JP2022130622A - PGC-1α活性化用組成物 - Google Patents
PGC-1α活性化用組成物 Download PDFInfo
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- JP2022130622A JP2022130622A JP2022105402A JP2022105402A JP2022130622A JP 2022130622 A JP2022130622 A JP 2022130622A JP 2022105402 A JP2022105402 A JP 2022105402A JP 2022105402 A JP2022105402 A JP 2022105402A JP 2022130622 A JP2022130622 A JP 2022130622A
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Abstract
Description
(1)カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物を含む、PGC-1α活性化用組成物。
(2)カルコン類が、2-ヒドロキシカルコン、trans-カルコン、イソリクイリチゲニン、4'-ヒドロキシカルコン、2',4'-ジヒドロキシ-4,6'-ジメトキシカルコン、4-ヒドロキシカルコン、4'-メトキシカルコン、ブテイン、2,3-ジメトキシ-2'-ヒドロキシカルコン、2',6'-ジヒドロキシ-4,4'-ジメトキシジヒドロカルコン、2',6'-ジヒドロキシ-4,4'-ジメトキシカルコン、4-メトキシカルコン、及び3,4,2',4',6'-ペンタヒドロキシカルコンからなる群より選択される少なくとも一つの化合物である、(1)に記載の組成物。
(3)アルカロイド類が、ピペルロングミン及び/又はマハニンである、(1)又は(2)に記載の組成物。
(4)アントラキノン類が、エモジン及び/又はアントラフラビン酸である、(1)~(3)のいずれかに記載の組成物。
(5)イソフラバン類が、(±)-エクオールである、(1)~(4)のいずれかに記載の組成物。
(6)イソフラボン類が、4',6,7-トリヒドロキシイソフラボン、5-メチル-7-メトキシ-イソフラボン、及びイプリフラボンからなる群より選択される少なくとも一つの化合物である、(1)~(5)のいずれかに記載の組成物。
(7)エラグ酸が、ウロリチン及び/又はエラグ酸である、(1)~(6)のいずれかに記載の組成物。
(8)クマリン類が、エスクレチンである、(1)~(7)のいずれかに記載の組成物。
(9)ジアリルヘプタノイド類が、クルクミン1、クルクミン2、及びクルクミン3からなる群より選択される少なくとも一つの化合物である、(1)~(8)のいずれかに記載の組成物。
(10)ジテルペノイド類が、イソステビオールである、(1)~(9)のいずれかに記載の組成物。
(11)セスキテルペン類が、(-)-transカリオフィレン及び/又はノートカトンである、(1)~(10)のいずれかに記載の組成物。
(12)トリテルペン類が、ヘデラゲニン及び/又はコロソリン酸である、(1)~(11)のいずれかに記載の組成物。
(13)ネオフラボン類が、ダルベルギンである、(1)~(12)のいずれかに記載の組成物。
(14)フィトケミカル類が、アポシニン、3-アニスアルデヒド、(+)-クパレン、及びヒドロキシチロソールからなる群より選択される少なくとも一つの化合物である、(1)~(13)のいずれかに記載の組成物。
(15)フラバノノール類が、(+)-タキシホリンである、(1)~(14)のいずれかに記載の組成物。
(16)フラバノン類が、4'-メトキシフラバノン、2'-ヒドロキシフラバノン、3'-ヒドロキシフラバノン、フラバノン、及び6-メトキシフラバノンからなる群より選択される少なくとも一つの化合物である、(1)~(15)のいずれかに記載の組成物。
(17)フラボノール類が、ガランギン、3-メトキシフラボン、ケンペロール、3',5,7-トリヒドロキシ-3,4'-ジメトキシフラボン、3',4',5,5',6,7,8-ヘプタメトキシフラボン、フィセチン、6-メトキシフラボノール、7-ヒドロキシフラボノール、及びイソラムネチンからなる群より選択される少なくとも一つの化合物である、(1)~(16)のいずれかに記載の組成物。
(18)フラボン類が、ビオランチン、3',4'-ジヒドロキシフラボン、タンゲレチン、2'-メトキシフラボン、7,4'-ジヒドロキシフラボン、クリソエリオール、3',4'-ジメトキシフラボン、フラボン、α-ナフトフラボン、ジオスメチン、4'-メトキシフラボン、オウゴニン、6-ヒドロキシフラボン、及び5-メトキシフラボンからなる群より選択される少なくとも一つの化合物である、(1)~(17)のいずれかに記載の組成物。
