JP2021531814A - インターフェロン−ガンマバイアス型アゴニスト - Google Patents

インターフェロン−ガンマバイアス型アゴニスト Download PDF

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Publication number
JP2021531814A
JP2021531814A JP2021505349A JP2021505349A JP2021531814A JP 2021531814 A JP2021531814 A JP 2021531814A JP 2021505349 A JP2021505349 A JP 2021505349A JP 2021505349 A JP2021505349 A JP 2021505349A JP 2021531814 A JP2021531814 A JP 2021531814A
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Japan
Prior art keywords
amino acid
ifn
polypeptide
acid sequence
seq
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JP2021505349A
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English (en)
Japanese (ja)
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JP2021531814A5 (enExample
Inventor
クリストファー ガルシア ケナン
ルイス メンドーザ ジュアン
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Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of JP2021531814A publication Critical patent/JP2021531814A/ja
Publication of JP2021531814A5 publication Critical patent/JP2021531814A5/ja
Priority to JP2024095641A priority Critical patent/JP2024137947A/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7156—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2021505349A 2018-07-30 2019-07-29 インターフェロン−ガンマバイアス型アゴニスト Ceased JP2021531814A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024095641A JP2024137947A (ja) 2018-07-30 2024-06-13 インターフェロン－ガンマバイアス型アゴニスト

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862712128P 2018-07-30 2018-07-30
US62/712,128 2018-07-30
PCT/US2019/043977 WO2020028275A1 (en) 2018-07-30 2019-07-29 Interferon-gamma biased agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024095641A Division JP2024137947A (ja) 2018-07-30 2024-06-13 インターフェロン－ガンマバイアス型アゴニスト

Publications (2)

Publication Number Publication Date
JP2021531814A true JP2021531814A (ja) 2021-11-25
JP2021531814A5 JP2021531814A5 (enExample) 2022-08-08

Family

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Family Applications (2)

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JP2021505349A Ceased JP2021531814A (ja) 2018-07-30 2019-07-29 インターフェロン−ガンマバイアス型アゴニスト
JP2024095641A Pending JP2024137947A (ja) 2018-07-30 2024-06-13 インターフェロン－ガンマバイアス型アゴニスト

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024095641A Pending JP2024137947A (ja) 2018-07-30 2024-06-13 インターフェロン－ガンマバイアス型アゴニスト

Country Status (7)

Country Link
US (1) US12410226B2 (enExample)
EP (1) EP3830115A4 (enExample)
JP (2) JP2021531814A (enExample)
AU (1) AU2019313339A1 (enExample)
CA (1) CA3108066A1 (enExample)
MX (1) MX2021001165A (enExample)
WO (1) WO2020028275A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020028275A1 (en) 2018-07-30 2020-02-06 The Board Of Trustees Of The Leland Stanford Junior University Interferon-gamma biased agonists
CN117242090A (zh) 2021-03-30 2023-12-15 希望之城公司 CAR T细胞疗法和IFNγ

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060251619A1 (en) * 2005-05-04 2006-11-09 Gilles Borrelly Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
WO2014106843A2 (en) * 2013-01-01 2014-07-10 Inuitive Ltd. Method and system for light patterning and imaging
WO2018077893A1 (en) * 2016-10-24 2018-05-03 Orionis Biosciences Nv Targeted mutant interferon-gamma and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS6124599A (ja) 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−ｒポリペプチド誘導体
US4845196A (en) 1985-06-24 1989-07-04 G. D. Searle & Co. Modified interferon gammas
JP2969461B2 (ja) * 1988-07-23 1999-11-02 株式会社林原生物化学研究所 ヒトγ−インターフェロンとその製造方法並びに用途
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
DE19535853C2 (de) 1995-09-18 1999-04-01 Fraunhofer Ges Forschung Varianten des rekombinanten humanen Interferon-gamma, Verfahren zu ihrer Herstellung und ihre Verwendung
CA2390292A1 (en) * 1999-11-12 2001-05-25 Maxygen Holdings Ltd. Interferon gamma conjugates
US7038015B2 (en) * 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
MXPA03011793A (es) 2001-06-29 2004-04-02 Maxygen Holdings Ltd Formulaciones de interferon.
CA2491178A1 (en) * 2002-07-03 2004-01-15 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants
WO2008076933A2 (en) 2006-12-14 2008-06-26 Bolder Biotechnology, Inc. Long acting proteins and peptides and methods of making and using the same
CA2809747C (en) * 2010-08-30 2018-05-01 Roberto Testi Compositions and methods for treating friedreich's ataxia with interferon gamma
WO2020028275A1 (en) 2018-07-30 2020-02-06 The Board Of Trustees Of The Leland Stanford Junior University Interferon-gamma biased agonists
US20220000921A1 (en) * 2018-11-20 2022-01-06 Innovative Cellular Therapeutics Holdings, Ltd. Modified Cell Expressing Therapeutic Agent and Uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060251619A1 (en) * 2005-05-04 2006-11-09 Gilles Borrelly Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
WO2014106843A2 (en) * 2013-01-01 2014-07-10 Inuitive Ltd. Method and system for light patterning and imaging
WO2018077893A1 (en) * 2016-10-24 2018-05-03 Orionis Biosciences Nv Targeted mutant interferon-gamma and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NATURE, vol. 567, JPN6023027217, 7 March 2019 (2019-03-07), pages 56 - 60, ISSN: 0005468469 *

Also Published As

Publication number Publication date
CA3108066A1 (en) 2020-02-06
EP3830115A1 (en) 2021-06-09
US12410226B2 (en) 2025-09-09
EP3830115A4 (en) 2022-08-10
WO2020028275A1 (en) 2020-02-06
US20210309707A1 (en) 2021-10-07
JP2024137947A (ja) 2024-10-07
AU2019313339A1 (en) 2021-03-11
MX2021001165A (es) 2021-07-15

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