JP2022162982A - Vitamin b2-containing oral liquid composition - Google Patents

Abstract

To provide an oral liquid composition containing galangal extract and a vitamin B2, the composition showing a reduction in unpleasant odor.SOLUTION: An oral liquid composition contains A) galangal extract, B) a vitamin B2, and C) caffeine and/or arginine.SELECTED DRAWING: None

Description

The present invention relates to oral liquid compositions incorporating galangal extracts. More particularly, it relates to an oral liquid composition in which the unpleasant odor peculiar to a composition containing a galangal extract and vitamin B2s is suppressed.

In recent years, there has been an increasing demand for energy drinks for the purpose of uplifting and refreshing the mood. Such energy drinks often contain vitamins such as vitamin B1, vitamin B2, vitamin B12, and ascorbic acid. In addition, it usually contains caffeine, which shows an awakening effect by stimulating the central nervous system, and some general consumers want a stronger sense of awakening and choose energy drinks with a large amount of caffeine. Sometimes.

In addition, food materials having stimulating effects similar to caffeine have been developed. As one of the materials, the rhizome of Alpinia galanga L., a plant belonging to the genus Zingiberaceae, has been shown to enhance alertness and alertness. The effect of raising the standard is recognized, and it is attracting attention (Non-Patent Document 1).
However, although there are, for example, Organics by RedBull Simply Cola (Red Bull Japan) and XS Energy Coffee (Amway Japan) as beverages containing galangal, they are few in number.

Shalini, S. et al. (2017) Journal of the American College of Nutrition, 36(8), 631-639.

Based on the above background, the inventors have newly found that a unique unpleasant odor is produced by blending vitamin B2 or its derivatives or salts thereof (hereinafter also referred to as "vitamin B2s") with galangal. .
Accordingly, the present invention is to provide an oral liquid composition containing a galangal extract and vitamins B2, in which the characteristic unpleasant odor is reduced.

The present inventors have made intensive studies to solve the above problems, and as a result, in a composition containing an extract of the rhizome of Alpinia galanga L., a plant belonging to the genus Zingiberaceae, and vitamin B2s, caffeine And/or it was found that the addition of arginine can reduce the peculiar unpleasant odor that occurs when the galangal extract and vitamin B2 are contained.

That is, the present invention is as follows.
(1) an oral liquid composition comprising A) a galangal extract, B) vitamin B2s, and C) caffeine and/or arginine;
(2) A) the oral liquid composition according to (1), wherein the concentration of the galangal extract is 0.001 to 10% by mass as a dry solid content;
(3) B) The oral liquid composition according to (1) or (2), wherein the concentration of vitamin B2 is 0.0001 to 0.1% by mass,
(4) C) The oral liquid composition according to any one of (1) to (3), wherein the caffeine concentration is 0.001 to 1% by mass.
(5) C) The oral liquid composition according to any one of (1) to (4), wherein the arginine concentration is 0.01 to 20% by mass.
(6) The oral liquid composition according to any one of (1) to (5), which has a pH of 2.0 to 7.0,
(7) the oral liquid composition according to any one of (1) to (6), wherein the oral liquid composition is a liquid drink;
(8) A method of suppressing an unpleasant odor in a liquid composition containing a galangal extract and vitamin B2s by adding caffeine and/or arginine.

INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to provide an oral liquid composition containing a galangal extract and vitamins B2, in which the unpleasant odor peculiar to the oral liquid composition is reduced.

The galangal extract in the present invention refers to the rhizome of Alpinia galanga L. (Alpinia galanga L.), which is a plant belonging to the genus Zingiberaceae (Alpinia galanga L.) (also known as galanga, nankyo, etc.). It can be obtained by extraction after crushing, pulverizing, or the like. That is, the galangal extract in the present invention is an extract of galangal rhizomes. Galangal is different from black ginger, which is a plant belonging to the genus Curcuma of the family Zingiberaceae, and turmeric, which is a plant of the genus Curcuma of the family Zingiberaceae.

