルコールエーテル、POEラノリンアルコールアセテート、POEコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、POE水素添加ラノリンアルコールエーテル等が挙げられる。 Waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, wart wax, whale wax, montan wax, bran wax, lanolin, kapok wax, lanolin acetate, liquid lanolin, sugarcane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojo Barlow, hard lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like.
高級脂肪酸としては、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、リノール酸、リノレン酸、ドコサヘキサエン酸(DHA)、エイコサペンタエン酸(EPA)等が挙げられる。 Higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA).
高級アルコールとしては、ラウリルアルコール、ステアリルアルコール、セチルアルコール、セトステアリルアルコール等の直鎖アルコール、モノステアリルグリセリンエーテル、ラノリンアルコール、コレステロール、フィトステロール(シトステロール,スチグマステロール,カンペステロールの混合物)、オクチルドデカノール等の分岐鎖アルコール等が挙げられる。 Higher alcohols include straight chain alcohols such as lauryl alcohol, stearyl alcohol, cetyl alcohol and cetostearyl alcohol, monostearyl glycerin ether, lanolin alcohol, cholesterol, phytosterol (mixture of sitosterol, stigmasterol and campesterol), octyldodecanol. and branched chain alcohols such as
界面活性剤としては、アニオン性界面活性剤、カチオン性界面活性剤、および両性界面活性剤のイオン性界面活性剤と非イオン性界面活性剤とのいずれであってもよい。イオン性界面活性剤の例としては、アルキルスルホン酸塩、アルキル硫酸塩、モノアルキルリン酸塩、レシチン等が挙げられる。非イオン性界面活性剤の例としては、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、有機酸モノグリセリド、ポリグリセリン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ポリグリセリン縮合リシノレイン酸エステル、ショ糖脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビトール脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンプロピレングリコール脂肪酸エステル、ポリオキシエチレンヒマシ油、ポリオキシエチレン硬化ヒマシ油等が挙げられる。 The surfactant may be an anionic surfactant, a cationic surfactant, an amphoteric surfactant, an ionic surfactant, or a nonionic surfactant. Examples of ionic surfactants include alkylsulfonates, alkylsulfates, monoalkylphosphates, lecithin, and the like. Examples of nonionic surfactants include sorbitan fatty acid esters, glycerin fatty acid esters, organic acid monoglycerides, polyglycerin fatty acid esters, propylene glycol fatty acid esters, polyglycerin condensed ricinoleic acid esters, sucrose fatty acid esters, polyethylene glycol fatty acid esters, Polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene Glycol fatty acid esters, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil and the like can be mentioned.
アルコール類としては、2-プロパノール(イソプロピルアルコール)、ブタノール、イソブチルアルコール等の低級アルコール類;グリセリン、1,3-ブチレングリコール、プロピレングリコール、3-メチル-1,3-ブタンジオール、1,3-プロパンジオール、2-メチル-1,3-プロパンジオール、トリメチロールプロパン、ペンタエリスリトール、ソルビトール、ペンチレングリコール、ヘキシレングリコール、1,2-ヘキサンジオール、カプリリルグリコール、ジグリセリン、ポリグリセリン、ジエチレングリコール、ポリエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール等の多価アルコール等が挙げられる。 Alcohols include lower alcohols such as 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3- propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, sorbitol, pentylene glycol, hexylene glycol, 1,2-hexanediol, caprylyl glycol, diglycerin, polyglycerin, diethylene glycol, polyhydric alcohols such as polyethylene glycol, dipropylene glycol and polypropylene glycol;
保湿剤としては、グリセリン、ソルビトール、プロピレングリコール、ジプロピレングリコール、1,3-ブチレングリコール、ペンチレングリコール、グルコース、キシリトール、マルチトール、ポリエチレングリコール、ヒアルロン酸、コンドロイチン硫酸、ピロリドンカルボン酸塩、ポリオキシエチレンメチルグルコシド、ポリオキシプロピレンメチルグルコシド、卵黄レシチン、大豆レシチン、ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファジチルセリン、ホスファチジルグリセロール、ホスファチジルイノシトール、スフィンゴリン脂質等が挙げられる。 Moisturizers include glycerin, sorbitol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, pentylene glycol, glucose, xylitol, maltitol, polyethylene glycol, hyaluronic acid, chondroitin sulfate, pyrrolidone carboxylate, polyoxy Ethylene methyl glucoside, polyoxypropylene methyl glucoside, egg yolk lecithin, soybean lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids and the like.
高分子・増粘剤・ゲル化剤としては、グアーガム、ローカストビーンガム、クィーンスシード、カラギーナン、ガラクタン、アラビアガム、タラガム、タマリンド、ファーセレラン、カラヤガム、トロロアオイ、キャラガム、トラガントガム、ペクチン、ペクチン酸およびナトリウム塩等の塩、アルギン酸およびナトリウム塩等の塩、マンナン;コメ、トウモロコシ、バレイショ、コムギ等のデンプン;キサンタンガム、デキストラン、サクシノグルカン、カードラン、ヒアルロン酸およびその塩、ザンサンガム、プルラン、ジェランガム、キチン、キトサン、寒天、カッソウエキス、コンドロイチン硫酸塩、カゼイン、コラーゲン、ゼラチン、アルブミン;メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロースおよびそのナトリウム等の塩、メチルヒドロキシプロピルセルロース、セルロース硫酸ナトリウム、ジアルキルジメチルアンモニウム硫酸セルロース、結晶セルロース、セルロース末等のセルロースおよびその誘導体;可溶性デンプン、カルボキシメチルデンプン、メチルヒドロキシプロピルデンプン、メチルデンプン等のデンプン系高分子、塩化ヒドロキシプロピルトリモニウムデンプン、オクテニルコハク酸トウモロコシデンプンアルミニウム等のデンプン誘導体;アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等アルギン酸誘導体;ポリビニルピドリドン(PVP)、ポリビニルアルコール(PVA)、ビニルピドリドン・ビニルアルコール共重合体、ポリビニルメチルエーテル;ポリエチレングリコール、ポリプロピレングリコール、ポリオキシエチレン・ポリオキシプロピレン共重合体;(メタクリロイルオキシエチルカルボキシベタイン/メタクリル酸アルキル)コポリマー、(アクリレーツ/アクリル酸ステアリル/メタクリル酸エチルアミンオキシド)コポリマー等の両性メタクリル酸エステル共重合体;(ジメチコン/ビニルジメチコン)クロスポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマー、(アクリル酸アルキル/ジアセトンアクリルアミド)コポリマーAMP;ポリ酢酸ビニル部分けん化物、マレイン酸共重合体;ビニルピロリドン・メタクリル酸ジアルキルアミノアルキル共重合体;アクリル樹脂アルカノールアミン;ポリエステル、水分散性ポリエステル;ポリアクリルアミド;ポリアクリル酸エチル等のポリアクリル酸エステル共重合体、カルボキシビニルポリマー、ポリアクリル酸およびそのナトリウム塩等の塩、アクリル酸・メタアクリル酸エステル共重合体;アクリル酸・メタアクリル酸アルキル共重合体;ポリクオタニウム-10等のカチオン化セルロース、ポリクオタニウム-7等のジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、ポリクオタニウム-22等のアクリル酸・ジアリルジメチルアンモニウムクロリド共重合体、ポリクオタニウム-39等のアクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・カチオン化メタアクリル酸アミド共重合体、ポリクオタニウム-47等のアクリル酸・アクリル酸メチル・塩化メタクリルアミドプロピルトリメチルアンモニウム共重合体、塩化メタクリル酸コリンエステル重合体;カチオン化オリゴ糖、カチオン化デキストラン、グアーヒドロキシプロピルトリモニウムクロリド等のカチオン化多糖類;ポリエチレンイミン;カチオンポリマー;ポリクオタニウム-51等の2-メタクリロイルオキシエチルホスホリルコリンの重合体およびメタクリル酸ブチル共重合体等との共重合体;アクリル樹脂エマルジョン、ポリアクリル酸エチルエマルジョン、ポリアクリルアルキルエステルエマルジョン、ポリ酢酸ビニル樹脂エマルジョン、天然ゴムラテックス、合成ラテックス等の高分子エマルジョン;ニトロセルロース;ポリウレタン類および各種共重合体;各種シリコーン類;アクリル-シリコーングラフト共重合体等のシリコーン系各種共重合体;各種フッ素系高分子;12-ヒドロキシステアリン酸およびその塩;パルミチン酸デキストリン、ミリスチン酸デキストリン等のデキストリン脂肪酸エステル;無水ケイ酸、煙霧状シリカ(超微粒子無水ケイ酸)、ケイ酸アルミニウムマグネシウム、ケイ酸ナトリウムマグネシウム、金属石鹸、ジアルキルリン酸金属塩、ベントナイト、ヘクトライト、有機変性粘土鉱物、ショ糖脂肪酸エステル、フラクトオリゴ糖脂肪酸エステル等が挙げられる。 Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcelleran, karaya gum, tororo mallow, cara gum, tragacanth gum, pectin, pectic acid and sodium. Salts such as salts, salts such as alginic acid and sodium salts, mannan; starches such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , chitosan, agar, cassava extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, dialkyldimethyl Cellulose and its derivatives such as ammonium sulfate cellulose, crystalline cellulose, and cellulose powder; starch-based polymers such as soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch, hydroxypropyltrimonium chloride starch, corn starch aluminum octenylsuccinate, etc. starch derivatives; sodium alginate, alginic acid derivatives such as propylene glycol alginate; Polyoxypropylene copolymer; Amphoteric methacrylic acid ester copolymer such as (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/stearyl acrylate/ethylamine methacrylate) copolymer; (dimethicone/vinyl dimethicone) cross Polymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; Acrylic resin alkanolamine; polyester, water-dispersible polyester polyacrylamide; polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its salt such as sodium salt, acrylic acid/methacrylic acid ester copolymer; acrylic acid/methacrylic acid Acid alkyl copolymer; cationized cellulose such as Polyquaternium-10, diallyldimethylammonium chloride/acrylamide copolymer such as Polyquaternium-7, acrylic acid/diallyldimethylammonium chloride copolymer such as Polyquaternium-22, Polyquaternium-39, etc. acrylic acid/diallyldimethylammonium chloride/acrylamide copolymer, acrylic acid/cationized methacrylic acid ester copolymer, acrylic acid/cationized methacrylic acid amide copolymer, acrylic acid/acrylic acid such as polyquaternium-47 Methyl/chlorinated methacrylamidopropyltrimethylammonium copolymer, chlorinated methacrylic acid choline ester polymer; cationized polysaccharides such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymer; polyquaternium- Polymers of 2-methacryloyloxyethylphosphorylcholine such as 51 and copolymers with butyl methacrylate copolymers; acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber Polymer emulsions such as latex and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymers; Stearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate Metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, fructo-oligosaccharide fatty acid esters, and the like.
