JP2022030024A - Gel induction type composition for aiding pet medication - Google Patents

Abstract

To provide a composition for aiding pet medication of a gel induction type.SOLUTION: Provided is a composition for aiding pet medication of a gel induction type which has viscosity so as to adhere to a palate of a pet by allowing vegetable oil to contain high-concentration viscosity modifier. Once powdered preparations prescribed by each prescription are input and mixed into the composition, the composition and the powdered preparation are mixed without causing layer separation therebetween, and the entire mixture adheres to the palate of a pet without flowing down of the mixture when scooped by a finger. The preparation is made to be naturally absorbed when composition components dissolve, and thus an appropriate content can be medicated when medicating a prescribed drug to a pet.SELECTED DRAWING: Figure 1

Description

The present invention relates to a gel-induced pet dosing aid composition, and more particularly, to the extent that the oil component alone or the oil component contains a high-concentration viscosity modifier so as to adhere to the pet's palate. Provided is a gel-induced pet dosing aid composition having the viscosity of It relates to a gel-induced pet dosing aid composition that adheres to the pet's palate and allows the drug to be naturally absorbed when the composition components dissolve.

In modern society, pets are companion animals that live with humans, typically dogs and cats, maintain close relationships around humans, and receive more interest and care than animals from humans. Will grow up.

Therefore, when the health of pets, which are companion animals, becomes abnormal and hurts, they go to a veterinary hospital to be diagnosed and take drugs, but these drugs consist mostly of powders or tablets and are taken orally. At this time, pets with a well-developed sense of smell often refuse to take the drug due to the smell of the drug, and it is inconvenient to administer the drug orally. It may not reach the dose content and improvement is required.

As part of efforts for this purpose, an oral drug solution container for pets (Patent Document 1) has been devised in order to allow pets to drink liquid drugs, nutritional supplements, etc. more easily. Is powdered, mixed with water, liquefied, and then forcibly administered to the pet's mouth using a drug injection spoon or syringe.

However, pets are difficult to swallow due to the smell and bitterness of orally administered drugs, and even if they take the administered drug, they will spit out again, which makes practical drug treatment difficult, especially when administering with a syringe. After finding that dogs and cats were bitter, there was the problem of avoiding them simply by picking up the syringe.

In other attempts, a storage space is formed inside the pet feed to store solid, capsule or powdered drug, and when the pet eats the feed, at the same time drinks the drug contained in the feed. There is a method (Patent Document 2) in which the pet is allowed to take the drug without a feeling of refusal, or a method in which the drug is mixed with jam or honey and administered is used, but in this case, the sugar content is too high. , Another problem has arisen that it is harmful to the body.

In addition to this, it has been proposed to freeze a capsule in which a drug is administered in a hollow space and orally administer it to a pet (Patent Document 3).

However, it is still difficult to solve the problem of dislike of drugs when administering a dispensing drug to pets, and it is difficult to administer an appropriate content.

Here, as a result of efforts to solve the conventional problems, the present inventor adjusts the viscosity by adding the oil component alone or a high-concentration viscosity adjusting agent to the oil component, and adheres to the palate of the pet. A gel-induced pet medication assisting composition having such a viscosity is provided, and when powdered agents prepared according to the respective formulations are added to the gel-like composition and mixed, when scooped with a finger. The present invention was completed by allowing the drug to be naturally absorbed when the entire mixture adheres to the pet's palate and the composition components dissolve without running off.

Korea Registered Utility Model No. 0329124 (2003.09.26) Korea Public Utility Model No. 2017-0000112 (2017.01.09) U.S. Patent Application Publication No. 2012/0321703 (2012.12.20)

An object of the present invention is to provide a gel-induced pet dosing assisting composition.

Another object of the present invention is to provide a gel dosage form product containing a dispensing powder drug in a gel-induced pet dosing assisting composition.

In order to achieve the above-mentioned object, the present invention provides a gel-induced pet dosing assisting composition containing a silicon-based or bio-gum-based viscosity modifier in the oil component alone or in the oil component.

