JP2021523210A - Mixtures containing benzpyrimoxane and oxazosulfyl and their use and application - Google Patents

Abstract

The present invention relates to a mixture containing benzpyrimoxane and oxazosulfyl, a method for controlling harmful invertebrates, particularly rice harmful invertebrates, including the application of such a mixture.
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Description

The present invention relates to pesticide mixtures of benzpyrimoxane and oxazosulfyl, and methods of applying such mixtures.

There is a need for effective and safe pesticides and pesticide mixtures, especially in agriculture, and especially for rice pest invertebrates. It has been found that these objectives can be achieved with a pesticide mixture containing the pesticides benzpyrimoxane and oxazosulfyl.

In a first aspect, the invention relates to a pesticide mixture (mixture according to the invention) containing benzpyrimoxane and the pesticide oxazosulfyl.

Benzpyrimoxane and oxazosulfyl are also referred to as Compound I and / or Compound II of the mixture according to the invention and are also referred to as compounds of the invention. It does not matter whether the compound is called compound I or compound II, as the order of the mixing partners in the name of the mixture is not important.

Benzpyrimoxane and some of its mixtures are described in WO2016104516.

Oxazosulfyl is described, for example, in WO2017104592, and some of its mixtures are described in WO2016002595.

One typical problem that arises in the field of pest control is effective pests while reducing the dose ratio of active ingredients to reduce or avoid unfavorable environmental or toxicological effects. There is still a need for control to be possible. Another issue encountered concerns the need to have available pest control agents that are effective against a wide range of pests.

There is also a need for pest control agents that have both knockdown activity and sustained control (ie, fast-acting and sustained action).

Another difficulty with the use of pesticides is that repeated and exclusive application of individual pesticide compounds often develops natural or adaptive resistance to the active compound. It is to bring about rapid selection. Therefore, there is a need for pest control agents that help prevent or overcome resistance.

In addition, there are demands for pesticidal compounds or combinations of compounds that, when applied, can improve the plant and result in "plant health", "vitality of plant propagation materials" or "increased plant yield".

Therefore, an object of the present invention is the following problem to be discussed:
--Reduction of dose ratio;
--Enhancement of activity spectrum;
--Combining knockdown activity and continuous control;
--Improved resistance management;
--Improvement of plant health;
--Improvement of vitality (also called seed vitality) of plant propagation materials;
-Providing a combination of pesticides that solves one or more of the increased plant yields.

Therefore, it was an object of the present invention to provide a pesticide mixture that solves at least one of the problems discussed above.

It has been found that this object is partially or wholly achieved by the combination of active compounds defined herein.

Further, the present invention is described in the following:
—— A composition comprising a pesticide mixture as defined herein and an acceptable carrier of at least one inert liquid and / or solid;
--A pesticide composition comprising a pesticide mixture as defined herein and an acceptable carrier of at least one inert liquid and / or solid;
--A method for controlling or exterminating invertebrate pests, said pests or their food supply, habitat, breeding grounds and pest-killing mixtures as defined herein in effective amounts of pest-killing organisms. Methods involving contacting with;
--A method of protecting a plant from infidelity pest attack or infestation, in which the plant, plant breeding material, or soil or water in which the plant grows and the effective amount of the pesticide are contained herein. Methods involving contact with a pesticide mixture as defined in;
--Plant propagation material containing 0.1 g to 10 kg of pesticide mixture as defined herein per 100 kg of seed;
—— A method for protecting a plant-growing material, which comprises contacting the plant-growing material with an amount of 0.1 g to 10 kg per 100 kg of the plant-growing material, as defined herein. Method;
--Use of pesticide mixtures as defined herein to protect growing plants or plant-growing materials from attack or harm by invertent pests;
--A method for controlling phytopathogenic pests, the plants, soils or seeds to be protected from fungi, their habitats, or fungal attacks are compound I and at least one specific compound B. Treated with an effective amount of pesticide mixture, including;
—— A method for protecting a plant from phytopathogenic harmful fungi, the plant, soil or seed to be protected from the fungus, their habitat, or the attack of the fungus, compound I and at least one specific species. Treatment with an effective amount of pesticidal mixture containing compound B, method;
--Methods for protecting an animal from parasitic infestation or infection, including administration of a parasitically effective amount of the pesticide mixture defined herein to the animal;
—— A method for treating an animal that is parasitized or infected with a parasite, and the pesticide mixture defined herein in an effective amount of the parasite is applied to the animal in need of treatment. Methods involving administration; and
—— With respect to the use of pesticide mixtures as defined herein to control animals and parasites on animals.

In a particular embodiment, the present invention relates to the use of a mixture according to the invention for exterminating or controlling rice-harmful invertebrates, respectively, by applying such a mixture to exterminate or control rice-harmful invertebrates. Regarding the method of control.

Rice (Oryza species, especially Oryza sativa) is an important basic food in the world. It is the main food in Asia and an important part of many cultures. Therefore, rice is an important crop and is cultivated in large areas, especially in Asia.

Invertebrate pests, especially insects, arthropods and nematodes, cause great damage to growing and harvested rice crops, resulting in significant economic losses to food supplies and possessions. Although many pesticides are known, new agents for combating invertebrate pests such as insects, arachnids and nematodes because the target pests can develop resistance to the agents. Is still needed. In addition, rice cultivation requires special pesticides suitable for the farming methods used for rice, such as nursery boxes, paddy fields, and aquatic environments. Pesticides suitable for use in rice must also be well tolerated by rice plants. Pesticides must also be well tolerated by the environment of the rice plant, for example from an ecotoxicological point of view, i.e. pesticides must not harm beneficial organisms. In addition, the pesticide must withstand the conditions under which the pesticide is applied to ensure its effectiveness. This is a particular challenge in aquatic environments and in high temperature climatic conditions where rice normally grows. On the other hand, pesticides must be decomposed within a reasonable period of time so as not to adversely affect the environment. Pesticides should not affect the health of farmers and consumers. Pesticides must not subsequently be present in rice products (low or non-residual) to ensure the safety of humans consuming rice. In addition, many pests have acquired resistance to the pesticides commonly used in rice. Therefore, pesticides suitable for use in rice should be effective against pests that have acquired resistance to other pesticides. Not all pesticides meet the requirements used under these conditions.

Therefore, an object of the present invention is to have good pesticidal activity and to a large number of various invertebrate pests occurring in rice, especially to difficult-to-control insects, arachnids and nematodes. To provide a compound that exhibits an activity spectrum and at the same time exhibits a good regulatory profile.

In a further embodiment of the invention, the invention relates to a mixture according to the invention, wherein benzpyrimoxane and oxazosulfyl are the only active ingredients (bicomponent mixture). However, they may contain additional ingredients such as carriers, adjuvants, adjuvants and other pharmaceutical ingredients.

As mentioned above, the mixture according to the invention is particularly suitable for rice.

In one embodiment of the invention, the invention relates to a particular method and use of a mixture according to the invention in rice:
--Mixture according to the invention for use in the control of rice pests (especially rice pest invertebrates) in rice;
--Composition containing a mixture according to the present invention for use in the control of rice pests (particularly rice pest invertebrates) in rice;
--A method for exterminating harm or infection by rice pest invertebrates, rice pest invertebrates, and the above-mentioned pest-killing organism effective amount in the pest or its food source, habitat or breeding ground. The above method comprising contacting a mixture according to the invention or a composition thereof as defined in.
-A method for controlling harm or infection by rice pest invertebrates and invertebrate pests, and the present invention of an effective amount of pest-killing organisms in the pests or their food supply sources, habitats or breeding sites. The above method comprising contacting the mixture according to or the composition comprising the mixture according to the invention;
—— A method for preventing or protecting rice-harmful invertebrates, in which the rice-harmful invertebrates, or their food sources, habitats or breeding grounds, are mixtures according to the invention as defined above. , Or a composition comprising a mixture according to the invention as defined above, or a method comprising contacting a composition comprising a mixture according to the invention;
--A method for protecting rice, rice plants, rice plant breeding materials and / or growing rice plants from attack or harm by rice harmful invertebrates, such as rice, rice plants, rice plant breeding materials and Growing rice plants, or soil, materials, surfaces, spaces, areas or water where rice, rice plants, rice plant breeding materials are preserved or where rice plants are growing, in an effective amount of pesticides, The method described above, comprising contacting or treating with the mixture according to the invention defined above or a composition comprising the mixture according to the invention;
--A method for increasing the health of rice plants, especially in paddy fields, which comprises treatment with a mixture according to the present invention;
—— A method for increasing the yield of rice plants, the method described above, which comprises treatment with a mixture according to the present invention.
--Rice seeds containing the mixture according to the invention as defined above, in an amount of 0.1 g to 10 kg per 100 kg of seeds;
--Use of the mixture according to the invention as defined above to protect rice plants or rice plant breeding materials growing from attack or harm by harmful invertebrates of rice.

All compounds of the mixture of the invention, including their stereoisomers, their tautomers, their salts or their N-oxides, if applicable, and their compositions are all invertebrate pests. It is particularly useful for controlling organisms, especially for arthropods and nematodes, especially insects. Accordingly, the present invention relates to the use of the compounds disclosed in the present invention to control or control invertic pests, in particular insects, arachnids or nematodes.

The term "composition according to the invention (s)" or "composition of the invention (s)" refers to a composition (s) comprising a mixture according to the invention as defined above. It also includes stereoisomers of each compound, agriculturally or veterinarily acceptable salts, tautomers or N-oxides.

In addition, simultaneous, combined or separate application of benzpyrimoxane and oxazosulfyl, or continuous application of benzpyrimoxane and oxazosulfyl, is compared to the control rates possible with the individual compounds. It has also been found to enable enhanced control of pests.

The mixture of the present invention may be a physical mixture of benzpyrimoxane and oxazosulfyl. Accordingly, the present invention also provides mixtures benzpyrimoxane and oxazosulfyl. However, the composition may be any combination of benzpyrimoxane and oxazosulfyl, and benzpyrimoxane and oxazosulfyl need not be present together in the same formulation.

An example of a composition according to the present invention or a composition used in accordance with the present invention, in which benzpyrimoxane and oxazosulfyl are not present together in the same formulation, is combipack. In a combination pack, two or more components of the combination pack are packaged separately, that is, they are not premixed together. Thus, combipacks include one or more separate containers such as vials, cans, bottles, pouches, bags or canisters, each containing a separate ingredient for the pesticide composition. One example is a two-component combination pack. Accordingly, the present invention also comprises at least one first component comprising Compound I, a liquid or solid carrier and, where appropriate, at least one surfactant and / or at least one conventional auxiliary agent, in that order. With respect to a two-component combipack comprising Compound II, a liquid or solid carrier and, where appropriate, a second component comprising at least one surfactant and / or at least one conventional adjunct. For example, further details regarding suitable liquid and solid carriers, surfactants and conventional auxiliaries are described below.

The "combination" use of "combination" of benzpyrimoxane with oxazosulfyl can be understood on the one hand as using a physical mixture of benzpyrimoxane and oxazosulfyl. .. On the other hand, combination use may also consist of using benzpyrimoxane and oxazosulfyl separately, but within a sufficiently short time each other so that the desired effect can occur. A more detailed description of the combination use can be found below in this specification.

As used herein, the term "invertent pest" (also referred to as animal pest) includes insects, spiders and nematodes that attack plants and cause substantial damage to the attacked plants. Animal populations, as well as ectoparasites that parasitize animals, especially warm-blooded animals such as mammals or birds, or other higher animals such as reptiles, amphibians or fish, thereby causing substantial damage to the parasites. Include.