The extraction treatment method is not particularly limited, and for example, a known extraction method such as a stirring/shaking/immersion extraction method using an organic solvent such as ethanol, water, or a mixture thereof, or a vacuum steam distillation extraction method may be used. If necessary, centrifugation, enzymatic treatment (treatment with an enzymatic agent based on koji mold or black koji mold), column or filtration (filtration with a strainer mesh, membrane filter, etc.) may be used to remove insoluble matter. . The galangal extract in the present invention preferably uses water and/or alcohol as an extraction solvent, more preferably ethanol as the alcohol, and particularly preferably water alone. The extract obtained by extraction as described above may be used in a liquid state, or may be dried and used in a powder state. Biolife's enXtra ^™ , etc.) may also be used.

The content of the galangal extract in the present invention is preferably 0.001 to 10% by mass, more preferably 0.01 to 5% by mass, in terms of the dry solid content of the galangal extract in the oral liquid composition of the present invention. Preferably, 0.02 to 1% by mass is more preferable, 0.05 to 0.5% by mass is even more preferable, and 0.06 to 0.3% by mass is particularly preferable.
Here, the term "dry solid content conversion amount" refers to the amount converted to the amount of the portion excluding water. Moisture content can be measured using a conventionally known heat drying method, Karl Fischer method, or the like.

In addition, the content of the galangal extract in the present invention is preferably 0.01 to 100% by mass, more preferably 0.1 to 50% by mass, in terms of galangal rhizome, in the oral liquid composition of the present invention. 0.2 to 10% by mass is more preferable, 0.5 to 5% by mass is even more preferable, and 0.6 to 3% by mass is particularly preferable.

The oral intake of the galangal extract in the present invention is preferably 10 to 1000 mg, more preferably 50 to 500 mg, more preferably 100 mg, in terms of the dry solid content of the galangal extract in the oral liquid composition of the present invention. ~400 mg is more preferred, and 150-300 mg is even more preferred. The term "per oral intake" as used herein refers to the amount of the oral liquid composition of the present invention that is ingested at one time, more It indicates the amount to be ingested for a period of time, and is, for example, 50 mL to 500 mL.

In the present invention, vitamin B2 refers to vitamin B2 or derivatives thereof or salts thereof, which are usually edible, and examples thereof include riboflavin, riboflavin phosphate, riboflavin butyrate, flavin adenine dinucleotide and salts thereof. be able to. The salt used in the present invention is preferably a sodium salt, and in the present invention, sodium riboflavin 5'-phosphate is particularly preferred. The vitamin B2s used in the present invention can be produced by known methods, and commercially available products (such as riboflavin 5'-phosphate sodium manufactured by DSM and riboflavin 5'-phosphate sodium manufactured by Iwaki Seiyaku Co., Ltd.) can also be used. can.

The content of vitamin B2 in the present invention is preferably 0.0001 to 0.1% by mass, more preferably 0.0005 to 0.02% by mass, more preferably 0.001 to 0.001% by mass, in the oral liquid composition of the present invention. 0.01% by weight is more preferred.

In the oral liquid composition of the present invention, the mass ratio of the dry solid content of the galangal extract and vitamin B2, that is, the content of vitamin B2 relative to 1 part by mass of the dry solid content of the galangal extract is 0 .0002 to 100 parts by mass is preferable, 0.0002 to 10 parts by mass is more preferable, 0.03 to 10 parts by mass is more preferable, 0.003 to 0.25 parts by mass is even more preferable, and 0.006 to 0 0.25 parts by weight is particularly preferred.

In the oral liquid composition of the present invention, the mass ratio of the galangal rhizome-equivalent amount of the galangal extract and the vitamin B2s, that is, the content of the vitamin B2s relative to 1 part by mass of the galangal extract-equivalent galangal rhizome is 0.00002. ~10 parts by mass is preferable, 0.00002 to 1 part by mass is more preferable, 0.003 to 1 part by mass is more preferable, 0.0003 to 0.025 parts by mass is even more preferable, and 0.0006 to 0.025 Parts by weight are particularly preferred.

In the present invention, caffeine is one of alkaloids whose chemical name is 1,3,7-trimethylxanthine, and is not particularly limited in the present invention, but is a chemically synthesized product that can be produced by a known method. Alternatively, extracts of caffeine-containing plants (coffee beans, tea leaves, cola seeds, etc.) and concentrated purified products thereof can be used. can also be used.

