JP2022161549A - Water-in-oil emulsion composition - Google Patents

Abstract

To provide a water-in-oil emulsion composition that does not cause stickiness during its application and does not cause dryness of the skin after the application.SOLUTION: A water-in-oil emulsion composition contains (A) organic modified bentonite and (B) at least one selected from glycyrrhetinic acid, a derivative thereof and salts thereof, and a resorcinol derivative and a salt thereof.SELECTED DRAWING: None

Description

The present invention relates to a water-in-oil emulsion composition.

A water-in-oil emulsifier type is one of the formulations of external preparations for skin such as cosmetics.
A water-in-oil emulsified composition has a high blocking effect due to the presence of an oily component in the continuous phase, and has advantages such as high moisture retention.
Moreover, in emulsifier-type emulsions, separation may occur over time and temperature, so it is common practice to incorporate an organically modified clay mineral for the purpose of stabilizing emulsified particles (for example, Patent Document 1).
In addition, glycyrrhetinic acid derivatives and salts thereof and resorcinol derivatives and salts thereof are used in external preparations for skin as ingredients having a whitening action (for example, Patent Document 2).

JP 2019-089744 A JP 2011-246353 A

While the water-in-oil emulsion composition is preferred for its moisturizing feeling after application, it may feel sticky when applied to the skin. Moreover, when the water-in-oil emulsified composition contains a glycyrrhetinic acid derivative, a salt thereof, or a resorcinol derivative, the skin may feel dry after application.
In view of such circumstances, it is an object of the present invention to provide a water-in-oil emulsifier type composition that is not sticky when applied and does not give dry feeling to the skin after application.

As a result of intensive research by the present inventors, it was found that by using a specific organically modified clay mineral together with one or more selected from glycyrrhetinic acid, derivatives thereof and salts thereof, resorcinol derivatives and salts thereof, , conceived that the above problems can be solved, and completed the present invention.

That is, the present invention is as follows.
[1] A water-in-oil emulsified composition containing the following component (A) and component (B).
(A) Organically modified bentonite (B) One or more selected from glycyrrhetinic acid, derivatives thereof and salts thereof, and resorcinol derivatives and salts thereof [2] Component (A) is quaternium-90 bentonite, [ 1].
[3] The composition according to [1] or [2], wherein (B) glycyrrhetinic acid, derivatives thereof and salts thereof are dipotassium glycyrrhizinate.
[4] The composition according to any one of [1] to [3], wherein the (B) resorcinol derivative is 4-n-butylresorcinol.
[5] The composition according to any one of [1] to [4], wherein the content of component (A) is 0.1 to 3% by mass.
[6] The composition according to any one of [1] to [5], wherein the content of component (B) is 0.01 to 10% by mass.
[7] The composition according to any one of [1] to [6], wherein the mass ratio (A)/(B) of component (A) to component (B) is 0.1-50.
[8] The composition according to any one of [1] to [7], which is an external preparation for skin.

The water-in-oil emulsion composition of the present invention is not sticky when applied, and the skin does not feel dry after application. In addition, it is stable over time and temperature, specifically, the emulsified system does not separate even in the presence of glycyrrhetinic acid, its derivatives and/or salts thereof, and discoloration of resorcinol derivatives is suppressed. Deterioration of quality of the composition is suppressed. Therefore, the present invention provides a water-in-oil emulsified composition suitable for use as an external preparation for skin.

The present invention will be described in detail below. In this specification, "-" means a range including the numerical values before and after it.
The water-in-oil emulsion composition of the present invention contains (A) organically modified bentonite and (B) one or more selected from glycyrrhetinic acid, derivatives thereof and salts thereof, resorcinol derivatives and salts thereof. .

(A) Organically Modified Bentonite In the present invention, organically modified bentonite refers to organically modified bentonite, which is a type of clay mineral. Here, the term “organic modification” refers to the formation of a strong or loose bond between a part of the bentonite and a part of an organic compound through covalent or ionic bonds, thereby imparting part or all of the properties of the organic compound to the bentonite. Say. Examples of such modification include a method of binding a quaternary amino group and an anion portion of bentonite, a method of binding a carboxyl group and a cationic portion of bentonite, and the like. A particularly preferred method can be exemplified by
A compound having a quaternary amino group is not particularly limited, but a compound called quaternium is exemplified. Quaternium is a low-molecular-weight substituted quaternary ammonium salt, preferably a cosmetic raw material registered in the International Standard Cosmetic Ingredients (INCI). Furthermore, among quaternium compounds, the compound having a quaternary amino group that modifies bentonite is preferably a quaternium compound contained in conventional external preparations for skin. Preferred examples of quaternium compounds conventionally used in external preparations for skin include stearyltrimethylammonium chloride and dimethyldistearylammonium chloride.
The organically modified bentonite can be produced by a conventional method, but commercially available products can also be preferably used. Preferred examples include quaternium-90 bentonite and quaternium-18 bentonite.