Pests The mixtures of the present invention are particularly suitable for the efficient control of animal pests such as arthropods, abdominals and nematodes (eg, but not limited to those listed below):

Insects from the order of the order Lepidoptera, such as Achroia grisella, species of the genus Acleris spp., Such as A. fimbriana, A. globerana. (A. gloverana), A. variana; Acrolepiopsis assectella, Acronicta major, Adoxophyes spp., For example, A. gloverana. A. cyrtosema, A. orana; Aedia leucomelas, Agrotis spp. For example, A. exclamationis, A. fucosa (A. fucosa), A. ipsilon, A. orthogoma, A. segetum, A. subterranea; Alabama argillacea, Aleurodicus dispersus, Alsophila pometaria, Ampelophaga rubiginosa, Amyelois transitella, Anacampsis sarcitella, Anacampsis sarcitella, Anacampsis sarcitella Anarsia lineatella, Anisota senatoria, Antheraea pernyi, Anticarsia (= Thermosia) spp., For example, A. gemmatalis ); Species of the genus Apamea (Apamea spp.), Species of the genus Aproaerema modicella (Archips spp.), For example. For example, A. argyrospila, A. fuscocupreanus, A. rosana, A. xyloseanus; apple fruit moth (Argyresthia conjugella), Species of the genus Argyroploce (Argyroploce spp.), Species of the genus Argyrotaenia (Argyrotaenia spp.), For example, A. velutinana; Silver Yuba (Autographa gamma), Autographa nigrisigna, Barathra brassicae, Bedellia spp., Bonagota salubricola, Borbo kinnara (Borbo) , Bucculatrix thurberiella, Bupalus piniarius,

Species of the genus Busseola (Busseola spp.), Species of the genus Cacoecia (Cacoecia spp.), For example, C. murinana, C. podana; Cadra cautella, Calingo braziliensis, Caloptilis theivora, Capua reticulana, Carposina spp., For example, C. niponensis (C. niponensis), C. sasakii; species of the genus Cephus (Cephus spp.), Chaetocnema aridula, Cheimatobia brumata, species of the genus Chilo (Chilo spp.), For example. C. Indicus, C. suppressalis, C. partellus; Choreutis pariana, Choristoneura spp., For example, C. C. conflictana, C. fumiferana, C. longicellana, C. murinana, C. occidentalis, C. rosaceana (C. . rosaceana); Species of the genus Chrysodeixis (= Pseudoplusia) spp., For example, C. eriosoma, C. includens; Cirphis unipuncta , Clysia ambiguella, Cnaphalocerus spp., Cnaphalocrocis medinalis, Cnephasia spp., Kokiluis hospes (C) ochylis hospes), Coleophora spp., Colias eurytheme, Conopomorpha spp., Conotrachelus spp., Copitarsia spp. ), Corcyra cephalonica, Crambus caliginosellus, Crambus teterrellus, Crocidosema (= Epinotia) apolema (= Epinotia) aporema Lis (Cydalima (= Diaphania) perspectalis), species of the genus Cydia (= Carpocapsa) spp., For example, C. pomonella, C. latiferreana; Dalaca noctuides, Datana integerrima, Dasychira pinicola, Dendrolimus spp., For example, D. pini, D. Spectabilis (D. pini) spectabilis), D. sibiricus; Desmia funeralis, Diaphania spp. For example, D. nitidalis, D. hyalinata Diatraea grandiosella, Diatraea saccharalis, Diphthera festiva, species of the genus Earias spp., For example, E. insulana, E. bittera. (E. vittella); Ecdytolopha aurantianu, Egira (= Xylomiguez), Clearis (Eg) ira (= Xylomyges) curialis), Elasmopalpus lignosellus, Eldana saccharina, Endopiza viteana, Ennomos subsignaria, Ennomos subsignaria Seeds (Ephestia spp.), For example, E. cautella, E. elutella, E. kuehniella; Epinotia aporema, Epiphyas postvittana), Erannis tiliaria, Erionota thrax, species of the genus Etiella (Etiella spp.),

Species of the genus Euxo (Eulia spp.), Eupoecilia ambiguella, Euproctis chrysorrhoea, Species of the genus Euxoa (Euxoa spp.), Evetria bouliana, Faronta albi. Faronta albilinea), species of the genus Feltia (Feltia spp.), For example, F. subterranean; Galleria mellonella, species of the genus Gracilaria (Gracillaria spp.), Species of the genus Grapholita (Grapholita) spp.), For example, G. funebrana, G. molesta, G. inopinata; species of the genus Halysidota (Halysidota spp.), Harrisina americana ), Hedirepta spp., Helicoverpa spp., For example, H. armigera (= Heliothis armigera), H. zea ) (= Heliothis zea); Heliothis spp., For example, H. assulta, H. subflexa, H. virescens Species of the genus Hellula (Hellula spp.), For example, H. undalis, H. rogatalis;・ Herpetogramma licarsisalis, Hibernia defoliaria, Hofmannophila pseudospretella, Homoeosoma electellum, Chi Homona magnanima, Hypena scabra, Fall webworm (Hyphantria cunea), Hyponomeuta padella, Hyponomeuta marinellus (Hyponomeuta malinellus), Kakivoria flavocia fla・ Keiferia lycopersicella, Lambdina fiscellaria fiscellaria, Lambdina fiscellaria lugubrosa, Lambdina fiscellaria lugubrosa, Lamprosema indicata, Lambrosema indicata glycinivorella), Lerodea eufala, Leucinodes orbonalis, Leucoma salicis, Leucoptera spp.,

For example, L. coffeella, L. scitella; Leuminivora lycinivorella, Lithocolletis blancardella, Lithocolletis blancardella, Lithophane antennata, Lithophane antennata octo (= Amyna axis), Lobesia botrana, Lophocampa spp., Loxagrotis albicosta, Loxostege spp., For example. , L. sticticalis, L. cereralis; Lymantria spp., For example, L. dispar, L. monacha; Momohamogriga (Lyonetia clerkella), Lyonetia prunifoliella, Malakosoma spp., For example, M. Americanum, M. californicum, M. constrictum (M. californicum) M. constrictum, M. neustria; species of the genus Mamestra spp., For example, M. brassicae, M. configurata; Mamstra. brassicae), Manduca spp., For example, M. quinquemaculata, M. sexta; Marasmia spp, Marmara spp. .), Maruca testulalis, Megalopyge lanata, Melanchra picta, Melanitis leda, Mocis spp. ), For example, M. lapites, M. repanda; Mocis latipes, Monochroa fragariae, Mythimna separata, Nemapogon croacera ( Nemapogon cloacella), Neoleucinodes elegantalis, Nepytia spp., Nymphula spp., Oiketicus spp., Omiodes indicata , Omphisa anastomosalis, Operophtera brumata, Orgyia pseudotsugata, Oria spp., Orthaga thyrisalis sp .), For example, O. nubilalis; Oulema oryzae, Paleacrita vernata, Panoris flammea, Parnara spp. Nebris (Papaipema nebris), Papilio cresphontes, Paramyelois transitella, Paranthrene regalis, Paysandisia archon, spectinophora species (Pectin) , P. gossypiella; Nisetamanayaga (Peridroma saucia), species of the genus Perileucoptera (Perileucoptera spp.), For example, P. coffeella; cali fornica), Phthorimaea spp., For example, P. operculella; Phyllocnistis citrella, Phyllonorycter spp.,

For example, P. blancardella, P. crataegella, P. issikii, P. ringoniella; species of the genus Pieris (Pieris spp.), For example. , P. brassicae, P. rapae, P. napi; Pilocrocis tripunctata, Platypena scabra, Platynota species spp.), For example, P. flavedana, P. idaeusalis, P. stultana; Platyptilia carduidactyla, Plebejus argus ), Plodia interpunctella, Plusia spp, Plutella maculipennis, Plutella xylostella, Pontia protodica, Price species (Plutia protodica) Prays spp.), Prodenia spp., Proxenus lepigone, Pseudaletia spp., For example, P. sequax, P. Unipunka (P. sequax) P. unipuncta; Pyrausta nubilalis, Rachiplusia nu, Richia albicosta, Rhizobius ventralis, Rhizobius ventralis, Rhyacionia frustan Sabulodes aegrotata), Schizura concinna, Schoenobius spp., Screkensteinia Festariella (S) chreckensteinia festaliella), species of the genus Scirpophaga spp., For example, S. incertulas, S. innotata; Scotia segetum, species of the genus Sesamia (Sesamia spp.). ), For example, S. inferens, Seudyra subflava, Sitotroga cerealella, Sparganothis pilleriana, Spironota lechriaspis, S. ocellana. , Spodoptera (= Lamphygma) spp., For example, S. cosmoides, S. eridania, S. exigua, S. S. frugiperda, S. latisfascia, S. littoralis, S. litura, S. omithogalli; Species of the genus Stigmella (Stigmella) spp.), Stomopteryx subsecivella, Strymon bazochii, Sylepta derogata, Synanthedon spp., For example, S. exitiosa Tecia solanivora, Telehin licus, Thaumatopoea pityocampa, Thaumatotibia (= Cryptoflebia), Leukotreta (= Cryptophlebia) leutopophlebia (= Cryptophlebia) leucotreta (= Cryptophlebia) leucotreta Species of the genus Tecla (Thecla spp.), Theresimima ampelophaga , Tyrinteina spp, Tildenia inconspicuella, Tinea spp. For example, T. cloacella, T. pellionella. Tineola bisselliella, species of the genus Tortrix (Tortrix spp.), For example, T. viridana; Trichoplusia tapetzella, species of the genus Trichoplusia spp., For example. , T. ni; Tuta (= Scrobipalpula) absoluta, species of the genus Udea (Udea spp.), For example, U. rubigalis, U. rubigalis (U. rubigalis); species of the genus Virachola (Virachola spp.), Yponomeuta padella, and Zeiraphera canadensis;

Insects from the order of the order Coleoptera, such as Acalymma vittatum, Acanthoscehdes obtectus, Adoretus spp., Agelastica alni, Agelastica alni. Species of the genus (Agrilus spp.), For example, A. anxius, A. planipennis, A. sinuatus; A. fuscicollis, A. lineatus, A. obscurus; Alphitobius diaperinus, Amphimallus solstitialis, Anisandrus Anisandrus dispar, Anisoplia austriaca, Anobium punctatum, Anomala corpulenta, Anomala rufocuprea, Anomala rufocuprea, species of the genus Anoprofora, for example Ano A. glabripennis; Anthonomus spp. For example, A. eugenii, A. grandis, A. pomorum; Species (Anthrenus spp.), Aphthona euphoridae, Apion spp., Apogonia spp., Athous haemorrhoidalis, Atomaria sp. .), For example, A. linearis; Agelastica spp., Agrilus femoralis, Blastfagus piniperda (B) lastophagus piniperda), Blitophaga undata, Bruchidius obtectus, Bruchidius spp., For example, B. lentis, B. pisorum, B. rufimanus; Byctiscus betulae, Callidiellum rufipenne, Callopistria floridensis, Azuki mamezoumushi (Callosobruchus chinensis) (Cassida nebulosa), Cerotoma trifurcata, Cetonia aurata, Ceuthorhynchus spp., For example, C. assimilis, C. napi Chaetocnema tibialis, Cleonus mendicus, Conoderus spp. For example, C. vespertinus; Conotrachelus nenuphar, Cosmo (Cosmopolites spp.), Costelitra zealandica, Crioceris asparagi, Cryptolestes ferrugineus, Cryptorhynchus lapathi, sp. ), For example, C. destructor; Species of the genus Curculio (Curculio spp.), Species of the genus Cylindrocopturus (Cylindrocopturus spp.), Species of the genus Cyclocephala spp. ), Dactylispa balyi, Dectes texanus, Dermestes spp., Diabrotica spp., For example, D. undecimpunctata ), D. speciosa, D. longicornis, D. semipunctata, D. virgifera; Diaprepes abbreviates, species of the genus Dicocrosis (Dichocrocis spp.), Dicladispa armigera, Diloboderus abderus, Diocalandra frumenti (Diocalandra stigmaticollis), Enafalodes halo , Epilacna spp., For example, E. varivestis, E. vigintioctomaculata; Epitrix spp., For example, E. hiruchipennis (E. hirtipennis), E. simiralis (E. similaris); Eutheola humilis, Eutinobothrus brasiliensis, Faustinus cubae, Gibium psilobies Gnathocerus cornutus, Hellula undalis, Heteronychus arator, Hylamorpha elegans,

