JP2022133018A - Labial agent attachment inhibitor - Google Patents
Labial agent attachment inhibitor Download PDFInfo
- Publication number
- JP2022133018A JP2022133018A JP2021031812A JP2021031812A JP2022133018A JP 2022133018 A JP2022133018 A JP 2022133018A JP 2021031812 A JP2021031812 A JP 2021031812A JP 2021031812 A JP2021031812 A JP 2021031812A JP 2022133018 A JP2022133018 A JP 2022133018A
- Authority
- JP
- Japan
- Prior art keywords
- lipstick
- adhesion
- agent
- lip
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 49
- 239000003112 inhibitor Substances 0.000 title claims abstract description 8
- 229960004949 glycyrrhizic acid Drugs 0.000 claims abstract description 25
- 235000019410 glycyrrhizin Nutrition 0.000 claims abstract description 25
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 25
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 24
- 238000002360 preparation method Methods 0.000 claims description 29
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 24
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 24
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 24
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 6
- -1 polyoxyethylene Polymers 0.000 description 35
- 235000002639 sodium chloride Nutrition 0.000 description 23
- 230000000694 effects Effects 0.000 description 15
- 210000000214 mouth Anatomy 0.000 description 15
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 238000012360 testing method Methods 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 5
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 229920001155 polypropylene Polymers 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 4
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- 229940051866 mouthwash Drugs 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 244000062730 Melissa officinalis Species 0.000 description 3
- 235000010654 Melissa officinalis Nutrition 0.000 description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 3
- 229960001950 benzethonium chloride Drugs 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000865 liniment Substances 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000001993 wax Substances 0.000 description 3
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 244000303040 Glycyrrhiza glabra Species 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 229960000458 allantoin Drugs 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 208000007287 cheilitis Diseases 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 235000019477 peppermint oil Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-QCYZZNICSA-N (5alpha)-cholestan-3beta-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-QCYZZNICSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 125000005274 4-hydroxybenzoic acid group Chemical class 0.000 description 1
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 1
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 241001303601 Rosacea Species 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- QYIXCDOBOSTCEI-UHFFFAOYSA-N alpha-cholestanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 QYIXCDOBOSTCEI-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960002684 aminocaproic acid Drugs 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 201000003465 angular cheilitis Diseases 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960003872 benzethonium Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- RFFOTVCVTJUTAD-UHFFFAOYSA-N cineole Natural products C1CC2(C)CCC1(C(C)C)O2 RFFOTVCVTJUTAD-UHFFFAOYSA-N 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- SIYLLGKDQZGJHK-UHFFFAOYSA-N dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium Chemical compound C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 SIYLLGKDQZGJHK-UHFFFAOYSA-N 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- FPAYXBWMYIMERV-UHFFFAOYSA-L disodium;5-methyl-2-[[4-(4-methyl-2-sulfonatoanilino)-9,10-dioxoanthracen-1-yl]amino]benzenesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC(C)=CC=C1NC(C=1C(=O)C2=CC=CC=C2C(=O)C=11)=CC=C1NC1=CC=C(C)C=C1S([O-])(=O)=O FPAYXBWMYIMERV-UHFFFAOYSA-L 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- QYIXCDOBOSTCEI-FBVYSKEZSA-N epidihydrocholesterin Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CCCC(C)C)[C@@]2(C)CC1 QYIXCDOBOSTCEI-FBVYSKEZSA-N 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940085991 phosphate ion Drugs 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940079841 sodium copper chlorophyllin Drugs 0.000 description 1
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 229950002760 sodium gualenate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- 229940048098 sodium sarcosinate Drugs 0.000 description 1
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- CCXAYLQLOLXXKE-DWJAGBRCSA-K trisodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-t Chemical compound [Na+].[Na+].[Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O CCXAYLQLOLXXKE-DWJAGBRCSA-K 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Images
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、口唇用剤付着抑制剤に関する。 TECHNICAL FIELD The present invention relates to an anti-adhesion agent for lips.
従来口紅は広く使用されているメイクアップ用品であり、種々の色彩や光沢を付与した商品が販売されている。しかし、飲食時などには、食器等に口紅が付着してしまうとともに、唇から口紅が離脱することにより唇の化粧効果までも損なわれやすい。また歯列が乱れている場合や、重ね塗り等の口紅の塗り方によっては、歯面に口紅が付着する「歯紅」という状態になりやすいことが知られている。同様の問題は、口紅に限らず、口唇に使用される剤（口唇用剤）一般に生じうる。 Conventionally, lipsticks are widely used makeup products, and products with various colors and glosses are available on the market. However, when eating and drinking, the lipstick tends to adhere to tableware and the like, and the lipstick tends to detach from the lips, thereby impairing the cosmetic effect of the lips. In addition, it is known that when the teeth are disordered or depending on how the lipstick is applied in multiple layers, the lipstick is likely to adhere to the tooth surface, resulting in a state called "tooth rouge". A similar problem can occur not only with lipstick but also with agents used on the lips (lip agents) in general.
食器等に口紅が付着すると、その除去には手間を要する。また、歯紅は審美性を損ねて顔全体の印象を悪くする。そのため、口紅の付着や離脱を抑制する技術が望まれており、唇からの口紅の離脱を防止する口紅おさえシートや口紅オーバーコートなどの商品が開発され販売されている。たとえば、特許文献１では、口紅の油分を吸着するシート本体に、口紅に吸着することで口紅の離脱を防止するマイカ等の粉体が添着された口紅おさえ用シートが開示されている。また特許文献２では、金属石鹸及び／またはアシル化アミノ酸と、多価アルコールと、水とを含有する非乳化型のリップオーバーコートが開示されている。 When lipstick adheres to tableware or the like, it takes time and effort to remove it. Moreover, the rouge impairs the aesthetics and makes the impression of the whole face worse. Therefore, there is a demand for a technique for suppressing the adhesion and detachment of lipstick, and products such as lipstick holding sheets and lipstick overcoats that prevent lipstick from detaching from the lips have been developed and sold. For example, Patent Literature 1 discloses a sheet for holding lipstick in which powder such as mica that prevents lipstick from coming off is attached to a sheet body that adsorbs the oil of lipstick. Patent Document 2 discloses a non-emulsified lip overcoat containing a metal soap and/or an acylated amino acid, a polyhydric alcohol, and water.
