KR20220068518A - Composition for companion animal voluntary administration of solid formulation - Google Patents

Abstract

The present invention relates to a composition for inducing voluntary solid preparation intake by a pet. The composition contains unsaturated fatty acid-containing oil, tackifier, sweetener, lactic acid mixture, flavoring agent, preservative, and emulsifier. The composition of the present invention containing the ingredients contains a palatable flavoring agent suitable for each pet and thus can be highly preferred by pets. In addition, the composition is highly adhesive with respect to a solid preparation to be administered. As a result, voluntary solid preparation intake by a pet can be achieved conveniently and a target efficacy can be achieved effectively.

Description

Composition for inducing voluntary intake of solid formulations for companion animals {COMPOSITION FOR　COMPANION ANIMAL VOLUNTARY ADMINISTRATION OF SOLID FORMULATION}

The present invention relates to a composition for inducing voluntary ingestion of a solid preparation for companion animals, and more particularly, it contains a palatable flavor suitable for each companion animal, so that the companion animal has a high degree of preference and high adhesion to the solid preparation to be administered. It relates to a composition for inducing voluntary intake of solid preparations for companion animals, which allows animals to voluntarily and conveniently ingest the solid preparations.

Humans have been raising animals for various purposes, and industrial animals for economic purposes and companion animals for emotional purposes are representative examples. In the process, for the purpose of preventing and treating diseases occurring in animals or promoting productivity and health, there are cases where it is necessary to feed specific functional active ingredients, such as pharmaceuticals or nutritional supplements, that are differentiated from the original palatability of animals.

Drugs mainly used for veterinary treatment can be administered by direct injection, such as subcutaneous, intramuscular, or intravenous injection. When a formulation containing a component or an active ingredient having a physiologically active function needs to be administered repeatedly over a long period of time, the invasive administration method using a syringe may not be appropriate, and in this case, the oral administration method by feeding is mainly selected. In the case of oral administration to companion animals, it is necessary to devise an effective method for inducing voluntary intake in terms of convenience of administration and efficacy and safety of the administered functional active ingredient.

In particular, as the number of companion animals is increasing recently as well as the number of elderly animals continuously increasing, the need to repeatedly orally administer dietary control prescription feeds, drugs, and nutrients for the prevention, treatment and management of chronic diseases over a long period of time is increasing, and various methods are being tried to induce voluntary intake of formulations that are inconsistent with the palatability of companion animals.

First, as a taste masking method for masking unpleasant flavors, various prescription and formulation technologies have been developed in addition to the bitter taste shielding coating technology (Korean Patent Registration No. 10-1609460). However, although this technique may be able to mask the unpleasant flavor, it is difficult to induce spontaneous ingestion due to poor palatability in animals.

Second, in order to increase the convenience of administration, a method of inducing spontaneous intake by crushing the formulated solid preparation into powder, dissolving it in water and then forcibly administering it with a syringe, or mixing it with the feed normally consumed by animals is used. However, this is effective when the dosage is relatively small compared to the amount of feed, but even if it is a small amount, it has a strong flavor such as a characteristic bitter taste, and animals sensitive to flavor may refuse to take it voluntarily. In addition, when ingested with food such as feed, there is a possibility that the functional active ingredient may be altered by the food, and the bioavailability of the active ingredient is caused by chemical change of the active ingredient by gastric acid secreted for digestion of the food ingested together. cannot guarantee In particular, in the case of a drug developed as a tablet or capsule formulation, a drug delivery system designed for the formulation itself is designed and developed. cannot guarantee In addition, animals may lick only highly palatable foods and fail to spontaneously consume solid preparations such as tablets or capsules by separating them.

Accordingly, in the case of companion animals, a pill pocket or a shapeable oral paste is used. In this method, the animal not only chews, but also separates the tablet or capsule after ingestion into a pocket or paste. It cannot be excluded that the functional active ingredient is not properly separated from the intestine and reaches the intestine without disintegration in the stomach, and the functional active ingredient is excreted as it is without being absorbed in the small intestine.