Hylobius abietis, Hylotrupes bajulus, species of the genus Hypera spp., For example, H. brunneipennis, H. postica; -Squamosus (Hypomeces squamosus), species of the genus Hypothenemus (Hypothenemus spp.), Ips typographus, Lachnosterna consanguinea, Lasioderma serricorne, Lasioderma serricorne Species of the genus Latrizius (Lathridius spp.), Species of the genus Lema (Lema spp.), For example, L. bilineata, L. melanopus; Species of the genus Leptinotarsa (Leptinotarsa spp.), For example, L. decemlineata; Leptispa pygmaea, Limonius californicus, Lissorhoptrus oryzophilus, Lissorhoptrus oryzophilus, Lixus sp. Luperodes spp.), Species of the genus Lyctus spp., For example, L. bruneus; Liogenys fuscus, Species of the genus Macrodactylus (Macrodactylus spp.), For example, M. Subspinosus; Maladera matrida, Megaplatypus mutates, Megascelis spp., Melanotus communis sp. , For example, M. aeneus; species of the genus Melolontha (Melolontha spp.), For example, M. hippocastani (M. hi) ppocastani), M. melolontha; Metamasius hemipterus, Microtheca spp., Migdolus spp., For example, M. fryanus. , Species of the genus Monochamus (Monochamus spp.), For example, M. alternatus; Naupactus xanthographus, Niptus hololeucus, Oberia brevis, Oberia brevis Oemona hirta, Oryctes rhinoceros, Oryzaephilus surinamensis, Oryzaphagus oryzae, Otiorrhynchus sulcatus, Otiorrhynchus sulcatus Otiorrhynchus sulcatus), Oulema melanopus, Oulema oryzae, Oxycetonia jucunda, Phaedon spp., For example, P. brassica (P. brassica) P. cochleariae; Phoracantha recurva, Phyllobius pyri, Phylopertha horticola, Phylopertha horticola, Phyllopaga spp., For example, P. heleli helleri); Phyllotreta spp., For example, P. chrysocephala, P. nemorum, P. striolata, P. vittula Phylloperth a horticola), Popilia japonica, Premnotrypes spp., Psacothea hilaris, Psylliodes chrysocephala, Psylliodes chrysocephala, Prostefanus stepus Species (Psylliodes spp.), Species of the genus Ptinus (Ptinus spp.), Pulga saltona, Rhizopertha dominica, Species of the genus Rhynchophorus spp. .Billineatus, R. ferrugineus, R. palmarum, R. phoenicis, R. vulneratus; Saperda candida, Scolitus. Scolytus schevyrewi, Scyphophorus acupunctatus, Sitona lineatus, Sitophilus spp., For example, S. granaria, S. oriza. ), S. zeamais; Sphenophorus spp., For example, S. levis; Stegobium paniceum, Sternechus spp. ), For example, S. subsignatus; Strophomorphus ctenotus, Symphyletes spp., Tanimecus spp., Tenebrio Morita, Tenebrio mol・ Mauretanix (Tenebrioides mauretanicus), species of the genus Tribolium (Tribolium spp) .), For example, T. castaneum; Trogoderma spp., Tychius spp., Xylotrechus spp., For example, Xylotrechus spp. X. pyrrhoderus); and species of the genus Zabrus (Zabrus spp.), For example, Z. tenebrioides;

Insects from the order Diptera, such as Aedes spp., For example, A. aegypti, A. albopictus, A. bexans. (A. vexans); Mexican Aedes (Anastrepha ludens), species of the genus Anopheles (Anopheles spp.), For example, A. albimanus, A. crucians, A. freeborni ), A. gambiae, A. leucosphyrus, A. maculipennis, A. minimus, A. quadrimaculatus , A. sinensis; Bactrocera invadens, Bibio hortulanus, Calliphora erythrocephala, Calliphora erythrocephala, Calliphora vicina capitata), Chrysomyia spp., For example, C. bezziana, C. hominivorax, C. macellaria; Chrysops atlanticus, Chrysops discalis, Chrysops silacea, Cochliomyia spp., For example, C. hominivorax; Contarinia spp., For example, C. sorghicola; Cordylobia anthropophaga, Culex spp. For example, C. nigripalpus, C. pipiens, C. kink Faciatus ( C. quinquefasciatus, C. tarsalis, C. tritaeniorhynchus; Culicoides furens, Culiseta inornata, Culiseta melanura, Culiseta melanura Genus species (Cuterebra spp.), Melon fly (Dacus cucurbitae), Dacus oleae, Dasineura brassicae, Dasineura oxycoccana, Delia spp. D. antique, D. coarctata, D. platura, D. radicum; Dermatobia hominis, Drosophila species spp.), For example, D. suzukii, species of the genus Fannia (Fannia spp.), For example, F. canicularis; species of the genus Gastraphilus (Gastraphilus spp.), For example. G. intestinalis; Geomyza tipunctata, Glossina spp. For example, G. fuscipes, G. morsitans, G. G. palpalis, G. tachinoides; Nosashibae (Haematobia irritans), Haplodiplosis equestris, Hippelates spp., Hylemy sp. ), For example, H. platura; species of the genus Hypoderma (Hypoderma spp.), For example, H. lineata; species of the genus Hippobosca (Hyppobosca spp.),

Hydrellia philippina, Leptoconops torrens, Liliomyza spp. For example, L. sativae, L. trifolii; Seeds (Lucilia spp.), For example, L. caprina, L. cuprina, L. sericata; Lycoria pectoralis, Mansonia titillanus), species of the genus Mayetiola (Mayetiola spp.), For example, M. destructor; species of the genus Musca (Musca spp.), For example, M. autumnalis, M. domestica (M. domestica; Muscina stabulans, Oestrus spp. For example, O. ovis; Opomyza florum, Oscinella spp. For example. , O. frit; Orseolia oryzae, Pegomya hysocyami, Phlebotomus argentipes, Phrobia spp., For example, P. antiqua (P. antiqua), P. brassicae, P. coarctata; Phytomyza gymnostoma, Prosimulium mixtum, Psila rosae, Psila rosae. Colophora columbiae, Psorophora discolor, Rhagoletis spp., For example, R. cerasi, R. cingulate, R. indife Lence (R. indiffe) rens, R. mendax, R. pomonella; Liberia quadrifasciata, Sarcophaga spp., For example, S. haemorrhoidalis ); Simulium vittatum, Sitodiplosis mosellana, Stomoxys spp., For example, S. calcitrans; Tabanus spp., For example, T. atratus, T. bovinus, T. lineola, T. similis; Tannia spp., Tecodiprosis. Japonensis (The codiplosis japonensis), Tipula oleracea, Tipula paludosa, and species of the genus Wohlfahrtia (Wohlfahrtia spp);

Insects from the order of the Thysanoptera, such as Baliothrips biformis, Dichromothrips corbetti, Dichromothrips ssp., Equinotrips Americanus. , Enneothrips flavens, Frankliniella spp., For example, F. fusca, F. occidentalis, F. tritici; Heliothrips spp., Hercinothrips femoralis, Kakothrips spp., Microcephalothrips abdominalis, Neohidatotrips Neohydatothrips samayunkur, Pezothrips kellyanus, Rhipiphorothrips cruentatus, Scirtothrips spp., For example, S. citri, S. citri . dorsalis), S. perseae; Stenchaetothrips spp, Taeniothrips cardamoni, Taeniothrips inconsequens, Thrips species spp.), For example, T. imagines, T. hawaiiensis, T. oryzae, T. palmi, T. parvispinus ), T. tabaci;

Insects from the order Hemiptera, such as Acizzia jamatonica, species of the genus Acrosternum spp., For example, A. hilare; Species (Acyrthosipon spp.), For example, A. onobrychis, A. pisum; Adelges laricis, Adelges tsugae, Adelphocoris species. spp.), For example, A. rapidus, A. superbus; Aeneolamia spp., Agonoscena spp., Aulacorthum solani. ), Aleurocanthus woglumi, Aleurodes spp., Aleurodicus disperses, Aleurolobus barodensis, Aleurolobus barodensis, Aleurolobus spp. Species (Amrasca spp.), Anasa tristis, Antestiopsis spp., Anuraphis cardui, Aonidiella spp. Aphanostigma piri, Aphidula nasturtii, species of the genus Aphis (Aphis spp.), For example, A. craccivora, A. fabae, A. horbesi (A. forbesi, A. gossypii, A. grossulariae, A. maidiradicis, A. pomi, A. sambuci, A. A. schnei deri), A. spiraecola; Arboridia apicalis, Arilus critatus, Aspidiella spp., Aspidiotus spp. , Atanus spp., Aulacaspis yasumatsui, Aulacorthum solani, Bactericera cockerelli (Bactericera cockerelli) (Paratrioza cockerelli) spp.), For example, B. argentifolii, B. tabaci (Aleurodes tabaci); species of the genus Blissus (Blissus spp.), For example, B. leucopterus (B. . leucopterus); Species of the genus Brachycaudus (Brachycaudus spp.), For example, B. cardui, B. helichrysi, B. persicae, B. prunicola ); Brachycolus spp., Brachycorynella asparagi, Brevicoryne brassicae, Cacopsylla spp., For example, C. fulguralis, C. fulguralis C. pyricola (Psylla piri);

Calligypona marginata, Calocoris spp., Campylomma livida, Capitophorus horni, Carneocephala fulgida, Carneocephala fulgida, Carneocephala fulgida ), Species of the genus Ceraplastes (Ceraplastes spp.), Ceratovacuna lanigera, Ceroplastes ceriferus, Cerosipha gossypii, Cerosipha gossypii ), Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, species of the genus Cimex spp. C. hemipterus, C. lectularius; Coccomytilus halli, Coccus spp. For example, C. hesperidum, C. lectularius. C. pseudomagnoliarum; Corythucha arcuata, Creontiades dilutus, Cryptomyzus ribis, Chrysomphalus aonidum, Chrysomphalus aonidum ), Ctenarytaina spatulata, Cyrtopeltis notatus, Dalbulus spp., Dacinus piperi Su (Dasynus piperis), species of the genus Dialeurodes spp., For example, D. citrifolii; Dalbulus maidis, species of the genus Diaphorina spp., For example, D. D. citri; species of the genus Diaspis spp. For example, D. bromeliae; Dichelops furcatus, Dichocoris hewetti, species of the genus Doralis (Diconocoris hewetti) Doralis spp.), Dreyfusia nordmannianae, Dreyfusia piceae, Drosicha spp., Dysaphis spp., For example, D. plantaginea (D. plantaginea), D. pyri, D. radicola; Dysaula corthum pseudosolani, Dysdercus spp., For example, D. cingulatus, D. intermedius; species of the genus Dismicoccus (Dysmicoccus spp.), Species of the genus Edessa (Edessa spp.), Species of the genus Geocoris (Geocoris spp.), Species of the genus Empoasca (Empoasca spp.) .), For example, E. fabae, E. solana; Epidiaspis leperii, species of the genus Eriosoma (Eriosoma spp.), For example, E. lanigerum ), E. pyricola; Species of the genus Erythroneura (Erythroneura spp.), Species of the genus Eurygaster (Eurygaster spp.), For example, E. integriceps; , Species of the genus Euschistus spp. ), For example, E. heros, E. impictiventris, E. servus; Fiorinia theae, Geococcus coffeae, Glycaspis brimblecombei, species of the genus Halyomorpha (Halyomorpha spp.), For example, H. halys; species of the genus Heliopeltis spp. Coagulata (Homalodisca vitripennis (= H. coagulata)), Horcias nobilellus, Hyalopterus pruni, Hyperomyzus lactucae, species of the genus Iserya (Icerya spp.) .Pulcase (I. purchase); Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lecanium spp. -Lecanoideus floccissimus, species of the genus Lepidosaphes (Lepidosaphes spp.), For example, L. ulmi; species of the genus Leptocorisa (Leptocorisa spp.), Leptoglossus phyllopus,

Lipaphis erysimi, species of the genus Lygus spp., For example, L. hesperus, L. lineolaris, L. pratensis; • Maconellicoccus hirsutus, Marchalina hellenica, Macropes excavatus, Macrosiphum spp., For example, M. rosae, M. rosae, M. rosae. avenae), M. euphorbiae; Macrosteles quadrilineatus, Mahanarva fimbriolata, Taiwan Marukamemushi (Megacopta cribraria), Soramamehigenaga ura (Melanaphis pyrarius), Melanaphis sacchari, Melanocallis (= Tinocallis) caryaefoliae, species of the genus Metcafiella spp. (Monellia costalis), Monelliopsis pecanis, Myzocallis coryli, Murgantia spp., Myzus spp., For example, M. ascaronics. ascalonicus, M. cerasi, M. nicotianae, M. persicae, M. varians; Nasonovia ribis-nigri, Neotoxoptera・ Holmosana (Neotoxoptera formosana), of the genus Neomegarotomus Species (Neomegalotomus spp), species of the genus Nephotettix (Nephotettix spp.), For example, N. malayanus, N. nigropictus, N. parvus, N. billessens (N. . virescens); Nezara spp., For example, N. viridula; Nilaparvata lugens, Nysius huttoni, Oebalus spp. , For example, O. pugnax; Oncometopia spp., Orthezia praelonga, Oxycaraenus hyalinipennis, Parabemicia myricae (Parlatoria spp.), Parthenolecanium spp., For example, P. corni, P. persicae; Pemphigus spp., For example. P. bursarius, P. populivenae; Peregrinus maidis, Perkinsiella saccharicida, Phenacoccus spp., For example, P. aceris (P. aceris), P. gossypii; Proeomyzus passerinii, Phorodon humuli, Phylloxera spp., For example, P. debastatricis (P. debastatrikis) ), Piezodorus spp., P. guildinii;

