JP2022036990A5 - - Google Patents
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- JP2022036990A5 JP2022036990A5 JP2021189726A JP2021189726A JP2022036990A5 JP 2022036990 A5 JP2022036990 A5 JP 2022036990A5 JP 2021189726 A JP2021189726 A JP 2021189726A JP 2021189726 A JP2021189726 A JP 2021189726A JP 2022036990 A5 JP2022036990 A5 JP 2022036990A5
- Authority
- JP
- Japan
- Prior art keywords
- epithelial cells
- maximizing
- tight junction
- junction integrity
- integrity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000968 intestinal effect Effects 0.000 claims description 5
- 210000002919 epithelial cell Anatomy 0.000 claims 18
- 210000001578 tight junction Anatomy 0.000 claims 15
- 102000000591 Tight Junction Proteins Human genes 0.000 claims 13
- 108010002321 Tight Junction Proteins Proteins 0.000 claims 13
- 206010061218 Inflammation Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 3
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- GCPYCNBGGPHOBD-UHFFFAOYSA-N Delphinidin Natural products OC1=Cc2c(O)cc(O)cc2OC1=C3C=C(O)C(=O)C(=C3)O GCPYCNBGGPHOBD-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 208000027244 Dysbiosis Diseases 0.000 claims 1
- 206010061958 Food Intolerance Diseases 0.000 claims 1
- 206010017964 Gastrointestinal infection Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 102100025255 Haptoglobin Human genes 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 102000001109 Leukocyte L1 Antigen Complex Human genes 0.000 claims 1
- 108010069316 Leukocyte L1 Antigen Complex Proteins 0.000 claims 1
- 102000019149 MAP kinase activity proteins Human genes 0.000 claims 1
- 108040008097 MAP kinase activity proteins Proteins 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 102000003945 NF-kappa B Human genes 0.000 claims 1
- 108010057466 NF-kappa B Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000001280 Prediabetic State Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000013553 cell monolayer Substances 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000021735 chronic enteritis Diseases 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000007336 cyanidin Nutrition 0.000 claims 1
- 235000007242 delphinidin Nutrition 0.000 claims 1
- JKHRCGUTYDNCLE-UHFFFAOYSA-O delphinidin Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 JKHRCGUTYDNCLE-UHFFFAOYSA-O 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007140 dysbiosis Effects 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 230000035987 intoxication Effects 0.000 claims 1
- 231100000566 intoxication Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000004666 short chain fatty acids Chemical class 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 108010027843 zonulin Proteins 0.000 claims 1
- 230000035699 permeability Effects 0.000 description 3
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021189726A JP7473516B2 (ja) | 2016-10-27 | 2021-11-22 | 腸の健康を促す組成物 |
| JP2024063716A JP2024099590A (ja) | 2016-10-27 | 2024-04-11 | 腸の健康を促す組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019545873A JP7011885B2 (ja) | 2016-10-27 | 2016-10-27 | 腸の健康を促す組成物 |
| PCT/US2016/059226 WO2018080510A1 (en) | 2016-10-27 | 2016-10-27 | Intestinal health promoting compositions |
| JP2021189726A JP7473516B2 (ja) | 2016-10-27 | 2021-11-22 | 腸の健康を促す組成物 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545873A Division JP7011885B2 (ja) | 2016-10-27 | 2016-10-27 | 腸の健康を促す組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063716A Division JP2024099590A (ja) | 2016-10-27 | 2024-04-11 | 腸の健康を促す組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022036990A JP2022036990A (ja) | 2022-03-08 |
| JP2022036990A5 true JP2022036990A5 (https=) | 2022-05-10 |
| JP7473516B2 JP7473516B2 (ja) | 2024-04-23 |
Family
ID=62023893
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545873A Active JP7011885B2 (ja) | 2016-10-27 | 2016-10-27 | 腸の健康を促す組成物 |
| JP2021189726A Active JP7473516B2 (ja) | 2016-10-27 | 2021-11-22 | 腸の健康を促す組成物 |
