JP2021529796A - 多特異性Ｗｎｔ代替分子及びその使用 - Google Patents

多特異性Ｗｎｔ代替分子及びその使用 Download PDF

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JP2021529796A
JP2021529796A JP2021500040A JP2021500040A JP2021529796A JP 2021529796 A JP2021529796 A JP 2021529796A JP 2021500040 A JP2021500040 A JP 2021500040A JP 2021500040 A JP2021500040 A JP 2021500040A JP 2021529796 A JP2021529796 A JP 2021529796A
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wnt
fzd
binding region
binding
molecule
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JP2021529796A5 (enExample
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ヤン リー，
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スロゼン， インコーポレイテッド
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=69059929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2021529796(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by スロゼン， インコーポレイテッド filed Critical スロゼン， インコーポレイテッド
Publication of JP2021529796A publication Critical patent/JP2021529796A/ja
Publication of JP2021529796A5 publication Critical patent/JP2021529796A5/ja
Priority to JP2023186681A priority Critical patent/JP2024001292A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2021500040A 2018-07-05 2019-07-05 多特異性Ｗｎｔ代替分子及びその使用 Pending JP2021529796A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023186681A JP2024001292A (ja) 2018-07-05 2023-10-31 多特異性Ｗｎｔ代替分子及びその使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862694339P 2018-07-05 2018-07-05
US62/694,339 2018-07-05
US201862782122P 2018-12-19 2018-12-19
US62/782,122 2018-12-19
US201962797772P 2019-01-28 2019-01-28
US62/797,772 2019-01-28
PCT/US2019/040687 WO2020010308A1 (en) 2018-07-05 2019-07-05 Multi-specific wnt surrogate molecules and uses thereof

Related Child Applications (1)

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JP2023186681A Division JP2024001292A (ja) 2018-07-05 2023-10-31 多特異性Ｗｎｔ代替分子及びその使用

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JP2021529796A true JP2021529796A (ja) 2021-11-04
JP2021529796A5 JP2021529796A5 (enExample) 2022-07-12

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JP2021500040A Pending JP2021529796A (ja) 2018-07-05 2019-07-05 多特異性Ｗｎｔ代替分子及びその使用
JP2023186681A Withdrawn JP2024001292A (ja) 2018-07-05 2023-10-31 多特異性Ｗｎｔ代替分子及びその使用

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US (1) US20210292422A1 (enExample)
EP (2) EP3820906B1 (enExample)
JP (2) JP2021529796A (enExample)
CN (2) CN120623353A (enExample)
AU (2) AU2019297522B2 (enExample)
CA (1) CA3104526A1 (enExample)
DK (1) DK3820906T3 (enExample)
ES (1) ES3058239T3 (enExample)
PL (1) PL3820906T3 (enExample)
WO (1) WO2020010308A1 (enExample)

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JP7418332B2 (ja) * 2017-12-19 2024-01-19 スロゼン オペレーティング， インコーポレイテッド 抗フリズルド抗体及び使用方法
CN118271444A (zh) * 2017-12-19 2024-07-02 瑟罗泽恩奥普瑞汀公司 Wnt替代分子和其用途
US20210032352A1 (en) * 2018-02-14 2021-02-04 Antera Therapeutics Inc. Multivalent Binding Molecules Activating WNT Signaling and Uses Thereof
JP2021530223A (ja) 2018-07-09 2021-11-11 スロゼン， インコーポレイテッド 組織特異性Ｗｎｔシグナル増強分子及びその使用
CA3144499A1 (en) * 2019-07-02 2021-01-07 Surrozen Operating, Inc. Monospecific anti-frizzled antibodies and methods of use
US20230138045A1 (en) * 2020-02-24 2023-05-04 Surrozen Operating, Inc. Wnt super agonists
WO2022104280A1 (en) 2020-11-16 2022-05-19 Surrozen Operating, Inc. Liver-specific wnt signal enhancing molecules and uses thereof
CA3204321A1 (en) 2020-12-18 2022-06-23 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
WO2023250402A2 (en) * 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof
CR20240266A (es) * 2021-12-31 2024-11-11 Surrozen Operating Inc Compuesto específico de receptor wnt y método relacionado con este
AU2024279826A1 (en) * 2023-05-29 2026-01-08 Surrozen Operating, Inc. Wnt surrogate agents and methods for lacrimal gland regeneration
WO2026044275A1 (en) * 2024-08-23 2026-02-26 Surrozen Operating, Inc. Wnt surrogate fusion molecule
WO2026044274A1 (en) * 2024-08-23 2026-02-26 Surrozen Operating, Inc. Wnt surrogate fusion molecule

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CA3104526A1 (en) 2020-01-09
EP3820906A4 (en) 2022-04-20
EP4733325A2 (en) 2026-04-29
WO2020010308A1 (en) 2020-01-09
CN120623353A (zh) 2025-09-12
EP4733325A3 (en) 2026-05-13
JP2024001292A (ja) 2024-01-09
AU2019297522B2 (en) 2026-04-23
AU2019297522A1 (en) 2021-01-28
CN112566940B (zh) 2025-06-13
ES3058239T3 (en) 2026-03-09
AU2026206257A1 (en) 2026-08-13
CN112566940A (zh) 2021-03-26
EP3820906B1 (en) 2025-10-15
DK3820906T3 (da) 2025-12-15
US20210292422A1 (en) 2021-09-23
PL3820906T3 (pl) 2026-04-13
EP3820906A1 (en) 2021-05-19

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