The content of (A) organically modified bentonite in the composition of the present invention is preferably 0.1 to 3% by mass, more preferably 0.2 to 2% by mass, and still more preferably 0% of the total composition. .4 to 1.5% by mass.
By using it in such a range, it becomes easier to suppress stickiness at the time of application of the composition, and it becomes easy to suppress the feeling of dryness of the skin after application while making the dosage form more stable.

(B) Glycyrrhetinic acid, derivatives thereof, and salts thereof in the composition of the present invention can optionally employ ingredients known as active ingredients of quasi-drugs. Specific examples of derivatives of glycyrrhetinic acid include glycyrrhetinic acid and alkyl glycyrrhetinates such as stearyl glycyrrhetinate and lauryl glycyrrhetinate. These salts are usually pharmacologically acceptable salts, preferably potassium or ammonium. As (B), stearyl glycyrrhizinate, ammonium glycyrrhizinate, and dipotassium glycyrrhizinate are more preferable, and dipotassium glycyrrhizinate is particularly preferable.

(B) resorcinol derivatives and salts thereof in the composition of the present invention are not particularly limited, but preferred examples include resorcinol, 4-alkylresorcinol and salts thereof. These salts are usually pharmacologically acceptable salts. The alkyl group in the 4-alkylresorcinol is preferably a linear or branched alkyl group having 1 to 10 carbon atoms, more preferably an alkyl group having 3 to 6 carbon atoms. Specifically, methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, isobutyl group, sec-butyl group, tert-butyl group, amyl group, n-hexyl group, cyclohexyl group, octyl group , an isooctyl group, and the like. Specific examples of 4-alkylresorcinol include 4-methylresorcinol, 4-ethylresorcinol, 4-propylresorcinol, 4-(1-methylethyl)resorcinol, and 4-n-butylresorcinol. , 4-(2-methylpropylresorcinol), 4-(1-methylethylresorcinol), 1-ethylpropylresorcinol, 1-ethyl-2-methylpropylresorcinol -, 1-isopropyl-2-methylpropylresorcinol, 1-butylpentylresorcinol, 1-isopropyl-2-methylpropylresorcinol, 1-butylpentylresorcinol , 1-isobutyl-3-methylbutylresorcinol, 4-(1-methylpropyl)resorcinol, 4-(1-methylbutyl)resorcinol, 4-tert-butylresorcinol, etc. Of these, 4-n-butylresorcinol is particularly preferred.

(B) Glycyrrhetinic acid, derivatives thereof and salts thereof, and resorcinol derivatives and salts thereof in the composition of the present invention may be used singly or in combination of two or more. The total content thereof is preferably 0.01 to 10% by mass, more preferably 0.02 to 5% by mass, still more preferably 0.05 to 3% by mass, and particularly preferably is 0.1 to 2% by mass.
By using it in such a range, it becomes easier to suppress stickiness at the time of application of the composition while obtaining desired effects such as anti-inflammatory action and whitening action.

In addition, in the composition of the present invention, (A) organically modified bentonite for the total content of one or more selected from (B) glycyrrhetinic acid, derivatives thereof and salts thereof, and resorcinol derivatives and salts thereof The content mass ratio (A)/(B) is preferably 0.1 to 50, more preferably 0.1 to 30, still more preferably 0.2 to 20, and particularly preferably 0 .5 to 10. By combining them in such a mass ratio, stickiness is easily suppressed when the composition is applied, and the dosage form is more likely to be stabilized. While obtaining the effect, it becomes easier to suppress the dryness of the skin after application.

The dosage form of the composition of the present invention is a water-in-oil emulsion.
Such dosage form in the present invention is not particularly limited as long as the outermost phase is an oil phase, and may be O/W/O type or (W ₁ +W ₂ )/O type in addition to W/O type. .