しかし、上述の口紅おさえシートや口紅オーバーコート等の技術は、口紅自体に所定の剤を適用する必要があり、その使用態様は限定的なものであった。例えば、口腔内や食器等の口紅の付着が想定される対象自体に適用することで、口紅の離脱や、歯面および食器等への口紅の付着を抑制する技術は知られていない。 However, the techniques of the lipstick holding sheet and lipstick overcoat described above require the application of a predetermined agent to the lipstick itself, and the mode of use thereof is limited. For example, there is no known technique for suppressing the detachment of lipstick or the adhesion of lipstick to tooth surfaces, tableware, etc., by applying it to objects such as the oral cavity and tableware to which lipstick is expected to adhere.
そこで本発明の目的は、口紅等の口唇用剤の離脱および歯面等への付着を抑制することのできる、新たな口唇用剤付着抑制剤を提供することを目的とする。 SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a novel anti-adhesion agent for lips, which can suppress detachment and adhesion of lip agents such as lipstick to tooth surfaces and the like.
本発明者は、鋭意研究を重ねた結果、（Ａ）第４級アンモニウム塩、及び（Ｂ）グリチルリチン酸又はその塩、の少なくともいずれか一方の成分を、口紅等の口唇用剤の付着を抑制したい対象に適用することにより、上記口唇用剤の離脱、及び口唇用剤の当該対象への付着を抑制できることを見出し、本発明を完成するに至った。 As a result of intensive research, the present inventors found that at least one of (A) a quaternary ammonium salt and (B) glycyrrhizic acid or a salt thereof is added to suppress the adhesion of lip agents such as lipstick. The present inventors have found that the detachment of the lip preparation and the adhesion of the lip preparation to the object can be suppressed by applying the lip preparation to the subject, and have completed the present invention.
したがって、本発明は、（Ａ）第４級アンモニウム塩、及び（Ｂ）グリチルリチン酸又はその塩が、口唇用剤の付着を抑制するという新たな用途を見出したことに基づくものであり、以下の（１）、（２）によって達成されるものである。
（１）下記成分（Ａ）および成分（Ｂ）の少なくともいずれか一方の成分を含有する口唇用剤付着抑制剤。
（Ａ）第４級アンモニウム塩
（Ｂ）グリチルリチン酸又はその塩
（２）下記成分（Ａ）および成分（Ｂ）の少なくともいずれか一方の成分を対象に適用することを含む、当該対象への口唇用剤の付着を抑制する方法。
（Ａ）第４級アンモニウム塩
（Ｂ）グリチルリチン酸又はその塩
Accordingly, the present invention is based on the discovery of a new use of (A) a quaternary ammonium salt and (B) glycyrrhizic acid or a salt thereof for suppressing adhesion of a lip preparation. This is achieved by (1) and (2).
(1) A lip agent adhesion inhibitor containing at least one of the following components (A) and (B).
(A) Quaternary ammonium salt (B) Glycyrrhizic acid or a salt thereof (2) Lips to the subject, including applying at least one of the following components (A) and (B) to the subject A method for suppressing adhesion of agents.
(A) quaternary ammonium salt (B) glycyrrhizic acid or a salt thereof
本発明の口唇用剤付着抑制剤は、（Ａ）第４級アンモニウム塩、及び（Ｂ）グリチルリチン酸又はその塩、の少なくともいずれか一方の成分を含有することにより、当該抑制剤を適用した対象への口唇用剤の付着を抑制できる。 The lip agent adhesion inhibitor of the present invention contains at least one component of (A) a quaternary ammonium salt and (B) glycyrrhizic acid or a salt thereof, so that the object to which the inhibitor is applied It is possible to suppress the adhesion of the lip preparation to.
以下、本発明をさらに詳細に説明する。
本明細書において、「口唇用剤」とは、口唇に使用される剤一般を意味し、口唇に使用される化粧品（口唇用化粧品）や医薬品（口唇用医薬品）等が挙げられる。口唇用化粧品としては、口紅やグロス等が挙げられ、油脂、ロウ、及びワックス等の油性基材や、染料や顔料等の色材等から構成されていてもよい。また口唇用医薬品としては、例えば口唇炎、口角炎、口唇ヘルペス等に対する口唇薬が挙げられる。口唇用剤としては、例えば、スティック状、ペンシル状、軟膏状の剤形のものが挙げられる。
The present invention will now be described in more detail.
As used herein, the term "lip preparation" means general preparations used for the lips, including cosmetics (lip cosmetics) and pharmaceuticals (lip pharmaceuticals) used for the lips. Lip cosmetics include lipsticks, glosses, and the like, and may be composed of oily base materials such as oils, waxes, and waxes, and coloring materials such as dyes and pigments. In addition, lip medicines include, for example, lip medicines for cheilitis, angular stomatitis, herpes labialis and the like. Lip preparations include, for example, stick-like, pencil-like and ointment-like dosage forms.
本発明の口唇用剤付着抑制剤（以下、本発明の剤と称することもある）は、（Ａ）第４級アンモニウム塩、及び（Ｂ）グリチルリチン酸又はその塩、の少なくともいずれか一方の成分を含有するものである。本発明は、（Ａ）第４級アンモニウム塩、及び（Ｂ）グリチルリチン酸又はその塩が、口唇用剤の付着を抑制できる点を見出したことに基づくものである。これは、第４級アンモニウム塩、及びグリチルリチン酸又はその塩を口唇用剤の付着を抑制したい対象に適用することにより、当該対象の表面に上記成分の相が形成され、口唇用剤との直接的な接触が抑制されるためだと推測される。なお、本発明は上記作用機序を有するものに限定されるものではない。 The lip agent adhesion inhibitor of the present invention (hereinafter sometimes referred to as the agent of the present invention) comprises at least one of (A) a quaternary ammonium salt and (B) glycyrrhizic acid or a salt thereof. contains The present invention is based on the discovery that (A) a quaternary ammonium salt and (B) glycyrrhizic acid or a salt thereof can suppress adhesion of a lip preparation. This is achieved by applying a quaternary ammonium salt and glycyrrhizic acid or a salt thereof to an object to be inhibited from adhering to the lip preparation, thereby forming a phase of the above components on the surface of the object, which directly adheres to the lip preparation. It is speculated that this is because physical contact is suppressed. In addition, the present invention is not limited to those having the above mechanism of action.