The content of caffeine in the present invention is preferably 0.001 to 1 mass%, preferably 0.01 to 0, in the oral liquid composition of the present invention from the viewpoint of sufficiently improving the unpleasant odor derived from the galangal extract. 0.5% by weight is more preferred, 0.01 to 0.2% by weight is more preferred, 0.02 to 0.2% by weight is even more preferred, and 0.05 to 0.2% by weight is even more preferred.

In the oral liquid composition of the present invention, the mass ratio of the dry solid content of the galangal extract and caffeine, that is, the content of caffeine relative to 1 part by mass of the dry solid content of the galangal extract is 0.0001. Up to 200 parts by mass is preferable, 0.0001 to 10 parts by mass is more preferable, and 0.005 to 2.5 parts by mass is even more preferable.

In the oral liquid composition of the present invention, the mass ratio of the amount of galangal extract converted to galangal rhizome and caffeine, that is, the content of caffeine relative to 1 part by mass of galangal extract converted to galangal rhizome is 0.00001 to 20. Parts by mass are preferable, 0.00001 to 1 part by mass is more preferable, and 0.0005 to 0.25 parts by mass is even more preferable.

The mass ratio of vitamin B2 and caffeine in the oral liquid composition of the present invention, that is, the content of caffeine relative to 1 part by mass of vitamin B2, is preferably 0.001 to 100 parts by mass, and 0.001 to 100 parts by mass. 001 to 50 parts by mass, more preferably 0.001 to 10 parts by mass, even more preferably 0.001 to 5 parts by mass, and particularly preferably 0.05 to 2.5 parts by mass.

Arginine or a salt thereof in the present invention refers to 2-amino-5-guanidinopentanoic acid or a salt thereof as a chemical name. Any of L-arginine, D-arginine, and racemic DL-arginine may be used. Free arginine may be used in the present invention, or arginine in the form of a salt may be used. The salt form of arginine is not particularly limited as long as it is a salt that is acceptable for eating and drinking, and examples thereof include hydrochloride, nitrate, sulfate, citrate, acetate and glutamate. The arginine or arginine salt used in the present invention can be produced by a known method, or commercially available products (L-arginine manufactured by Nakahara, arginine manufactured by Kyowa Hakko Bio, L-arginine manufactured by Ajinomoto Healthy Supply, etc.). can.

The content of arginine or a salt thereof in the present invention is preferably 0.001 to 10% by mass in the oral liquid composition of the present invention from the viewpoint of sufficiently improving the unpleasant odor derived from the galangal extract, and 0.01 ~5% by mass is more preferred, and 0.05 to 1.5% by mass is particularly preferred.

In the oral liquid composition of the present invention, the mass ratio of the dry solid content of the galangal extract and arginine or its salt, that is, the content of arginine or its salt relative to 1 part by mass of the dry solid content of the galangal extract , preferably 0.001 to 100 parts by mass, more preferably 0.01 to 50 parts by mass, and even more preferably 0.3 to 15 parts by mass.

In the oral liquid composition of the present invention, the mass ratio of the galangal rhizome equivalent amount of the galangal extract and arginine, that is, the content of arginine relative to 1 part by mass of the galangal extract equivalent galangal rhizome amount is 0.0001 to 10 parts by mass. is preferred, 0.001 to 5 parts by weight is more preferred, and 0.03 to 1.5 parts by weight is even more preferred.

The mass ratio of vitamin B2 and arginine in the oral liquid composition of the present invention, that is, the content of arginine per 1 part by mass of vitamin B2 is preferably 0.1 to 200000 parts by mass, more preferably 10 to 15000 parts by mass. It is preferably 10 to 1000 parts by mass, particularly preferably 10 to 300 parts by mass.