The compositions of the invention usually contain an aqueous component and an oily component. The aqueous component may be any component other than water as long as it is soluble in water at 25 to 90° C., and surfactants are usually included therein. The oily component may be any component that phase-separates from the water after being suspended in water at 25 to 90° C. and allowed to stand for 1 hour.
In the emulsified composition of the present invention, the mass ratio of the content of the aqueous component and the oily component is not particularly limited, but is preferably 30:70 to 90:10, more preferably 60:40 to 85:15.

The water-in-oil emulsion composition of the present invention is less sticky when applied. In addition, the skin after application has a good feeling of use without feeling of dryness. Furthermore, it has excellent stability such that the emulsified system does not separate or undergo discoloration even after storage over time and temperature.

Therefore, the composition of the present invention can be preferably applied to external skin preparations.
The external preparation for skin is preferably in the form of cosmetics or quasi-drugs, and more preferably skin care cosmetics, sunscreen cosmetics, and make-up cosmetics.

The water-in-oil emulsion composition of the present invention can be produced according to a standard method.

The composition of the present invention may optionally contain other components commonly used in cosmetics as long as the effects of the present invention are not impaired. Such optional ingredients include, for example, oils, alcohols, ethers, powders, humectants, surfactants, sequestering agents, pearlescent agents, amino acids, organic amines, polymer emulsions, pH adjusters, vitamins, and antioxidants. agents, preservatives, water-soluble polymers, fragrances, various active ingredients other than (B), and the like.

Examples of oils include silicone oils, polar oils, natural oils, and hydrocarbon oils.

Examples of silicone oils include dimethylpolysiloxane (dimethicone), cyclopentasiloxane, decamethylcyclopentasiloxane, caprylyl methicone, trimethylsiloxysilicate, (dimethicone/vinyl dimethicone) crosspolymer, (dimethicone/phenyl vinyl dimethicone) crosspolymer, etc. are mentioned.

Polar oils include synthetic ester oils such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, and lactic acid. Cetyl, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl dicaprate Glycol, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexylate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexylate, tri-2-ethylhexanoic acid Glyceryl, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, cetostearyl alcohol , acetoglyceride, 2-heptylundecyl palmitate, diisobutyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-sebacate ethylhexyl, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, isononyl isononanoate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, octyl methoxycinnamate, 2-ethylhexyl para-methoxycinnamate, hexyl diethylaminohydroxybenzoylbenzoate and the like.

Natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, and linseed oil. Flower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, sinagiri oil, Japanese paulownia oil, jojoba oil, germ oil, sunflower oil, triglycerin, glyceryl trioctanoate, triisopalmitin and glyceryl acid.

Hydrocarbon oils include isododecane, isohexadecane, squalane, hydrogenated poly(C6-12) olefins, hydrogenated polyisobutene and the like.

Examples of alcohols include cetanol, batyl alcohol, behenyl alcohol, palmitoleyl alcohol, heptadecanol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, and elaidolinoleyl alcohol. , linolenyl alcohol, elide linolenyl alcohol, ricinoleyl alcohol, nonadecyl alcohol, arachidyl alcohol, heneicosanol, behenyl alcohol, erucyl alcohol and other monohydric alcohols; ethylene glycol, 1,3-butylene Glycol, trimethylene glycol, 1,2-butylene glycol, propylene glycol, dipropylene glycol, propanediol, 1,2-pentanediol, 3-methyl-1,3-butanediol, tetramethylene glycol, 2,3-butylene dihydric alcohols such as glycol, pentamethylene glycol, 2-butene-1,4-diol, hexylene glycol and octylene glycol; trihydric alcohols such as trimethylolpropane; tetrahydric alcohols such as pentaerythritol; xylitol pentahydric alcohols such as triglycerin, tetraglycerin, polyglycerin polyhydric alcohol polymers such as polyglycerin; sugar alcohols such as starch-degrading sugar reducing alcohol; polyglycerin;
Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, ethylene glycol monophenyl ether, ethylene glycol monohexyl ether, ethylene glycol mono-2-methylhexyl ether, ethylene glycol isoamyl ether, ethylene glycol benzyl ether, ethylene glycol isopropyl alcohol alkyl ethers such as ethers;
Diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol alcohol alkyl ethers such as methyl ether, dipropylene glycol ethyl ether, and dipropylene glycol butyl ether;
glycerin monoalkyl ethers such as xyl alcohol, selachyl alcohol, and batyl alcohol;
Alcohol polymers such as diethylene glycol, triethylene glycol, polypropylene glycol, tetraethylene glycol and polyethylene glycol;
Glysolid; Tetrahydrofurfuryl alcohol; POE-Tetrahydrofurfuryl alcohol; POP-Butyl ether; POP POE-Butyl ether; Tripolyoxypropylene glycerin ether; POP-Glycerin ether; erythritol ether, and the like.