本発明の剤は、口唇用剤の付着を抑制したい対象に適用することで、当該対象への口唇用剤の付着を抑制できる。例えば、口腔内に適用した場合は、歯面に対する口唇用剤の付着、例えば歯紅等の発生を抑制できる。そのため、口唇用剤の効果を持続させることができ、例えば口紅等の口唇用化粧品においては、口元さらには顔全体の印象を良好に保つことができる。また、例えば、口唇用剤の付着しやすい食器類等の対象に適用することにより、対象自体への口唇用剤の付着を抑制することもできる。 By applying the agent of the present invention to a subject to which adhesion of the lip agent is to be suppressed, adhesion of the lip agent to the subject can be suppressed. For example, when applied in the oral cavity, adhesion of the lip preparation to the tooth surface, for example, generation of rosacea, etc., can be suppressed. Therefore, the effect of the lip preparation can be maintained, and for example, in the case of lip cosmetics such as lipstick, it is possible to maintain a favorable impression of the mouth and the entire face. In addition, for example, by applying to objects such as tableware to which the lip preparation tends to adhere, adhesion of the lip preparation to the object itself can be suppressed.
＜成分（Ａ）：第４級アンモニウム塩＞
本発明における（Ａ）第４級アンモニウム塩は、第４級アンモニウムカチオンと他のアニオンとの塩をいう。本発明における（Ａ）第４級アンモニウム塩において、主に第４級アンモニウムカチオンが、口唇用剤の付着抑制機能を担っていると推測される。そのため、第４級アンモニウム塩であれば、その種類は特に制限はなく、目的に応じて適宜選択することができる。好ましくは、塩化セチルピリジニウム、塩化ベンゼトニウム、塩化ベンザルコニウム、臭化ヘキサデシルトリメチルアンモニウム等が挙げられる。これらは、１種単独で使用してもよいし、２種以上を併用してもよい。これらの中でも、口唇用剤の付着抑制効果が高い点から、塩化セチルピリジニウム及び塩化ベンゼトニウムが特に好ましい。
<Component (A): Quaternary ammonium salt>
The (A) quaternary ammonium salt in the present invention refers to a salt of a quaternary ammonium cation and another anion. In the (A) quaternary ammonium salt in the present invention, it is presumed that mainly the quaternary ammonium cation has the function of suppressing adhesion of the lip preparation. Therefore, as long as it is a quaternary ammonium salt, the type is not particularly limited and can be appropriately selected according to the purpose. Preferred are cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, hexadecyltrimethylammonium bromide and the like. These may be used individually by 1 type, and may use 2 or more types together. Among these, cetylpyridinium chloride and benzethonium chloride are particularly preferred because they are highly effective in suppressing adhesion of the lip preparation.
本発明の剤が第４級アンモニウム塩を含む場合、本発明の剤全量に対して、第４級アンモニウム塩を、例えば０．００１質量％以上含有し、好ましくは０．０１質量％以上含有し、より好ましくは０．０４質量％以上含有する。第４級アンモニウム塩を０．００１質量％以上含有することにより、口唇用剤の付着抑制効果を十分に発揮することができる。また、本発明の剤全量に対して、第４級アンモニウム塩を、例えば０．５質量％以下含有し、好ましくは０．１質量％以下含有し、より好ましくは０．０６質量％以下含有する。第４級アンモニウム塩を０．５質量％以下含有することにより、口腔粘膜への刺激を抑えることができる。 When the agent of the present invention contains a quaternary ammonium salt, the amount of the quaternary ammonium salt is, for example, 0.001% by mass or more, preferably 0.01% by mass or more, relative to the total amount of the agent of the present invention. , more preferably 0.04% by mass or more. By containing 0.001% by mass or more of the quaternary ammonium salt, the effect of suppressing adhesion of the lip preparation can be sufficiently exhibited. Further, the quaternary ammonium salt is contained, for example, 0.5% by mass or less, preferably 0.1% by mass or less, more preferably 0.06% by mass or less, relative to the total amount of the agent of the present invention. . By containing 0.5% by mass or less of the quaternary ammonium salt, irritation to the oral mucosa can be suppressed.
＜成分（Ｂ）：グリチルリチン酸又はその塩＞
本発明における（Ｂ）グリチルリチン酸又はその塩は、生薬の一種である甘草の根や茎に含まれている成分である。本発明に用いられるグリチルリチン酸又はその塩の種類は、特に制限はなく、目的に応じて適宜選択することができる。例えば、グリチルリチン酸、グリチルリチン酸ジカリウム（ＧＫ２）、グリチルリチン酸トリナトリウム、グリチルリチン酸モノアンモニウム、グリチルリチン酸ジアンモニウム、及びグリチルリチン酸ジナトリウム等が挙げられる。これらは、１種単独で使用してもよいし、２種以上を併用してもよい。こられの中でも、製剤安定性に優れるという点から、グリチルリチン酸ジカリウムが特に好ましい。
<Component (B): Glycyrrhizic acid or its salt>
(B) Glycyrrhizic acid or a salt thereof in the present invention is a component contained in the roots and stems of licorice, which is a type of crude drug. The type of glycyrrhizic acid or a salt thereof used in the present invention is not particularly limited and can be appropriately selected depending on the intended purpose. Examples include glycyrrhizic acid, dipotassium glycyrrhizinate (GK 2 ), trisodium glycyrrhizinate, monoammonium glycyrrhizinate, diammonium glycyrrhizinate, and disodium glycyrrhizinate. These may be used individually by 1 type, and may use 2 or more types together. Among these, dipotassium glycyrrhizinate is particularly preferred from the viewpoint of excellent formulation stability.
グリチルリチン酸又はその塩は、甘草から従来公知の方法を用いて抽出して得ることもできるし、市販品を使用することもできる。市販品として、例えば、アルプス薬品工業社製や丸善製薬社製のグリチルリチン酸ジカリウム、グリチルリチン酸モノアンモニウム等を使用することができる。 Glycyrrhizic acid or a salt thereof can be obtained by extracting from licorice using a conventionally known method, or a commercially available product can be used. As commercially available products, for example, dipotassium glycyrrhizinate and monoammonium glycyrrhizinate manufactured by Alps Yakuhin Kogyo Co., Ltd. and Maruzen Pharmaceutical Co., Ltd. can be used.