Republic of Korea Patent Registration No. 10-1609460 (2016.03.30) Korean Patent Publication No. 10-2020-0094979 (2020.08.10)

It is an object of the present invention to include a palatable flavoring agent suitable for each companion animal, so that the companion animal has a high preference for it, and it exhibits high adhesion to the solid preparation to be administered, so that the companion animal can voluntarily and conveniently ingest the solid preparation. It is to provide a composition for inducing voluntary intake of solid preparations for companion animals that can be exhibited with a high effect.

An object of the present invention is achieved by providing a composition for inducing spontaneous ingestion of solid preparations for companion animals, characterized in that it consists of an oil containing unsaturated fatty acids, a tackifier, a sweetener, a lactic acid bacteria mixture, a flavoring agent, a preservative and an emulsifier.

According to a preferred feature of the present invention, the composition for inducing spontaneous intake of the solid preparation for companion animals is 100 parts by weight of an oil containing unsaturated fatty acids, 20 to 30 parts by weight of a tackifier, 5 to 10 parts by weight of a sweetener, 20 to 20 parts by weight of a lactic acid bacteria mixture. 25 parts by weight, 10 to 15 parts by weight of a flavoring agent, 0.1 to 0.2 parts by weight of a preservative, and 4 to 5 parts by weight of an emulsifier.

According to a more preferred feature of the present invention, the oil containing the unsaturated fatty acids is avocado oil, canola oil, evening primrose oil, coconut oil, Brazil nut oil, corn oil, cottonseed oil, flaxseed oil, grape seed oil, hemp oil, olive oil , palm oil, safflower seed oil, soybean oil, peanut oil, sunflower seed oil, krill oil, anchovy oil, salmon oil and tuna oil.

According to a more preferred feature of the present invention, the tackifier is at least one selected from the group consisting of sodium silicoaluminate, xanthan gum, carrageenan, guar gum, diutan gum, cellulose gum, gellan gum, pectin and carboxymethyl cellulose. to be done

According to an even more preferred feature of the present invention, the sweetener is made of fructooligosaccharide.

According to an even more preferred feature of the present invention, the lactic acid bacteria mixture is Bacillus subtilis ( Bacillus subtilis ), Enterococcus faecium ( Enterococcus faecium ), Lactobacillus acidophilus ( Lactobacillus acidophilus ), Bifidobacterium longum ( Bifidobacterium longum ) and Bifidobacterium thermophilum ( Bifidobacterium thermophilum ) It shall consist of two or more selected from the group consisting of.

According to an even more preferred feature of the present invention, the flavoring agent is to be made of one or more selected from the group consisting of chicken liver powder, tuna by-product and bukeo powder.

According to a further preferred feature of the present invention, the emulsifier is composed of two or more selected from the group consisting of lecithin, glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, soybean phospholipid and calcium stearyl lactate. do.

The composition for inducing voluntary intake of solid preparations for companion animals according to the present invention contains a palatable flavoring agent suitable for each companion animal, so it has a high degree of preference for companion animals and exhibits high adhesion to the solid preparation to be administered. Because it can be consumed conveniently with

1 is a schematic diagram showing a mixed state of a composition for inducing spontaneous ingestion of a solid preparation for companion animals according to the present invention, in which an adhesion providing part and a component for improving palatability of companion animals are mixed.

Hereinafter, a preferred embodiment of the present invention and the physical properties of each component will be described in detail, which is intended to describe in detail enough that a person of ordinary skill in the art to which the present invention pertains can easily carry out the invention, This does not mean that the technical spirit and scope of the present invention is limited.

The composition for inducing voluntary intake of solid preparations for companion animals according to the present invention consists of an oil containing unsaturated fatty acids, a tackifier, a sweetener, a lactic acid bacteria mixture, a flavoring agent, a preservative and an emulsifier, and 100 parts by weight of an oil containing unsaturated fatty acids , 20 to 30 parts by weight of a tackifier, 5 to 10 parts by weight of a sweetener, 20 to 25 parts by weight of a lactic acid bacteria mixture, 10 to 15 parts by weight of a flavoring agent, 0.1 to 0.2 parts by weight of a preservative, and 4 to 5 parts by weight of an emulsifier. .