As ethers, in addition to those corresponding to the above alcohols,
Ethylene glycol dimethyl ether, ethylene glycol diethyl ether, ethylene glycol dibutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol methyl ethyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether Acetate, ethylene glycol diazibate, ethylene glycol disuccinate, diethylene glycol monoethyl ether acetate, diethylene glycol monobutyl ether acetate, propylene glycol monomethyl ether acetate, propylene glycol monoethyl ether acetate, propylene glycol monopropyl ether acetate, propylene glycol monophenyl ether Acetate etc. are mentioned.

The shape of the powder is not particularly limited, such as spherical, needle-like, and plate-like. Pleurotite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, silica, alumina, zeolite, barium sulfate, Calcined calcium sulfate (calcined gypsum), calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, boron nitride, etc.); organic powders (e.g., polyamide resin powder (nylon powder), polyethylene powder, poly(meth)acrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, silicone resin powder, benzoguanamine resin powder, polytetrafluoroethylene powder, cellulose powder, etc.); metal soap (e.g. zinc myristate, calcium palmitate, aluminum stearate) Inorganic white pigments (e.g., titanium dioxide, zinc oxide, etc.); Inorganic red pigments (e.g., iron oxide (red iron oxide), iron titanate, etc.); Inorganic brown pigments (e.g., γ-iron oxide, etc.); Inorganic yellow system pigments (e.g., yellow iron oxide, ocher, etc.); inorganic black pigments (e.g., black iron oxide, low order titanium oxide, etc.); inorganic purple pigments (e.g., mango violet, cobalt violet, etc.); inorganic green pigments (e.g., chromium oxide, chromium hydroxide, cobalt titanate, etc.); inorganic blue pigments (e.g., ultramarine, navy blue, etc.); pearl pigments (e.g., titanium oxide-coated mica, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc , colored titanium oxide-coated mica, bismuth oxychloride, fish scale foil, etc.); metal powder pigments (e.g., aluminum powder, copper powder, etc.); organic pigments such as zirconium, barium, or aluminum lakes (e.g., Red No. 201, Red No. 202 , Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 228, Red No. 405, Orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, and Blue No. 404; Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Green 3 No. and Blue No. 1, etc.); natural pigments (eg, chlorophyll, β-carotene, etc.); and other organically modified clay minerals (eg, organically modified hectorite, etc.).

Examples of moisturizing agents include chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caroninic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, dl-pyrrolidone carboxylate, short-chain soluble collagen, and diglycerin (EO) PO. Examples include adducts, Isophylla extract, Achillea millefolium extract, Melilot extract and the like.

Surfactants include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.

Examples of anionic surfactants include fatty acid soaps (e.g., sodium laurate, sodium palmitate, etc.); higher alkyl sulfate salts (e.g., sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates (e.g., , POE lauryl sulfate triethanolamine, POE sodium lauryl sulfate, etc.); N-acylsarcosic acid (e.g., sodium lauroyl sarcosinate, etc.); higher fatty acid amide sulfonates (e.g., N-myristoyl-N-methyltaurate sodium, coconut oil fatty acid methyl tauride sodium, lauryl methyl tauride sodium, etc.); phosphate ester salts (POE oleyl ether phosphate, POE stearyl ether phosphate, etc.); lauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.); higher fatty acid ester sulfate (e.g., sodium hydrogenated coconut oil fatty acid glycerol sulfate, etc.); sodium, etc.); sulfated oil (e.g., funnel oil, etc.); POE alkyl ether carboxylic acid; POE alkyl allyl ether carboxylate; α-olefin sulfonate; higher fatty acid ester sulfonate; higher fatty acid alkylolamide sulfate; sodium lauroyl monoethanolamide succinate; N-palmitoyl aspartic acid ditriethanolamine; sodium caseinate;

Examples of cationic surfactants include alkyltrimethylammonium salts (e.g., stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (e.g., cetylpyridinium chloride, etc.); distearyldimethylammonium chloride dialkyldimethylammonium salts; poly(N,N'-dimethyl-3,5-methylenepiperidinium) chloride; alkyl quaternary ammonium salts; alkyldimethylbenzylammonium salts; alkylisoquinolinium salts; dialkylmorphonium salts; POE alkylamines; alkylamine salts; polyamine fatty acid derivatives; amyl alcohol fatty acid derivatives; benzalkonium chloride; benzethonium chloride and the like.