| JP2024063716A Pending JP2024099590A (ja) | 2016-10-27 | 2024-04-11 | 腸の健康を促す組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019545873A Active JP7011885B2 (ja) | 2016-10-27 | 2016-10-27 | 腸の健康を促す組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024063716A Pending JP2024099590A (ja) | 2016-10-27 | 2024-04-11 | 腸の健康を促す組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20190255134A1 (https=) |
| JP (3) | JP7011885B2 (https=) |
| KR (1) | KR20190079641A (https=) |
| CN (1) | CN110636760B (https=) |
| WO (1) | WO2018080510A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190079641A (ko) * | 2016-10-27 | 2019-07-05 | 엔에스이 프로덕츠, 인크. | 장 건강 촉진 조성물 |
| KR102178556B1 (ko) * | 2019-03-21 | 2020-11-13 | 강원대학교산학협력단 | 마늘껍질 추출물을 포함하는 장내균총 개선용 프리바이오틱스 조성물 및 이를 포함하는 기능성 식품 |
| FR3097122B1 (fr) * | 2019-06-11 | 2021-06-18 | Valbiotis | Melange d’extraits de plantes pour son utilisation dans la prevention et/ou le traitement des maladies chroniques inflammatoires de l’intestin |
| CN110283754B (zh) * | 2019-07-11 | 2021-02-02 | 中国科学院北京基因组研究所 | 用于类风湿关节炎炎症状态评估及预后评价的肠道微生物菌群 |
| IT201900019325A1 (it) * | 2019-10-18 | 2021-04-18 | Ghs Gemelli Health System S R L | Miscela comprendente estratti di frutti, e polifenoli estratti da foglie o frutti di Olea Europaea L. e inulina e uso di tale composizione nel trattamento di malattie infiammatorie acute e croniche, localizzate o sistemiche, o conseguenti ad un’ischemia o a un’alterazione della funzionalità dell’endotelio vasale |
| US20230293482A1 (en) * | 2020-03-24 | 2023-09-21 | Shibaura Institute Of Technology | Central nervous system potentiating composition |
| KR20210156445A (ko) | 2020-06-18 | 2021-12-27 | 종근당건강 주식회사 | 들쭉나무 열매 분말 또는 추출물을 함유하는 장내 환경 개선용 조성물 |
| WO2022045211A1 (ja) * | 2020-08-25 | 2022-03-03 | 国立大学法人 熊本大学 | 月経に伴う不快状態の改善用組成物 |
| JP2023124967A (ja) * | 2022-02-28 | 2023-09-07 | アスパック企業株式会社 | 腸内環境改善剤 |
| CN115645429B (zh) * | 2022-12-12 | 2023-05-16 | 汤臣倍健股份有限公司 | 一种花色苷组合物及其应用 |
| KR20250167568A (ko) * | 2023-01-04 | 2025-12-01 | 엔에스이 프로덕츠, 인크. | 대사 건강 증진 조성물 |
| CN116790402B (zh) * | 2023-01-14 | 2024-05-14 | 西北农林科技大学 | 一株具有抗炎特性的单形拟杆菌菌株、培养方法及应用 |
| CN117085117B (zh) * | 2023-09-14 | 2024-03-12 | 浙江花开星辰生物科技有限公司 | 一种洋甘菊提取物的抗幽门螺旋杆菌组合物及其制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060123663A (ko) * | 1999-08-27 | 2006-12-01 | 미시간 스테이트 유니버시티 | 천연 사이클로옥시게나제 저해물질을 함유하는 조성물 |
| US8337914B2 (en) * | 2002-02-27 | 2012-12-25 | Access Business Group International Llc | Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation |
| JP2004099578A (ja) | 2002-09-04 | 2004-04-02 | Oriza Yuka Kk | 美肌用組成物 |
| US20070243268A1 (en) * | 2005-11-07 | 2007-10-18 | Jaffe Russell M | Compositions for regulating intestinal disorders and methods of use thereof |
| EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
| JP2008271878A (ja) | 2007-04-27 | 2008-11-13 | Wakasa Seikatsu:Kk | 新規飲食品 |
| JP5877902B2 (ja) * | 2011-08-17 | 2016-03-08 | マイクロバイオーム セラピューティクス，エルエルシー | バクテロイデス門の胃腸管微生物相対フィルミクテス門の微生物相の比を上昇させるための組成物および製剤の使用 |
| EP2682005A1 (en) * | 2012-07-05 | 2014-01-08 | Symrise AG | A dietary supplement composition |
| EP2710901A1 (en) * | 2012-09-20 | 2014-03-26 | Symrise AG | Dietary supplement compositions |
| US20140128333A1 (en) * | 2012-11-02 | 2014-05-08 | Maqui New Life S.A. | Compounds, Compositions, and Methods for Decreasing Intestinal Glucose Uptake and Inducing Incretin Release |
| AU2014236655B2 (en) * | 2013-03-15 | 2017-06-29 | Mars, Incorporated | Edible pet chew and method of making the same |
| KR20190079641A (ko) | 2016-10-27 | 2019-07-05 | 엔에스이 프로덕츠, 인크. | 장 건강 촉진 조성물 |
-
2016
- 2016-10-27 KR KR1020197015224A patent/KR20190079641A/ko active Pending
- 2016-10-27 WO PCT/US2016/059226 patent/WO2018080510A1/en not_active Ceased
- 2016-10-27 JP JP2019545873A patent/JP7011885B2/ja active Active
- 2016-10-27 CN CN201680091887.7A patent/CN110636760B/zh active Active
- 2016-10-27 US US16/346,100 patent/US20190255134A1/en not_active Abandoned
-
2021
- 2021-11-22 JP JP2021189726A patent/JP7473516B2/ja active Active
-
2024
- 2024-04-11 JP JP2024063716A patent/JP2024099590A/ja active Pending
- 2024-08-12 US US18/801,755 patent/US20250114419A1/en active Pending
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