酸化防止剤としては、トコフェロール(ビタミンE)、酢酸トコフェロール等のトコフェロール誘導体;BHT、BHA;没食子酸プロピル等の没食子酸誘導体;ビタミンC(アスコルビン酸)および/またはその誘導体;エリソルビン酸およびその誘導体;亜硫酸ナトリウム等の亜硫酸塩;亜硫酸水素ナトリウム等の亜硫酸水素塩;チオ硫酸ナトリウム等のチオ硫酸塩;メタ亜硫酸水素塩;チオタウリン、ヒポタウリン;チオグリセロール、チオ尿素、チオグリコール酸、システイン塩酸塩等が挙げられる。 Antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite; thiotaurine, hypotaurine; be done.
抗菌剤または防腐剤としては、メチルパラベン、エチルパラベン、プロピルパラベン、ブチルパラベン等のパラベン(ヒドロキシ安息香酸エステル)類;フェノキシエタノール;1,2-ペンタンジオール、1,2-ヘキサンジオール、1,2-オクタンジオール等の1,2-アルカンジオール類;2-エチルヘキシルグリセリルエーテル(エチルヘキシルグリセリン)等のアルキルグリセリルエーテル類;サリチル酸;安息香酸ナトリウム;メチルクロロイソチアゾリノン、メチルイソチアゾリノン等のイソチアゾリンオン誘導体;イミダゾリニウムウレア;デヒドロ酢酸およびその塩;フェノール類;トリクロサン等のハロゲン化ビスフェノール類、酸アミド類、四級アンモニウム塩類;トリクロロカルバニド、ジンクピリチオン、塩化ベンザルコニウム、塩化ベンゼトニウム、ソルビン酸、クロルヘキシジン、グルコン酸クロルヘキシジン、ハロカルバン、ヘキサクロロフェン、ヒノキチオール;フェノール、イソプロピルフェノール、クレゾール、チモール、パラクロロフェノール、フェニルフェノール、フェニルフェノールナトリウム等のその他フェノール類;フェニルエチルアルコール、感光素類、抗菌性ゼオライト、銀イオン等が挙げられる。 Antibacterial agents or antiseptics include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, 1,2-octane 1,2-alkanediols such as diols; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; linium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, glucon Chlorhexidine acid, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, phenylphenol sodium; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion etc.
キレート剤としては、EDTA、EDTA2Na、EDTA3Na、EDTA4Na等のエデト酸塩(エチレンジアミン四酢酸塩);HEDTA3Na等のヒドロキシエチルエチレンジアミン三酢酸塩;ペンテト酸塩(ジエチレントリアミン五酢酸塩);フィチン酸;エチドロン酸等のホスホン酸およびそのナトリウム塩等の塩類;シュウ酸ナトリウム;ポリアスパラギン酸、ポリグルタミン酸等のポリポリアミノ酸類;ポリリン酸ナトリウム、メタリン酸ナトリウム、リン酸;クエン酸ナトリウム、クエン酸、アラニン、ジヒドロキシエチルグリシン、グルコン酸、アスコルビン酸、コハク酸、酒石酸等が挙げられる。 Chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediamine triacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and salts such as sodium salts thereof; Sodium oxalate; Polyamino acids such as polyaspartic acid and polyglutamic acid; Sodium polyphosphate, sodium metaphosphate, phosphoric acid; Sodium citrate, citric acid, alanine, dihydroxyethylglycine , gluconic acid, ascorbic acid, succinic acid, tartaric acid and the like.
pH調整剤・酸・アルカリとしては、クエン酸、クエン酸ナトリウム、乳酸、乳酸ナトリウム、グリコール酸、コハク酸、酢酸、酢酸ナトリウム、リンゴ酸、酒石酸、フマル酸、リン酸、塩酸、硫酸、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、イソプロパノールアミン、トリイソプロパノールアミン、2-アミノ-2-メチル-1,3ープロパンジオール、2-アミノ-2-ヒドロキシメチル-1,3ープロパンジオール、アルギニン、水酸化ナトリウム、水酸化カリウム、アンモニア水、炭酸グアニジン、炭酸アンモニウム等が挙げられる。 pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, and monoethanol. Amines, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxide sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, ammonium carbonate and the like.
粉体類としては、マイカ、タルク、カオリン、セリサイト、モンモリロナイト、カオリナイト、雲母、白雲母、金雲母、合成雲母、紅雲母、黒雲母、パーミキュライト、炭酸マグネシウム、炭酸カルシウム、ケイ酸アルミニウム、ケイ酸バリウム、ケイ酸カルシウム、ケイ酸マグネシウム、ケイ酸ストロンチウム、タングステン酸金属塩、マグネシウム、ゼオライト、硫酸バリウム、焼成硫酸カルシウム、リン酸カルシウム、弗素アパタイト、ヒドロキシアパタイト、セラミックパウダー、ベントナイト、スメクタイト、粘土、泥、金属石鹸(例えば、ミリスチン酸亜鉛、パルミチン酸カルシウム、ステアリン酸アルミニウム)、炭酸カルシウム、ベンガラ、黄酸化鉄、黒酸化鉄、群青、紺青、カーボンブラック、酸化チタン、微粒子および超微粒子酸化チタン、酸化亜鉛、微粒子および超微粒子酸化亜鉛、アルミナ、シリカ、煙霧状シリカ(超微粒子無水ケイ酸)、雲母チタン、魚鱗箔、窒化ホウ素、ホトクロミック顔料、合成フッ素金雲母、微粒子複合粉体、金、アルミニウム等の各種の大きさ・形状の無機粉体、および、これらをハイドロジェンシリコーン、環状ハイドロジェンシリコーン等のシリコーン若しくはその他のシラン若しくはチタンカップリング剤等の各種表面処理剤で処理を行って疎水化若しくは親水化した粉体等の無機粉体;デンプン、セルロース、ナイロンパウダー、ポリエチレン末、ポリメタクリル酸メチル末、ポリスチレン末、スチレンとアクリル酸の共重合体樹脂粉末、ポリエステル末、ベンゾグアナミン樹脂粉末、ポリエチレンテレフタレート・ポリメチルメタクリレート積層末、ポリエチレンテレフタレート・アルミニウム・エポキシ積層末等、ウレタン粉末、シリコーン粉末、テフロン(登録商標)粉末等の各種の大きさ・形状の有機系粉体および表面処理粉体、有機無機複合粉体等が挙げられる。 Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soaps (e.g. zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide , fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, fine particle composite powder, gold, aluminum, etc. Inorganic powders of various sizes and shapes, and these are treated with various surface treatment agents such as silicone such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents to make them hydrophobic or Inorganic powder such as hydrophilized powder; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate・Organic powders and surface-treated powders of various sizes and shapes, such as polymethyl methacrylate layered powder, polyethylene terephthalate/aluminum/epoxy layered powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc., organic and inorganic Composite powder etc. are mentioned.