Amphoteric surfactants include, for example, imidazoline amphoteric surfactants (e.g., 2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide side-1-carboxyethyloxy disodium salt, etc.); betaine surfactants (e.g., 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amidobetaine , sulfobetaine, etc.) and the like.

Nonionic surfactants include polyether-modified silicones (e.g., polyethylene glycol-10 dimethicone, polyethylene glycol-12 dimethicone, etc.); polyglycerin-modified silicones (e.g., polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 poly dimethylsiloxyethyl dimethicone, etc.); sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, etc.); , α,α'-glyceryl pyroglutamate, (monostearate/malate) glyceryl, etc.); propylene glycol fatty acid esters (e.g., propylene glycol monostearate, etc.); POE castor oil/hydrogenated castor oil derivative (POE castor oil, POE hydrogenated castor oil, etc.); and non-hydrophilic nonionic surfactants such as glycerin alkyl ether. Also, polyglycerin fatty acid esters (e.g., polyglyceryl monooleate, polyglyceryl monostearate, etc.); POE sorbitan fatty acid esters (e.g., POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, etc.); POE Sorbit fatty acid esters (e.g., POE sorbitol monolaurate, POE sorbitol monooleate, POE sorbitol pentaoleate, POE sorbitol monostearate, etc.); POE glycerin fatty acid esters (e.g., POE glycerin monostearate, POE glycerin monostearate); isostearate,
POE monooleates such as POE glycerol triisostearate, etc.); POE fatty acid esters (e.g., POE distearate, POE monodioleate, ethylene glycol distearate, etc.); POE alkyl ethers (e.g., POE lauryl ether, POE oleyl ether, POE stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE cholestanol ether, etc.); POE alkylphenyl ethers (eg, POE nonylphenyl ether, etc.); Pluronic types (eg, Pluronic (registered trademark), etc.) POE/POP alkyl ethers (e.g., POE/POP cetyl ether, POE/POP-2-decyltetradecyl ether, POE/POP monobutyl ether, POE/POP hydrogenated lanolin, POE/POP glycerin ether, etc.); Tetra POE TetraPOP ethylenediamine condensates (e.g. Tetronic etc.); POE castor oil hydrogenated castor oil derivatives (e.g. POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate POE hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, POE hydrogenated castor oil maleic acid, etc.); POE beeswax/lanolin derivatives (e.g., POE sorbitol beeswax, etc.); monoethanolamide, fatty acid isopropanolamide, etc.); POE propylene glycol fatty acid ester; POE alkylamine; POE fatty acid amide; sucrose fatty acid ester; Activators are also included.

Examples of sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate. , sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, and the like.

Pearl agents include, for example, glycol distearate and titanium mica.

Amino acids include, for example, neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like. Examples of amino acid derivatives include sodium acyl sarcosinate (sodium lauroyl sarcosinate), acyl glutamate, sodium acyl β-alanine, glutathione, pyrrolidone carboxylic acid and the like.

Examples of organic amines include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol, and the like. are mentioned.

Examples of polymer emulsions include acrylic resin emulsions, polyethyl acrylate emulsions, acrylic resin liquids, polyacryl alkyl ester emulsions, polyvinyl acetate resin emulsions, and natural rubber latex.

Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, succinic acid-sodium succinate, etc., and usually for adjusting the pH of the internal phase (aqueous component). Used.

Examples of vitamins include vitamins A, B1, B2, B6, C, E and derivatives thereof, pantothenic acid and derivatives thereof, biotin and the like.

Examples of antioxidants include tocopherols, dibutylhydroxytoluene (BHT), butylhydroxyanisole, pyrosulfite, gallic acid ester, phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, and fumaric acid. , cephalin, hexametaphosphate, phytic acid, ethylenediaminetetraacetic acid, and the like.

Examples of antiseptics include parabens and phenoxyethanol.

Examples of water-soluble polymers include plant-based polymers (e.g., gum arabic, tragacanth gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, agar, quince seed (quince), algae colloid (cassou extract), starch (rice , corn, potato, wheat), glycyrrhizic acid); microbial macromolecules (e.g., xanthan gum, dextran, succinoglucan, bullulan, etc.); animal macromolecules (e.g., collagen, casein, albumin, gelatin, etc.) a water-soluble polymer of
starch-based polymers (e.g., carboxymethyl starch, methylhydroxypropyl starch, etc.); methyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.);
Vinyl-based polymers (e.g., polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene-based polymers (e.g., polyethylene glycol 20,000, 40,000, 60,000, etc.); acrylic-based Polymers (eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); polyethylenimine; synthetic water-soluble polymers such as cationic polymers.