本発明の剤がグリチルリチン酸又はその塩を含む場合、本発明の剤全量に対してグリチルリチン酸又はその塩を、例えば０．００１質量％以上含有し、好ましくは０．００５質量％以上含有し、より好ましくは０．０１質量％以上含有する。グリチルリチン酸又はその塩を０．００１質量％以上含有することにより、口唇用剤の付着抑制効果を十分に発揮することができる。また、本発明の剤全量に対して、グリチルリチン酸又はその塩を、例えば０．１質量％以下含有し、好ましくは０．０５質量％以下含有し、より好ましくは０．０２質量％以下含有する。グリチルリチン酸又はその塩を０．１質量％以下含有することにより、製剤の嗜好性を損ねることなく効果を発揮することができる。 When the agent of the present invention contains glycyrrhizic acid or a salt thereof, it contains glycyrrhizic acid or a salt thereof, for example, 0.001% by mass or more, preferably 0.005% by mass or more, relative to the total amount of the agent of the present invention, More preferably, it is contained in an amount of 0.01% by mass or more. By containing 0.001% by mass or more of glycyrrhizic acid or a salt thereof, the effect of suppressing adhesion of the lip preparation can be sufficiently exhibited. Further, glycyrrhizic acid or a salt thereof is contained, for example, in an amount of 0.1% by mass or less, preferably 0.05% by mass or less, more preferably 0.02% by mass or less, relative to the total amount of the agent of the present invention. . By containing 0.1% by mass or less of glycyrrhizic acid or a salt thereof, the effect can be exhibited without impairing the palatability of the formulation.
本発明の剤は、（Ａ）第４級アンモニウム塩、及び（Ｂ）グリチルリチン酸又はその塩、の少なくともいずれか一方の成分を含有するものであるが、口唇用剤の付着抑制効果を十分に発揮できるという点で、成分（Ａ）と成分（Ｂ）の両方の成分を含有することが好ましい。この場合、成分（Ａ）と成分（Ｂ）の含有量比（質量基準）は、例えば１００：１～１：１０であり、５０：１～１：５であることが好ましく、２０：１～１：１であることがより好ましい。上記範囲であることにより、口唇用剤の付着抑制効果をより強く発揮できる。 The agent of the present invention contains at least one of (A) a quaternary ammonium salt and (B) glycyrrhizic acid or a salt thereof. It is preferable to contain both the component (A) and the component (B) in terms of being able to exhibit the effect. In this case, the content ratio (by mass) of component (A) and component (B) is, for example, 100:1 to 1:10, preferably 50:1 to 1:5, and 20:1 to A ratio of 1:1 is more preferred. By being in the above range, the effect of suppressing adhesion of the lip preparation can be exhibited more strongly.
本発明の剤は、その用途に応じて任意の剤形とすることができ、例えば、液体、固体、ゲル、及びペースト等の半固体等の形態が例示される。 The agent of the present invention can be in any dosage form depending on its use, and examples thereof include liquids, solids, gels, and semi-solid forms such as pastes.
本発明の剤は、口唇用剤の付着を抑制したい任意の対象に適用することができる。
本発明の剤を適用する対象としては、例えば、口腔組織、及び肌等の対象部位や、食器類、衣類、及びマスク等の対象物が挙げられる。なかでも、口唇用剤の付着しやすい対象に適用することが好ましく、例えば口腔組織や食器類等が挙げられる。本発明の剤を口腔組織に適用する場合は、例えば歯面に対する口唇用剤の付着を抑制することができる。また、口唇用剤の付着しやすい食器類等の対象物に適用することにより、当該対象物に対する口唇用剤の付着を抑制することができる。
The agent of the present invention can be applied to any object to which adhesion of a lip agent is desired to be suppressed.
Targets to which the agent of the present invention is applied include, for example, target sites such as oral tissues and skin, and target objects such as tableware, clothes, and masks. In particular, it is preferable to apply the lip preparation to objects to which the lip preparation is likely to adhere, such as oral tissues and tableware. When the agent of the present invention is applied to oral tissues, adhesion of the lip agent to tooth surfaces can be suppressed, for example. In addition, by applying it to an object such as tableware to which the lip preparation tends to adhere, adhesion of the lip preparation to the object can be suppressed.
本発明の剤は、口腔内に適用する場合、上記成分（Ａ）および（Ｂ）以外の所定の成分を含有する口腔用組成物（口腔内への口唇用剤付着抑制用組成物）とすることができる。具体的には、上記口腔用組成物には、使用感の低下を招いたり、本発明の効果を損なわない限り、口腔内に適用できる各種の成分を共に含有することができ、例えば、溶媒、殺菌剤、歯面強化作用のある物質、湿潤剤、発泡剤、甘味料、防腐剤、及びその他成分が挙げられる。 When applied to the oral cavity, the agent of the present invention is an oral composition (a composition for suppressing adhesion of the lip agent to the oral cavity) containing predetermined components other than the above components (A) and (B). be able to. Specifically, the oral composition may contain various components that can be applied to the oral cavity, as long as they do not reduce the feeling of use or impair the effects of the present invention. Bactericides, tooth-strengthening agents, wetting agents, foaming agents, sweeteners, preservatives, and other ingredients.
溶媒としては、例えば、精製水及びイオン水等の水、エタノール、プロピレングリコール、ブチレングリコール、及びポリエチレングリコール等の多価アルコール等が挙げられる。
なかでも、口腔内に適用する観点から、水を主体とした溶媒とすることが好ましく、水よりも少ない量においては上記アルコール等の他の溶媒を含んでもよい。例えば、溶媒中に含まれるアルコールの量としては、通常０～３０質量％である。また、溶媒中に含まれる水の量としては、例えば５０～９８質量％である。
Examples of solvents include water such as purified water and ion water, polyhydric alcohols such as ethanol, propylene glycol, butylene glycol, and polyethylene glycol.
Among them, from the viewpoint of application in the oral cavity, it is preferable to use a solvent mainly composed of water, and other solvents such as the above-mentioned alcohols may be included in an amount smaller than that of water. For example, the amount of alcohol contained in the solvent is usually 0 to 30% by mass. Also, the amount of water contained in the solvent is, for example, 50 to 98% by mass.