無機塩類としては、食塩、並塩、岩塩、海塩、天然塩等の塩化ナトリウム含有塩類;塩化カリウム、塩化アルミニウム、塩化カルシウム、塩化マグネシウム、にがり、塩化亜鉛、塩化アンモニウム;硫酸ナトリウム、硫酸アルミニウム、硫酸アルミニウム・カリウム(ミョウバン)、硫酸アルミニウム・アンモニウム、硫酸バリウム、硫酸カルシウム、硫酸カリウム、硫酸マグネシウム、硫酸亜鉛、硫酸鉄、硫酸銅;リン酸1Na・2Na・3Na等のリン酸ナトリウム類、リン酸カリウム類、リン酸カルシウム類、リン酸マグネシウム類等が挙げられる。 Examples of inorganic salts include sodium chloride-containing salts such as table salt, common salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum/potassium sulfate (alum), aluminum/ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na, and 3Na phosphate, phosphoric acid Potassiums, calcium phosphates, magnesium phosphates and the like can be mentioned.
消炎剤・抗炎症剤としては、グリチルリチン酸およびその誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、グアイアズレン、アラントイン、インドメタシン、酸化亜鉛、酢酸ヒドロコーチゾン、プレドニゾン、塩酸ジフェドラミン、マレイン酸クロルフェニラミン;桃葉エキス、蓬葉エキス等の植物エキス等が挙げられる。 Antiphlogistic and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhizic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract and plant extracts such as mugwort leaf extract.
ホルモン類としては、エストラジオール、エストロン、エチニルエストラジオール、コルチゾン、ヒドロコルチゾン、プレドニゾン等が好ましいものとして挙げられる。 Preferred hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, and the like.
植物・動物・微生物エキス類としては、アイリスエキス、アシタバエキス、アスナロエキス、アスパラガスエキス、アボガドエキス、アマチャエキス、アーモンドエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、インチコウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、ウワウルシエキス、エイジツエキス、エチナシ葉エキス、エンメイソウエキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オタネニンジンエキス、オトギリソウエキス、オドリコソウエキス、オノニスエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、カキ葉エキス、カキョクエキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カッコンエキス、カモミラエキス、油溶性カモミラエキス、カロットエキス、カワラヨモギエキス、カラスムギエキス、カルカデエキス、カンゾウエキス、油溶性カンゾウエキス、キウイエキス、キオウエキス、キクラゲエキス、キナエキス、キューカンバーエキス、キリ葉エキス、グアノシン、グアバエキス、クジンエキス、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、クリエキス、グレープフルーツエキス、クレマティスエキス、黒米エキス、黒砂糖抽出物、黒酢、クロレラエキス、クワエキス、ゲンチアナエキス、ゲンノショウコエキス、紅茶エキス、酵母エキス、コウボクエキス、コーヒーエキス、ゴボウエキス、コメエキス、コメ発酵エキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サフランエキス、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンシャエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、ジャトバエキス、シャクヤクエキス、ショウキュウエキス、ショウブ根エキス、シラカバエキス、白キクラゲエキス、スギナエキス、ステビアエキス、ステビア発酵物、西河柳エキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セージエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ソウハクヒエキス、ダイオウエキス、ダイズエキス、タイソウエキス、タイムエキス、タンポポエキス、地衣類エキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、ティートリー油、甜茶エキス、トウガラシエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、ハスエキス、パセリエキス、バーチエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ヒノキエキス、ビフィズス菌エキス、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、ブドウ種子エキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マイカイカエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モズクエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ユズエキス、ユリエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、緑茶エキス、卵殻膜エキス、リンゴエキス、ルイボス茶エキス、レイシエキス、レタスエキス、レモンエキス、レンギョウエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス、ワレモコウエキス等が挙げられる。 Plant/animal/microorganism extracts include iris extract, angelica keiskei extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, and ginkgo biloba extract. , inchkou extract, fennel extract, turmeric extract, oolong tea extract, urticaria extract, age extract, Echinashi leaf extract, trillium extract, Scutellaria root extract, Phellodendron bark extract, Coptis extract, Barley extract, Panax ginseng extract, Hypericum extract, Dead nettle extract, Ononis extract , Dutch mustard extract, orange extract, seawater dried matter, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, kakkon extract, chamomile extract, oil-soluble chamomile extract, carrot extract, wormwood extract, oat extract, karkade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiwi extract, cloud ear extract, cinchona extract, cucumber extract, paulownia leaf extract, guanosine, guava extract, kujin extract, gardenia extract, kumazasa extract, clara extract, walnut Extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentian extract, Gennoshoko extract, Black tea extract, Yeast extract, Koboku extract, Coffee extract, Burdock extract, Rice extract, Rice Fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, collagen, cowberry extract, rhinoceros extract, rhinoceros extract, rhinoceros extract, saffron extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, sansha extract, Japanese pepper extract, shiitake extract, reed extract, licorice extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony extract, ginger extract, calamus root extract, white birch extract, white fungus extract, horsetail extract, stevia extract, fermented stevia, Nishikawayanagi extract, Ivy extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, neem extract, jersey extract, sage extract, rhubarb extract, dai Sunflower extract, turmeric extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, cinnamon extract, chimp extract, tea tree oil, sweet tea extract, capsicum extract, angelica extract, calendula officinalis extract, tonin extract, spruce extract, Houttuynia cordata extract, tomato Extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bakumondou extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietalia extract, Hikiokoshi extract, Bisabolol, Hinoki extract, Bifidobacterium extract, Loquat extract, coltsfoot extract, coltsfoot extract, coltsfoot extract, bukuryo extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, bodaiju extract, botan extract, hop extract, mica extract, pine extract, horse chestnut extract , Asian skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract , litchi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, burnet extract and the like.
鎮痒剤としては、塩酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、カンファー、サブスタンス-P阻害剤等が挙げられる。 Antipruritics include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitors and the like.
角質剥離・溶解剤としては、サリチル酸、イオウ、レゾルシン、硫化セレン、ピリドキシン等を例示することができる。制汗剤としては、クロルヒドロキシアルミニウム、塩化アルミニウム、酸化亜鉛、パラフェノールスルホン酸亜鉛等が挙げられる。 Examples of exfoliating/dissolving agents include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, and the like. Antiperspirants include aluminum chlorohydroxy, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, and the like.
清涼剤としては、メントール、サリチル酸メチル等が挙げられる。 Cooling agents include menthol and methyl salicylate.
収れん剤としては、クエン酸、酒石酸、乳酸、硫酸アルミニウム・カリウム、タンニン酸等が挙げられる。 Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum/potassium sulfate, and tannic acid.
酵素類としては、スーパーオキサイドディスムターゼ、カタラーゼ、塩化リゾチーム、リパーゼ、パパイン、パンクレアチン、プロテアーゼ等を例示することができる。 Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like.
核酸類としては、リボ核酸およびその塩、デオキシリボ核酸およびその塩、アデノシン三リン酸二ナトリウムが好ましいものとして挙げられる。 Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.