The pH of the oral liquid composition of the present invention is not particularly limited, but from the viewpoint of being suitable for drinking, the lower limit is preferably 2.0 to 7.0, more preferably 2.5 to 4.5, and 3.0 4.0 is more preferred. The pH of the oral liquid composition of the present invention can be adjusted using commonly used pH adjusters. Specific pH adjusters include organic acids such as citric acid, malic acid, tartaric acid, succinic acid, lactic acid, acetic acid, maleic acid, gluconic acid, aspartic acid, adipic acid, glutamic acid, and fumaric acid, salts thereof, and hydrochloric acid. and inorganic bases such as sodium hydroxide. Preferred pH adjusters are citric acid and/or salts thereof, hydrochloric acid, and sodium hydroxide.

In addition, the oral liquid composition of the present invention may contain other ingredients such as vitamins other than vitamin B2, minerals, amino acids other than arginine or salts thereof, herbal medicines, as long as the effects of the present invention are not impaired. Herbal medicine extracts, royal jelly and the like can be blended as appropriate. Furthermore, the oral liquid composition of the present invention may contain antioxidants, coloring agents, flavoring agents, corrigents, surfactants, thickeners, stabilizers, preservatives, and sweeteners as long as they do not impair the effects of the present invention. , an acidulant, etc., can be added as appropriate.

The oral liquid composition in the present invention is not particularly limited as long as it is a liquid composition that can be taken orally. ). Examples of pharmaceuticals and quasi-drugs include internal liquids and drinks. Foods include soft drinks, carbonated drinks, sports/functional drinks, non-alcoholic drinks, milk drinks, tea drinks, coffee drinks, fruit/vegetable drinks, jelly drinks and the like.

The oral liquid composition of the present invention can be produced by a conventionally known method. For example, after adding galangal extract and vitamin B2 to water and adding caffeine and/or arginine, if desired, the other components described above are added and dissolved, and water is added to adjust the volume. It can be provided as an easy-to-carry oral liquid composition by subjecting it to pH adjustment and heat sterilization as necessary and filling it in a container.

When the oral liquid composition of the present invention is a carbonated drink, for example, water is added with galangal extract and vitamin B2, caffeine and / or arginine is added, and if desired, the other ingredients described above are added. Add and dissolve to prepare a beverage concentrate. After adjusting the pH and sterilizing by heating as necessary, after cooling, carbon dioxide is injected (carbonation), filled in a container, and sterilized as appropriate. The gas volume is preferably between 0.5 and 4.0. The gas volume is the volume ratio of carbon dioxide dissolved in liquid 1 as a solvent under standard conditions (1 atm, 20° C.). There are a premix method and a postmix method for producing carbonated beverages, and either method may be employed in the present invention.

EXAMPLES The present invention will be described in more detail below with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples and the like. Riboflavin 5'-phosphate sodium, caffeine extract, and L-arginine are commercially available products (riboflavin 5'-phosphate sodium: manufactured by DSM, caffeine extract: manufactured by Shiratori Pharmaceutical, L-arginine: Kyowa Fermented Bio) was used in the following examples and comparative examples.
(Extraction Examples 1-2, Comparative Examples 1-13, Examples 1-1-13)

Preparation of galangal extract:
[Extraction Example 1: Hereinafter, referred to as galangal extract A in the present invention]
Galangal rhizomes were extracted with hot water and concentrated under reduced pressure using a conventional method to obtain a dry powdery (solid) extract of 1/10 of the mass of galangal rhizomes.
[Extraction Example 2: Hereinafter, referred to as galangal extract B in the present invention]
Galangal rhizomes were extracted with hot water, and subjected to enzymatic treatment, filtration, and concentration under reduced pressure using conventional methods to obtain a liquid (liquid) extract of Brix 15 (soluble solid content: 15%).
In the tables of test examples, both galangal extracts A and B are described in terms of galangal dry solid content.

Preparation of oral liquid composition:
Oral liquid compositions were prepared according to the formulations shown in Tables 2-8 below and the following method. First, sodium riboflavin 5′-phosphate as vitamin B2, galangal extract A or galangal extract B, caffeine or arginine was added to approximately 90% of the total amount of purified water, and the mixture was thoroughly stirred. After stirring, the pH was adjusted using hydrochloric acid and sodium hydroxide solution, and purified water was added to make up the total volume to obtain oral liquid compositions (Examples 1-1 to 1-13). Oral liquid compositions without addition of galangal extract A or galangal extract B (Comparative Examples 1-13) served as controls.