殺菌剤としては、例えば、トリクロサン、イソプロピルメチルフェノール、プロテアーゼ、及び塩酸アルキルジアミノエチルグリシン等が挙げられる。 Bactericides include, for example, triclosan, isopropylmethylphenol, protease, and alkyldiaminoethylglycine hydrochloride.
歯面強化作用のある物質として、例えば、フッ化ナトリウム、フルオロリン酸塩、フルオロホウ酸塩等のフッ素イオン源、リン酸カルシウム、及びハイドロキシアパタイト等のリン酸イオン源等が挙げられる。 Examples of substances having a tooth surface strengthening effect include fluoride ion sources such as sodium fluoride, fluorophosphates and fluoroborates, and phosphate ion sources such as calcium phosphate and hydroxyapatite.
さらに、グリセリン及びソルビット等の湿潤剤、ラウリル硫酸ナトリウム等の発泡剤、ステビオサイド、キシリトール、エリスリトール、ソルビトール、サッカリンナトリウム、及びスクラロース等の甘味料、パラヒドロキシ安息香酸エステル及び安息香酸ナトリウム等の防腐剤等が挙げられる。なかでもグリセリン等の湿潤剤は、口唇用剤の付着抑制効果を促進させる効果がある。 In addition, wetting agents such as glycerin and sorbitol, foaming agents such as sodium lauryl sulfate, sweeteners such as stevioside, xylitol, erythritol, sorbitol, sodium saccharin and sucralose, preservatives such as parahydroxybenzoic acid esters and sodium benzoate, and the like. mentioned. Among them, humectants such as glycerin have the effect of promoting the effect of suppressing adhesion of the lip preparation.
その他に、例えば、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレン・ポリオキシプロピレンブロックポリマー、ポリオキシエチレン・ポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレン高級アルコールエーテル、ポリオキシエチレン・ポリオキシプロピレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタンモノラウレート、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ポリオキシエチレンコレステリルエーテル、及びポリオキシエチレンフィトステロールエーテル等のノニオン性界面活性剤、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、ポリオキシエチレンアルキルエーテル硫酸塩、ラウロイルサルコシナトリウム、ミリストイルサルコシンナトリウム、アルキルエーテルカルボン酸塩、アルキルリン酸塩、ポリオキシエチレンアルキルエーテルリン酸塩、Ｎ－アシルタウリン塩、ポリオキシエチレンアルキルエーテルリン酸・リン酸塩、及びスルホン酸塩等のアニオン性界面活性剤、リン酸二水素ナトリウム、リン酸水素ナトリウム、クエン酸、及びクエン酸ナトリウム等のｐＨ調整剤、ペパーミントオイル、ハッカ油、メントール、カルバクロール、ユーカリオイル、オイゲノール、アネトール、及びシネオール等の香料、青色１号、黄色４号、赤色１０２号、及び緑色２０１号等法定色素等の色素、塩化リゾチーム、デキストラナーゼ、ムタナーゼ、アズレン、アズレンスルホン酸塩、ジヒドロコレステロール、エピジヒドロコレステリン、オウバクエキス、トウキ軟エキス、ヒノキチオール、アラントイン、アラントインクロルヒドロキシアルミニウム、塩化ナトリウム、酢酸ｄｌ－α－トコフェロール、ニコチン酸ｄｌ－α－トコフェロール、イプシロンアミノカプロン酸、トラネキサム酸、ポリリン酸塩、チモール、銅クロロフィリンナトリウム、及びロウ等を含有することができる。 In addition, for example, polyoxyethylene hydrogenated castor oil, polyoxyethylene/polyoxypropylene block polymer, polyoxyethylene/polyoxypropylene alkyl ether, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene fatty acid ester , polyoxyethylene higher alcohol ether, polyoxyethylene/polyoxypropylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan monolaurate, glycerin fatty acid ester, polyglycerin Nonionic surfactants such as fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene cholesteryl ethers, and polyoxyethylene phytosterol ethers, sodium lauryl sulfate, sodium myristyl sulfate, polyoxyethylene alkyl ether sulfates, sodium lauroyl sarcosinate, myristoyl Anionic interfaces such as sodium sarcosinate, alkyl ether carboxylates, alkyl phosphates, polyoxyethylene alkyl ether phosphates, N-acyl taurate salts, polyoxyethylene alkyl ether phosphates/phosphates, and sulfonates Active agents, pH adjusters such as sodium dihydrogen phosphate, sodium hydrogen phosphate, citric acid and sodium citrate, fragrances such as peppermint oil, peppermint oil, menthol, carvacrol, eucalyptus oil, eugenol, anethole, and cineole , Blue No. 1, Yellow No. 4, Red No. 102, and Green No. 201, etc. Legal pigments, lysozyme chloride, dextranase, mutanase, azulene, azulene sulfonate, dihydrocholesterol, epidihydrocholesterin, oak extract , angelica soft extract, hinokitiol, allantoin, allantoin chlorohydroxyaluminum, sodium chloride, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, epsilon aminocaproic acid, tranexamic acid, polyphosphate, thymol, sodium copper chlorophyllin, and It can contain wax or the like.
上記口腔用組成物としては、洗口液、液体歯磨き、口中清涼剤、うがい薬（含嗽剤）、液状歯磨きおよび練り歯磨き等の歯磨き類、トローチ、及びチューインガム等の形態とすることができる。
なかでも、上記成分（Ａ）や成分（Ｂ）を口腔内に十分にいきわたらせるため、口腔内に適量を含み使用する洗口液としての用途が好適である。洗口液とするには、例えば、水やエタノール等を溶剤とし、常法によって調製すればよい。
また、例えば、液体歯磨き剤としては、リン酸水素カルシウム、水酸化アルミニウム、無水ケイ酸、炭酸カルシウム等の研磨剤を必要に応じて含有したものとして使用することもできる。
The oral cavity composition may be in the form of mouthwash, liquid toothpaste, mouth freshener, gargle (gargle), toothpaste such as liquid toothpaste and toothpaste, troche, chewing gum, and the like.
In particular, it is suitable for use as a mouthwash that is used in an appropriate amount in the oral cavity in order to sufficiently spread the components (A) and (B) in the oral cavity. Mouthwash may be prepared by a conventional method using water, ethanol, or the like as a solvent.
In addition, for example, liquid dentifrices may be used that contain abrasives such as calcium hydrogen phosphate, aluminum hydroxide, silicic anhydride, and calcium carbonate, if necessary.
