JP2022069377A5 - - Google Patents
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- Publication number
- JP2022069377A5 JP2022069377A5 JP2021074664A JP2021074664A JP2022069377A5 JP 2022069377 A5 JP2022069377 A5 JP 2022069377A5 JP 2021074664 A JP2021074664 A JP 2021074664A JP 2021074664 A JP2021074664 A JP 2021074664A JP 2022069377 A5 JP2022069377 A5 JP 2022069377A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- angioedema
- bradykinin
- administered
- attack
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 60
- 208000028185 Angioedema Diseases 0.000 claims 26
- 101800004538 Bradykinin Proteins 0.000 claims 20
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 20
- 102100035792 Kininogen-1 Human genes 0.000 claims 20
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 20
- 230000001404 mediated effect Effects 0.000 claims 20
- 239000003826 tablet Substances 0.000 claims 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 8
- 206010019860 Hereditary angioedema Diseases 0.000 claims 5
- 208000024891 symptom Diseases 0.000 claims 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 4
- 235000019359 magnesium stearate Nutrition 0.000 claims 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 4
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 4
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 3
- 229930195725 Mannitol Natural products 0.000 claims 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 3
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 3
- 239000007919 dispersible tablet Substances 0.000 claims 3
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 3
- 239000000594 mannitol Substances 0.000 claims 3
- 235000010355 mannitol Nutrition 0.000 claims 3
- 239000008185 minitablet Substances 0.000 claims 3
- 229940079832 sodium starch glycolate Drugs 0.000 claims 3
- 229920003109 sodium starch glycolate Polymers 0.000 claims 3
- 239000008109 sodium starch glycolate Substances 0.000 claims 3
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 3
- 229960000187 tissue plasminogen activator Drugs 0.000 claims 3
- 208000004998 Abdominal Pain Diseases 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- 206010042674 Swelling Diseases 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 229940057948 magnesium stearate Drugs 0.000 claims 2
- 229960001855 mannitol Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- 229960004274 stearic acid Drugs 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 230000008961 swelling Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims 1
- 206010002198 Anaphylactic reaction Diseases 0.000 claims 1
- 241000723346 Cinnamomum camphora Species 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 claims 1
- 206010013952 Dysphonia Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 206010015150 Erythema Diseases 0.000 claims 1
- 206010015218 Erythema multiforme Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000010473 Hoarseness Diseases 0.000 claims 1
- 206010027940 Mood altered Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- FUSGACRLAFQQRL-UHFFFAOYSA-N N-Ethyl-N-nitrosourea Chemical compound CCN(N=O)C(N)=O FUSGACRLAFQQRL-UHFFFAOYSA-N 0.000 claims 1
- 206010028813 Nausea Diseases 0.000 claims 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims 1
- 239000004376 Sucralose Substances 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000005707 acquired angioedema Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 238000003915 air pollution Methods 0.000 claims 1
- 230000036783 anaphylactic response Effects 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 229960000846 camphor Drugs 0.000 claims 1
- 229930008380 camphor Natural products 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 229940068682 chewable tablet Drugs 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000030407 hereditary angioedema with normal C1Inh Diseases 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 230000007510 mood change Effects 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000008693 nausea Effects 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 208000035824 paresthesia Diseases 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229940069328 povidone Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 230000009747 swallowing Effects 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000008673 vomiting Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063104919P | 2020-10-23 | 2020-10-23 | |
| US63/104,919 | 2020-10-23 | ||
| US202163147595P | 2021-02-09 | 2021-02-09 | |
| US63/147,595 | 2021-02-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022069377A JP2022069377A (ja) | 2022-05-11 |
| JP2022069377A5 true JP2022069377A5 (https=) | 2024-04-23 |
Family
ID=81521900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021074664A Pending JP2022069377A (ja) | 2020-10-23 | 2021-04-27 | 血管性浮腫の処置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2022069377A (https=) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201721515D0 (en) * | 2017-12-21 | 2018-02-07 | Kalvista Pharmaceuticals Ltd | Dosage forms comprising a plasma kallikrein inhibtor |
-
2021
- 2021-04-27 JP JP2021074664A patent/JP2022069377A/ja active Pending
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