香料としては、アセチルセドレン、アミルシンナムアルデヒド、アリルアミルグリコレート、β-イオノン、イソイースーパー、イソブチルキノリン、イリス油、イロン、インドール、イランイラン油、ウンデカナール、ウンデセナール、γ-ウンデカラクトン、エストラゴール、オイゲノール、オークモス、オポポナックスレジノイド、オレンジ油、オイゲノール、オーランチオール、ガラクソリッド、カルバクロール、L-カルボン、カンファー、キャノン、キャロットシード油、クローブ油、ケイヒ酸メチル、ゲラニオール、ゲラニルニトリル、酢酸イソボルニル、酢酸ゲラニル、酢酸ジメチルベンジルカルビニル、酢酸スチラリル、酢酸セドリル、酢酸テレピネル、酢酸p-t-ブチルシクロヘキシル、酢酸ベチベリル、酢酸ベンジル、酢酸リナリル、サリチル酸イソペンチル、サリチル酸ベンジル、サンダルウッド油、サンタロール、シクラメンアルデヒド、シクロペンタデカノリド、ジヒドロジャスモン酸メチル、ジヒドロミルセノール、ジャスミンアブソリュート、ジャスミンラクトン、cis-ジャスモン、シトラール、シトロネノール、シトロネラール、シナモンバーク油、1,8-シネオール、シンナムアルデヒド、スチラックスレジノイド、セダーウッド油、セドレン、セドロール、セロリシード油、タイム油、ダマスコン、ダマセノン、チモール、チュベローズアブソリュート、デカナール、デカラクトン、テルピネオール、γ-テルピネン、トリプラール、ネロール、ノナナール、2,6-ノナジエノール、ノナラクトン、パチョリアルコール、バニラアブソリュート、バニリン、バジル油、パチョリ油、ヒドロキシシトロネラール、α-ピネン、ピペリトン、フェネチルアルコール、フェニルアセトアルデヒド、プチグレン油、ヘキシルシンナムアルデヒド、cis-3-ヘキセノール、ペルーバルサム、ベチバー油、ベチベロール、ペパーミント油、ペパー油、ヘリオトロピン、ベルガモット油、ベンジルベンゾエート、ボルネオール、ミルレジノイド、ムスクケトン、メチルノニルアセトアルデヒド、γ-メチルヨノン、メントール、L-メントール、L-メントン、ユーカリ油、β-ヨノン、ライム油、ラベンダー油、D-リモネン、リナロール、リラール、リリアール、レモン油、ローズアブソリュート、ローズオキシド、ローズ油、ローズマリー油、各種精油等の合成香料および天然香料並びに各種調合香料等が挙げられる。 Fragrances include acetylcedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, iso-e-super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, γ-undecenal, Estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile , isobornyl acetate, geranyl acetate, dimethylbenzyl carbyl acetate, styraryl acetate, cedryl acetate, terpinel acetate, p-t-butylcyclohexyl acetate, betiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, Cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineol, cinnamaldehyde, styrax Resinoids, cedarwood oil, cedren, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli Alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexylcinnamaldehyde, cis-3-hexenol, peruvian balsam, vetiver oil, vetiverol , peppermint oil, pepper oil, heliotropine, bergamot oil, benzyl benzoate, borneol, myresinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-mentone, eucalyptus oil, β-ionone, lime oil , lavender oil, D-limonene, linalool, lilal, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils and other synthetic fragrances and natural oils. Examples include natural perfumes and various compounded perfumes.
色素・着色剤・染料・顔料としては、褐色201号、黒色401号、紫色201号、紫色401号、青色1号、青色2号、青色201号、青色202号、青色203号、青色204号、青色205号、青色403号、青色404号、緑色201号、緑色202号、緑色204号、緑色205号、緑色3号、緑色401号、緑色402号、赤色102号、赤色104-1号、赤色105-1号、赤色106号、赤色2号、赤色201号、赤色202号、赤色203号、赤色204号、赤色205号、赤色206号、赤色207号、赤色208号、赤色213号、赤色214号、赤色215号、赤色218号、赤色219号、赤色220号、赤色221号、赤色223号、赤色225号、赤色226号、赤色227号、赤色228号、赤色230-1号、赤色230-2号、赤色231号、赤色232号、赤色3号、赤色401号、赤色404号、赤色405号、赤色501号、赤色502号、赤色503号、赤色504号、赤色505号、赤色506号、橙色201号、橙色203号、橙色204号、橙色205号、橙色206号、橙色207号、橙色401号、橙色402号、橙色403号、黄色201号、黄色202-1号、黄色202-
2号、黄色203号、黄色204号、黄色205号、黄色4号、黄色401号、黄色402号、黄色403-1号、黄色404号、黄色405号、黄色406号、黄色407号、黄色5号等の法定色素;Acid Red 14等のその他酸性染料;Arianor Sienna Brown、Arianor Madder Red、Arianor Steel Blue、Arianor Straw Yellow等の塩基染料;HC Yellow 2、HC Yellow 5、HC Red 3、4-hydoxypropylamino-3-nitrophenol、N,N’-bis(2-hydroxyethyl)-2-nitro-p- phenylenediamine、HC Blue 2、Basic Blue 26等のニトロ染料;分散染料;二酸化チタン、酸化亜鉛等の無機白色顔料;酸化鉄(ベンガラ)、チタン酸鉄等の無機赤色系顔料;γ-酸化鉄等の無機褐色系顔料;黄酸化鉄、黄土等の無機黄色系顔料;黒酸化鉄、低次酸化チタン等の無機黒色系顔料;マンゴバイオレット、コバルトバイオレット等の無機紫色系顔料;酸化クロム、水酸化クロム、チタン酸コバルト等の無機緑色系顔料;群青、紺青等の無機青色系顔料;酸化チタンコーテッドマイカ、酸化チタンコーテッドオキシ塩化ビスマス、酸化チタンコーテッドタルク、着色酸化チタンコーテッドマイカ、オキシ塩化ビスマス、魚鱗箔等のパール顔料;アルミニウムパウダー、カッパーパウダー、金等の金属粉末顔料;表面処理無機および金属粉末顔料;赤色201号、赤色202号、赤色204号、赤色205号、赤色220号、赤色226号、赤色228号、赤色405号、橙色203号、橙色204号、黄色205号、黄色401号、青色404号、赤色3号、赤色104号、赤色106号、赤色227号、赤色230号、赤色401号、赤色505号、橙色205号、黄色4号、黄色5号、黄色202号、黄色203号、緑色3号、青色1号等のジルコニウム、バリウムまたはアルミニウムレーキ等の有機顔料;表面処理有機顔料;アスタキサンチン、アリザリン等のアントラキノン類、アントシアニジン、β-カロチン、カテナール、カプサンチン、カルコン、カルサミン、クエルセチン、クロシン、クロロフィル、クルクミン、コチニール、シコニン等のナフトキノン類、ビキシン、フラボン類、ベタシアニジン、ヘナ、ヘモグロビン、リコピン、リボフラビン、ルチン等の天然色素・染料;p-フェニレンジアミン、トルエン-2,5-ジアミン、o-,m-,若しくはp-アミノフェノール、m-フェニレンジアミン、5-アミノ-2-メチルフェノール、レゾルシン、1-ナフトール、2,6-ジアミノピリジン等およびその塩等の酸化染料中間体およびカップラー;インドリン等の自動酸化型染料;ジヒドロキシアセトン等が挙げられる。
Colorants/colorants/dyes/pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203 and Blue No. 204. , Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red No. 104-1 , Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213 , Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1 , Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505 , Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1 , yellow 202-
Yellow No. 2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow Legal dyes such as No. 5; Other acid dyes such as Acid Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow;
抗しわ剤、抗老化剤、ひきしめ剤、冷感剤、温感剤、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤等のその他の薬効剤としては、レチノイン酸類、レチノイン酸トコフェリル;乳酸、グリコール酸、グルコン酸、フルーツ酸、サリチル酸およびその配糖体・エステル化物等の誘導体、ヒドロキシカプリン酸、長鎖α-ヒドロキシ脂肪酸、長鎖α-ヒドロキシ脂肪酸コレステリル等のα-またはβ-ヒドロキシ酸類およびその誘導体類;γ-アミノ酪酸、γ-アミノ-β-ヒドロキシ酪酸;カルニチン;カルノシン;クレアチン;セラミド類、スフィンゴシン類;カフェイン、キサンチン等およびその誘導体;コエンザイムQ10、カロチン、リコピン、アスタキサンチン、ルテイン、α-リポ酸、白金ナノコロイド、フラーレン類等の抗酸化・活性酸素消去剤;カテキン類;ケルセチン等のフラボン類;イソフラボン類;没食子酸およびエステル糖誘導体;タンニン、セサミン、プロトアントシアニジン、クロロゲン酸、リンゴポリフェノール等のポリフェノール類;ルチンおよび配糖体等の誘導体;ヘスペリジンおよび配糖体等の誘導体;リグナン配糖体;グラブリジン、グラブレン、リクイリチン、イソリクイリチン等のカンゾウエキス関連物質;ラクトフェリン;ショウガオール、ジンゲロール;メントール、カンファー、セドロール等の香料物質およびその誘導体;カプサイシン、バニリン等および誘導体;ジエチルトルアミド等の昆虫忌避剤;生理活性物質とシクロデキストリン類との複合体が好ましいものとして挙げられる。 Other medicinal agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoting agents, stimulating agents, analgesics, and cell activators include retinoic acids and tocopheryl retinoic acid; Lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and derivatives such as glycosides and esters thereof, hydroxycapric acid, long-chain α-hydroxy fatty acids, α- or β-hydroxy such as long-chain α-hydroxy fatty acid cholesteryl Acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; Antioxidants/reactive oxygen scavengers such as lutein, α-lipoic acid, platinum nanocolloids, fullerenes; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; Acids, polyphenols such as apple polyphenol; derivatives such as rutin and glycosides; derivatives such as hesperidin and glycosides; lignan glycosides; , gingerol; flavoring substances such as menthol, camphor, cedrol, and derivatives thereof; capsaicin, vanillin, etc. and their derivatives; insect repellents such as diethyltoluamide;
これらの他、化粧品原料基準、化粧品種別配合成分規格、日本化粧品工業連合会成分表示名称リスト、INCI辞書(The International Cosmetic Ingredient Dictionary and Handbook)、医薬部外品原料規格、日本薬局方、医薬品添加物規格、食品添加物公定書等に記載されている成分、および、国際特許分類IPCがA61K7およびA61K8の分類に属する日本国および諸外国特許公報および特許公開公報(公表公報・再公表を含む)に記載されている成分等、公知の化粧料成分、医薬品成分、食品成分などを、公知の組み合わせおよび配合比・配合量で含有させることが可能である。 In addition to these, the Standards for Cosmetic Ingredients, Standards for Ingredients by Cosmetic Type, List of Ingredients Displayed by the Japan Cosmetic Industry Association, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Standards for Quasi-drug Ingredients, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, food additive standards, etc., and in Japanese and foreign patent publications and patent publications (including publications and republications) that belong to the classification of A61K7 and A61K8 in the international patent classification IPC Known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as those described, can be contained in known combinations and blending ratios and blending amounts.
