JP2021523733A - 動物病原体由来ポリペプチドおよびその遺伝子工学的利用 - Google Patents

動物病原体由来ポリペプチドおよびその遺伝子工学的利用 Download PDF

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JP2021523733A
JP2021523733A JP2021506378A JP2021506378A JP2021523733A JP 2021523733 A JP2021523733 A JP 2021523733A JP 2021506378 A JP2021506378 A JP 2021506378A JP 2021506378 A JP2021506378 A JP 2021506378A JP 2021523733 A JP2021523733 A JP 2021523733A
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gene
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sequence
amino acid
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JP2021523733A5 (https=
Inventor
フョードル ウルノフ、
フョードル ウルノフ、
ジョン エー. スタマトヤンノポウロス、
ジョン エー. スタマトヤンノポウロス、
アリステア ピーダヴリュ— ファンネル、
アリステア ピーダヴリュ― ファンネル、
Original Assignee
アルティウス インスティテュート フォー バイオメディカル サイエンスィズ
アルティウス インスティテュート フォー バイオメディカル サイエンスィズ
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Publication of JP2021523733A publication Critical patent/JP2021523733A/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4705Regulators; Modulating activity stimulating, promoting or activating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/80Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2021506378A 2018-04-18 2019-04-18 動物病原体由来ポリペプチドおよびその遺伝子工学的利用 Pending JP2021523733A (ja)

Priority Applications (1)

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JP2024198757A JP2025037883A (ja) 2018-04-18 2024-11-14 動物病原体由来ポリペプチドおよびその遺伝子工学的利用

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201862659656P 2018-04-18 2018-04-18
US62/659,656 2018-04-18
US201862690905P 2018-06-27 2018-06-27
US62/690,905 2018-06-27
US201862716223P 2018-08-08 2018-08-08
US62/716,223 2018-08-08
US201862738825P 2018-09-28 2018-09-28
US62/738,825 2018-09-28
US201962819237P 2019-03-15 2019-03-15
US62/819,237 2019-03-15
PCT/US2019/028174 WO2019204643A2 (en) 2018-04-18 2019-04-18 Animal pathogen-derived polypeptides and uses thereof for genetic engineering

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JP2024198757A Division JP2025037883A (ja) 2018-04-18 2024-11-14 動物病原体由来ポリペプチドおよびその遺伝子工学的利用

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JP2021523733A true JP2021523733A (ja) 2021-09-09
JP2021523733A5 JP2021523733A5 (https=) 2022-04-20

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JP2024198757A Pending JP2025037883A (ja) 2018-04-18 2024-11-14 動物病原体由来ポリペプチドおよびその遺伝子工学的利用