本発明の剤を口腔用組成物、特に洗口液として用いる場合、２０～３０秒間、口腔内でゆすぐように使用することで、本発明の剤が十分に口腔内にいきわたらせることができ、口唇用剤付着抑制効果を十分に発揮することができる。 When the agent of the present invention is used as an oral composition, particularly as a mouthwash, the agent of the present invention can be sufficiently spread in the oral cavity by rinsing it in the oral cavity for 20 to 30 seconds. , the effect of suppressing adhesion of the lip agent can be sufficiently exhibited.
また、本発明の剤を、口腔内以外の任意の対象に適用する場合であっても、当該対象の特性に合わせて、その他の任意の成分を配合したり、任意の剤形に調製することが可能である。また、例えば、本発明の剤が液体である場合は、対象を当該剤に浸漬させたり、塗布、スプレーしたりする態様が挙げられる。また、本発明の剤が、固体、ゲル、及びペースト等の半固体等である場合は、本発明の剤を対象に塗布する態様が挙げられる。 In addition, even when the agent of the present invention is applied to any target other than the oral cavity, other optional ingredients may be blended or any dosage form may be prepared according to the characteristics of the target. is possible. Further, for example, when the agent of the present invention is a liquid, there are embodiments in which the subject is immersed in the agent, applied, or sprayed. Moreover, when the agent of the present invention is a solid, a gel, a semi-solid such as a paste, or the like, there is an embodiment in which the agent of the present invention is applied to an object.
以下、本発明を実施例によりさらに説明するが、本発明は下記例に制限されるものではない。 The present invention will be further described below with reference to examples, but the present invention is not limited to the following examples.
（試験例１）
本発明の剤の、歯面に対する口紅の付着抑制効果を確認すべく、歯面モデルとしてハイドロキシアパタイト板（以下、ＨＡ板と称する）を用いて以下の試験を行った。
(Test example 1)
In order to confirm the effect of the agent of the present invention in suppressing adhesion of lipstick to the tooth surface, the following test was conducted using a hydroxyapatite plate (hereinafter referred to as HA plate) as a tooth surface model.
［検体の調製］
下記表１の配合処方に従い各種成分を混合し、実施例１～５及び参考例１の各検体を調製した。なお、表１中の「－」は、当該成分を含有しないことを意味する。
[Preparation of specimen]
Each sample of Examples 1 to 5 and Reference Example 1 was prepared by mixing various components according to the formulation shown in Table 1 below. In addition, "-" in Table 1 means that the component is not contained.
各種成分について詳細を下記する。
成分（Ａ）
・塩化セチルピリジニウム：商品名ＲｏｎａＣａｒｅ（登録商標）ＣＰＣ、メルク社製
・塩化ベンゼトニウム：商品名Ｌｏｎｚａｇａｒｄ Ｂｅｎｚｅｔｈｏｎｉｕｍ Ｃｈｌｏｒｉｄｅ－Ｍ（登録商標）、ロンザ社製
成分（Ｂ）
・グリチルリチン酸ジカリウム：商品名グリチルリチン酸ジカリウム、アルプス薬品工業社製
グリセリン：商品名濃グリセリン、阪本薬品工業社製
Details of the various components are provided below.
Component (A)
・Cetylpyridinium chloride: trade name RonaCare (registered trademark) CPC, manufactured by Merck Co., Ltd. ・Benzethonium chloride: trade name Lonzagard Benzethonium Chloride-M (registered trademark), manufactured by Lonza Co., Ltd. Component (B)
・ Dipotassium glycyrrhizinate: Product name: dipotassium glycyrrhizinate, Glycerin manufactured by Alps Pharmaceutical Co., Ltd.: Product name: Concentrated glycerin, manufactured by Sakamoto Pharmaceutical Co., Ltd.
［試験方法］
１．スポンジの表面に口紅（商品名：レディット クリーミーバームルージュ ０１ テラコッタレッド、（株）スタイリングライフ・ホールディングス製）を塗布した。
２．ポリプロピレン樹脂製のキャップ外側の底部にＨＡ板（１０ｍｍ×１０ｍｍ）を固定した後、上記各検体中に当該ＨＡ板を３０秒間浸漬した。
３．各検体中に浸漬後、上記キャップ外側の底部に固定されたＨＡ板を、上記スポンジ上の口紅塗布部に１Ｎ程度の圧で押し付けた。
４．以下の式により、ＨＡ板への口紅付着率を求めた。
口紅付着率（％）＝（口紅付着面積値／接触面積値）×１００
なお、口紅付着面積値および接触面積値は以下により求めた。
まず、スポンジ上の口紅塗布部に押圧したＨＡ板の主表面を撮影した。次に、当該ＨＡ板の主表面の面積１００ｍｍ２（１０ｍｍ×１０ｍｍ）の画像中のピクセル数（ｐｘ）を、画像処理ソフト「ＩｍａｇｅＪ」を用いて測定した。さらに、当該ＨＡ板の主表面に付着した口紅の面積（ｐｘ）を、同様に画像処理ソフト「ＩｍａｇｅＪ」を用いて計算した。得られたＨＡの主表面の面積（ｐｘ）を「接触面積値」（ａ）、口紅付着面積（ｐｘ）を「口紅付着面積値」（ｂ）とした。
なお「ＩｍａｇｅＪ」はアメリカ国立衛生研究所（ＮＩＨ）で開発されたオープンソースでパブリックドメインの画像処理ソフトウェアである。
[Test method]
1. Lipstick (trade name: Reddit Creamy Balm Rouge 01 Terracotta Red, manufactured by Styling Life Holdings Co., Ltd.) was applied to the surface of the sponge.
2. After fixing an HA plate (10 mm×10 mm) to the bottom of the cap made of polypropylene resin, the HA plate was immersed in each sample for 30 seconds.
3. After being immersed in each sample, the HA plate fixed to the bottom outside the cap was pressed against the lipstick-applied portion of the sponge with a pressure of about 1N.
4. The lipstick adhesion rate to the HA plate was determined by the following formula.
Lipstick adhesion rate (%) = (lipstick adhesion area value / contact area value) x 100
The lipstick adhesion area value and the contact area value were determined as follows.