The gel-induced pet dosing assisting composition according to the present invention may contain an enzyme in the oil component.

The enzyme is preferably more than a proteolytic enzyme (Protease), a carbohydrate degrading enzyme (Alpha Amyrace), a dietary fiber cellulolytic enzyme (Cellulase), a lipolytic enzyme (Lipase), and a polysaccharide pectinase (Pectinase). It may contain any one selected from the group.

The above-mentioned gel-induced pet dosing assisting composition according to the present invention is characterized by having a viscosity of 9,500 to 100,000 cP at a temperature of 25 ° C. and a measurement standard of 10 rpm of a rotary viscometer. And.

At this time, the oil component according to the present invention contains vegetable oil or animal oil, and the vegetable oil was selected from the group consisting of canola oil, soybean oil, corn oil, grape seed oil, and brown rice oil. Use one of them.

Further, the silicon-based viscosity regulator is preferably sodium aluminate, and the bio-gum-based viscosity regulator is any one selected from the group consisting of xanthan gum, carrageenan, guar gum, deutan gum, cellulose gum, and gellan gum. Use one.

INDUSTRIAL APPLICABILITY The present invention comprises a gel-induced pet dosing assisting composition containing 5 to 10% by weight of a standard daily dietary intake per pet's body weight and packaged with a formulated powdered drug. To provide gel dosage form products for use.

The gel dosage form product has the characteristics of being poorly soluble in the aqueous phase and soluble in the oil phase.

The gel-induced pet dosing assisting composition according to the present invention provides a viscosity sufficient to adhere to the pet's palate by containing the oil component alone or the oil component containing a high-concentration viscosity modifier. be able to.

The gel-induced pet dosing assisting composition according to the present invention may further contain a powdered drug prepared according to each formulation, and when scooped with a finger, the entire mixture does not run off and the entire mixture is the pet's palate. By allowing the drug to be naturally absorbed when the composition component dissolves in the pet, the pet can be dosed with the proper content at the time of dosing the dispensing drug.

Therefore, the gel-induced pet dosing aid composition according to the present invention can be easily mixed with a fixed amount of powdered drug manufactured in a veterinary hospital by adding a taste preferred by pets or adding an enzyme to enhance digestion and absorption. It is possible to provide a customized dosage form having a desired viscosity.

It is a photograph which shows the gel form which the powder drug was put into the gel-inducing type pet dosing assist composition which concerns on this invention. It is a photograph showing the dissolution behavior in the aqueous phase between the gel-induced pet dosing assisting composition and the powdered drug according to the present invention. The gel-induced pet dosing assisting composition according to the present invention is mixed with a powdered drug according to a prescription, and the test animal is administered with enrofloxacin (5 mg / kg), and then the drug is added to the body over time. It is a graph which shows the dynamics (AUC result). It is a graph which shows the drug blood concentration with time after the powder drug by a prescription was prepared and administered by the dosage form to the gel-induced pet dosing auxiliary composition which concerns on this invention.

Hereinafter, the present invention will be described in detail.

The present invention provides a gel-induced pet dosing assisting composition containing an oil component alone or a viscosity modifier in the oil component.

As the first embodiment of the gel-induced pet medication assisting composition according to the present invention, the oil component is contained alone, and the oil component contains vegetable oil or animal oil, and is a plant. As a preferable example of the sex oil, any one selected from the group consisting of canola oil, soybean oil, corn oil, grape seed oil, and brown rice oil is used.

Further, any animal oil can be used as long as it maintains a liquid state at room temperature, and horse oil, squalene, lanolin and the like are used, but the animal oil is not limited thereto.

As a second embodiment of the gel-induced pet dosing assisting composition according to the present invention, the oil component further contains a silicon-based or bio-gum-based viscosity modifier. At this time, it is more preferable to use vegetable oil as the oil component.

As the vegetable oil in the gel-induced pet medication assisting composition according to the present invention, any one selected from the group consisting of canola oil, soybean oil, corn oil, grape seed oil, and brown rice oil is used. The oil component may be selected in consideration of compatibility and compatibility between the composition components.