Pinnaspis aspidistrae, species of the genus Planococcus (Planococcus spp.), For example, P. citri, P. ficus; Prosapia bicincta, Proto Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus, Pseudococcus , P. comstocki; Psylla spp., For example, P. mali; Pteromalus spp., Pulvinaria amygdali, Pirilla Genus species (Pyrilla spp.), Quadraspidiotus spp., For example, Q. perniciosus; Quesada gigas, Rastrococcus spp. , Reduvius senilis, Rhizoecus americanus, Rhodnius spp., Rhopalomyzus ascalonicus, Rhopalosiphum spp. R. pseudobrassicas, R. insertum, R. maidis, R. padi; Sagatodes spp., Saarbergera Singularis (Sahlbergella singularis), species of the genus Cysetia (Saissetia spp.), Sappaphis mala, Sappaphis mali, species of the genus Scaptocholis (Scaptocoris spp.), Scaphoides titanus, Schizaphis graminum, Schizoneura lanuginosa, Scotinophora spp., Scotinophora spp. Sitobion avenae, Sogata spp., Sogatella furcifera, Solubea insularis, Spissistil = Stickocephala festina)), Stephanitis nashi, Stephanitis pyrioides, Stephanitis takeyai, Tenaraphala malayensis, Tetraloylodes persea ), Therioaphis maculate, species of the genus Thianta (Thyanta spp.), For example, T. accerra, T. perditor; species of the genus Tibraca (Tibraca spp.), Species of the genus Tomaspis (Tomaspis spp.), Species of the genus Toxoptera (Toxoptera spp.), For example, T. aurantii; ), T. ricini, T. vaporariorum; Triatoma spp., Triosa spp., Typhlocyba spp., Species of the genus Unaspis (Unaspis spp.), For example, U. citri, U. Janonensis ( U. yanonensis); and Viteus vitifolii,

Insects from the order of the Hymenoptera, such as Acanthomyops interjectus, Athalia rosae, Atta spp., For example, A. A. capiguara, A. cephalotes, A. cephalotes, A. laevigata, A. robusta, A. sexdens (A. sexdens), A. texana, Bombus spp., Brachymyrmex spp., Camponotus spp., For example, C. Floridanus (C. floridanus), C. pennsylvanicus, C. modoc; Cardiocondyla nuda, Calibion sp, Crematogaster species (Crematogaster spp.), Dasymutilla occidentalis, Diprion spp., Dolicovespula maculata, Dorymyrmex spp., Dorymyrmex spp. , Formica spp., Hoplocampa spp., For example, H. minuta, H. testudinea; Iridomyrmex humilis, Lasius Genus species (Lasius spp.), For example, L. niger, Argentine ant (Linepithema humile), Liometopum spp., Leptocybe invasa, Monomorium species (Leptocybe invasa) Monomorium spp.), For example, M. pharaonis, mono Monomorium, Nylandria fulva, Pachycondyla chinensis, Paratrechina longicornis, Paratrechina spp., For example, P. germanica , P. pennsylvanica, P. vulgaris; species of the genus Pheidole (Pheidole spp.), For example, P. megacephala; species of the genus Pogonomyrmex spp. ), For example, P. barbatus, P. californicus, Polistes rubiginosa, Prenorepis impairs, Pseudomyrmex gracilis, Pseudomyrmex gracilis, for example. Species of the genus Schelipron (Schelipron spp.), Sirex cyaneus, Species of the genus Solenopsis (Solenopsis spp.), For example, S. geminata, S. invicta, S. Moresta (S. molesta), S. richteri (S. richteri), S. xyloni, Sphecius speciosus, Sphex genus (Sphex spp.), Tapinoma spp .), For example, T. melanocephalum, T. sessile; species of the genus Tetramorium (Tetramorium spp.), For example, T. caespitum, T. bicarinatum (T. bicarinatum), species of the genus Vespa (Vespa spp.), For example, V. crabro; species of the genus Vespula (Vespula spp.), For example, V. squamosal; auropunctata), key Species of the genus Sylocopa (Xylocopa sp);

Insects from the Orthoptera order, such as Acheta domesticus, Calliptamus italicus, Chortoicetes terminifera, Ceuthophilus spp .), Diastrammena asynamora, Dociostaurus maroccanus, Gryllotalpa spp., For example, G. africana, G. gryllotalpa; Genus species (Gryllus spp.), Hieroglyphus daganensis, Kraussaria angulifera, Loxta species (Locusta spp.), For example, L. migratoria, L. L. pardalina; species of the genus Melanoplus spp., For example, M. bivittatus, M. femurrubrum, M. mexicanus, M. sanguinipes. (M. sanguinipes), M. spretus; Acatobibatta (Nomadacris septemfasciata), Oedaleus senegalensis, Scapteriscus spp., Scapteriscus spp. , For example, S. Americana, S. gregaria, Stemopelmatus spp., Tachycines asynamorus, and Zonozerus variegatus;

Harmful organisms from the Arachnida Class, such as Acari, such as the following families, Argasidae, Ixodidae and Sarcoptidae , For example, Amblyomma spp. (For example, A. Americanum, A. variegatum, A. maculatum), Argas species (Argas). spp.), For example, A. persicu), species of the genus Boophilus (Boophilus spp.), For example, B. annulatus, B. decoloratus, B. micropurus ( B. microplus), species of the genus Dermacentor (Dermacentor spp.), For example, D. silvarum, D. andersoni, D. variabilis, species of the genus Argasidae (D. variabilis) Hyalomma spp.), For example, H. truncatum, species of the genus Ixodes spp., For example, I. ricinus, I. rubicundus, I. I. scapularis, I. holocyclus, I. pacificus, Rhipicephalus sanguineus, Ornithodorus spp., For example, O. moubata (O. moubata, O. hermsi, O. turicata, Ornithonyssus bacoti, Otobius megnini, Dermanyssus gallinae, Psoroptes sp .), For example, P. ovis, species of the genus Rhipicephalus spp., For example, R. sanguineus, R. appen diculatus), Rhipicephalus evertsi, Rhizoglyphus spp., Sarcoptes spp. For example, S. Scabiei; and Family Eriophyidae (Family) Eriophyidae), for example, species of the genus Aceria (Aceria spp.), For example, A. sheldoni, A. anthocoptes, species of the genus Acallitus (Acallitus spp.), Species of the genus Acrops (. Aculops spp.), For example, A. lycopersici, A. pelekassi; species of the genus Aculus (Aculus spp.), For example, A. schlechtendali; Colomerus vitis, Epitrimerus pyri, Phyllocoptruta oleivora; Eriophytes ribis and Eriophyes spp., For example, Eriophyes sheldoni. Family) Eriophyidae (Tarsonemidae), for example, species of the genus Hemitarsonemus spp., Phytonemus pallidus and Polyphagotarsonemus latus, species of the genus Stenotarsonemus sp. Steneotarsonemus spinki; Family, Tenuipalpidae, for example, Brevipalpus spp., For example, B. phoenicis; Family, Eriophyidae (Tetranychidae), for example, species of the genus Eotetranychus (Eotetranychus spp.), Species of the genus Eutetranychus (Eutetranychus spp.), Oligonik Species of the genus Oligonychus (Oligonychus spp.), Petrobia latens, Species of the genus Tetranychus (Tetranychus spp.), For example, T. cinnabarinus, T. evansi, T. T. kanzawai, T. pacificus, T. phaseulus, T. telarius and T. urticae; Briobia praetiosa Panonychus spp., For example, P. ulmi, P. citri; Metatetranychus spp. And Oligonychus. spp.), For example, O. pratensis, O. perseae, Vasates lycopersici; Raoiella indica, Family, Carpoglyphidae, For example, a species of the genus Carpoglyphus (Carpoglyphus spp.); A species of the genus Penthaleidae (Penthaleidae spp.), For example, Halotydeus destructor; Species (Demodex spp.); Family Trombicidea, eg, Trombicula spp.; Family, Macronyssidae, eg Ornothonyssus spp.; Family Pyemotidae, for example, Pyemotes tritici; Tyrophagus putrescentiae; Family, Acaridae, for example, Acarus s amily Authentic spiders (Araneida), such as Latrodectus mactans, Tegenaria agrestis, Chiracanthium sp, Lycosa sp, Lycosa sp tepidariorum) and brown recluse spider (Loxosceles reclusa);

Pesticides from the phylum Nematoda (Phylum), such as plant-parasitic nematodes, such as root-knot nematodes, species of the genus Meloidogyne spp., Such as M. hapla (M. .hapla), M. incognita, M. javanica; cyst-forming nematodes, Globodera spp., For example, G. lostkiensis (G. rostochiensis); Heterodera spp., For example, H. avenae, H. glycines, H. schachtii, H. trihorii (H. schachtii) . trifolii); Seed gall nematodes, Anguina spp.; Stem and foliar nematodes, Aphelenchoides spp., For example, A. Besseyi; Sting nematodes, Belonolaimus spp., For example, B. longicaudatus; Pine nematodes, Bruceferenx Species (Bursaphelenchus spp.), For example, B. lignicolus, B. xylophilus; Ring nematodes, Criconema spp., Criconema spp. Species (Criconemella spp.), For example, C. xenoplax and C. ornata; and species of the genus Criconemoides (Criconemoides spp.), For example, Criconemoides informis; Mesocriconema. Genus species (Mesocriconema spp.); Namiku nematodes (Stem and bulb nematodes), species of the genus Ditrenx (Dit) ylenchus spp.), For example, D. destructor, D. dipsaci; Awl nematodes, Dolicodorus spp.; Spiral nematodes. , Heliocotylenchus multicinctus; Sheath and sheathoid nematodes, Hemicriciophora spp. And Hemicriconemoides spp.; Species of the genus Manniella (Hirsh manniella spp.); Spear nematodes (Lance nematodes), Species of the genus Hoploaimus (Hoploaimus spp.); Insects (Needle nematodes), species of the genus Longidorus (Longidorus spp.), For example, L. elongatus; (P. brachyurus), P. neglectus, P. penetrans, P. curvitatus, P. goodeyi; Burrowing nematodes, Radopholus spp., For example, R. similis; Rhadopholus spp.; Rhodopholus spp.; Reniform nematodes, Rotilenks Genus species (Rotylenchus spp.), For example, R. robustus, R. reniformis; Scutellonema spp.; Yumihari nematod (Stubby-root nematod) e), Trichodolus species (Trichodorus spp.), For example, T. obtusus, T. primitivus; Paratrichodolus species (Paratrichodorus spp.), For example, P. minor (P. . minor); Stunt nematodes, species of the genus Tylenchorhynchus spp., For example, T. claytoni, T. dubius; Citrus nematodes. ), Tylenchulus spp., For example, T. semipenetrans; Dagger nematodes, Xiphinema spp.; And other plant-parasitic nematodes. seed;

Insects from the order of the order Cockroach (Blattodea), such as Macrotermes spp., For example, M. natalensis; Cornitermes cumulans, Procorniterumes. Genus species (Procornitermes spp.), Globitermes sulfureus, Neocapritermes spp., For example, N. opacus, N. parvus; Species of the genus Dontotermes (Odontotermes spp.), Species of the genus Nastitermes (Nasutitermes spp.), For example, N. corniger; .formosanus), C. gestroi, C. acinaciformis; species of the genus Reticulitermes spp., For example, R. hesperus, R. Chibiaris (R. . tibialis), R. speratus, R. flavipes, R. grassei, R. lucifugus, R. virginicus; hetero Species of the genus Heterotermes (Heterotermes spp.), For example, H. aureus, H. longiceps, H. tenuis; Species of the genus Cryptotermes (Cryptotermes spp.), For example, C. brevis, C. cavifrons; species of the genus Incisitermes (Incisitermes spp)., For example, I. Minor (I. minor), I. Snidel (I. Snyder) i; Marginitermes hubbardi, Kalotermes flavicollis, Neotermes spp. , For example, N. castaneus, species of the genus Zootermopsis (Zootermopsis spp.), For example, Z. an-gusticollis, Z. nevadensis, of the genus Musttermes. Species (Mastotermes spp.), For example, M. darwiniensis; Species of the genus Blata (BlAtta spp.), For example, B. orientalis, B. lateralis; Species of the genus Blattella (Blattella spp.), For example, B. asahinae, B. germani-ca; Rhyparobia maderae, Panchlora nivea, Periplaneta Species (Periplaneta spp.), For example, P. Americana (P. americana), P. australasiae, P. brunnea, P. fuliginosa, P. japonica (P. japonica); Supella longipalpa, Parcoblatta pennsylvanica, Eurycotis floridana, Pycnoscelus surinamensis,