First, the main surface of the HA plate pressed against the lipstick-applied part on the sponge was photographed. Next, the number of pixels (px) in an image of a main surface area of 100 mm 2 (10 mm×10 mm) of the HA plate was measured using image processing software "ImageJ". Further, the area (px) of the lipstick adhering to the main surface of the HA plate was similarly calculated using the image processing software "ImageJ". The obtained main surface area (px) of HA was defined as the "contact area value" (a), and the lipstick adhesion area (px) was defined as the "lipstick adhesion area value" (b).
"ImageJ" is open source and public domain image processing software developed by the National Institutes of Health (NIH).
表２および図１に、実施例１～５及び参考例１の各検体を用いた場合の口紅付着率を示す。 Table 2 and FIG. 1 show the lipstick adhesion rate when each sample of Examples 1 to 5 and Reference Example 1 was used.
本発明の剤を用いた実施例１～５の検体の場合、水を用いた参考例１と比較して、ＨＡ板に対する口紅付着率が顕著に低い結果となった。
水を用いた参考例１において口紅が多く付着した理由としては、スポンジ上の口紅塗布部にＨＡ板を押し付けた際に、ＨＡ板に付着した水滴が油溶性の口紅に弾かれることにより、ＨＡ板と口紅が直接接触したためだと考えられる。
一方、本発明の剤を用いた実施例１～５の検体で処理した場合に口紅の付着率が低かった理由としては、当該検体がＨＡ板に付着し残存するため、スポンジ上の口紅塗布部にＨＡ板を押し付けた際に、ＨＡ板と口紅の間に当該検体の相が形成されることにより、ＨＡ板と口紅との直接的な接触が抑制されたためだと考えられる。
以上の結果から、第４級アンモニウム塩、及びグリチルリチン酸又はその塩は、歯面に対する口紅の付着を抑制することが示された。
In the case of the specimens of Examples 1 to 5 using the agent of the present invention, the lipstick adhesion rate to the HA plate was significantly lower than that of Reference Example 1 using water.
The reason why a large amount of lipstick adhered in Reference Example 1 using water was that when the HA plate was pressed against the lipstick-applied portion of the sponge, water droplets adhering to the HA plate were repelled by the oil-soluble lipstick. This is thought to be due to direct contact between the plate and the lipstick.
On the other hand, the reason why the lipstick adhesion rate was low when treated with the specimens of Examples 1 to 5 using the agent of the present invention is that the specimen adhered to the HA plate and remained, so that the lipstick applied part on the sponge This is probably because the specimen phase was formed between the HA plate and the lipstick when the HA plate was pressed against the lipstick, thereby suppressing direct contact between the HA plate and the lipstick.
From the above results, it was shown that the quaternary ammonium salt and glycyrrhizic acid or its salt suppress the adhesion of lipstick to the tooth surface.
（試験例２）
本発明の剤の、樹脂に対する口紅の付着抑制効果を確認すべく、ポリプロピレン樹脂製のボトルキャップを用いて以下の試験を行った。検体は試験例１と同じものを用いた。
(Test example 2)
In order to confirm the effect of the agent of the present invention in suppressing adhesion of lipstick to the resin, the following test was conducted using a bottle cap made of polypropylene resin. The same sample as in Test Example 1 was used.
（試験例２－１）
［試験方法］
１．スポンジの表面に口紅（商品名：レディット クリーミーバームルージュ ０１ テラコッタレッド、（株）スタイリングライフ・ホールディングス製）を塗布した。
２．ポリプロピレン樹脂製のボトルキャップ外側の底部を、各検体中に３０秒間浸漬した。
３．各検体中に浸漬した上記ボトルキャップ外側の底部を、上記スポンジ上の口紅塗布部に１Ｎ程度の圧で押し付けた。
４．以下の式により、ボトルキャップ外側の底部への口紅付着率を求めた。
口紅付着率（％）＝（口紅付着面積値／接触面積値）×１００
なお、口紅付着面積値および接触面積値は以下により求めた。
まず、スポンジ上の口紅塗布部に押圧したボトルキャップ外側底部の主表面を撮影した。次に、当該ボトルキャップ外側底部の主表面の画像中のピクセル数（ｐｘ）を、画像処理ソフト「ＩｍａｇｅＪ」を用いて測定した。さらに、当該ボトルキャップ外側底部の主表面に付着した口紅の面積（ｐｘ）を、同様に画像処理ソフト「ＩｍａｇｅＪ」を用いて計算した。得られたＨＡの主表面の面積（ｐｘ）を「接触面積値」（ａ）、口紅付着面積（ｐｘ）を「口紅付着面積値」（ｂ）とした。
(Test Example 2-1)
[Test method]
1. Lipstick (trade name: Reddit Creamy Balm Rouge 01 Terracotta Red, manufactured by Styling Life Holdings Co., Ltd.) was applied to the surface of the sponge.
2. The bottom of the outer bottle cap made of polypropylene resin was immersed in each sample for 30 seconds.
3. The bottom outside of the bottle cap immersed in each sample was pressed against the lipstick-applied portion of the sponge with a pressure of about 1N.
4. The lipstick adhesion rate to the bottom outside the bottle cap was obtained by the following formula.
Lipstick adhesion rate (%) = (lipstick adhesion area value / contact area value) x 100
The lipstick adhesion area value and the contact area value were determined as follows.
First, the main surface of the outer bottom portion of the bottle cap pressed against the lipstick applied portion on the sponge was photographed. Next, the number of pixels (px) in the image of the main surface of the outer bottom of the bottle cap was measured using image processing software "ImageJ". Further, the area (px) of the lipstick adhering to the main surface of the outer bottom of the bottle cap was similarly calculated using the image processing software "ImageJ". The obtained main surface area (px) of HA was defined as the "contact area value" (a), and the lipstick adhesion area (px) was defined as the "lipstick adhesion area value" (b).
表３および図２に、実施例１～５及び参考例１の各検体を用いた場合の口紅付着率を示す。 Table 3 and FIG. 2 show the lipstick adhesion rate when each sample of Examples 1 to 5 and Reference Example 1 was used.