Further, the gel-induced pet dosing assisting composition according to the first and second embodiments of the present invention does not run off when scooped with a finger, leaves no residue in the container, and the entire mixture is taken out. Designed to have a viscosity of.

A suitable viscosity is 9,500 to 100,000 cP at a temperature of 25 ° C. and a rotation speed of a rotary viscometer of 10 rpm as a measurement standard, and if the composition has the above viscosity, it is attached to the palate of a pet. Therefore, it is preferable. At this time, if the viscosity is less than 9,500 cP, the composition flows down too much, the whole cannot be scooped up with a finger, it is difficult to administer an appropriate dispensing drug, and if it exceeds 100,000 cP, the composition is too much. It is not preferable because it is dry and does not mix with the dispensing drug and it is difficult to administer the drug.

FIG. 1 is a photograph showing a gel dosage form in which a powdered drug is added to a gel-induced pet dosing assisting composition according to the present invention, and when scooped with a finger, the entire mixture does not run off and the whole mixture is pet. By allowing the drug to be naturally absorbed when it adheres to the palate and the composition component dissolves, the proper content can be administered when the preparation drug is administered to the pet.

More preferably, the gel-induced pet dosing assisting composition according to the second embodiment of the present invention has a viscosity adjusted according to the content of a silicon-based or bio-gum-based viscosity modifier in the oil component. In the embodiment of the present invention, the viscosity is satisfied when 20 to 45 parts by weight of sodium siliconaluminate used as a silicon-based viscosity modifier is contained in 100 parts by weight of the vegetable oil. At this time, if it is out of the above range, the desired viscosity cannot be achieved. That is, when scooped with a finger, it does not run off, no residue remains in the container, and it is not possible to achieve a viscosity that allows the entire mixture to be taken out.

Further, in the example of the present invention, when xanthan gum is used as the bio-gum-based viscosity regulator, if xanthan gum is contained in an amount of 110 to 160 parts by weight with respect to 100 parts by weight of vegetable oil, the desired viscosity is satisfied.

In the examples of the present invention, canola oil is mentioned and described, but the present invention is not limited thereto.

The silicon-based viscosity modifier used in the present invention is preferably sodium aluminate containing Na ₂ O: Al ₂ O ₃ : SiO ₂ in a ratio of 1: 1: 13 mol.

The sodium aluminate is a white fine amorphous powder or contents, and the weight is reduced when dried at 105 ° C. for 2 hours. At this time, the weight loss must be 8.0% by weight or less. Here, when quantified after drying at 105 ° C. for 2 hours, 6.0 to 76.0% by weight of silicon oxide (SiO ₂ ) and 9.0 to 13.0% by weight of aluminum oxide (Al ₂ O). , Contains 4.0 to 7.0% by weight of sodium oxide (Na ₂ O).

Further, after drying at 150 ° C. for 2 hours, when about 5 g is precisely weighed and heated to a content at 90 ° C., the weight loss must meet the requirement of 8.0 to 13.0% by weight. It doesn't become.

Further, as the biogum-based viscosity regulator used in the present invention, any one selected from the group consisting of xanthan gum, carrageenan, guar gum, deutan gum, cellulose gum, and gellan gum is used, and in the examples of the present invention, xanthan gum is used. It is used, but is not limited to this.

The gel-induced pet dosing assisting composition according to the first and second embodiments of the present invention may further contain an enzyme-mixed preparation.

The enzyme is a protein that helps to obtain energy by hydrolyzing food from a high molecular weight organic compound to a low molecular weight organic compound in the digestive tract of an animal, and is a protein degrading enzyme (Protease) or a carbohydrate degrading enzyme (Alpha). It may be selected from the group consisting of Amylase), cellulolytic enzyme (Cellulase) of dietary fiber, lipase (Lipase), and pectinase (Pectinase) of polysaccharide.