Examples of various active ingredients include antiphlogistic agents (e.g., salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.); whitening agents (e.g., placenta extract, saxifrage extract, arbutin, etc.); coptis, rhizome, peony, japonica, birch, sage, loquat, carrot, aloe, mallow, iris, grape, coix seed, loofah, lily, saffron, cnidium, ginger, hypericum, ononis, garlic, hot pepper, chimp, angelica, seaweed etc.), activators (e.g., royal jelly, photosensitizers, cholesterol derivatives, etc.); , tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, etc.); anti-inflammatory agents (eg, tranexamic acid, thiotaurine, hypotaurine, etc.) and the like.

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples as long as the gist thereof is not exceeded.

<Production example and evaluation 1>
With the ingredients shown in Table 1, the oil phase component and the water phase component are heated to 70° C. and dissolved respectively, the water phase is added to the oil phase component, and the mixture is emulsified while stirring with a homomixer to obtain a water-in-oil type. An emulsion composition was prepared.
Each obtained composition was evaluated according to the following items and criteria. The results are also shown in Table 1.

(Stability over time)
Each composition was allowed to stand at 50 ° C. for 30 days, and the separation of the emulsion was visually observed by 10 professional evaluators and evaluated in the following 5 stages. did.
5: No separation at all 4: Almost no separation 3: Some separation but no effect on use 2: Some separation 1: Severe separation

(No stickiness)
Each of 10 professional evaluators applied the composition to the skin, and evaluated the stickiness of the skin during application on the following 5-grade scale.
5: No stickiness felt during application 4: Almost no stickiness felt during application 3: Some stickiness felt during application 2: Stickiness felt during application 1: Strong stickiness felt during application

(Moist feeling)
Each of 10 professional evaluators applied the composition to the skin, and evaluated the moist feeling of the skin after application on the following 5-grade scale.
5: Very moist 4: Quite moist 3: Almost no dryness 2: Slightly dry 1: Extremely dry

<Production example and evaluation 2>
With the formulation ingredients shown in Table 2, the oil phase component and the water phase component are heated to 70° C. and dissolved respectively, the water phase is added to the oil phase component, and the mixture is emulsified while stirring with a homomixer to obtain a water-in-oil type. An emulsion composition was prepared.
Each obtained composition was evaluated according to the following items and criteria. The results are also shown in Table 2.

(Stability over time)
Each composition was allowed to stand at 50° C. for 30 days, and then visually observed by 10 professional evaluators for discoloration and evaluated on the following 5-grade scale.
5: No discoloration at all 4: Almost no discoloration 3: Slight discoloration but no effect on use 2: Slight discoloration 1: Severe discoloration

(No stickiness)
Each of 10 professional evaluators applied the composition to the skin, and evaluated the stickiness of the skin during application on the following 5-grade scale.
5: No stickiness felt during application 4: Almost no stickiness felt during application 3: Some stickiness felt during application 2: Stickiness felt during application 1: Strong stickiness felt during application

(Moist feeling)
Each of 10 professional evaluators applied the composition to the skin, and evaluated the moist feeling of the skin after application on the following 5-grade scale.
5: Very moist 4: Quite moist 3: Almost no dryness 2: Slightly dry 1: Extremely dry

Claims (8)

A water-in-oil emulsified composition containing the following component (A) and component (B).
(A) organically modified bentonite (B) one or more selected from glycyrrhetinic acid, derivatives thereof and salts thereof, and resorcinol derivatives and salts thereof A composition according to claim 1, wherein component (A) is quaternium-90 bentonite. 3. The composition according to claim 1 or 2, wherein (B) glycyrrhetinic acid, derivatives thereof and salts thereof are dipotassium glycyrrhizinate. The composition according to any one of claims 1 to 3, wherein the (B) resorcinol derivative is 4-n-butylresorcinol. The composition according to any one of claims 1 to 4, wherein the content of component (A) is 0.1 to 3% by weight. The composition according to any one of claims 1 to 5, wherein the content of component (B) is 0.01 to 10% by weight. The composition according to any one of claims 1 to 6, wherein the mass ratio (A)/(B) of component (A) to component (B) is 0.1-50. The composition according to any one of claims 1 to 7, which is an external preparation for skin.