本発明に係るヒアルロン酸産生促進剤は、化粧料の成分として含有させてもよい。化粧料の種類としては、基礎化粧料、毛髪化粧料、メイクアップ化粧料、芳香化粧料、ボディ化粧料、軟膏等の皮膚外用剤等が例示される。 The hyaluronic acid production promoter according to the present invention may be contained as a component of cosmetics. Examples of the types of cosmetics include basic cosmetics, hair cosmetics, make-up cosmetics, aromatic cosmetics, body cosmetics, skin external preparations such as ointments, and the like.
本発明に係るヒアルロン酸産生促進剤を含む化粧料中のフラーレン(A)の含有量(フラーレンそのものの含有量)は、例えば、2.0×10-4~2.5×10-3質量%であり、好適には2.0×10-4~2.25×10-3質量%であり、さらに好適には2.0×10-4~2.0×10-3質量%である。また、本発明に係るヒアルロン酸産生促進剤がレチノール(B)を含有する場合における化粧料中のレチノール(B)の含有量は、例えば、2.5×10-4~4.0×10-4質量%であり、好適には2.5×10-4~3.5×10-4質量%であり、さらに好適には2.5×10-4~3.0×10-4質量%である。ただし、化粧料中のレチノール(B)の含有量は以上の例示には限定されない。 The content of fullerene (A) in the cosmetic containing the hyaluronic acid production promoter according to the present invention (the content of fullerene itself) is, for example, 2.0×10 −4 to 2.5×10 −3 % by mass. , preferably 2.0×10 −4 to 2.25×10 −3 mass %, more preferably 2.0×10 −4 to 2.0×10 −3 mass %. Further, when the hyaluronic acid production promoter according to the present invention contains retinol (B), the content of retinol (B) in the cosmetic is, for example, 2.5×10 −4 to 4.0×10 − 4 % by mass, preferably 2.5×10 −4 to 3.5×10 −4 % by mass, more preferably 2.5×10 −4 to 3.0×10 −4 % by mass is. However, the content of retinol (B) in cosmetics is not limited to the above examples.
以下に、実施例により本発明を更に詳しく説明するが、本発明はこれらの実施例に限定されるものではない。 EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these Examples.
表1の配合になるように実施例1-12を調製し、表2の配合になるように比較例1-12および参考例1,2を調製した。なお、フラーレンは水に不溶性であるため、PVP(ポリビニルピロリドン)修飾複合化またはリポソーム複合化処理を行い、培地中へ可溶化した。各実施例では、C60を使用した。具体的には、PVP(ポリビニルピロリドン)修飾複合化処理後のC60およびリポソーム複合化処理後のC60をフラーレン(A)として使用した。 Examples 1-12 were prepared so as to have the composition shown in Table 1, and Comparative Examples 1-12 and Reference Examples 1 and 2 were prepared so as to have the composition shown in Table 2. Since fullerene is insoluble in water, it was solubilized in the medium by subjecting it to PVP (polyvinylpyrrolidone) modification conjugation or liposome conjugation treatment. In each example, C60 was used. Specifically, C60 after PVP (polyvinylpyrrolidone) modification complexing treatment and C60 after liposome complexing treatment were used as fullerene (A).
<実施例1-3>
実施例1-3では、PVP(ポリビニルピロリドン)-フラーレン複合体(粉末Radical Sponge:粉末RS、ビタミンC60バイオリサーチ株式会社製、登録商標)を使用した。PVP-フラーレン複合体は、C60を0.367質量%含む。
<Example 1-3>
In Example 1-3, a PVP (polyvinylpyrrolidone)-fullerene complex (Powder Radical Sponge: Powder RS, Vitamin C60 Bioresearch Co., Ltd., registered trademark) was used. The PVP-fullerene complex contains 0.367 wt% C60 .
実施例1-3は、以下の通り、調製した。 Examples 1-3 were prepared as follows.
まず、DMSO(Dimethyl sulfoxide)520μLに培地51.48mLを加えて1.0%DMSO含有培地を調製した。上記のPVP-フラーレン複合体11.3mgを2mLの培地(1.0%DMSO)に溶解することでC60の含量が20ppmとなる実施例3のPVP-フラーレン複合体含有培地を調製した。実施例3のPVP-フラーレン複合体含有培地をさらに培地(1.0%DMSO)にて段階希釈し、C60の含量が10ppmである実施例2のPVP-フラーレン複合体含有培地(1.0%DMSO)と、C60の含量が2ppmである実施例1のPVP-フラーレン複合体含有培地(1.0%DMSO)とを調製した。 First, 51.48 mL of medium was added to 520 μL of DMSO (Dimethyl sulfoxide) to prepare a medium containing 1.0% DMSO. A PVP-fullerene complex-containing medium of Example 3 having a C 60 content of 20 ppm was prepared by dissolving 11.3 mg of the above PVP-fullerene complex in 2 mL of medium (1.0% DMSO). The PVP-fullerene complex-containing medium of Example 3 was further serially diluted with a medium (1.0% DMSO), and the PVP-fullerene complex-containing medium of Example 2 having a C 60 content of 10 ppm (1.0 % DMSO) and the PVP-fullerene complex-containing medium of Example 1 with a C60 content of 2 ppm (1.0% DMSO).
<実施例4-6>
実施例4-6では、実施例1-3と同様のPVP-フラーレン複合体を使用した。
<Example 4-6>
In Examples 4-6, the same PVP-fullerene complexes as in Examples 1-3 were used.
実施例4-6は、以下の通り、調製した。 Examples 4-6 were prepared as follows.
まず、DMSOを溶媒とし、100mMレチノール溶液を調製した。調製した100mMレチノール溶液を培地にて段階希釈し、10μMレチノール含有培地(1.0%DMSO)を得た。 First, DMSO was used as a solvent to prepare a 100 mM retinol solution. The prepared 100 mM retinol solution was serially diluted with medium to obtain a medium containing 10 μM retinol (1.0% DMSO).
C60の含量が20ppmとなるように、PVP-フラーレン複合体11.3mgを2mLの10μMレチノール含有培地(1.0%DMSO)に溶解することで、実施例6のPVP-フラーレン複合体・10μMレチノール含有培地を調製した。実施例6のPVP-フラーレン複合体・10μMレチノール含有培地(1.0%DMSO)を、10μMレチノール含有培地(1.0%DMSO)にて段階希釈し、C60の含量が10ppmである実施例5のPVP-フラーレン複合体・10μMレチノール溶液含有培地(1.0%DMSO)と、C60の含量が2ppmである実施例4のPVP-フラーレン複合体・10μMレチノール溶液含有培地(1.0%DMSO)を調製した。 11.3 mg of the PVP-fullerene conjugate of Example 6 was dissolved in 2 mL of 10 μM retinol-containing medium (1.0% DMSO) so that the C 60 content was 20 ppm. A retinol-containing medium was prepared. The PVP-fullerene complex/10 μM retinol-containing medium (1.0% DMSO) of Example 6 was serially diluted with 10 μM retinol-containing medium (1.0% DMSO), and the C 60 content was 10 ppm. 5 PVP-fullerene complex/10 μM retinol solution-containing medium (1.0% DMSO) and the PVP-fullerene complex/10 μM retinol solution-containing medium (1.0% DMSO) of Example 4 with a C 60 content of 2 ppm DMSO) was prepared.
<実施例7-9>
実施例7-9では、リポソーム複合化フラーレン(粉末Moist Fullerene:粉末MF、ビタミンC60バイオリサーチ株式会社製、登録商標)を使用した。リポソーム複合化フラーレンは、C60を0.131質量%含むほか、水添レシチンとフィトステロールとを含む。
<Example 7-9>
In Examples 7-9, liposome-complexed fullerene (powder Moist Fullerene: powder MF, vitamin C60 Bioresearch Co., Ltd., registered trademark) was used. The liposome-complexed fullerene contains 0.131% by mass of C60 , as well as hydrogenated lecithin and phytosterol.