In addition, the inclusion of the enzyme and complex lactic acid bacteria together provides a balance between biodegradation, digestion and excretion of toxins, especially in dogs and cats with loose stools or diarrhea, prevention of enteritis, intestines. It can be administered to weak old dogs, dogs and cats with weakened immunity.

In addition, chicken liver powder (chicken liver powder) and sugar (Dextrose monohydrate) as usual additives, emulsifiers, preservatives and the like may be contained.

The chicken liver powder is an excellent source of protein, rich in vitamin A and vitamin B, especially vitamin B12, containing trace elements such as iron, copper, zinc and chromium, and is a spray-dried powder. It is a type, can be stored for a long period of time, and can be used regardless of the season.

Further, in the present invention, the gel-induced pet dosing assisting composition according to the first and second embodiments described above contains a prescription dispensing powder drug, and the powder drug is standard per day per pet body weight. Provided is a dosing aid gel formulation packaged in 5-10% by weight of food intake.

The type of the dispensing powdered drug according to each of the above formulations is not particularly limited, but a suitable example includes a powdered drug for the prevention or treatment of diseases of eyes, joints, skin, liver, kidneys, heart and teeth.

The drug good for the eyes contains lutein and astaxanthin, the drug good for the joints contains green mussel and glucosamine, and the drug good for the skin contains aloe, cysteine and L-methionine, and the liver. Good agents may contain milk sisul, L-carnitine, omega 3 fatty acids, and good agents for elongation may include omega 3 fatty acids, B vitamins, antioxidants. Further, as a drug good for the heart, L-carnitine, taurine, green tea extract (polyphenol), rosemary extract (polyphenol) may be contained, and as a preventive agent for stomatitis and gingival inflammation of dogs and cats, Mutanase, tartar removing enzyme, celery oil is used.

At this time, the dosage form of the packaging is not particularly limited, but is preferably provided as a paste gel formulation, such as a disposable stick package or a toothpaste package.

Further, in the present invention, the gel-induced pet dosing assisting composition and the powdered drug prepared according to the respective formulations are added, mixed to form a gel, and the gel is scooped with a finger into the pet's palate. By adhering, the dispensing drug can be administered to the pet in an appropriate content.

That is, the present invention was subsequently dispensed according to each formulation by a gel-induced pet dosing assisting composition prepared in advance with an optimum viscosity that does not become dry or run off when mixed between the respective components. If the agent is a powder, even simple mixing means can be provided in gel-type dosage form.

FIG. 2 is a photograph showing the dissolution behavior in the aqueous phase between the gel-induced pet dosing assisting composition according to the present invention and the powdered drug, and the result of not dissolving at all in the aqueous phase is confirmed.

Therefore, the composition according to the present invention contains an oil component as a main component, and when mixed with a powdered drug, the whole is coated with the oil component and does not dissolve even when dissolved in water, so that the powdered drug comes into contact with gastric acid. It is expected that the dosage form will block the oil and allow it to reach the intestine safely and be absorbed. Here, the composition according to the present invention can provide a drug at a higher blood concentration than that of other methods of administering the drug of the same sex and amount.

FIG. 3 shows the gel-induced pet dosing assisting composition according to the present invention mixed with a powdered drug by prescription, and after administration of the enrofloxacin (5 mg / kg) drug to the test animal, the drug body over time. It is a graph which showed the result of AUC _t (n = 4, mean +/- s.d.) Among the dynamic parameters.

At this time, the enrofloxacin powder drug as an antibiotic component was mixed with the compositions produced in Examples 2 and 11, and the results of administration to the test animals (B, C) were mixed with sterile distilled water. The initial concentration of the drug component in blood was expressed relatively higher than that in the control group (A), and the sustainability of the concentration was confirmed.

Hereinafter, the present invention will be described in more detail based on Examples.

The present embodiment is for the purpose of explaining the present invention more specifically, and the scope of the present invention is not limited to these examples.