The oil containing the unsaturated fatty acid is a main component constituting the composition for inducing voluntary intake of the solid preparation for companion animals according to the present invention, and is preferably composed of a plant-derived omega fatty acid oil or a fish-derived omega fatty acid oil, and the plant-derived omega fatty acid Oils include avocado oil, canola oil, evening primrose oil, coconut oil, brazil nut oil, corn oil, cottonseed oil, flaxseed oil, grapeseed oil, hemp oil, olive oil, palm oil, safflower seed oil, soybean oil, peanut oil and sunflower seed More preferably, it consists of at least one selected from the group consisting of oil, and the fish-derived omega fatty acid oil is more preferably composed of at least one selected from the group consisting of krill oil, anchovy oil, salmon oil and tuna oil.

The oil containing unsaturated fatty acids composed of the above components contains 50% or more of unsaturated fatty acids, has resistance to salivary digestive enzymes, promotes absorption of functional active ingredients, and provides a composition for inducing voluntary intake of solid preparations for companion animals. It acts as a protection against acid degeneration.

At this time, the oil containing the unsaturated fatty acid is mainly composed of a composition that can help health promotion according to the physiological activity of the unsaturated fatty acid when ingested, and a solid preparation by salivary enzyme action and a solid preparation for companion animals In order to prevent the adhesive separation of the composition for inducing spontaneous intake, it is characterized in that the carbohydrate component, including starch, which is digested by amylase, a digestive enzyme in saliva, is minimized and gelled as much as possible.

The adhesive agent contains 20 to 30 parts by weight, and serves to impart adhesiveness to the composition for inducing spontaneous ingestion of the solid preparation for companion animals according to the present invention. Sodium silicoaluminate, xanthan gum, carrageenan, guar gum, di It is preferably made of at least one selected from the group consisting of utan gum, cellulose gum, gellan gum, pectin and carboxymethyl cellulose.

If the content of the tackifier is less than 20 parts by weight, the above effect is insignificant, and if the content of the tackifier exceeds 30 parts by weight, the viscosity of the composition for inducing voluntary intake of the solid preparation for companion animals increases excessively, resulting in workability this may be lowered.

The sweetener is contained in 5 to 10 parts by weight, and serves to enhance the palatability of companion animals by imparting sweetness to the composition for inducing spontaneous intake of the solid preparation for companion animals according to the present invention, and is preferably made of fructooligosaccharide.

The fructooligosaccharide dissolves well in water and exhibits refreshing sweetness and physical properties similar to sucrose. When ingested as a sugar that is not digested by the digestive tract enzymes of animals and is not used by caries bacteria, it proliferates enteric bacteria, bifidobacteria, in the lower small intestine and acts as a bowel movement. It exhibits several physiological effects, including

The lactic acid bacteria mixture contains 20 to 25 parts by weight, and serves to promote the efficacy and effect of a target product by helping intestinal intestinal function. Bacillus subtilis , Enterococcus faecium , Lactobacillus Acidophilus ( Lactobacillus acidophilus ), Bifidobacterium longum ( Bifidobacterium longum ) and Bifidobacterium thermophilium ( Bifidobacterium thermophilum ) It is preferable that it consists of two or more selected from the group consisting of.

The flavoring agent contains 10 to 15 parts by weight, and serves to improve the palatability of the composition for inducing spontaneous ingestion of the solid preparation for companion animals according to the present invention.

The palatability of animals may vary depending on the species of animals, but in the case of dogs and cats, which are representative companion animals, the palatability of protein and fat components is high. Accordingly, it is preferable to use a protein hydrolyzate or poultry or pig liver as a flavoring agent, and it is more preferable to use at least one selected from the group consisting of chicken liver powder, tuna by-product and bukeo powder.

In addition, when the above-listed flavoring ingredients are roasted, heated, or enzymatically decomposed, the palatability can be increased. , spray-dried plasma, yeast extract, etc., food additives such as vanilla flavor, and sodium pyrophosphate to improve texture.

In addition, in the case of cats, it is preferable to apply various flavoring agents because there is a large difference in taste between individuals. Salmon may be used.