実施例7-9は、以下の通り、調製した。 Examples 7-9 were prepared as follows.
まず、DMSO520μLに培地51.48mLを加えて1.0%DMSO含有培地を調製した。上記のリポソーム複合化フラーレン30mgを2mLの培地(1.0%DMSO)に溶解することで、C60の含量が20ppmとなる実施例9を調製した。実施例9のリポソーム複合化フラーレン含有培地をさらに培地(1.0%DMSO)にて段階希釈し、C60の含量が10ppmである実施例8のリポソーム複合化フラーレン含有培地(1.0%DMSO)と、C60の含量が2ppmである実施例7のリポソーム複合化フラーレン含有培地(1.0%DMSO)を調製した。 First, 51.48 mL of medium was added to 520 μL of DMSO to prepare a medium containing 1.0% DMSO. Example 9 with a C60 content of 20 ppm was prepared by dissolving 30 mg of the above liposome-complexed fullerene in 2 mL of medium (1.0% DMSO). The liposome-complexed fullerene-containing medium of Example 9 was further serially diluted with the medium (1.0% DMSO), and the liposome-complexed fullerene-containing medium of Example 8 having a C60 content of 10 ppm (1.0% DMSO ) and the liposome-complexed fullerene-containing medium of Example 7 (1.0% DMSO) with a C60 content of 2 ppm.
<実施例10-12>
実施例10-12では、実施例7-9と同様のリポソーム複合化フラーレンを使用した。
<Examples 10-12>
Examples 10-12 used the same liposome-complexed fullerenes as in Examples 7-9.
実施例10-12は、以下の通り、調製した。 Examples 10-12 were prepared as follows.
まず、DMSOを溶媒とし、100mMレチノール溶液を調製した。調製した100mMレチノール溶液を培地にて段階希釈し、10μMレチノール含有培地(1.0%DMSO)を調製した。 First, DMSO was used as a solvent to prepare a 100 mM retinol solution. The prepared 100 mM retinol solution was serially diluted with a medium to prepare a 10 μM retinol-containing medium (1.0% DMSO).
上記のリポソーム複合化フラーレン約0.304gに、調製した10μMレチノール溶液20μL、クロロホルム5mL、メタノール3mLを添加した後に、超音波を1分間照射して、溶解させた。エバポレーターにて溶媒を留去し、15分間減圧乾燥して、培地(1.0%DMSO)2mlに溶解した際にC60が200ppmでありレチノール100μMとなるレチノール含有リポソーム複合化フラーレンを得た。なお、レチノール含有リポソーム複合化フラーレンについては、レチノールについてもリポソーム化している。レチノール含有リポソーム複合化フラーレンを用いると、ヒアルロン酸産生促進剤および化粧料にレチノールを安定して配合できるという利点もある。 After adding 20 μL of the prepared 10 μM retinol solution, 5 mL of chloroform, and 3 mL of methanol to about 0.304 g of the liposome-complexed fullerene, the solution was dissolved by irradiation with ultrasonic waves for 1 minute. The solvent was distilled off with an evaporator and dried under reduced pressure for 15 minutes to obtain a retinol-containing liposome-complexed fullerene having a C60 of 200 ppm and a retinol of 100 μM when dissolved in 2 ml of a medium (1.0% DMSO). Regarding the retinol-containing liposome-complexed fullerene, retinol is also formed into liposomes. The use of retinol-containing liposome-complexed fullerenes also has the advantage that retinol can be stably incorporated in hyaluronic acid production promoters and cosmetics.
次に、得られたレチノール含有リポソーム複合化フラーレンに培地(1.0%DMSO)20mLを加え、超音波を2分間照射した後に、器壁に残存したレチノール含有リポソーム複合化フラーレンをスパーテル(滅菌済)でこそいだ。本作業を5回繰り返し、C60の含量が20ppmである実施例12のリポソーム複合化フラーレン・10μMレチノール含有培地を得た。 Next, 20 mL of medium (1.0% DMSO) was added to the obtained retinol-containing liposome-complexed fullerene, and after 2 minutes of ultrasonic irradiation, the retinol-containing liposome-complexed fullerene remaining on the vessel wall was removed with a spatula (sterilized ). This operation was repeated five times to obtain a liposome-complexed fullerene/10 μM retinol-containing medium of Example 12 having a C60 content of 20 ppm.
実施例12のリポソーム複合化フラーレン・10μMレチノール含有培地を10μMレチノール含有培地(1.0%DMSO)にて段階希釈し、C60の含量が10ppmである実施例11のリポソーム複合化フラーレン・10μMレチノール溶液含有培地(1.0%DMSO)と、C60の含量が2ppmである実施例10のリポソーム複合化フラーレン・10μMレチノール溶液含有培地(1.0%DMSO)を調製した。 The liposome-complexed fullerene/10 μM retinol-containing medium of Example 12 was serially diluted with a 10 μM retinol-containing medium (1.0% DMSO), and the liposome-complexed fullerene/10 μM retinol of Example 11 having a C60 content of 10 ppm was obtained. A solution-containing medium (1.0% DMSO) and a liposome-complexed fullerene/10 μM retinol solution-containing medium (1.0% DMSO) of Example 10 having a C60 content of 2 ppm were prepared.
<比較例1-3>
比較例1-3は、以下の通り、調製した。
<Comparative Example 1-3>
Comparative Examples 1-3 were prepared as follows.
PVP(ポリビニルピロリドン)11.3mgを2mLの培地に溶解した。得られたPVP含有培地を実施例1-3と同様に段階希釈し、比較例1-3を調製した。 11.3 mg of PVP (polyvinylpyrrolidone) was dissolved in 2 mL of medium. The resulting PVP-containing medium was serially diluted in the same manner as in Example 1-3 to prepare Comparative Example 1-3.
比較例4-6は、以下の通り、調製した。 Comparative Examples 4-6 were prepared as follows.
DMSOを溶媒とし、100mMレチノール溶液を調製した。調製した100mMレチノール溶液を培地にて段階希釈し、10μMレチノール含有培地(1.0%DMSO)を調製した。 A 100 mM retinol solution was prepared using DMSO as a solvent. The prepared 100 mM retinol solution was serially diluted with a medium to prepare a 10 μM retinol-containing medium (1.0% DMSO).
11.3mgのPVPを2mLの10μMレチノール含有培地(1.0%DMSO)に溶解した。得られたPVP・10μMレチノール含有培地(1.0%DMSO)を実施例4-6と同様に10μMレチノール含有培地(1.0%DMSO)にて段階希釈し、比較例4-6を調製した。 11.3 mg of PVP was dissolved in 2 mL of 10 μM retinol-containing medium (1.0% DMSO). The obtained PVP/10 μM retinol-containing medium (1.0% DMSO) was serially diluted with 10 μM retinol-containing medium (1.0% DMSO) in the same manner as in Example 4-6 to prepare Comparative Example 4-6. .
<比較例7-9>
比較例7-9では、リポソーム前駆体はPhytopresome F-2S(日本精化株式会社製、登録商標)を使用した。リポソーム前駆体は、水添レシチンとフィトステロールとを含む。
<Comparative Example 7-9>
In Comparative Examples 7-9, Phytopresome F-2S (manufactured by Nippon Fine Chemical Co., Ltd., registered trademark) was used as the liposome precursor. Liposome precursors include hydrogenated lecithin and phytosterols.
比較例7-9は、以下の通り、調製した。 Comparative Examples 7-9 were prepared as follows.
上記のリポソーム前駆体30mgを培地に溶解した。得られたリポソーム前駆体含有培地を実施例7-9と同様に段階希釈し、比較例7-9を調製した。 30 mg of the above liposome precursor was dissolved in the medium. The resulting liposome precursor-containing medium was serially diluted in the same manner as in Example 7-9 to prepare Comparative Example 7-9.
<比較例10-12>
比較例10-12では、比較例7-9と同様のリポソーム前駆体を使用した。
<Comparative Example 10-12>
In Comparative Examples 10-12, the same liposome precursors as in Comparative Examples 7-9 were used.
比較例10-12は、以下の通り、調製した。 Comparative Examples 10-12 were prepared as follows.
DMSOを溶媒とし、100mMレチノール溶液を調製した。調製した100mMレチノール溶液を培地にて段階希釈し、10μMレチノール含有培地(1.0%DMSO)を調製した。 A 100 mM retinol solution was prepared using DMSO as a solvent. The prepared 100 mM retinol solution was serially diluted with a medium to prepare a 10 μM retinol-containing medium (1.0% DMSO).