<Example 1>
Of the components shown in Table 1, the remaining components excluding sodium aluminate were put into a container according to their respective contents and mixed at 20 ° C. for 60 minutes. After that, after going through the aging stage, sodium aluminate (dry content 6% by weight, average particle size 8 μm, pH 10) was slowly added and mixed to produce a composition.

<Example 3>
As shown in Table 2 below, a composition was produced in the same manner as in Example 1 described above, except that the content of sodium aluminate was changed and added to 100 parts by weight of canola oil.

<Comparative Example 3>
As shown in Table 2 below, a composition was produced in the same manner as in Example 1 described above, except that the content of sodium aluminate was changed and added to 100 parts by weight of canola oil.

<Examples 5 to 10>
Of the composition components in Table 1 above, xanthan gum was contained as a viscosity modifier with 100 parts by weight of canola oil, which is a vegetable oil component, except that the content was changed and mixed as shown in Table 4. The composition was produced in the same manner as in Example 1 described above.

<Comparative Examples 3 to 5>
As shown in Table 3 below, a composition was produced in the same manner as in Example 1 described above, except that the content of xanthan gum was changed and added to 100 parts by weight of canola oil.

<Example 11>
The composition components shown in Table 2 below were put into a container according to their respective contents and mixed at 20 ° C. for 60 minutes. After that, the composition was produced through the aging stage.

<Experimental Example 1> Measurement of Viscosity The compositions produced in the above-mentioned Examples and Comparative Examples were measured in viscosity using a rotary viscometer (BROOKFIELD (USA), model number: RVT).

A spindle was added to each of the compositions to be measured so that the indicated portion of the spindle was immersed. When the spindle sinks, it is generally tilted slightly so that bubbles do not occur, and the viscosity changes greatly depending on the temperature. Therefore, after the temperature was stabilized, the viscosity was measured under the following conditions.

After selecting the appropriate spindle and speed (rpm), the motor on / off key was pressed to start the measurement, wait until a stable value was reached, and record the value. The operation was stopped by pressing the motor on / off key, and the sample was replaced.

1) Spindle No. : No. RV / HA / HB-6
2) Rotation speed (rpm): 10
3) Sample temperature: 25 ° C
The results are shown in Tables 3 and 4.

From the results of Tables 3 and 4 above, based on the range that satisfies the viscosity of 9,500 to 100,000 cP (centi Poise, centipoise) at a temperature of 25 ° C. based on the condition of the rotation speed of the rotary viscometer of 10 rpm. , The type and content of viscosity modifiers were selected for vegetable oils. Specifically, the compositions of Examples 1 to 4 satisfy the viscosity when they are contained in 20 to 45 parts by weight of sodium aluminate with respect to 100 parts by weight of canola oil, and the compositions of Examples 5 to 10 are satisfied. In the case of a product, when it was contained in 110 to 160 parts by weight of xanthan gum with respect to 100 parts by weight of canola oil, the desired viscosity was satisfied.

In the case of the composition having the above viscosity range, it was confirmed that when scooped with a finger, it did not run off, no residue remained in the container, and the whole mixture was taken out.

<Experimental Example 2> Evaluation of dosage form stability Normally, when food enters the stomach, the liquid stays in the stomach for 2 hours and the solid matter stays for 4 hours. A certain mucus comes out and becomes soft like porridge, and during a long period of gastric stagnation, gastric acid (pH = 2 hydrochloric acid) is secreted from the stomach to disinfect food.

Due to this relationship, when taking medications for pets, especially powdered medicines, they have traditionally been mixed with wet canned feed, honey, jam, water, dry feed, liquid nutritional supplements, snacks, etc. It remains a question as to whether the medicinal effect is maintained when a mixture of various dosage forms and powdered drugs is administered.

FIG. 2 is a photograph showing the dissolution behavior in the aqueous phase between the gel-induced pet dosing assisting composition according to the present invention and the powdered drug.

(A) is a commercial product for a pet liquid nutritional supplement containing vitamins and essential amino acids as effective components, (b) is the composition of Example 2, and (c) is a tuna or chicken extract. The commercial product for pet snacks, (d), is a commercial product for pet snacks containing chicken breast and pork liver. This is the result of mixing with water for 5 minutes and leaving it for 5 minutes.

