JP2021534735A5 - - Google Patents
Info
- Publication number
- JP2021534735A5 JP2021534735A5 JP2021502951A JP2021502951A JP2021534735A5 JP 2021534735 A5 JP2021534735 A5 JP 2021534735A5 JP 2021502951 A JP2021502951 A JP 2021502951A JP 2021502951 A JP2021502951 A JP 2021502951A JP 2021534735 A5 JP2021534735 A5 JP 2021534735A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antigen
- seq
- binding fragment
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024083589A JP7793679B2 (ja) | 2018-08-21 | 2024-05-22 | ヒトＴｉｍ－３に対するモノクローナル抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862720234P | 2018-08-21 | 2018-08-21 | |
| US62/720,234 | 2018-08-21 | ||
| PCT/US2019/047573 WO2020041520A1 (en) | 2018-08-21 | 2019-08-21 | Monoclonal antibodies against human tim-3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024083589A Division JP7793679B2 (ja) | 2018-08-21 | 2024-05-22 | ヒトＴｉｍ－３に対するモノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021534735A JP2021534735A (ja) | 2021-12-16 |
| JP2021534735A5 true JP2021534735A5 (enExample) | 2022-07-27 |
| JP7543247B2 JP7543247B2 (ja) | 2024-09-02 |
Family
ID=69591459
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021502951A Active JP7543247B2 (ja) | 2018-08-21 | 2019-08-21 | ヒトＴｉｍ－３に対するモノクローナル抗体 |
| JP2024083589A Active JP7793679B2 (ja) | 2018-08-21 | 2024-05-22 | ヒトＴｉｍ－３に対するモノクローナル抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024083589A Active JP7793679B2 (ja) | 2018-08-21 | 2024-05-22 | ヒトＴｉｍ－３に対するモノクローナル抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12134645B2 (enExample) |
| EP (1) | EP3841125A4 (enExample) |
| JP (2) | JP7543247B2 (enExample) |
| KR (1) | KR102917630B1 (enExample) |
| CN (3) | CN112566936B (enExample) |
| AU (1) | AU2019325558B2 (enExample) |
| BR (1) | BR112021003018A2 (enExample) |
| CA (1) | CA3108879A1 (enExample) |
| IL (1) | IL280757A (enExample) |
| MX (1) | MX2020013428A (enExample) |
| SG (1) | SG11202012148RA (enExample) |
| WO (1) | WO2020041520A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102917630B1 (ko) * | 2018-08-21 | 2026-01-27 | 앨버트 아인슈타인 컬리지 오브 메디신 | 인간 Tim-3에 대한 모노클로날 항체 |
| WO2021175191A1 (zh) * | 2020-03-02 | 2021-09-10 | 信达生物制药(苏州)有限公司 | 抗tim-3抗体及其用途 |
| CN117377692A (zh) | 2021-04-23 | 2024-01-09 | 苏州逻晟生物医药有限公司 | Tim-3-靶向抗体及其用途 |
| US20250230242A1 (en) | 2022-03-14 | 2025-07-17 | Nanjing Shunxin Pharmaceuticals Co., Ltd. Of Chiatai Tianqing Pharm. Group | Pharmaceutical composition of anti-tim-3 antibody and hypomethylating agent |
| WO2023174408A1 (zh) * | 2022-03-18 | 2023-09-21 | 正大天晴药业集团南京顺欣制药有限公司 | 抗tim-3抗体与抗pd-l1抗体的药物组合 |
| US20250282873A1 (en) | 2022-05-13 | 2025-09-11 | Nanjing Shunxin Pharmaceuticals Co., Ltd. Of Chiatai Tianqing Pharmaceutical Group | Drug combination of anti-tim-3 antibody and anti-pd-1 antibody |
| CN119789867A (zh) * | 2022-09-06 | 2025-04-08 | 正大天晴药业集团股份有限公司 | 结合tim-3的抗体与结合pd-1的抗体的药物组合 |
| CN120752053A (zh) * | 2023-03-03 | 2025-10-03 | 正大天晴药业集团南京顺欣制药有限公司 | 含抗tim-3抗体的药物组合 |
| WO2025056014A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 包含抗pd-1抗体和第二抗体的药物组合物 |
| WO2025056005A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 抗tim-3抗体的药物组合物及用途 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
| CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| US6210671B1 (en) | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| WO1999029888A1 (en) | 1997-12-05 | 1999-06-17 | The Scripps Research Institute | Humanization of murine antibody |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| JP2002522063A (ja) | 1998-08-17 | 2002-07-23 | アブジェニックス インコーポレイテッド | 増加した血清半減期を有する改変された分子の生成 |