(19)リグナン類が、ユーデスミン、(-)-セサミン、ホノキオール、セサモリン、セサミン、ノルジヒドログアイアレチン酸、セサミノール、セサモール、エピセサミン、及びマタイレシノールからなる群より選択される少なくとも一つの化合物である、(1)~(18)のいずれかに記載の組成物。
(20)持久力向上用、筋肥大用、肥満抑制用、ストレス軽減用、糖代謝機能改善用、又は筋委縮抑制用である、(1)~(19)のいずれかに記載の組成物。
(21)PGC-1αの活性化により発揮される機能の表示を付した、(1)~(20)のいずれかに記載の組成物。
(22)機能の表示が、「持久力を高める」、「持久力をサポートする」、「持久力を維持する」、「持久力をつける」、「スタミナアップに役立つ」、「疲れにくい体にする」、「疲れを軽減する」、「疲労を抑える」、「疲労回復を早める」、「筋肉をつける」、「筋肉を増やす」、「筋肉をつくる」、「脂肪を減らす」、「脂肪を燃やす」、「肥満を抑える」、「肥満を防ぐ」、「脂質代謝を高める」、「ストレスを軽減する」、「ストレス耐性を高める」、「うつ状態を抑制する」、「うつを予防する」、「糖代謝を促す」、「糖代謝を高める」、「糖の燃焼を促す」、「糖代謝をサポートする」、「糖を消費させる」、「筋肉を維持する」、「筋委縮を抑制する」、「筋肉の減少を防ぐ」、「筋肉の減少を抑える」、「筋肉の衰えを防ぐ」、及び「筋肉の衰えを抑える」からなる群より選択されるものである、(21)に記載の組成物。
(23)PGC-1αを活性化するための、カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物の使用。
(24)カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物を使用する、PGC-1αを活性化する方法。
本発明の一態様は、所定の化合物を含有する組成物である。本発明の組成物は、当該所定の化合物を有効成分とするものである。
本発明の組成物は、上記の化合物を有効成分として用いることによってPGC-1αを活性化することができる。そのため、本発明の組成物は、PGC-1α活性化用組成物として用いることができる。PGC-1αは、Peroxisome proliferator-activated receptor gamma coactivator 1-alphaの名称で表される転写コアクチベーターである。その機能としては、種々の転写因子と相互作用する等して、ミトコンドリアの生合成促進作用を有することや、グルコーストランスポーターGLUT4の発現量増加作用を有すること等が知られている。
本発明の組成物における上記の化合物の含有量は、その投与形態及び投与方法等を考慮し、本発明の所望の効果が得られるような量であればよく、特に限定されるものではない。例えば、上記の化合物の含有量は、本発明の組成物の全重量に対して0.1重量%以上、好ましくは0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1、1.5、2、5、又は10重量%以上であり、90重量%以下、好ましくは80、70、60、50、40、30、20、又は15重量%以下である。上述した通り、本発明の組成物において、上記の化合物は一種のみが含まれていてもよく、或いは二種以上が含まれていてもよい。二種以上の化合物が含まれる場合、前記の含有量は、各種化合物の含有量の合計値で規定される。なお、本明細書において用いる「重量%」は、特に断りがない限り重量/重量(w/w)を意味する。
本発明の一態様は、PGC-1αを活性化するための、カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物の使用である。
本発明の一態様は、カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物を使用する、PGC-1αを活性化する方法である。また、当該方法に関する別の態様は、PGC-1αの活性化を必要とする対象に、上記の化合物を有効成分として治療有効量を投与することを含む、PGC-1αを活性化する方法である。
Claims (24)
- カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物を含む、PGC-1α活性化用組成物。
- カルコン類が、2-ヒドロキシカルコン、trans-カルコン、イソリクイリチゲニン、4'-ヒドロキシカルコン、2',4'-ジヒドロキシ-4,6'-ジメトキシカルコン、4-ヒドロキシカルコン、4'-メトキシカルコン、ブテイン、2,3-ジメトキシ-2'-ヒドロキシカルコン、2',6'-ジヒドロキシ-4,4'-ジメトキシジヒドロカルコン、2',6'-ジヒドロキシ-4,4'-ジメトキシカルコン、4-メトキシカルコン、及び3,4,2',4',6'-ペンタヒドロキシカルコンからなる群より選択される少なくとも一つの化合物である、請求項1に記載の組成物。
- アルカロイド類が、ピペルロングミン及び/又はマハニンである、請求項1又は2に記載の組成物。
- アントラキノン類が、エモジン及び/又はアントラフラビン酸である、請求項1~3のいずれか1項に記載の組成物。