As a result, it is confirmed that the known commercial products are partially dissolved in water or suspended as an emulsion. From these results, it is expected that the powdered drug component will be exposed to gastric acid under mucous (moisture) conditions, and the powdered drug component will be partially destroyed.

On the other hand, it is confirmed that the composition of Example 2 was completely insoluble in water.

Based on these results, the composition according to the present invention contains an oil component as a main component, and when mixed with a powdered drug, the whole is coated with the oil component, and not only is it insoluble even when dissolved in water. It is expected to remain sparingly soluble in the gastrointestinal tract in a mucous (moisture) environment, blocking contact with gastric acid from the powdered drug, safely reaching the intestine and being absorbed in the intestine.

Therefore, the composition according to the present invention is a dosage form in which the drug is provided at a higher blood concentration than that of administering the drug of the same sex and amount by other methods.

<Experimental Example 3> Analysis of drug dynamics When the above-mentioned enrofloxacin is orally administered to companion animals such as dogs and cats, it has no choice but to be crushed into powder and then dispensed because of its low body weight. , Companion animals refused to take the drug, and the drug often disappeared in the process. Moreover, even if it is administered, the experimental results on how it affects the blood concentration and effect of the drug are meaningful.

As test animals, nine clinically healthy male beagle dogs were tested in this clinical trial. Animals that had been treated with antibiotics for the last month were not included in the experiment, and the test group was divided into 3 groups, and 3 animals were randomly assigned to each group. In the test group, a powdered antibiotic (enrofloxacin, 5 mg / kg) was used in the composition of Example 2, the composition of Example 11, and as a control group in sterile distilled water instead of the composition. Antibiotics were mixed and prepared for each test group, and the test animals were orally administered once. 2.4 ml each was administered regardless of body weight.

At this time, after oral administration of the antibiotic and the test product, blood samples were collected from the intravenous vein at 0, 15, 30, 45, 60, 90, 120, 180, 300, 420, and 960 minutes, respectively, and in vitro ( It was placed in a heparin tube) and centrifuged at 1500 rpm for 5 minutes. The separated plasma was transferred to an E-tube (E-tube) and stored frozen at −80 ° C. until the time of analysis.

The blood antibiotic concentration was measured by measuring the temporal concentration of enrofloxacin in plasma using HPLC-MS / MS (API 4000 LC-MS / MS system) [Kyungpook National University Veterinary Medical University] Implementation commissioned research result report 2019.04].

Pharmacokinetic parameters were calculated using a model-independent analysis method. The maximum blood concentration (C _max ) and the time to reach the maximum blood concentration (T _max ) were immediately determined from the blood concentration curves over time of each individual. The disappearance rate constant (k) was obtained by least squares the log-converted blood concentration in the disappearance period, and the half-life (t _1/2 ) was calculated from 0.693 / k.

The area under the blood concentration-time curve (AUC _t ) was obtained by the trapezoidal method, and the value obtained by dividing the final measured concentration by k was added to obtain AUC (Area Under the Curve, AUC _inf ) up to infinite time. .. AUC _inf was divided by the dose to calculate the total clearance (Cl). Pharmacokinetic parameters are expressed as the mean and standard deviation of the data obtained from each individual. The results are shown in Table 6 and FIG.

FIG. 3 shows a gel-induced pet dosing aid composition according to the present invention mixed with a prescribed powdered drug, and the test animal was administered with the enrofloxacin (5 mg / kg) drug, and then the drug over time. It is a graph showing the AUC result among the pharmacokinetic parameters of, and the experimental result, when the enrofloxacin powder drug is mixed with the composition of Example 2 and administered to a dog, the control group (drinking water) The degree of absorption was significantly increased (p <0.005) as compared with the administration with.

In addition, when the enrofloxacin powder drug was mixed with the composition of Example 11 and administered, the blood concentration of enrofloxacin tended to increase, but the variation between individuals was large and statistically. No significant significance was observed.