Insects from the order of the order Siphonoptera, such as Cediopsylla simples, Ceratophyllus spp., Ctenocephalides spp., For example. C. felis, C. canis, Xenopsylla cheopis, Pulex irritans, Trichodectes canis, Tunga penetrans, and European rat fleas. (Nosopsyllus fasciatus),

Insects from the order of Thysanura, such as Lepisma saccharina, Ctenolepisma urbana, and Thermobia domestica,

Pesticides from the class of the class Chilopoda, eg, species of the genus Geophilus (Geophilus spp.), Species of the genus Scutigera (Scutigera spp.), For example, Scutigera coleoptrata;

Pests from the Diplopoda class, such as Blaniulus guttulatus, Julus spp., Narceus spp.,

Pests from the Symphyla Class, such as Scutigerella immaculata,

Insects from the order of the order Dermaptera, for example, the European earwig (Forficula auricularia),

Insects from the order Collembola, such as the genus Onychiurus spp., For example, Onychiurus armatus,

Pests from the order of the Isopoda, such as Armadillidium vulgare, Oniscus asellus, Porcellio scaber,

Insects from the order of the order Lice (Phthiraptera), such as the species of the genus Damalinia (Damalinia spp.), The species of the genus Lice (Pediculus spp.), For example, the head lice (Pediculus humanus capitis), the lice (Pediculus humanus corporis). ), Pediculus humanus humanus; lice (Pthirus pubis), species of the genus Haematopinus (Haematopinus spp.), For example, lice (Haematopinus eurysternus), lice (Haematopinus suis); .), For example, cow lice (Linognathus vituli); cow lice (Bovicola bovis), chicken lice (Menopon gallinae), chicken lice (Menacanthus stramineus) and lice head lice (Solenopotes capillatus)

Examples of additional pest species that can be controlled by the compound of formula (I) include: From the phylum Mollusca (Phylum), the class Bivalvia (Class), for example: , Dreissena spp.; Class: Gastropoda, for example, Arion spp., Biomphalaria spp., Brinus species. (Bulinus spp.), Deloceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Pomacea canaliculata ( Pomacea canaliclata), species of the genus Succinea (Succinea spp.); From the class of mollusca (helminths), for example, Ancylostoma duodenale, Ancylostoma ceylanicum, Ansirostoma ceylanicum. -Acylostoma braziliensis, Ancylostoma spp., Ascaris lubricoides, Ascaris spp., Brugia malayi, Brugia timori (Brugia timori), genus Bunostomum (Bunostomum spp.), Species of the genus Cabertia (Chabertia spp.), Species of the genus Clonorchis (Clonorchis spp.), Species of the genus Couperia (Cooperia spp.), Seeds (Dicrocoelium spp.), Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus granulosus Loculalis (Echinococcus multilocul) aris), Enterobius vermicularis, Faciola spp., Haemonchus spp., For example, Haemonchus contortus; Heterakis spp. , Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp. ), Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp., Strongyloides fuelleborni, Strongyloides stercora lis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella solium (Trichinella spiralis), Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp. , Trichuris trichuria, Wuchereria bancrofti.

Rice pests:
In the context of the present invention, rice pest invertebrates are animal pests that occur in rice. Examples of rice-harmful invertebrates include insects, mites and nematodes, preferably insects. Well-known rice-harmful invertebrates in rice include, but are not limited to, the following species:

Hemiptera:
Brown planthopper (brown planthopper)-Nilaparvata lugens
Himetobiunka (small brown planthopper)-Laodelphax striatellus
Segatella furcifera (white-backed planthopper)-Sogatella furcifera
Leafhopper (white leafhopper)-Cofana spectra
Nephotettix virescens, N. nigriceps, N. cincticeps, N. malayanus
Leafhopper (zig zag leafhopper)-Recilia dorsalis
Leafhopper (maize orange leafhopper) --Cicadulina bipunctata
Leafhopper (aster leafhopper)-Macrosteles fascifrons
Taiwan spider helicopter bug (rice earhead bug), Leptocorisa oratorius, L. acuta
Rice stink bugs-Nezara viridula, Pygomenida varipennis, Eysarcoris, Tibraca limbatriventris, Esarcoris ventralis ventris
Brown marmorated stink bug (small stink bug)-Oebalus poecilus, O. pugnax
Helicopter bug (coreid bug)-Eysarcoris sp
Chinch bug-Chinch bug-Blissus leucopterus, leucopterus
Rice mealybug, Brevennia rehi, Pseudococcus saccharicola
Rice aphids, Rhopalosiphum rufiabdominalis, Macrosiphum avenae, Hysteroneura setariae, Tetraneulo nigriabdominalis
Kebukachichuwatamushi (bean root aphid) --Smynthurodes betae

Lepidoptera:
Parnara guttata (rice skipper)-Parnara guttata, Melanitis Ieda ismene
Chilo suppressalis (rice stem borer / striped stem borer)-Chilo suppressalis, Chilo polychrusus, Chilo partellus, Kilo Pleasure Dels (Chilo plejadellus)
Rice stalk borer-Chilotraea polychrysa
Sesamia inferens (pink rice borer)-Sesamia inferens
Sankameiga (yellow rice borer)-Triporyza (= Scirpophaga) incertulas
Shiromeichu (white rice borer)-Tryporyza innotata
Covenomeiga (rice leaf roller / rice leaf folder)-Cnaphalocrocis medinalis, Marasmia patnalis, M. exigua
Mythimna separata (rice ear-cutting caterpillar / armyworm) --Pseudaletia separata
Xanthodes transversa (green caterpillar)-Xanthodes transversa
Futaobikoyaga (green rice caterpillar) --Narnaga aenescens
Green horned caterpillars-Melanitis Ieda ismene, Mycalesis sp
Fall armyworm (fall army worm)-Spodoptera frugiperda
Nekirimushi (cutworm)-Mythimna separata
Rice case worm (rice case worm)-Nymphula depunctalis
Black hairy caterpillar, Amata sp.
Hairy caterpillar-Mocis frugalis
Obiga (yellow caterpillar), Psalis pennatula
Rice semi-brown looper, Mocis frugalis
Rice semi-looper, Chrysodeixis chalcites
Kuroobi Chronomeiga (grass webworm)-Herpetogramma licarsisalis
Sugar cane borer-Diatraea saccharalis
Corn stalk borer-Elasmopalpus lignosellus
Striped grass looper-Mocis latipes
European corn borer-Ostrinia nubilalis
Mexican rice borer-Eoreuma loftini

Coleoptera:
Lissorhoptrus (water weevil)-Lissorhopterus oryzophilus
Rice plant weevil-Echinocnemus squamous
Rice weevil (rice weevil) --Oryzophagus oryzae
Rice hispa --Diclodispa armigera Rice leaf beetle --Oulema oryzae
Rice blackbug-Scotinophora vermidulate, S. vermidulate, S. lurida, S. latiuscula
Rice flea beetle-Chaetocnima basalis
Grubs-Leucopholis irrorata, Leucopholis irrorata, Phyllophaga sp, Heteronychus sp
Scarab beetle (bicho torito)-Diloboderus abderus
Weevils (billbugs)-Sphenophorus spp
Grape colaspis-Colaspis brunnea, C. louisianae
Rice pollen beetle, Chilolaba acuta

Diptera:
Stem maggot-Chlorops oryzae
Leafminer-Agromyza oryzae
Rice whorl maggot / rice stem maggot --Hydrellia sasakii
Rice whorl maggot / small rice leaf miner --Hydrellia griseola
Rice gall midge-Orseolia (= Pachydiplosis) oryzae
Rice shoot fly-Atherigona oryzae
Rice seed midge-Chironomus cavazzai, Chironomus spp, Cricotopus spp

Thrips (Thysanoptera):
Rice thrips-Chloethrips oryzae, Stenochaetothrips biformis, Perrisothrips sp., Hoplothrips sp.,

Orthoptera:
Locusts (rice grasshoppers), Hieroglyphus banian, Hieroglyphus nigrorepletus, Catantops pinguis, Attractomorpha burri, A. A. crenulate, A. psittacina, A. Bedeli, Oxya adenttata, Oxya ebneri, Oxya hyla intricata, Acrida turricata
Grasshoppers (locusts)-Locusta migratoria manilensis
Mole cricket, Grylotalpa africana
Crickets (field crickets): Gryllus bimaculatus, Teleogryllus occipitalis, Euscyrtus concinus
Grasshopper (katydid)-Conocephalus longipennis

Termite (Isoptera):
Termites-Macrotermes gilvus, Syntermes molestans

Hymenoptera:
Ants-Akakami ants (Solenopsis geminata)
Rice white tip nematode (rice white tip nematode) --Aphelenchoides besseyi

Mites (Acari):
Rice panicle mite --Steotarsonemus pinki

Crustacea:
Triops longicauda (tadpole shrimp)-Triops longicauda (Triops longicaudatus), Triops longicauda (T. cancriformis)
Rice crayfish-Crayfish (Procambarus clarkii), Orconectes virilis.

In addition, the rice plants are Leptocorisa chinensiss, Lagynotomus elongates, Nerzara viridula, Eysacoris parvus, Eysacoris parvus, Leptocorisa ora trius It is affected by pugnax, Cletus trigonus, and a wide range of insects, including various mites, caterpillars, beetles, rootworms and maggots.

In one embodiment, the rice-harmful invertebrate is a biting / chewing insect.

In one embodiment, the rice-harmful invertebrate is a piercing / sucking insect.

In one embodiment, the rice-harmful invertebrate is a rasping insect.

In one embodiment, the rice-harmful invertebrate is a siphoning insect.

In one embodiment, the rice-harmful invertebrate is a sponging insect.

In one embodiment, the rice-harmful invertebrates are the brown planthopper (brown planthopper) (Nilaparvata lugens), the brown planthopper (small brown planthopper) (Lao delfax). Lao delphax striatellus, Sedirounka (white-backed planthopper) (Sogatella furcifera), Nikameiga (rice stem borer / rice striped stem borer) striped stem borer) (Chilo suppressalis), Sankameiga (yellow rice borer) (Triporyza (= Scirpophaga) incertulas), Kobunomeiga (rice leaf roller) (rice leaf roller) / rice leaf folder (Cnaphalocrocis medinalis), brown planthopper (water weevil) (Lissorhopterus oryzophilus) ..

In one embodiment, rice-harmful invertebrates are selected from Hemiptera or Lepidoptera.

In one embodiment, rice-harmful invertebrates are selected from Hemiptera. In a further embodiment, the rice-harmful invertebrate is a leafhopper, preferably a brown planthopper (brown planthopper) (Nilaparvata lugens), a brown planthopper (small brown planthopper). brown planthopper)) (Laodelphax striatellus), brown planthopper (white-backed planthopper) (Sogatella furcifera), rice leafhopper (green leafhopper) )) (Nephotettix virescens). In a further embodiment, the rice-harmful invertebrates are the brown planthopper (brown planthopper) (Nilaparvata lugens) and the green leafhopper (green leafhopper) (Nephotettix). virescens)), preferably selected from brown planthoppers (Nilaparvata lugens).

In one embodiment, the rice-harmful invertebrate is the brown planthopper (brown plant hopper) (Nila parvata lugens).

In one embodiment, the rice-harmful invertebrate is the rice leafhopper (green leafhopper) (Nephotettix virescens).

In a further embodiment, the rice-harmful invertebrates are stink bugs, preferably rice stink bugs (Nezara viridula), Pygomenida varipennis, Eysarcoris. , Tibraca limbatriventris, Eysarcoris ventralis, or stink bug (small stink bug) (Oebalus poecilus), O. pugnax (Oebalus poecilus) It is selected from O. pugnax)).

In one embodiment, rice-harmful invertebrates are selected from the order Lepidoptera. In a further embodiment, the rice-harmful invertebrate is a borer, preferably a stem borer, preferably a Nikameiga (rice stem borer (Chilo suppressalis)). Or Sankameiga (yellow rice borer) (Triporyza (= Scirpophaga) incertulas).

In a further embodiment, the rice-harmful invertebrates are rice leaf roller / rice leaf folder (Cnaphalocrocis medinalis), Marasmia patnalis. ), M. exigua).