The resulting oral liquid composition was passed through a screw tube no. 6 (manufactured by Maruem Co., Ltd.) was filled with 30 ml and sterilized at 80° C. for 25 minutes. After leaving the oral liquid composition prepared as described above under an illumination of 3000 lux for 7 days using a standard light source D65 defined by the International Commission on Illumination (CIE), it was smelled and measured according to the criteria in Table 1. The degree of reduction of unpleasant odor was evaluated.

As is clear from Tables 2 to 8, the composition containing galangal extract and vitamin B2, and containing caffeine or arginine, compared to the comparative example, when containing galangal extract and vitamin B2 It showed the effect of reducing the peculiar unpleasant odor that occurs.

(Examples 14-16)
Liquid beverages and carbonated beverages were prepared according to the formulations listed in Table 9 and the following methods.

Preparation of liquid beverages:
Ingredients other than sodium riboflavin 5′-phosphate and sodium benzoate were added and dissolved in about 50% of the total amount of water. Separately, about 10% of the total amount of sodium riboflavin 5′-phosphate and sodium benzoate were added and dissolved in water at 70° C., and the mixture was thoroughly stirred. After stirring, trisodium citrate was used to adjust the pH, and purified water was added to make up the total volume to obtain oral liquid compositions (Examples 14 and 15). The obtained oral liquid composition was filled in a 100 ml tea bottle, sealed, and then sterilized at 80° C. for 25 minutes. After sterilization, the prepared oral liquid composition was allowed to stand under illumination of standard light source D65, 3000 lux for 7 days. In the same manner as in Examples 1-1 to 1-13 and Comparative Examples 1-13, the evaluation criteria in Table 1 were used to evaluate the peculiar unpleasant odors produced when the galangal extract and vitamin B2 were contained.

Preparation of carbonated drinks:
Ingredients other than sodium riboflavin 5′-phosphate and sodium benzoate were added and dissolved in about 10% of the total amount of water. Separately, about 2.5% of the total amount of sodium riboflavin 5′-phosphate and sodium benzoate were added and dissolved in water at 70° C., and the mixture was thoroughly stirred. After stirring, the pH was adjusted with trisodium citrate and water was added to 25% of the total volume to prepare a beverage concentrate. This undiluted beverage was sterilized at 80° C. for 25 minutes, carbonated water was added to make up the total volume, and 250 ml was filled in a transparent sealed container (Example 16). After filling, the prepared oral liquid composition was allowed to stand under illumination of standard light source D65, 3000 lux for 7 days. In the same manner as in Examples 1-1 to 1-13 and Comparative Examples 1-13, the evaluation criteria in Table 1 were used to evaluate the peculiar unpleasant odors produced when the galangal extract and vitamin B2 were contained.

As is clear from Table 9, in Examples 14 to 16, it was confirmed that almost no unpleasant odor was felt when the galangal extract and vitamin B2 were blended, or only a slight odor was felt.

INDUSTRIAL APPLICABILITY According to the present invention, it has become possible to suppress the unpleasant odor when a galangal extract and vitamin B2 are added to an oral liquid composition. It is expected to provide a high oral liquid composition.

Claims (8)

An oral liquid composition, characterized in that it contains A) a galangal extract, B) vitamins B2, and C) caffeine and/or arginine. A) The oral liquid composition according to (1), wherein the concentration of the galangal extract is 0.001 to 10% by mass in terms of dry solid content. B) The oral liquid composition according to claim 1 or 2, wherein the concentration of vitamin B2 is 0.0001 to 0.1% by mass. C) The oral liquid composition according to any one of claims 1 to 3, wherein the concentration of caffeine is 0.001-1% by weight. C) The oral liquid composition according to any one of claims 1 to 4, wherein the arginine concentration is 0.01 to 20% by mass. The oral liquid composition according to any one of claims 1 to 5, which has a pH of 2.0 to 7.0. Oral liquid composition according to any one of claims 1 to 6, wherein the oral liquid composition is a liquid drink. A method for suppressing an unpleasant odor in a liquid composition containing a galangal extract and B2 vitamins by adding caffeine and/or arginine.