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US (2) US12312383B2 (https=)
EP (1) EP3781193A4 (https=)
JP (2) JP2021523733A (https=)
AU (1) AU2019256517B2 (https=)
CA (1) CA3097648A1 (https=)
WO (1) WO2019204643A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4010004A4 (en) * 2019-08-07 2023-09-13 Altius Institute For Biomedical Sciences Compositions and methods for modulation of gene expression
JP7507242B2 (ja) * 2020-08-25 2024-06-27 中興通訊股▲ふん▼有限公司 無線ネットワーク一時識別子に関連する方法および装置
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AR124414A1 (es) 2020-12-18 2023-03-22 Century Therapeutics Inc Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable
WO2025034754A2 (en) * 2023-08-08 2025-02-13 Altius Institute For Biomedical Sciences Nucleic acid binding domains and methods of use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014018601A2 (en) * 2012-07-24 2014-01-30 Cellectis New modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
CA2769262C (en) 2009-07-28 2019-04-30 Sangamo Biosciences, Inc. Methods and compositions for treating trinucleotide repeat disorders
US8586526B2 (en) 2010-05-17 2013-11-19 Sangamo Biosciences, Inc. DNA-binding proteins and uses thereof
WO2011072246A2 (en) 2009-12-10 2011-06-16 Regents Of The University Of Minnesota Tal effector-mediated dna modification
EP2660318A1 (en) 2010-02-09 2013-11-06 Sangamo BioSciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
US9499592B2 (en) 2011-01-26 2016-11-22 President And Fellows Of Harvard College Transcription activator-like effectors
US9410134B2 (en) 2011-06-07 2016-08-09 Helmholtz Zentrum München—Deutsches Forschungszentrum für Gesundheit und Umwelt Protein having nuclease activity, fusion proteins and uses thereof
JP6214530B2 (ja) 2011-07-15 2017-10-18 ザ ジェネラル ホスピタル コーポレイション 転写活性化因子様エフェクターの組立て方法
WO2013015220A1 (ja) 2011-07-22 2013-01-31 株式会社東芝 X線診断装置及び制御プログラム
CA2848417C (en) 2011-09-21 2023-05-02 Sangamo Biosciences, Inc. Methods and compositions for regulation of transgene expression
HK1200871A1 (en) 2011-11-16 2015-08-14 Sangamo Therapeutics, Inc. Modified dna-binding proteins and uses thereof
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
DK2825190T3 (en) 2012-03-15 2017-02-27 Cellectis REPEAT VARIABLE DIRESTS FOR TARGETING NUCLEOTIDES
WO2013152220A2 (en) * 2012-04-04 2013-10-10 Life Technologies Corporation Tal-effector assembly platform, customized services, kits and assays
KR102357105B1 (ko) 2012-09-04 2022-02-08 더 스크립스 리서치 인스티튜트 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들
US9181535B2 (en) 2012-09-24 2015-11-10 The Chinese University Of Hong Kong Transcription activator-like effector nucleases (TALENs)
KR102121086B1 (ko) 2012-11-01 2020-06-09 팩터 바이오사이언스 인크. 세포에서 단백질을 발현시키는 방법들과 생성물들
CA2891510C (en) 2012-11-16 2022-10-18 Transposagen Biopharmaceuticals, Inc. Site-specific enzymes and methods of use
US9708589B2 (en) 2012-12-18 2017-07-18 Monsanto Technology Llc Compositions and methods for custom site-specific DNA recombinases
EP2951295B1 (en) 2013-02-01 2018-08-01 Cellectis Tevi chimeric endonucleases and their preferential cleavage sites
CA2927965A1 (en) 2013-10-25 2015-04-30 Cellectis Design of rare-cutting endonucleases for efficient and specific targeting dna sequences comprising highly repetitive motives
US9850497B2 (en) 2013-11-04 2017-12-26 Regents Of The University Of Minnesota Gene targeting methods and tools
WO2015164748A1 (en) 2014-04-24 2015-10-29 Sangamo Biosciences, Inc. Engineered transcription activator like effector (tale) proteins
WO2017019895A1 (en) 2015-07-30 2017-02-02 President And Fellows Of Harvard College Evolution of talens
US20190234874A1 (en) 2016-07-19 2019-08-01 Altius Institute For Biomedical Sciences Methods for fluorescence imaging microscopy
WO2018035387A1 (en) 2016-08-17 2018-02-22 The Broad Institute, Inc. Novel crispr enzymes and systems
KR102455249B1 (ko) 2016-08-24 2022-10-17 상가모 테라퓨틱스, 인코포레이티드 가공된 표적 특이적 뉴클레아제
EP3583203B1 (en) 2017-02-15 2023-11-01 2seventy bio, Inc. Donor repair templates multiplex genome editing
US12264181B2 (en) 2018-06-27 2025-04-01 Altius Institute For Biomedical Sciences Nucleic acid binding domains and methods of use thereof
US12209259B2 (en) 2018-06-27 2025-01-28 Altius Institute For Biomedical Sciences Nucleases for genome editing

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014018601A2 (en) * 2012-07-24 2014-01-30 Cellectis New modular base-specific nucleic acid binding domains from burkholderia rhizoxinica proteins

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"DE SubName: Full=Avirulence protein AvrBs3 {ECO:0000313|EMBL:KTD30443.1}", DATABASE UNIPROT [ONLINE],AC A0A0W0WDL4, JPN6023012099, 28 March 2018 (2018-03-28), ISSN: 0005370048 *
"DE SubName: Full=IcmE/DotG protein {ECO:0000313|EMBL:KTD51021.1}", DATABASE UNIPROT [ONLINE],AC A0A0W0Y1V4, JPN6023012098, 28 March 2018 (2018-03-28), ISSN: 0005370047 *
"DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:OGV28801.1}", DATABASE UNIPROT [ONLINE],AC A0A1G0X562, JPN6023012100, 7 June 2017 (2017-06-07), ISSN: 0005370049 *

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US20210115093A1 (en) 2021-04-22
EP3781193A4 (en) 2022-01-26
AU2019256517B2 (en) 2025-05-29
JP2025037883A (ja) 2025-03-18
US20250361275A1 (en) 2025-11-27
US12312383B2 (en) 2025-05-27
AU2019256517A1 (en) 2020-11-12
CA3097648A1 (en) 2019-10-24
WO2019204643A2 (en) 2019-10-24
WO2019204643A3 (en) 2019-11-28
EP3781193A2 (en) 2021-02-24

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