From the above results, it is possible that the blood drug concentration and the degree of absorption increase when the gel-induced pet dosing assisting composition according to the present invention is mixed and fed, rather than the drinking water and the drug are mixed and administered. confirmed.

Therefore, the compositions of Examples 2 and 11 can function as a dosing aid that does not reduce the efficacy of the drug for parents who are reluctant to feed the crushed drug.

In particular, in the compositions of Example 2 and Example 11 containing canola oil, it was confirmed that in the case of Example 2 further containing an enzyme-mixed preparation, the absorption capacity of the medicinal ingredient was enhanced.

<Experimental Example 4> Changes in drug concentration by dosage form The composition produced in Example 2 was mixed with an enrofloxacin powder drug as an antibiotic component to produce a gel-type product in stick packaging. .. At this time, 5 mg of enrofloxacin was contained per 1 kg of the body weight of the dog.

In the other test group, the composition produced in Example 2 was mixed with the tablet form of enrofloxacin, and in the control group, the sterilized distilled water was mixed with the enrofloxacin powder drug and prepared. , Each dosage form-specific test group was orally administered to dogs.

Blood samples were taken for 12 hours of dosing (0, 5, 10, 15, 30, 45, 60, 90, 120, 180, 300, 420, 720 minutes) and HPLC-MS / MS (API 4000 LC), respectively. -MS / MS system) was used to analyze blood enrofloxacin concentration.

The results are shown in Table 7 and FIG. 4 below.

FIG. 4 is a graph showing the drug blood concentration over time after dispensing and administering a powdered drug by prescription to the gel-induced pet dosing assisting composition according to the present invention according to the dosage form. From the results, the result of the test group A in which the powdered drug was mixed with the composition produced in Example 2 showed that the initial concentration of the drug component in the blood was remarkably high.

Although the present invention has been described in detail only with respect to the specific examples described above, it is clear to those skilled in the art that various modifications and modifications can be made within the scope of the technical idea of the present invention. It goes without saying that these modifications and amendments fall within the scope of the claims attached.

Claims (11)

A gel-induced pet dosing assisting composition containing an oil component, which is useful for dosing applications for pets. The gel-induced pet dosing assisting composition according to claim 1, wherein the oil component further contains a silicon-based or bio-gum-based viscosity modifier. The gel-induced pet dosing assisting composition according to claim 1 or 2, wherein the oil component contains an enzyme. The enzyme consists of a group consisting of a proteolytic enzyme (Protease), a carbohydrate degrading enzyme (Alpha Amyrace), a dietary fiber cellulolytic enzyme (Cellulase), a lipolytic enzyme (Lipase), and a polysaccharide pectinase (Pectinase). The gel-induced pet dosing aid composition according to claim 3, wherein the composition is any one of the selected ones. 1. Item 2. The gel-induced pet dosing assisting composition according to Item 2. The gel-induced pet dosing assisting composition according to claim 1 or 2, wherein the oil component is selected from vegetable oil or animal oil. The gel-induced type according to claim 6, wherein the vegetable oil is any one selected from the group consisting of canola oil, soybean oil, corn oil, grape seed oil, and brown rice oil. Composition for assisting pet medication. The gel-induced pet dosing assisting composition according to claim 2, wherein the silicon-based viscosity modifier is sodium aluminate. The gel-induced pet according to claim 2, wherein the biogum-based viscosity regulator is any one selected from the group consisting of xanthan gum, carrageenan, guar gum, deutan gum, cellulose gum, and gellan gum. Dosing aid composition. The gel-induced pet dosing assisting composition according to claim 1 or 2, is packaged with a formulated powdered drug in an amount of 5 to 10% by weight of the daily standard dietary intake per pet's body weight. Gel dosage form products for pet dosing aids. The gel dosage form product for pet dosing assistance according to claim 10, wherein the gel dosage form is sparingly soluble in the aqueous phase and soluble in the oil phase.

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