In one embodiment, rice-harmful invertebrates are selected from the order Coleoptera. In a further embodiment, the rice-harmful invertebrate is the rice weevil (water weevil) (Lissorhopterus oryzophilus). In a further embodiment, the rice-harmful invertebrate is the rice weevil (rice weevil) (Oryzophagus oryzae).

In one embodiment, rice-harmful invertebrates are selected from the family Termites (Isoptera).

Mixtures of two or more ingredients Combining mixtures of the present invention, as mixtures with additional active ingredients, for example, other pesticides, especially pesticides, nematodes, bactericides, herbicides, pesticides, It can be applied to agriculture as a mixture with fertilizers (eg ammonium nitrate, urea, potash, and superphosphates), phytotoxicants and plant growth regulators.

These mixtures are also included in the terms "mixtures of the invention (s)" or "mixtures of the invention (s)".

These additional components may be used continuously or in combination with the mixture of the present invention, and may be added and used immediately before use if appropriate (tank mixing). For example, the plant (s) may be sprayed with the mixture of the invention either before or after being treated with another active ingredient.

In one embodiment, the invention relates to a mixture of the invention which is a binary mixture of compounds I and II, i.e., these active ingredients are the only active ingredients. Preferred weight ratios for such binary mixtures are 5000: 1 to 1: 5000, preferably 1000: 1 to 1: 1000, more preferably 100: 1 to 1: 100, particularly preferably 10: 1 to 1: 1. It is 10. In such a two-component mixture, compounds I and II may be used in equal amounts, or excess component I or excess component II may be used.

In one embodiment, the preferred weight ratios of benzpyrimoxane and oxazosulfyl are 100: 1 to 1: 1, 50: 1 to 1: 1, 40: 1 to 1: 1, 20: 1 to 1: 1. 1, 16: 1 to 1: 1 or 10: 1 to 1: 1. In another embodiment, the preferred weight ratios are 100: 1 to 1: 3, 50: 1 to 1: 3, 40: 1 to 1: 3, 20: 1 to 1: 3, 16: 1 to 1: 3. Or 10: 1 to 1: 3. In another embodiment, the preferred weight ratios are 100: 1 to 3: 1, 50: 1 to 3: 1, 40: 1 to 3: 1, 20: 1 to 3: 1, 16: 1 to 3: 1. Or 10: 1 to 3: 1.

The same preferred mixture ratio also applies to compounds I and II if the mixture is not a binary mixture, i.e. if the mixture contains more active compounds.

The invention also relates to a method according to the invention, wherein the mixture of the mixture according to the invention is applied with at least one additional mixing partner as defined below of the specification (provided that additional mixing partners are compound I and Not yet contained in the mixture of II). These mixtures are also considered mixtures of the present invention.

The following pesticides, grouped and numbered according to the Insecticide Resistance Countermeasures Commission (IRAC) Action Classification Mode, which can be used with the mixtures of the invention and may produce synergistic effects. List M is for illustration of possible combinations and does not impose any restrictions:

M.1 Acetylcholine Esterase (AChE) Inhibitors: M.1A carbamates, such as aldicarb, alanycarb, bendiocarb, benfuracarb, butocaboxim, butoxy Butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb methiocarb, metomyl, metolcarb, oxamyl, pyrimicarb, propoxur, thiodicarb, thiofanox, trimetacarb, XMC, xylylcarb ) And triazamate; or M.1B organic phosphates, such as acephate, azamethiphos, azinphos-ethyl, azinphosmethyl, cadusafos, chlorpyrifos ( chlorethoxyfos), chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl methyl, diazinon, dichlorvos / DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethi Ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, imicyafos, isophos Isopropyl O- (methoxyaminothio-phosphoryl) salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos (methidathion) mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate ), Phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, pyraclophos pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, tetrachlorvinphos, thiometon , Trichlorfon and vamidothion;

M.2. GABAergic chloride channel antagonist: M.2A cyclodiene organochlorine compounds such as endosulfan or chlordane; or M.2B fiproles (phenylpyrazoles). ), For example, ethiprole, fipronil, flufiprole, pyrafluprole and pyriprole;

M.3 sodium channel regulator: From the class of M.3A pyrethroids, for example, acrinathrin, allethrin, d-cis-trans, d-cis-trans allethrin, d-trans Areslin (d-trans allethrin), bifenthrin, kappa-bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl, bioresmethrin, cycloprothrin cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin (alpha-cypermethrin), beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphenothrin, deltamethrin, empentrin ), Esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau-fluvalinate , Halfenprox, heptafluthrin, imiprothrin, meperfluthrin, metofluthrin, momfluorothrin, epsilon-monfluorothrin (ep) silon-momfluorothrin, permethrin, phenothrin, prallethrin, profluthrin, pyrethrin (pyrethrum), resmethrin, tefluthrin, tefluthrin, tefluthrin , Kappa-tefluthrin, tetramethylfluthrin, tetramethrin, tralomethrin and transfluthrin; or M.3B sodium channel regulators such as DDT or methoxychlor ( methoxychlor);

M.4 nicotinic acetylcholine receptor agonist (nAChR): M.4A neonicotinoids, such as acetamiprid, clothianidin, cycloxaprid, dinotefuran, imidacloprid , Nitenpyram, thiacloprid and thiamethoxam; or compound M.4A.1 4,5-dihydro-N-nitro-1- (2-oxylanylmethyl) -1H-imidazol-2- Amine, M.4A.2: (2E-)-1-[(6-chloropyridin-3-yl) methyl] -N'-nitro-2-pentylidenehydrazinecarboxyimideamide; or M4.A.3: 1-[(6-chloropyridin-3-yl) methyl] -7-methyl-8-nitro-5-propoxy-1,2,3,5,6,7-hexahydroimidazole [1,2-a] Pyridine; or M.4B nicotine; M.4C sulfoxaflor; M.4D flupyradifurone; M.4E triflumezopyrim; M.4E.1a) (3R) -3- ( 2-Chlorothiazole-5-yl) -8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a] pyrimidine-8-ium-7-olate, M.4E. 1b) (3S) -3- (6-Chloro-3-pyridyl) -8-methyl-5-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a] pyrimidin-8-ium- 7-Olate, M.4E.1c) (3S) -8-Methyl-5-oxo-6-phenyl-3-pyrimidine-5-yl-2,3-dihydrothiazolo [3,2-a] pyrimidin- 8-Ium-7-olate, M.4E.1d) (3R) -3- (2-chlorothiazole-5-yl) -8-methyl-5-oxo-6- [3- (trifluoromethyl) phenyl ] -2,3-dihydrothiazolo [3,2-a] pyrimidine-8-ium-7-olate; M.4E.1e) (3R) -3- (2-chlorothiazole-5-yl) -6 -(3,5-dichlorophenyl) -8-methyl-5-oxo-2 , 3-Dihydrothiazolo [3,2-a] Pyrimidine-8-ium-7-olate, M.4E.1f) (3R) -3- (2-chlorothiazole-5-yl) -8-ethyl- 5-oxo-6-phenyl-2,3-dihydrothiazolo [3,2-a] pyrimidine-8-ium-7-olate;

M.5 Nicotinic Acetylcholine Receptor Allosteric Activator: Spinosads, eg spinosad or spine toram;

From the class of M.6 chloride channel activators, avermectins and milbemycins, for example, abamectin, emamectin benzoate, ivermectin, lepimectin or Milbemectin;

M.7 Juvenile hormone mimics, such as M.7A juvenile hormone analogues hydroprene, kinoprene and methoprene; or M.7B phenoxy Calve (fenoxycarb) or M.7C pyriproxyfen;

M.8 Miscellaneous non-specific (multisite) inhibitors such as M.8A alkyl halides (eg methyl bromide) and other alkyl halides, M.8B chloropicrin, M.8C sulfuryl fluoride (sulfuryl fluoride), M.8D borax, or M.8E antimony stone (tartar emetic);

M.9 string organ TRPV channel modulators, such as M.9B pymetrozine; pyrifluquinazon;

M.10 mite growth inhibitors, such as M.10A clofentezine, hexythiazox and diflovidazin, or M.10B etoxazole;

M.11 Bacillus thuringiensis or bacillus sphaericus and the insecticidal proteins they produce, such as Bacillus thuringiensis (bacillus thuringiensis) or Bacillus thuringiensis (Bacillus thuringiensis) bacillus thuringiensis subsp. Israelensis), Bacillus sphaericus, Bacillus thuringiensis subsp. Aizawai, Bacillus thuringiensis subsp. Aizawai, Bacillus thuringiensis subsp. Species Bacillus thuringiensis subsp. Tenebrionis or Bt crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, and Cry34 / 35Ab1;

M.12 mitochondrial ATP synthase inhibitors, such as M.12A diafenthiuron, or M.12B organotin acaricides, such as azocyclotin, cyhexatin, or fenbutatin oxide (. fenbutatin oxide), M.12C propargite, or M.12D tetradifon;

M.13 Decoupling agents of oxidative phosphorylation by disrupting proton gradients, such as chlorfenapyr, DNOC or sulfluramid;

M.14 Nicotinic acetylcholine receptor (nAChR) channel blockers, such as nereistoxin analogues, bensultap, cartap hydrochloride, thiocyclam, or sodium thiosultap. (thiosultap sodium);

M.15 Chitin Biosynthesis Inhibitor Type 0, eg, benzoylureas, eg, bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, Flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, or triflumuron;

M.16 Chitin Biosynthesis Inhibitor Type 1, eg buprofezin;

M.17 molting disturber, Dipteran, eg cyromazine;

M.18 ecdysone receptor agonists such as diacylhydrazines, such as methoxyfenozide, tebufenozide, halofenozide, fufenozide, or chromafenozide;

M.19 Octopamine receptor agonists such as amitraz;

M.20 mitochondrial complex III electron transport inhibitor, eg, M.20A hydramethylnon, or M.20B acequinocyl, or M.20C fluacrypyrim; or M.20D bifenazate. ;

M.21 mitochondrial complex I electron transport inhibitors, such as M.21A METI acaricides and pesticides, such as fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad. ) Or tolfenpyrad, or M.21B rotenone;

M.22 potential-dependent sodium channel blocker, eg, M.22A indoxacarb, or M.22B metaflumizone, or M.22B.1: 2- [2- (4-cyanophenyl). -1- [3- (Trifluoromethyl) phenyl] ethylidene] -N- [4- (difluoromethoxy) phenyl] -hydrazine carboxamide or M.22 B.2: N- (3-chloro-2-methylphenyl)- 2-[(4-Chlorophenyl) [4- [methyl (methylsulfonyl) amino] phenyl] methylene] -hydrazine carboxamide;

Inhibitors of M.23 acetyl-CoA carboxylase, such as tetrolic acid and tetramic acid derivatives, such as spirodiclofen, spiromesifen, or spirotetramat; M.23.1 spiropidion.