The preservative contains 0.1 to 0.2 parts by weight, and serves to inhibit the deterioration of the composition for inducing spontaneous intake of the solid preparation for companion animals according to the present invention. It is not particularly limited as long as it is a component that has a function that can be used.

The emulsifier contains 4 to 5 parts by weight, and it is preferably made of two or more selected from the group consisting of lecithin, glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, soybean phospholipid and calcium stearyl lactate. .

As shown in FIG. 1 below, the composition for inducing voluntary intake of solid preparations for companion animals comprising the above components is prepared in a mixed form with a part that provides adhesion and a component that improves palatability of companion animals, and a tablet to be ingested Alternatively, it is manufactured in a gel formulation that can be applied to the target substance in the form of a capsule, and the adhesion with the target substance to be administered is maintained until ingestion, and exhibits resistance to salivary enzymes so that it is not easily separated even in the oral cavity.

The target substance may be a solid preparation such as a tablet or capsule, and the tablet is made by compressing a medicine into a certain shape. In addition, the tablet may be coated with an appropriate coating agent such as sugars or sugar alcohols and high molecular compounds in order to facilitate administration or to prevent decomposition of the main component, and may be applied as a sustained-release tablet or enteric-coated tablet by an appropriate method.

In addition, the capsule preparation is a solid preparation made by filling a capsule with a liquid, suspension, semi-solid, powder, granular, or molded product (hard capsule) or encapsulating it with a capsule base (soft capsule). It is usually manufactured by mixing medicines or excipients suitable for pharmaceuticals in capsules evenly, or by making them into granules by an appropriate method or manufacturing them into granules and then coating them with a suitable skinning agent as it is or lightly molding it and filling the capsules. Soft capsules are usually manufactured by encapsulating drugs or excipients suitable for pharmaceuticals, including glycerin or sorbitol, and encapsulating them with a suitable capsule base, such as gelatin, etc. to increase plasticity. A preservative, a coloring agent, etc. can be mixed.

Hereinafter, a method for inducing spontaneous ingestion of a solid preparation for companion animals according to the present invention and the physical properties of the composition prepared through the method will be described with reference to Examples.

<Example 1> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

After heating 100 parts by weight of canola oil to 73°C, 4.3 parts by weight of an emulsifier (lecithin and glycerin fatty acid ester mixed in 1:1 parts by weight) was added, stirring was continued until an emulsion started to form in the mixture, and an emulsion was formed in the mixture. When cooled to 40 ° C, in the cooled mixture, 6.4 parts by weight of a sweetener (fructooligosaccharide), a lactic acid bacteria mixture (Bacillus subtilis and Enterococcus paechium are mixed in a 1:1 ratio by weight) 22.5 parts by weight, flavoring agent ( Chicken liver powder) 11.6 parts by weight and 0.17 parts by weight of a preservative were mixed and stirred, followed by mixing 25.6 parts by weight of a tackifier (sodium silicoaluminate) with a viscosity of 55000 to 60000 cP.

<Example 2> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

A composition for inducing voluntary intake of a solid preparation for companion animals was prepared using the same procedure as in Example 1, but using tuna by-product as a flavoring agent.

<Example 3> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

A composition for inducing voluntary intake of solid preparations for companion animals was prepared using the same procedure as in Example 1, but using booka powder as a flavoring agent.

<Example 4> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

The same procedure as in Example 1 was performed, except that 0.1 parts by weight of carboxymethyl cellulose as an adhesive agent was further included to prepare a composition for inducing spontaneous ingestion of a solid preparation for companion animals.

<Example 5> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

The same procedure as in Example 1, except that 0.2 parts by weight of carboxymethyl cellulose as an adhesive agent was further included to prepare a composition for inducing spontaneous ingestion of a solid formulation for companion animals.

<Example 6> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

The same procedure as in Example 1, except that 0.5 parts by weight of carboxymethyl cellulose as an adhesive agent was further included to prepare a composition for inducing spontaneous ingestion of a solid preparation for companion animals.

<Example 7> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

The same procedure as in Example 1, except that 1.0 parts by weight of carboxymethyl cellulose as an adhesive agent was further included to prepare a composition for inducing spontaneous ingestion of solid preparations for companion animals.