上記のリポソーム前駆体約0.304gに、調製した10μMレチノール溶液20μL、クロロホルム5mL、メタノール3mLを添加した後に、超音波を1分間照射して、溶解させた。エバポレーターにて溶媒を留去し、15分間減圧乾燥して、レチノール含有リポソーム前駆体を得た。 After adding 20 μL of the prepared 10 μM retinol solution, 5 mL of chloroform, and 3 mL of methanol to about 0.304 g of the liposome precursor, the mixture was dissolved by ultrasonic irradiation for 1 minute. The solvent was distilled off with an evaporator and dried under reduced pressure for 15 minutes to obtain a retinol-containing liposome precursor.
得られたレチノール含有リポソーム前駆体に1%DMSO含有培地20mLを加え、超音波を2分間照射した後に、器壁に残存したレチノール含有リポソーム前駆体をスパーテル(滅菌済)でこそいだ。本作業を5回繰り返し、リポソーム前駆体・10μMレチノール含有培地を得た。 20 mL of a 1% DMSO-containing medium was added to the obtained retinol-containing liposome precursor, and after 2 minutes of ultrasonic irradiation, the retinol-containing liposome precursor remaining on the vessel wall was scraped off with a spatula (sterilized). This operation was repeated 5 times to obtain a liposome precursor/10 μM retinol-containing medium.
得られたリポソーム前駆体・10μMレチノール含有培地を実施例10-12と同様に10μMレチノール含有培地(1.0%DMSO)にて段階希釈し、比較例10-12を調製した。 The obtained liposome precursor/10 μM retinol-containing medium was serially diluted with a 10 μM retinol-containing medium (1.0% DMSO) in the same manner as in Examples 10-12 to prepare Comparative Examples 10-12.
<参考例1>
参考例1は、DMSO520μLに培地51.48mLを加えて調製した。
<Reference example 1>
Reference Example 1 was prepared by adding 51.48 mL of medium to 520 μL of DMSO.
<参考例2>
参考例2は、DMSOを溶媒とし、100mMレチノール溶液を調製した。調製した100mMレチノール溶液を培地にて段階希釈し、10μMレチノール含有培地(1.0%DMSO)を調製した。
<Reference example 2>
In Reference Example 2, a 100 mM retinol solution was prepared using DMSO as a solvent. The prepared 100 mM retinol solution was serially diluted with a medium to prepare a 10 μM retinol-containing medium (1.0% DMSO).
実施例1-12、比較例1-12、参考例1,2は、下記の「細胞毒性」と「ヒアルロン酸量」とについて評価した。 Examples 1-12, Comparative Examples 1-12, and Reference Examples 1 and 2 were evaluated for the following "cytotoxicity" and "hyaluronic acid amount".
<1>細胞毒性
正常ヒト表皮角化細胞(NHEK細胞)の生存率に影響を与えるかを、クリスタルバイオレットを用いる細胞染色法により確認した。
<1> Cytotoxicity It was confirmed by a cell staining method using crystal violet whether the viability of normal human epidermal keratinocytes (NHEK cells) was affected.
具体的には、以下の通りである。
(1)ウェルプレート(1.0×104cells/well)に正常ヒト表皮角化細胞を播種する。
(2)37℃で24時間、インキュベートする。
(3)培地をアスピレートし、実施例、比較例、参考例および標準液を120μL添加する。
(4)37℃で24時間、インキュベートする。
(5)クリスタルバイオレット溶液を100μLずつ添加して染色する。
(6)正常ヒト表皮角化細胞を顕微鏡により撮影する(倍率:4倍、scalebar:10μm)。
Specifically, it is as follows.
(1) Seed normal human epidermal keratinocytes in a well plate (1.0×10 4 cells/well).
(2) Incubate at 37°C for 24 hours.
(3) Aspirate the medium and add 120 μL of the examples, comparative examples, reference examples and standard solutions.
(4) Incubate at 37°C for 24 hours.
(5) Stain by adding 100 μL of crystal violet solution each.
(6) Normal human epidermal keratinocytes are photographed under a microscope (magnification: 4x, scalebar: 10 µm).
図1は、実施例、比較例、参考例における正常ヒト表皮角化細胞の写真である。図1から把握される通り、実施例、比較例、参考例の全てについて、細胞の形態変化は観測されず、細胞数にも変化が見られなかった。すなわち、フラーレン(A)が含有される実施例1-6、および、フラーレン(A)に加えてレチノール(B)が含有される実施例7-12は、細胞毒性がないことが確認できた。以上の通り、本発明に係るヒアルロン酸産生促進剤は、安全性も高いことが把握できる。 FIG. 1 shows photographs of normal human epidermal keratinocytes in Examples, Comparative Examples, and Reference Examples. As can be seen from FIG. 1, no change in cell morphology was observed and no change in the number of cells was observed in any of Examples, Comparative Examples, and Reference Examples. That is, it was confirmed that Examples 1-6 containing fullerene (A) and Examples 7-12 containing retinol (B) in addition to fullerene (A) had no cytotoxicity. As described above, it can be understood that the hyaluronic acid production promoter according to the present invention is highly safe.
<2>ヒアルロン酸
実施例、比較例、参考例におけるヒアルロン酸産生促進効果を確認した。なお、実施例、比較例、参考例および標準液は、<1>細胞毒性の評価において(4)の手順の後に採取した培養上清を使用する。
<2> Hyaluronic acid Hyaluronic acid production promoting effect was confirmed in Examples, Comparative Examples, and Reference Examples. For the examples, comparative examples, reference examples and standard solutions, the culture supernatant collected after the procedure (4) in the evaluation of <1> cytotoxicity is used.
ヒアルロン酸産生促進効果の確認は、ELISA(Enzyme-Linked Immuno Sorbent Assay)法により行った。ELISA法は、試料溶液中に含まれる目的の抗原あるいは抗体を、物質抗体あるいは抗原で捕捉するとともに、酵素反応を利用して検出および定量する方法である。酵素活性の検出には、反応によって吸光スペクトルが変化する基質が用いられ、吸光度測定で数値化される。 Hyaluronic acid production promoting effect was confirmed by ELISA (Enzyme-Linked Immuno Sorbent Assay) method. The ELISA method is a method in which a target antigen or antibody contained in a sample solution is captured with a substance antibody or antigen, and detected and quantified using an enzymatic reaction. Enzyme activity is detected using a substrate whose absorbance spectrum changes depending on the reaction, and is quantified by absorbance measurement.
具体的には、以下の通りである。なお、本測定では、Hyaluronan Enzyme-Linked Immunosorbent Assay Kit(Echelon Biosciences Inc.)を使用した。 Specifically, it is as follows. In this measurement, Hyaluronan Enzyme-Linked Immunosorbent Assay Kit (Echelon Biosciences Inc.) was used.
(1)3200ng/mLのヒアルロン酸(HA)標準液を希釈液にて段階希釈を行い、1600,800,400,200,100,50ng/mLのヒアルロン酸標準液を調製した。
(2)培養プレート(ウェルプレート)の各ウェルそれぞれに、希釈液140μL(BlankControl)、培養上清90μL(Control、実施例、比較例、参考例)とヒアルロン酸(HA)検出液50μL、調製したヒアルロン酸標準液90μLとヒアルロン酸(HA)検出液50μL、希釈液90μLとヒアルロン酸(HA)検出液50μL(zeroHA)に調製する。
(3)37℃で1時間、インキュベートする。
(4)各ウェルから100μLを培養プレートから検出プレートに移す。
(5)検出プレートを4℃で30分間、インキュベートする。
(6)200μLの洗浄液で3回洗浄し、その後、酵素液を100μL加える。
(7)37℃で30分間、インキュベートする。
(8)200μLの洗浄液で3回洗浄し、その後、基質溶液を100μL加える。
(9)室温・暗所で45分間にわたりインキュベートする。インキュベートを開始してから15分、30分、45分経過した各時点で405nmの吸光度を測定する。
(10)停止溶液を50μL加えて、反応を停止する。
(1) A 3200 ng/mL hyaluronic acid (HA) standard solution was serially diluted with diluents to prepare 1600, 800, 400, 200, 100 and 50 ng/mL hyaluronic acid standard solutions.
(2) In each well of a culture plate (well plate), 140 μL of diluent (Blank Control), 90 μL of culture supernatant (Control, Example, Comparative Example, Reference Example) and 50 μL of hyaluronic acid (HA) detection solution were prepared. Prepare 90 μL of hyaluronic acid standard solution, 50 μL of hyaluronic acid (HA) detection solution, 90 μL of diluent and 50 μL of hyaluronic acid (HA) detection solution (zeroHA).
(3) Incubate at 37°C for 1 hour.