M.24 mitochondrial complex IV electron transfer inhibitor, eg, M.24A phosphine, eg aluminum phosphide, calcium phosphide, phosphine, or zinc phosphide. phosphide) or M.24B cyanide;

M.25 Mitochondrial Complex II Electron Transfer Inhibitors, eg Beta-ketonitrile Derivatives, eg Cyenopyrafen or cyflumetofen;

From the class of M.28 lianodine receptor regulators, diamides, for example, flubendiamide, chlorantraniliprole, cyantraniliprole, tetraniliprole, M.28.1: (R) -3-Chloro-N1- {2-methyl-4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl] phenyl} -N2- (1-) Methyl-2-methylsulfonylethyl) phthalamide, M.28.2: (S) -3-chloro-N1- {2-methyl-4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl)) Ethyl] phenyl} -N2- (1-methyl-2-methylsulfonylethyl) phthalamide, M.28.3: cyclaniliprol, or M.28.4: methyl-2- [3,5-dibromo-2- ({[ 3-Bromo-1- (3-chloropyridine-2-yl) -1H-pyrazol-5-yl] carbonyl} amino) benzoyl] -1,2-dimethylhydrazine carboxylate; M.28.5i) N- [2 -(5-Amino-1,3,4-thiasiazol-2-yl) -4-chloro-6-methylphenyl] -3-bromo-1- (3-chloro-2-pyridinyl) -1H-pyrazol-5 -Carboxamide; M.28.5j) 3-Chloro-1- (3-chloro-2-pyridinyl) -N- [2,4-dichloro-6-[[(1-cyano-1-methylethyl) amino] carbonyl ] Phenyl] -1H-pyrazole-5-carboxamide; M.28.5k) tetrachlorolantraniliprol; M.28.5L) N- [4-chloro-2-[[(1,1-dimethylethyl) amino] Carbonyl] -6-methylphenyl] -1- (3-chloro-2-pyridinyl) -3- (fluoromethoxy) -1H-pyrazol-5-carboxamide; or

M.28.6: cyhalodiamide; or

M.29: String organ modulators-undefined target sites, such as flonicamid;

M.UN. Insecticidal active compounds of unknown and unclear mechanism of action, such as afidopyropen, afoxolaner, azadirachtin, amidoflumet, benzoximate, brofuranilide (broflanilide), bromopropylate, chinomethionat, cryolite, dicloromezotiaz, dicofol, flufenerim, flometoquin, fluensulfone , Fluhexafon, fluopyram, fluralaner, metaldehyde, metoxadiazone, piperonyl butoxide, pyflubumide, pyridalyl, tioxazafen

M.UN.3: 11- (4-Chloro-2,6-dimethylphenyl) -12-hydroxy-1,4-dioxa-9-azaspiro [4.2.4.2] -tetradeca-11-ene-10-one,

M.UN.4: 3- (4'-fluoro-2,4-dimethylbiphenyl-3-yl) -4-hydroxy-8-oxa-1-azaspiro [4.5] deca-3-en-2-one,

M.UN.5: 1- [2-Fluoro-4-methyl-5-[(2,2,2-trifluoroethyl) sulfinyl] phenyl] -3- (trifluoromethyl) -1H-1,2, 4-Triazole-5-amine, or activator based on Bacillus firmus (Votivo, I-1582);

M.UN.6: flupyrimin;

M.UN.8: fluazaindolizine; M.UN.9.a): 4- [5- (3,5-dichlorophenyl) -5- (trifluoromethyl) -4H-isoxazole-3 -Il] -2-Methyl-N- (1-oxothietan-3-yl) benzamide; M.UN.9.b): Fluxametamide; M.UN.10: 5-[3- [2,6] -Dichloro-4- (3,3-dichloroallyloxy) phenoxy] propoxy] -1H-pyrazole;

M.UN.11.i) 4-Cyano-N- [2-Cyano-5-[[2,6-Dibromo-4- [1,2,2,3,3,3-Hexafluoro-1- (1,2,2,3,3,3-Hexafluoro-1-)" Trifluoromethyl) propyl] phenyl] carbamoyl] phenyl] -2-methyl-benzamide; M.UN.11.j) 4-cyano-3-[(4-cyano-2-methyl-benzoyl) amino] -N- [2,6-dichloro-4- [1,2,2,3,3,3-hexafluoro-1- (trifluoromethyl) propyl] phenyl] -2-fluoro-benzamide; M.UN.11.k ) N- [5-[[2-Chloro-6-cyano-4- [1,2,2,3,3,3-hexafluoro-1- (trifluoromethyl) propyl] phenyl] carbamoyl] -2- Cyano-phenyl] -4-cyano-2-methyl-benzamide; M.UN.11.l) N- [5-[[2-Bromo-6-chloro-4- [2,2,2-trifluoro-] 1-Hydroxy-1- (trifluoromethyl) ethyl] phenyl] carbamoyl] -2-cyano-phenyl] -4-cyano-2-methyl-benzamide; M.UN.11.m) N- [5-[[[ 2-Bromo-6-chloro-4- [1,2,2,3,3,3-hexafluoro-1- (trifluoromethyl) propyl] phenyl] carbamoyl] -2-cyano-phenyl] -4-cyano -2-Methyl-benzamide; M.UN.11.n) 4-Cyano-N- [2-Cyano-5-[[2,6-Dichloro-4- [1,2,2,3,3,3,3" -Hexafluoro-1- (trifluoromethyl) propyl] phenyl] carbamoyl] phenyl] -2-methyl-benzamide; M.UN.11.o) 4-cyano-N- [2-cyano-5-[[2 , 6-dichloro-4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl] phenyl] carbamoyl] phenyl] -2-methyl-benzamide; M.UN.11.p) N -[5-[[2-Bromo-6-chloro-4- [1,2,2,2-tetrafluoro-1- (trifluoromethyl) ethyl] phenyl] carbamoyl] -2-cyano-phenyl] -4 -Cyano-2-methyl-benzamide; or

M.UN.12.a) 2- (1,3-dioxane-2-yl) -6- [2- (3-pyrimidine) -5-thiazolyl] -pyridine; M.UN.12.b) 2- [6- [2- (5-fluoro-3-pyridinyl) -5-thiazolyl] -2-pyridinyl] -pyrimidine; M.UN.12.c) 2- [6- [2- (3-pyridinyl)- 5-Thiazolyl] -2-pyridinyl] -pyrimidine; M.UN.12.d) N-methylsulfonyl-6- [2- (3-pyridyl) thiazole-5-yl] pyridin-2-carboxamide; M.UN 12.e) N-Methylsulfonyl-6- [2- (3-pyridyl) thiazole-5-yl] Pyridine-2-carboxamide;

M.UN.14a) 1-[(6-chloro-3-pyridinyl) methyl] -1,2,3,5,6,7-hexahydro-5-methoxy-7-methyl-8-nitro-imidazole [1 , 2-a] Pyridine; or M.UN.14b) 1-[(6-chloropyridin-3-yl) methyl] -7-methyl-8-nitro-1,2,3,5,6,7- Hexahydroimidazole [1,2-a] Pyridine-5-ol;

M.UN.16a) 1-isopropyl-N, 5-dimethyl-N-pyridazine-4-yl-pyrazole-4-carboxamide; or M.UN.16b) 1- (1,2-dimethylpropyl) -N- Ethyl-5-methyl-N-pyridazine-4-yl-pyrazole-4-carboxamide; M.UN.16c) N,5-dimethyl-N-pyridazine-4-yl-1- (2,2,2-tri) Fluoro-1-methyl-ethyl) pyrazole-4-carboxamide; M.UN.16d) 1- [1- (1-cyanocyclopropyl) ethyl] -N-ethyl-5-methyl-N-pyridazine-4-yl -Pyrazole-4-carboxamide; M.UN.16e) N-ethyl-1- (2-fluoro-1-methyl-propyl) -5-methyl-N-pyridazine-4-yl-pyrazole-4-carboxamide; M .UN.16f) 1- (1,2-dimethylpropyl) -N,5-dimethyl-N-pyridazine-4-yl-pyrazole-4-carboxamide; M.UN.16g) 1- [1- (1- (1-) Cyanocyclopropyl) ethyl] -N, 5-dimethyl-N-pyridazine-4-yl-pyrazole-4-carboxamide; M.UN.16h) N-methyl-1- (2-fluoro-1-methyl-propyl] -5-Methyl-N-pyridazine-4-yl-pyrazole-4-carboxamide; M.UN.16i) 1- (4,4-difluorocyclohexyl) -N-ethyl-5-methyl-N-pyridazine-4- Il-pyrazole-4-carboxamide; or M.UN.16j) 1- (4,4-difluorocyclohexyl) -N,5-dimethyl-N-pyridazine-4-yl-pyrazole-4-carboxamide,

M.UN.17a) N- (1-methylethyl) -2- (3-pyridinyl) -2H-indazole-4-carboxamide; M.UN.17b) N-cyclopropyl-2- (3-pyridinyl)- 2H-indazole-4-carboxamide; M.UN.17c) N-cyclohexyl-2- (3-pyridinyl) -2H-indazole-4-carboxamide; M.UN.17d) 2- (3-pyridinyl) -N- (2,2,2-trifluoroethyl) -2H-indazole-4-carboxamide; M.UN.17e) 2- (3-pyridinyl) -N-[(tetrahydro-2-furanyl) methyl] -2H-indazole -5-carboxamide; M.UN.17f) Methyl 2-[[2- (3-pyridinyl) -2H-indazole-5-yl] carbonyl] hydrazine carboxylate; M.UN.17g) N-[(2,, 2-Difluorocyclopropyl) methyl] -2- (3-pyridinyl) -2H-indazole-5-carboxamide; M.UN.17h) N- (2,2-difluoropropyl) -2- (3-pyridinyl)- 2H-indazole-5-carboxamide; M.UN.17i) 2- (3-pyridinyl) -N- (2-pyrimidinylmethyl) -2H-indazole-5-carboxamide; M.UN.17j) N-[(5) -Methyl-2-pyrazinyl) Methyl] -2- (3-pyridinyl) -2H-indazole-5-carboxamide,

M.UN.18. tyclopyrazoflor;

M.UN.19 sarolaner, M.UN.20 lotilaner;

M.UN.21 N- [4-Chloro-3-[[(phenylmethyl) amino] carbonyl] phenyl] -1-methyl-3- (1,1,2,2,2-pentafluoroethyl) -4 -(Trifluoromethyl) -1H-pyrazole-5-carboxamide; M.UN.22a 2- (3-ethylsulfonyl-2-pyridyl) -3-methyl-6- (trifluoromethyl) imidazole [4,5- b] pyridine or M.UN.22b 2- [3-ethylsulfonyl-5- (trifluoromethyl) -2-pyridyl] -3-methyl-6- (trifluoromethyl) imidazo [4,5-b] Ppyridine;

M.UN.23 Isocycloseram;

M.UN.24a) N- [4-Chloro-3- (cyclopropylcarbamoyl) phenyl] -2-methyl-5- (1,1,2,2,2-pentafluoroethyl) -4- (trifluoro) Methyl) pyrazole-3-carboxamide or M.UN.24b) N- [4-chloro-3-[(1-cyanocyclopropyl) carbamoyl] phenyl] -2-methyl-5- (1,1,2,2) , 2-Pentafluoroethyl) -4- (trifluoromethyl) pyrazole-3-carboxamide; M.UN.25 acynonapyr; M.UN.26 benzpyrimoxan; M.UN.27 tigolanel (tigolaner); M.29.28 oxazosulfyl;

M.UN.29a) [(2S, 3R, 4R, 5S, 6S) -3,5-dimethoxy-6-methyl-4-propoxy-tetrahydropyran-2-yl] N- [4- [1- [4] -(Trifluoromethoxy) phenyl] -1,2,4-triazole-3-yl] phenyl] carbamate; M.UN.29b) [(2S, 3R, 4R, 5S, 6S) -3,4,5- Trimethoxy-6-methyl-tetrahydropyran-2-yl] N- [4- [1- [4- (trifluoromethoxy) phenyl] -1,2,4-triazole-3-yl] phenyl] carbamate; M. UN.29c) [(2S, 3R, 4R, 5S, 6S) -3,5-dimethoxy-6-methyl-4-propoxy-tetrahydropyran-2-yl] N- [4- [1- [4- ( 1,1,2,2,2-pentafluoroethoxy) phenyl] -1,2,4-triazole-3-yl] phenyl] carbamate; M.UN.29d) [(2S, 3R, 4R, 5S, 6S) )-3,4,5-Trimethoxy-6-methyl-tetrahydropyran-2-yl] N- [4- [1- [4- (1,1,2,2,2-pentafluoroethoxy) phenyl]- 1,2,4-triazole-3-yl] phenyl] carbamate; M.UN.29.e) (2Z) -3- (2-isopropylphenyl) -2-[(E)-[4- [1-] [4- (Trifluoromethoxy) phenyl] -1,2,4-triazole-3-yl] phenyl] Methylene hydrazono] thiazolidine-4-one or M.UN.29f) (2Z) -3- (2-) Isopropylphenyl) -2-[(E)-[4- [1- [4- (1,1,2,2,2-pentafluoroethoxy) phenyl] -1,2,4-triazole-3-yl] Phenyl] Methyl hydrazono] Thiazolidine-4-one;

M.UN.30a) 2- (6-Chloro-3-ethylsulfonyl-imidazole [1,2-a] pyridin-2-yl) -3-methyl-6- (trifluoromethyl) imidazole [4,5- b] Pyridine, M.UN.30b) 2- (6-Bromo-3-ethylsulfonyl-imidazole [1,2-a] pyridin-2-yl) -3-methyl-6- (trifluoromethyl) imidazole [ 4,5-b] Pyridine, M.UN.30c) 2- (3-Ethylsulfonyl-6-iodo-imidazo [1,2-a] pyridin-2-yl) -3-methyl-6- (trifluoro) Methyl) imidazo [4,5-b] pyridine, M.UN.30d) 2- [3-ethylsulfonyl-6- (trifluoromethyl) imidazo [1,2-a] pyridin-2-yl] -3- Methyl-6- (trifluoromethyl) imidazole [4,5-b] pyridine, M.UN.30e) 2- (7-chloro-3-ethylsulfonyl-imidazole [1,2-a] pyridine-2-yl ) -3-Methyl-6- (trifluoromethyl) imidazole [4,5-b] pyridine, M.UN.30f) 2- (3-ethylsulfonyl-7-iodo-imidazole [1,2-a] pyridine -2-yl) -3-Methyl-6- (Trifluoromethyl) Imidazo [4,5-b] Pyridine, M.UN.30g) 3-Ethylsulfonyl-6-iodo-2- [3-Methyl-6 -(Trifluoromethyl) imidazole [4,5-b] pyridin-2-yl] imidazole [1,2-a] pyridine-8-carbonitrile, M.UN.30h) 2- [3-ethylsulfonyl-8 -Fluoro-6- (trifluoromethyl) imidazole [1,2-a] pyridin-2-yl] -3-methyl-6- (trifluoromethyl) imidazole [4,5-b] pyridine, M.UN. 30i) 2- [3-Ethylsulfonyl-7- (trifluoromethyl) imidazole [1,2-a] pyridin-2-yl] -3-methyl-6- (trifluoromethylsulfinyl) imidazole [4,5- b] Pyridine, M.UN.30j) 2- [3-Ethylsulfonyl-7- (trifluoromethyl) imidazo [1,2-a] pyridin-2-yl] -3-methyl-6- (trifluoromethyl) ) Imidazo [4,5-c] Pyridine, M.UN.30k) 2- (6-Bromo-3-ethylsulfonyl-Imidazo [1,2-a] Pyridine-2-yl) -6- (Trifluoromethyl) ) Pyrazolo [4,3-c] Pyridine ..