| US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
| JP2008500013A (ja) | 2003-10-03 | 2008-01-10 | ザ ブライハム アンド ウイメンズ ホスピタル，インコーポレイテッド | Ｔｉｍ−３ポリペプチド |
| AU2004292180A1 (en) | 2003-11-13 | 2005-06-02 | Genentech, Inc. | Screening assays and methods of tumor treatment |
| RU2415871C2 (ru) | 2005-03-31 | 2011-04-10 | Байомедикс Инк. | Моноклональное анти-cd20-антитело |
| US20100036091A1 (en) | 2006-11-10 | 2010-02-11 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
| WO2008148884A1 (en) | 2007-06-08 | 2008-12-11 | Universite De La Mediterranee | Compositions and methods for treating pancreatic tumors |
| NZ601580A (en) | 2010-02-11 | 2014-11-28 | Alexion Pharma Inc | Therapeutic methods using anti-cd200 antibodies |
| CN103079644B (zh) * | 2010-06-11 | 2017-02-15 | 协和发酵麒麟株式会社 | 抗tim‑3抗体 |
| US9321833B2 (en) | 2011-04-04 | 2016-04-26 | The Trustees Of Dartmouth College | Methods of therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties |
| AU2014346792A1 (en) * | 2013-11-06 | 2016-06-02 | Abbvie Stemcentrx Llc | Novel anti-claudin antibodies and methods of use |
| PL3099717T3 (pl) | 2014-01-31 | 2019-10-31 | Novartis Ag | Cząsteczki przeciwciała dla TIM-3 i ich zastosowanie |
| MY193661A (en) * | 2014-11-06 | 2022-10-24 | Hoffmann La Roche | Anti-tim3 antibodies and methods of use |
| US20160200815A1 (en) | 2015-01-05 | 2016-07-14 | Jounce Therapeutics, Inc. | Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof |
| AU2016229189A1 (en) * | 2015-03-06 | 2017-09-21 | Sorrento Therapeutics, Inc. | Antibody therapeutics that bind TIM3 |
| WO2017153955A1 (en) | 2016-03-09 | 2017-09-14 | Prothena Biosciences Limited | Use of anti-mcam antibodies for treatment or prophylaxis of granulomatous lung diseases |
| CN116693685A (zh) | 2016-04-12 | 2023-09-05 | 法国施维雅药厂 | 抗tim-3抗体及组合物 |
| US20190248893A1 (en) | 2016-07-14 | 2019-08-15 | Bristol-Myers Squibb Company | Antibodies against tim3 and uses thereof |
| MX2019002242A (es) | 2016-08-26 | 2019-08-16 | Beigene Ltd | Anticuerpos anti-tim-3 y uso de los mismos. |
| MA50677A (fr) | 2016-11-01 | 2021-07-14 | Anaptysbio Inc | Anticorps dirigés contre la protéine d'immunoglobuline de lymphocytes t et mucine 3 (tim-3) |
| KR102917630B1 (ko) | 2018-08-21 | 2026-01-27 | 앨버트 아인슈타인 컬리지 오브 메디신 | 인간 Tim-3에 대한 모노클로날 항체 |
-
2019
- 2019-08-21 KR KR1020217004986A patent/KR102917630B1/ko active Active
- 2019-08-21 JP JP2021502951A patent/JP7543247B2/ja active Active
- 2019-08-21 CN CN201980037800.1A patent/CN112566936B/zh active Active
- 2019-08-21 AU AU2019325558A patent/AU2019325558B2/en active Active
- 2019-08-21 US US17/270,405 patent/US12134645B2/en active Active
- 2019-08-21 CN CN202410802940.6A patent/CN118667019A/zh active Pending
- 2019-08-21 CN CN202410802960.3A patent/CN118667020A/zh active Pending
- 2019-08-21 BR BR112021003018-2A patent/BR112021003018A2/pt unknown
- 2019-08-21 MX MX2020013428A patent/MX2020013428A/es unknown
- 2019-08-21 EP EP19852182.5A patent/EP3841125A4/en active Pending
- 2019-08-21 WO PCT/US2019/047573 patent/WO2020041520A1/en not_active Ceased
- 2019-08-21 CA CA3108879A patent/CA3108879A1/en active Pending
- 2019-08-21 SG SG11202012148RA patent/SG11202012148RA/en unknown
-
2021
- 2021-02-09 IL IL280757A patent/IL280757A/en unknown
-
2024
- 2024-05-22 JP JP2024083589A patent/JP7793679B2/ja active Active
- 2024-10-02 US US18/904,972 patent/US20250034248A1/en active Pending