(4)
(5) Incubate the detection plate for 30 minutes at 4°C.
(6) Wash three times with 200 μL of washing solution, and then add 100 μL of enzyme solution.
(7) Incubate at 37°C for 30 minutes.
(8) Wash three times with 200 μL of washing solution, then add 100 μL of substrate solution.
(9) Incubate for 45 minutes at room temperature in the dark. Absorbance at 405 nm is measured at 15, 30, and 45 minutes after starting the incubation.
(10) Add 50 μL of stop solution to stop the reaction.
表1および表2には、実施例、比較例および参考例について吸光度の測定結果から特定したヒアルロン酸量(Controlにおけるヒアルロン酸量を100%としたときの相対値)が記載されている。なお、表1および表2におけるヒアルロン酸量は、上記(8)において45分経過した時点における吸光度から算出したヒアルロン酸量の平均値(サンプル数n=3)である。 Tables 1 and 2 show the amount of hyaluronic acid (relative value when the amount of hyaluronic acid in Control is 100%) specified from the results of absorbance measurement for Examples, Comparative Examples, and Reference Examples. The amount of hyaluronic acid in Tables 1 and 2 is the average amount of hyaluronic acid (sample number n=3) calculated from the absorbance after 45 minutes in (8) above.
図2は、実施例1-3および比較例1-3のヒアルロン酸量を表すグラフであり、図3は、実施例4-6および比較例4-6のヒアルロン酸量を表すグラフであり、図4は、実施例1-3および実施例4-6のヒアルロン酸量を表すグラフである。 FIG. 2 is a graph showing the amounts of hyaluronic acid in Examples 1-3 and Comparative Examples 1-3, and FIG. 3 is a graph showing the amounts of hyaluronic acid in Examples 4-6 and Comparative Examples 4-6. FIG. 4 is a graph showing the amounts of hyaluronic acid in Examples 1-3 and 4-6.
図2から把握される通り、フラーレン(A)が含有される実施例1-3は、フラーレン(A)が含有されない比較例1-3と比較して、ヒアルロン酸量が大きく増加した。また、図3から把握される通り、フラーレン(A)が含有される実施例4-6は、フラーレン(A)が含有されない参考例2および比較例4-6と比較して、ヒアルロン酸量が大きく増加した。以上の通り、フラーレン(A)がヒアルロン酸産生促進効果を有することが確認できた。 As can be seen from FIG. 2, Example 1-3 containing fullerene (A) had a significantly increased amount of hyaluronic acid compared to Comparative Example 1-3 containing no fullerene (A). Further, as can be seen from FIG. 3, Example 4-6 containing fullerene (A) has a higher amount of hyaluronic acid than Reference Example 2 and Comparative Example 4-6, which do not contain fullerene (A). increased significantly. As described above, it was confirmed that fullerene (A) has a hyaluronic acid production promoting effect.
そして、図4から把握される通り、レチノール(B)が含有される実施例4-6は、レチノール(B)が含有されない実施例1-3と比較して、ヒアルロン酸産生促進効果が顕著であった。具体的には、フラーレン(A)とレチノール(B)とを併用すると、フラーレン(A)のみを配合する場合と比較して、ヒアルロン酸量が約2倍になった。以上の通り、フラーレン(A)に加えてレチノール(B)を配合することで、ヒアルロン酸産生促進効果が更に向上することが確認できた。 As can be seen from FIG. 4, Examples 4-6 containing retinol (B) have a remarkable effect of promoting hyaluronic acid production compared to Examples 1-3 containing no retinol (B). there were. Specifically, when fullerene (A) and retinol (B) were used in combination, the amount of hyaluronic acid was approximately doubled compared to when only fullerene (A) was blended. As described above, it was confirmed that the addition of retinol (B) to fullerene (A) further improved the effect of promoting hyaluronic acid production.
図5は、実施例7-9および比較例7-9のヒアルロン酸量を表すグラフであり、図6は、実施例10-12および比較例10-12のヒアルロン酸量を表すグラフであり、図7は、実施例7-9および実施例10-12のヒアルロン酸量を表すグラフである。 FIG. 5 is a graph showing the amounts of hyaluronic acid in Examples 7-9 and Comparative Examples 7-9, and FIG. 6 is a graph showing the amounts of hyaluronic acid in Examples 10-12 and Comparative Examples 10-12. FIG. 7 is a graph showing the amounts of hyaluronic acid in Examples 7-9 and Examples 10-12.
図5から把握される通り、フラーレン(A)が含有される実施例7-9は、フラーレン(A)が含有されない比較例7-9と比較して、ヒアルロン酸量が大きく増加した。また、図6から把握される通り、フラーレン(A)が含有される実施例10-12は、フラーレン(A)が含有されない参考例2,比較例10-12と比較して、ヒアルロン酸量が大きく増加した。以上の通り、フラーレン(A)がヒアルロン酸産生促進効果を有することが確認できた。 As can be seen from FIG. 5, Example 7-9 containing fullerene (A) had a significantly increased amount of hyaluronic acid compared to Comparative Example 7-9 containing no fullerene (A). Further, as can be seen from FIG. 6, Examples 10-12 containing fullerene (A) have a higher amount of hyaluronic acid than Reference Example 2 and Comparative Examples 10-12, which do not contain fullerene (A). increased significantly. As described above, it was confirmed that fullerene (A) has a hyaluronic acid production promoting effect.
そして、図7から把握される通り、レチノール(B)が含有される実施例10-12は、レチノール(B)が含有されない実施例7-9と比較して、ヒアルロン酸産生促進効果が顕著であった。具体的には、フラーレン(A)とレチノール(B)とを併用すると、フラーレン(A)のみを配合する場合と比較して、ヒアルロン酸量が2倍以上になった。以上の通り、フラーレン(A)に加えてレチノール(B)を配合することで、ヒアルロン酸産生促進効果が更に向上することが確認できた。言い換えれば、レチノール(B)はフラーレン(A)が有するヒアルロン酸産生促進効果をさらに向上させる向上剤として機能することが確認できた。 As can be seen from FIG. 7, Examples 10-12 containing retinol (B) have a remarkable hyaluronic acid production promoting effect compared to Examples 7-9 containing no retinol (B). there were. Specifically, when fullerene (A) and retinol (B) were used in combination, the amount of hyaluronic acid was more than doubled compared to when only fullerene (A) was blended. As described above, it was confirmed that the addition of retinol (B) to fullerene (A) further improved the effect of promoting hyaluronic acid production. In other words, it was confirmed that retinol (B) functions as an enhancer that further enhances the hyaluronic acid production promoting effect of fullerene (A).
図8は、実施例1-3および実施例7-9のヒアルロン酸量を表すグラフであり、図9は、実施例4-6および実施例10-12のヒアルロン酸量を表すグラフである。 FIG. 8 is a graph showing the amounts of hyaluronic acid in Examples 1-3 and 7-9, and FIG. 9 is a graph showing the amounts of hyaluronic acid in Examples 4-6 and 10-12.
図8から把握される通り、実施例7-9は、実施例1-3と比較して、ヒアルロン酸量が高い。また、図9から把握される通り、実施例10-12は、実施例4-6と比較して、ヒアルロン酸量が高い。以上の通り、ヒアルロン酸産生促進剤にフラーレン(A)としてリポソーム複合化フラーレンを使用すると、PVP-フラーレン複合体をフラーレン(A)として使用する場合と比較して、ヒアルロン酸産生促進効果が更に向上することが確認できた。 As can be seen from FIG. 8, Examples 7-9 have a higher amount of hyaluronic acid than Examples 1-3. Moreover, as can be seen from FIG. 9, Examples 10-12 have a higher amount of hyaluronic acid than Examples 4-6. As described above, when the liposome-complexed fullerene is used as the fullerene (A) for the hyaluronic acid production promoter, the hyaluronic acid production promoting effect is further improved compared to the case where the PVP-fullerene complex is used as the fullerene (A). It was confirmed that
Claims (6)
ヒアルロン酸産生促進剤。 A hyaluronic acid production promoter containing fullerene as an active ingredient.
請求項1のヒアルロン酸産生促進剤。 The hyaluronic acid production promoter according to claim 1, which contains retinol.
請求項2の酸産生促進剤。 3. The acid production accelerator according to claim 2, wherein the blending ratio of said fullerene and said retinol is 1:2 to 10:1.
請求項1または請求項2のヒアルロン酸産生促進剤。 3. The agent for promoting hyaluronic acid production according to claim 1, wherein the fullerene is formulated as a liposome-complexed fullerene.
化粧料。 A cosmetic comprising the hyaluronic acid production promoter of claim 1 or claim 2.
ヒアルロン酸産生促進剤の製造方法。 A method for producing a hyaluronic acid production promoter containing fullerene as an active ingredient.
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