本発明の剤を用いた実施例１～５の検体の場合、水を用いた参考例１と比較して、樹脂製のボトルキャップに対する口紅付着率が顕著に低い結果となった。これは試験例１と同様、当該検体が樹脂製のボトルキャップ底部に付着し残存するため、スポンジ上の口紅塗布部にボトルキャップを押し付けた際に、ボトルキャップと口紅の間に当該検体の相が形成されることにより、ボトルキャップと口紅との直接的な接触が抑制されたためだと考えられる。
以上の結果から、第４級アンモニウム塩、及びグリチルリチン酸又はその塩は、樹脂に対する口紅の付着を抑制することが示された。
In the case of the specimens of Examples 1 to 5 using the agent of the present invention, the lipstick adhesion rate to the resin bottle cap was significantly lower than that of Reference Example 1 using water. As in Test Example 1, the specimen adheres to the bottom of the resin bottle cap and remains there. It is thought that this is because direct contact between the bottle cap and the lipstick is suppressed by the formation of .
From the above results, it was shown that the quaternary ammonium salt and glycyrrhizic acid or its salt suppress adhesion of lipstick to resin.
（試験例２－２）
［試験方法］
１．試験例２－１で用いたポリプロピレン樹脂製のボトルキャップ内に、各検体を注入した。
２．口紅（商品名：レディット クリーミーバームルージュ ０１ テラコッタレッド、（株）スタイリングライフ・ホールディングス製）を口唇に過剰塗布した状態で、上記ボトルキャップを用い、各検体を口に含ませた。
３．ボトルキャップに付着した口紅を観察した。
(Test example 2-2)
[Test method]
1. Each sample was injected into the polypropylene resin bottle cap used in Test Example 2-1.
2. Lipstick (trade name: Reddit Creamy Balm Rouge 01 Terracotta Red, manufactured by StylingLife Holdings Co., Ltd.) was applied excessively to the lips, and each sample was placed in the mouth using the bottle cap.
3. The lipstick adhering to the bottle cap was observed.
図３に、実施例１及び参考例１の各検体を適用した場合のボトルキャップ外側の写真図を示す。
図３の写真図からも分かるように、実施例１の検体を用いた場合は、矢印で示した箇所に対して、ボトルキャップへの口紅の付着が抑制され、ボトルキャップに付着した口紅の除去が容易になる傾向が確認された。一方、参考例１の水を用いた場合は、丸で囲んだ箇所等に口紅が付着しており、口紅の付着抑制効果が十分得られなかった。
以上の結果から、第４級アンモニウム塩、及びグリチルリチン酸又はその塩は、ポリプロピレン樹脂製ボトルキャップへの口紅の付着を抑制することが示された。また、本作用は、ボトルキャップを介した口唇用剤由来成分の製品本体への混入、及び、口唇用剤由来成分の他者への付着・摂取のリスクを軽減するなど、複数人が使用する状態においても製品を衛生的に保つことに寄与する可能性が示された。
FIG. 3 shows a photograph of the outside of the bottle cap when each sample of Example 1 and Reference Example 1 is applied.
As can be seen from the photograph of FIG. 3, when the sample of Example 1 was used, the lipstick adhered to the bottle cap was suppressed in the areas indicated by the arrows, and the lipstick adhered to the bottle cap was removed. was confirmed to be easier. On the other hand, when the water of Reference Example 1 was used, lipstick adhered to the circled portions, etc., and the effect of suppressing lipstick adhesion was not sufficiently obtained.
From the above results, it was shown that the quaternary ammonium salt and glycyrrhizic acid or its salt inhibited the adhesion of lipstick to the bottle cap made of polypropylene resin. In addition, this function is used by multiple people, such as reducing the risk of contamination of the lip preparation-derived ingredients into the product body through the bottle cap, and the attachment and intake of the lip preparation-derived ingredients to others. Possibility of contributing to keeping products hygienic was shown.
Claims (2)
（Ａ）第４級アンモニウム塩
（Ｂ）グリチルリチン酸又はその塩 A lip agent adhesion inhibitor containing at least one of the following component (A) and component (B).
(A) quaternary ammonium salt (B) glycyrrhizic acid or a salt thereof
（Ａ）第４級アンモニウム塩
（Ｂ）グリチルリチン酸又はその塩 A method for suppressing adhesion of a lip preparation to a subject, comprising applying at least one of the following components (A) and (B) to the subject.
(A) quaternary ammonium salt (B) glycyrrhizic acid or a salt thereof
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021031812A JP2022133018A (en) | 2021-03-01 | 2021-03-01 | Labial agent attachment inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021031812A JP2022133018A (en) | 2021-03-01 | 2021-03-01 | Labial agent attachment inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2022133018A true JP2022133018A (en) | 2022-09-13 |
Family
ID=83229342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021031812A Pending JP2022133018A (en) | 2021-03-01 | 2021-03-01 | Labial agent attachment inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2022133018A (en) |
-
2021
- 2021-03-01 JP JP2021031812A patent/JP2022133018A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104822360B (en) | Surfactant system is used to contain Zn composition | |
| TWI507211B (en) | Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine | |
| US6475472B2 (en) | Oral bleaching composition | |
| JPH10251131A (en) | Composition for oral cavity | |
| TW200927184A (en) | Dentifrice composition containing silicone oil beads | |
| JP2009274967A (en) | Composition for oral spray and preparation for oral cavity | |
| WO2002089755A1 (en) | Cationic antibacterial dentifrice exhibiting superior foaming properties | |
| JP2013151473A (en) | Composition for oral cavity | |
| JP2007001954A (en) | Toothpaste composition | |
| JP2022133018A (en) | Labial agent attachment inhibitor | |
| CA3218885A1 (en) | Oral care compositions | |
| JP3241922B2 (en) | Oral composition | |
| JP3511727B2 (en) | Oral composition | |
| JPH1112144A (en) | Liquid oral composition | |
| JP4632553B2 (en) | Oral composition | |
| JP2001158725A (en) | Agent for preventing acid erosion of tooth | |
| JP5845603B2 (en) | Liquid or liquid oral composition and tongue coating adhesion inhibitor | |
| JPWO2018043717A1 (en) | Oral composition | |
| JP3838604B2 (en) | Liquid oral composition | |
| JP3575999B2 (en) | Cosmetic and modified mint oil for the cosmetic | |
| JP2004018521A (en) | Formulation for oral cavity | |
| WO2022102628A1 (en) | Composition for oral cavity | |
| JPH10152424A (en) | Composition for oral cavity | |
| WO2022145160A1 (en) | Composition for oral cavity | |
| JP2022085871A (en) | Oral composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20231228 |