- イソフラバン類が、(±)-エクオールである、請求項1~4のいずれか1項に記載の組成物。
- イソフラボン類が、4',6,7-トリヒドロキシイソフラボン、5-メチル-7-メトキシ-イソフラボン、及びイプリフラボンからなる群より選択される少なくとも一つの化合物である、請求項1~5のいずれか1項に記載の組成物。
- エラグ酸が、ウロリチン及び/又はエラグ酸である、請求項1~6のいずれか1項に記載の組成物。
- クマリン類が、エスクレチンである、請求項1~7のいずれか1項に記載の組成物。
- ジアリルヘプタノイド類が、クルクミン1、クルクミン2、及びクルクミン3からなる群より選択される少なくとも一つの化合物である、請求項1~8のいずれか1項に記載の組成物。
- ジテルペノイド類が、イソステビオールである、請求項1~9のいずれか1項に記載の組成物。
- セスキテルペン類が、(-)-transカリオフィレン及び/又はノートカトンである、請求項1~10のいずれか1項に記載の組成物。
- トリテルペン類が、ヘデラゲニン及び/又はコロソリン酸である、請求項1~11のいずれか1項に記載の組成物。
- ネオフラボン類が、ダルベルギンである、請求項1~12のいずれか1項に記載の組成物。
- フィトケミカル類が、アポシニン、3-アニスアルデヒド、(+)-クパレン、及びヒドロキシチロソールからなる群より選択される少なくとも一つの化合物である、請求項1~13のいずれか1項に記載の組成物。
- フラバノノール類が、(+)-タキシホリンである、請求項1~14のいずれか1項に記載の組成物。
- フラバノン類が、4'-メトキシフラバノン、2'-ヒドロキシフラバノン、3'-ヒドロキシフラバノン、フラバノン、及び6-メトキシフラバノンからなる群より選択される少なくとも一つの化合物である、請求項1~15のいずれか1項に記載の組成物。
- フラボノール類が、ガランギン、3-メトキシフラボン、ケンペロール、3',5,7-トリヒドロキシ-3,4'-ジメトキシフラボン、3',4',5,5',6,7,8-ヘプタメトキシフラボン、フィセチン、6-メトキシフラボノール、7-ヒドロキシフラボノール、及びイソラムネチンからなる群より選択される少なくとも一つの化合物である、請求項1~16のいずれか1項に記載の組成物。
- フラボン類が、ビオランチン、3',4'-ジヒドロキシフラボン、タンゲレチン、2'-メトキシフラボン、7,4'-ジヒドロキシフラボン、クリソエリオール、3',4'-ジメトキシフラボン、フラボン、α-ナフトフラボン、ジオスメチン、4'-メトキシフラボン、オウゴニン、6-ヒドロキシフラボン、及び5-メトキシフラボンからなる群より選択される少なくとも一つの化合物である、請求項1~17のいずれか1項に記載の組成物。
- リグナン類が、ユーデスミン、(-)-セサミン、ホノキオール、セサモリン、セサミン、ノルジヒドログアイアレチン酸、セサミノール、セサモール、エピセサミン、及びマタイレシノールからなる群より選択される少なくとも一つの化合物である、請求項1~18のいずれか1項に記載の組成物。
- 持久力向上用、筋肥大用、肥満抑制用、ストレス軽減用、糖代謝機能改善用、又は筋委縮抑制用である、請求項1~19のいずれか1項に記載の組成物。
- PGC-1αの活性化により発揮される機能の表示を付した、請求項1~20のいずれか1項に記載の組成物。
- 機能の表示が、「持久力を高める」、「持久力をサポートする」、「持久力を維持する」、「持久力をつける」、「スタミナアップに役立つ」、「疲れにくい体にする」、「疲れを軽減する」、「疲労を抑える」、「疲労回復を早める」、「筋肉をつける」、「筋肉を増やす」、「筋肉をつくる」、「脂肪を減らす」、「脂肪を燃やす」、「肥満を抑える」、「肥満を防ぐ」、「脂質代謝を高める」、「ストレスを軽減する」、「ストレス耐性を高める」、「うつ状態を抑制する」、「うつを予防する」、「糖代謝を促す」、「糖代謝を高める」、「糖の燃焼を促す」、「糖代謝をサポートする」、「糖を消費させる」、「筋肉を維持する」、「筋委縮を抑制する」、「筋肉の減少を防ぐ」、「筋肉の減少を抑える」、「筋肉の衰えを防ぐ」、及び「筋肉の衰えを抑える」からなる群より選択されるものである、請求項21に記載の組成物。
- PGC-1αを活性化するための、カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物の使用。
- カルコン類、アルカロイド類、アントラキノン類、イソフラバン類、イソフラボン類、エラグ酸、クマリン類、ジアリルヘプタノイド類、ジテルペノイド類、セスキテルペン類、トリテルペン類、ネオフラボン類、フィトケミカル類、フラバノノール類、フラバノン類、フラボノール類、フラボン類、及びリグナン類からなる群から選択される少なくとも一つの化合物を使用する、PGC-1αを活性化する方法。
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