JP2021523696A - Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節 - Google Patents

Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節 Download PDF

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JP2021523696A
JP2021523696A JP2020558973A JP2020558973A JP2021523696A JP 2021523696 A JP2021523696 A JP 2021523696A JP 2020558973 A JP2020558973 A JP 2020558973A JP 2020558973 A JP2020558973 A JP 2020558973A JP 2021523696 A JP2021523696 A JP 2021523696A
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snca
fusion protein
seq
grna
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オーニット チバ−ファレク
オーニット チバ−ファレク
ボリス カンター
ボリス カンター
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Duke University
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/10—Transferases (2.)
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Virology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020558973A 2018-04-23 2019-04-23 Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節 Pending JP2021523696A (ja)

Priority Applications (1)

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JP2024019364A JP2024073420A (ja) 2018-04-23 2024-02-13 Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862661134P 2018-04-23 2018-04-23
US62/661,134 2018-04-23
US201862676149P 2018-05-24 2018-05-24
US62/676,149 2018-05-24
US201962789932P 2019-01-08 2019-01-08
US62/789,932 2019-01-08
US201962824195P 2019-03-26 2019-03-26
US62/824,195 2019-03-26
PCT/US2019/028786 WO2019209869A2 (en) 2018-04-23 2019-04-23 Downregulation of snca expression by targeted editing of dna-methylation

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JP2024019364A Division JP2024073420A (ja) 2018-04-23 2024-02-13 Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節

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JP2021523696A true JP2021523696A (ja) 2021-09-09
JP2021523696A5 JP2021523696A5 (https=) 2022-05-06

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JP2024019364A Pending JP2024073420A (ja) 2018-04-23 2024-02-13 Ｄｎａメチル化の標的化された編集によるｓｎｃａ発現の下方調節

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US (1) US20210189361A1 (https=)
EP (1) EP3784785A4 (https=)
JP (2) JP2021523696A (https=)
CN (1) CN112166194A (https=)
AU (1) AU2019261361A1 (https=)
CA (1) CA3097755A1 (https=)
WO (1) WO2019209869A2 (https=)

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Publication number Priority date Publication date Assignee Title
KR102922694B1 (ko) 2018-04-19 2026-02-03 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 유전자 편집을 위한 조성물 및 방법
SG11202102012SA (en) * 2018-08-28 2021-04-29 Pharos Vaccine Inc Improved lentiviral vector
SG11202111031RA (en) 2019-04-26 2021-11-29 Allogene Therapeutics Inc Rituximab-resistant chimeric antigen receptors and uses thereof
WO2021007457A1 (en) * 2019-07-09 2021-01-14 Urfer Buchwalder Anne Use of snca-mediated genes for diagnosis and treatment of parkinson's disease
GB202010075D0 (en) * 2020-07-01 2020-08-12 Imp College Innovations Ltd Therapeutic nucleic acids, peptides and uses
JP2024518553A (ja) * 2021-05-13 2024-05-01 フォージ バイオロジクス，インコーポレイテッド アデノウイルスヘルパープラスミド
CN114790463B (zh) * 2022-04-15 2023-10-13 中山大学 稳定转染CRISPR/dCas9系统的单克隆细胞株的构建方法及其应用
EP4342988A1 (en) 2022-09-20 2024-03-27 Eberhard Karls Universität Tübingen, Medizinische Fakultät Compositions and methods for modification of the expression of a snca gene
CN120230839A (zh) * 2025-04-30 2025-07-01 北京凯祥弘康生物科技有限公司 一种检测snca基因dna甲基化水平的引物探针组合物及其应用

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JP2016521555A (ja) * 2013-06-05 2016-07-25 デューク ユニバーシティ Ｒｎａガイド遺伝子編集及び遺伝子調節
JP2016521995A (ja) * 2013-06-17 2016-07-28 ザ・ブロード・インスティテュート・インコーポレイテッド ウイルス成分を使用して障害および疾患をターゲティングするためのＣＲＩＳＰＲ−Ｃａｓ系および組成物の送達、使用および治療上の適用
WO2016205711A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2016205749A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
JP2017501149A (ja) * 2013-12-12 2017-01-12 ザ・ブロード・インスティテュート・インコーポレイテッド 粒子送達構成成分を用いた障害及び疾患の標的化のためのｃｒｉｓｐｒ−ｃａｓ系及び組成物の送達、使用及び治療適用
US20170035860A1 (en) * 2015-04-02 2017-02-09 Alexander C. Flynn Compositions and methods for treatment of neurogenerative diseases
WO2018035495A1 (en) * 2016-08-19 2018-02-22 Whitehead Institute For Biomedical Research Methods of editing dna methylation

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JP2016521995A (ja) * 2013-06-17 2016-07-28 ザ・ブロード・インスティテュート・インコーポレイテッド ウイルス成分を使用して障害および疾患をターゲティングするためのＣＲＩＳＰＲ−Ｃａｓ系および組成物の送達、使用および治療上の適用
JP2017501149A (ja) * 2013-12-12 2017-01-12 ザ・ブロード・インスティテュート・インコーポレイテッド 粒子送達構成成分を用いた障害及び疾患の標的化のためのｃｒｉｓｐｒ−ｃａｓ系及び組成物の送達、使用及び治療適用
US20170035860A1 (en) * 2015-04-02 2017-02-09 Alexander C. Flynn Compositions and methods for treatment of neurogenerative diseases
WO2016205711A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2016205749A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Novel crispr enzymes and systems
WO2018035495A1 (en) * 2016-08-19 2018-02-22 Whitehead Institute For Biomedical Research Methods of editing dna methylation

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Publication number Publication date
WO2019209869A2 (en) 2019-10-31
CN112166194A (zh) 2021-01-01
CA3097755A1 (en) 2019-10-31
US20210189361A1 (en) 2021-06-24
JP2024073420A (ja) 2024-05-29
AU2019261361A1 (en) 2020-11-19
EP3784785A4 (en) 2022-02-16
WO2019209869A3 (en) 2019-12-26
EP3784785A2 (en) 2021-03-03

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