<Example 8> Preparation of a composition for inducing spontaneous intake of solid preparations for companion animals

The same procedure as in Example 1, except that 2.0 parts by weight of carboxymethyl cellulose as an adhesive agent was further included to prepare a composition for inducing spontaneous ingestion of a solid preparation for companion animals.

<Comparative Example 1>

Solid formulation (200mg dried cabbage extract).

The spontaneous intake-inducing effect of the composition for inducing spontaneous intake of solid preparations for companion animals prepared in Examples 1 to 8 was measured and shown in Table 1 below.

{However, for the effect of inducing spontaneous intake, 10 dogs and 10 cats were selected, and the composition for inducing voluntary intake of solid preparations of companion animals prepared in Examples 1 to 8 was mixed with 200 mg of dried cabbage extract, which is a solid preparation, A method of determining the number of dogs and cats consuming the mixture was used.}

<Table 1>

As shown in Table 1, it can be seen that the composition for inducing spontaneous ingestion of solid preparations for companion animals prepared through Examples 1 to 8 of the present invention is superior in the effect of inducing intake of solid preparations.

Therefore, the composition for inducing voluntary intake of solid preparations for companion animals according to the present invention contains a palatable flavoring agent suitable for each companion animal, so the companion animal has a high degree of acceptance and high adhesion to the solid preparation to be administered. Because it allows users to voluntarily and conveniently ingest the

Claims (8)

A composition for inducing spontaneous intake of solid formulations for companion animals, characterized in that it consists of an oil containing unsaturated fatty acids, a tackifier, a sweetener, a lactic acid bacteria mixture, a flavoring agent, a preservative and an emulsifier.
The method according to claim 1,
The composition for inducing voluntary intake of the solid preparation for companion animals is 100 parts by weight of an oil containing unsaturated fatty acids, 20 to 30 parts by weight of a tackifier, 5 to 10 parts by weight of a sweetener, 20 to 25 parts by weight of a lactic acid bacteria mixture, 10 to 10 parts by weight of a flavoring agent. 15 parts by weight, 0.1 to 0.2 parts by weight of a preservative, and 4 to 5 parts by weight of an emulsifier A composition for inducing spontaneous ingestion of a solid formulation for companion animals.
The method according to claim 1 or 2,
The oil containing the unsaturated fatty acids is avocado oil, canola oil, evening primrose oil, coconut oil, Brazil nut oil, corn oil, cottonseed oil, flaxseed oil, grape seed oil, hemp oil, olive oil, palm oil, safflower seed oil, soybean oil , Peanut oil, sunflower seed oil, krill oil, anchovy oil, salmon oil, and a composition for inducing voluntary intake of solid formulations for companion animals, characterized in that it consists of at least one selected from the group consisting of tuna oil.
The method according to claim 1 or 2,
The adhesive agent comprises at least one selected from the group consisting of sodium silicoaluminate, xanthan gum, carrageenan, guar gum, diutan gum, cellulose gum, gellan gum, pectin and carboxymethyl cellulose. A composition for inducing spontaneous intake of the formulation.
The method according to claim 1 or 2,
The sweetener is a composition for inducing spontaneous intake of a solid preparation for companion animals, characterized in that it consists of fructooligosaccharide.
The method according to claim 1 or 2,
The lactic acid bacteria mixture is Bacillus subtilis ( Bacillus subtilis ), Enterococcus faecium ( Enterococcus faecium ), Lactobacillus acidophilus ( Lactobacillus acidophilus ), Bifidobacterium longum ( Bifidobacterium longum ) and Bifidobacterium thermophil A composition for inducing spontaneous intake of solid preparations for companion animals, characterized in that it consists of two or more selected from the group consisting of Bifidobacterium thermophilum .
The method according to claim 1 or 2,
The flavoring agent is a composition for inducing voluntary intake of solid preparations for companion animals, characterized in that it consists of at least one selected from the group consisting of chicken liver powder, tuna by-products, and bukeo powder.
The method according to claim 1 or 2,
The emulsifier comprises at least two selected from the group consisting of lecithin, glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, soybean phospholipid and calcium stearyl lactate. Induction composition.

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