The commercially available compounds of Group M listed above can be found, among other publications, in The Pesticide Manual, 17th Edition, C. MacBean, British Crop Protection Council (2015). The online Pesticide Manual is updated regularly and is accessible through http://bcpcdata.com/pesticide-manual.html.

M.4 cycloxapride is known from WO 2010/069266 and WO 2011/069456. M.4A.1 is known from CN 103814937; CN105367557, CN 105481839. M.4A.2 and guadipyr are known from WO 2013/003977, and M.4A.3 (approved as paichongding in China) is known from WO 2007/101369. M.4E.1a) to M.4E.1f) are known from WO2018177970. M.22B.1 is described in CN10171577. M.22B.2 is described in CN102126994. Spiropidion M.23.1 is known from WO 2014/192171. M.28.1 and M.28.2 are known from WO2007 / 101540. M.28.3 is described in WO 2005/077934. M.28.4 is described in WO2007 / 043677. M.28.5a) to M.28.5d) and M.28.5h) are described in WO 2007/006670, WO2013 / 024009 and WO 2013/024010, and M.28.5i) is described in WO2011 / 085575. M.28.5j) is described in WO2008 / 134969, M.28.5k) is described in US2011 / 046186, and M.28.5L) is described in WO2012 / 034403. M.28.6 can be found in WO2012 / 034472. M.UN.3 is known from WO2006 / 089633, and M.UN.4 is known from WO2008 / 067911. M.UN.5 is described in WO2006 / 043635, and biological regulators based on Bacillus firmus are described in WO2009 / 124707. Flupyrimin is described in WO 2012/029672. M.UN.8 is known from WO2013 / 055584. M.UN.9.a) is described in WO2013 / 050317. M.UN.9.b) is described in WO2014 / 126208. M.UN.10 is known from WO2010 / 060379. Broflanilide and M.UN.11.b) to M.UN.11.h) are listed in WO2010 / 018714, and M.UN.11.i) to M.UN.11.p) , WO 2010/127926. M.UN.12.a) to M.UN.12.c) are known from WO2010 / 006713, and M.UN.12.d) and M.UN.12.e) are known from WO2012 / 000896. be. M.UN.14a) and M.UN.14b) are known from WO2007 / 101369. M.UN.16.a) to M.UN.16h) are described in WO2010 / 034737, WO2012 / 084670, and WO2012 / 143317, respectively, and M.UN.16i) and M.UN.16j) are , WO2015 / 055497. M.UN.17a) to M.UN.17.j) are described in WO 2015/038503. M.UN.18 tyclopyrazoflor is described in US 2014/0213448. M.UN.19 is described in WO2014 / 036056. M.UN.20 is known from WO2014 / 090918. M.UN.21 is known from EP2910126. M.UN.22a and M.UN.22b are known from WO2015 / 059039 and WO2015 / 190316. M.UN.23a and M.UN.23b are known from WO2013 / 050302. M.UN.24a and M.UN.24b are known from WO2012 / 126766. Acynonapyr M.UN.25 has been known since WO 2011/105506. Benzpyrimoxan M.UN.26 is known from WO2016 / 104516. M.UN.27 is known from WO2016174049. M.UN.28 Oxazosulfyl has been known since WO2017 / 104592. M.UN.29a) to M.UN.29f) are known from WO2009 / 102736 or WO2013116053. M.UN.30 is known from WO2013 / 050302. M.UN.30a) to M.UN.30k) are known from WO2018 / 052136.

The list of disinfectants below that can be used with the mixtures of the invention is intended to illustrate the possibilities of combination in the methods according to the invention and does not impose any restrictions:

A) Respiratory inhibitors
--Complex III inhibitors at the Qo site: azoxystrobin (A.1.1), coumethoxystrobin (A.1.2), coumoxystrobin (A.1.3), dimo Dimoxystrobin (A.1.4), enestroburin (A.1.5), fenaminstrobin (A.1.6), fenoxystrobin / flufenoxystrobin (A.1.7), fluoxastrobin (A.1.8), cresoxim-methyl (A.1.9), mandestrobin (A.1.10), metominostrobin ) (A.1.11), orysastrobin (A.1.12), picoxystrobin (A.1.13), pyraclostrobin (A.1.14), pyrametostrobin (A) .1.15), pyraoxystrobin (A.1.16), trifloxystrobin (A.1.17), 2 (2- (3- (2,6-dichlorophenyl) -1-methyl-ant Redenaminooxymethyl) -phenyl) -2-methoxyimino-N-methyl-acetamide (A.1.18), pyribencarb (A.1.19), trilopyricarb / chlorodincarb (A) 1.20), famoxadone (A.1.21), fenamidone (A.1.21), methyl-N- [2-[(1,4-dimethyl-5-phenyl-pyrazol-3-yl) oxyl Methyl] phenyl] -N-methoxy-carbamate (A.1.22), methyltetrapole (A.1.25), (Z, 2E) -5- [1- (2,4-dichlorophenyl) pyrazole-3- Il]-Oxy-2-Methyl Siimino-N, 3-dimethyl-penta-3-enamide (A.1.34), (Z, 2E) -5- [1 (4-chlorophenyl) pyrazole-3-yl] oxy-2-methoxyimino-N, 3 -Dimethyl-penta-3-enamide (A.1.35), pyriminostrobin (A.1.36), bifujunzhi (A.1.37), 2- (ortho-((2,5-dimethylphenyl)) -Oxymethylene) Phenyl) -3-Methoxy-Acrylic acid methyl ester (A.1.38);

-Complex III inhibitors at the Qi site: cyazofamid (A.2.1), amisulbrom (A.2.2), [(6S, 7R, 8R) -8-benzyl-3-[(3-hydroxy) -4-Methoxy-pyridin-2-carbonyl) amino] -6-methyl-4,9-dioxo-1,5-dioxonan-7-yl] -2-methylpropanoate (A.2.3), fempicoxa Mid (fenpicoxamid) (A.2.4), florylpicoxamid (A.2.5);

-Complex II inhibitors: benodanil (A.3.1), benzovindiflupyr (A.3.2), bixafen (A.3.3), boscalid (A.3.4), Carboxin (A.3.5), fenfuram (A.3.6), fluopyram (A.3.7), flutolanil (A.3.8), fluxapyroxad (A) .3.9), furametpyr (A.3.10), isofetamid (A.3.11), isopyrazam (A.3.12), mepronil (A.3.13), oxycarboxin (A.3.14), penflufen (A.3.15), penthiopyrad (A.3.16), pydiflumetofen (A.3.17), pyraziflumid (A.3.18), sedaxan (sedaxane) (A.3.19), tecloftalam (A.3.20), thifluzamide (A.3.21), impyrfluxam (A.3.22), pyrapropoyne (A.3.23) ), Fluindapyr (A.3.28), N- [2- [2-chloro-4- (trifluoromethyl) phenoxy] phenyl] -3- (difluoromethyl) -5-fluoro-1-methyl-pyrazole -4-Carboxamide (A.3.29), Methyl (E) -2- [2-[(5-Cyano-2-methyl-phenoxy) methyl] phenyl] -3-methoxy-propa-2-enoate (A.3.30) ), Isoflucypram (A.3.31), 2- (difluoromethyl) -N- (1,1,3-trimethyl-indan-4-yl) pyridine-3-carboxamide (A.3.32), 2 -(Difluoromethyl) -N-[(3R) -1,1,3-trimethylindan-4-yl] pyridine-3-carboxamide (A.3.33), 2- (difluoromethyl) Le) -N- (3-Ethyl-1,1-dimethyl-indan-4-yl) Pyridine-3-Carboxamide (A.3.34), 2- (Difluoromethyl) -N-[(3R) -3-ethyl -1,1-dimethyl-indan-4-yl] Pyridine-3-carboxamide (A.3.35), 2- (difluoromethyl) -N- (1,1-dimethyl-3-propyl-indan-4-yl) Pyridine-3-carboxamide (A.3.36), 2- (difluoromethyl) -N-[(3R) -1,1-dimethyl-3-propyl-indan-4-yl] Pyridine-3-carboxamide (A.3.37) ), 2- (Difluoromethyl) -N- (3-isobutyl-1,1-dimethyl-indan-4-yl) pyridin-3-carboxamide (A.3.38), 2- (difluoromethyl) -N-[(( 3R) -3-isobutyl-1,1-dimethyl-indan-4-yl] pyridine-3-carboxamide (A.3.39);

-Other respiratory inhibitors: diflumetorim (A.4.1); nitrophenyl derivatives: binapacryl (A.4.2), dinobuton (A.4.3), dinocap (A.4.4) , Fluazinam (A.4.5), meptyldinocap (A.4.6), ferimzone (A.4.7); organic metal compounds: fentin salts, eg fentin-acetate ( fentin-acetate (A.4.8), fentin chloride (A.4.9) or fentin hydroxide (A.4.10); ametoctradin (A.4.11); silthiofam ) (A.4.12);

B) Sterol biosynthesis inhibitor (SBI fungicide)
--C14 demethylase inhibitors: triazoles: azaconazole (B.1.1), bitertanol (B.1.2), bromuconazole (B.1.3), cyproconazole (B.1.4), diphenoconazole (B.1.5), diniconazole (B.1.6), diniconazole-M (diniconazole-M) (B.1.7), epoxyconazole (B.1.8) ), Fenbuconazole (B.1.9), fluquinconazole (B.1.10), flusilazole (B.1.11), flutriafol (B.1.12), hexaco Nazole (hexaconazole) (B.1.13), imibenconazole (B.1.14), ipconazole (B.1.15), metconazole (metconazole) (B.1.17), microbutanil (myclobutanil) (B.1.18) ), Oxpoconazole (B.1.19), paclobutrazol (B.1.20), penconazole (B.1.21), propiconazole (B.1.22), Prothioconazole (B.1.23), simeconazole (B.1.24), tebuconazole (B.1.25), tetraconazole (B.1.26), triadimefon (B) 1.27), triadimenol (B.1.28), triticonazole (B.1.29), uniconazole (B.1.30), 2- (2,4-difluorophenyl) -1 , 1-Difluoro-3- (tetrazol-1-yl) -1- [5- [4- (2,2,2-trifluoroethoxy) fu Enyl] -2-pyridyl] Propyl-2-ol (B.1.31), 2- (2,4-difluorophenyl) -1,1-difluoro-3- (tetrazol-1-yl) -1- [5- [4- (Trifluoromethoxy) phenyl] -2-pyridyl] Propyl-2-ol (B.1.32), 4-[[6- [2- (2,4-difluorophenyl) -1,1-difluoro- 2-Hydroxy-3- (5-sulfanyl-1,2,4-triazole-1-yl) propyl] -3-pyridyl] oxy] benzonitrile (B.1.33), ipfentrifluconazole (B.1.37), Mefentrifluconazole (B.1.38), 2- (chloromethyl) -2-methyl-5- (p-trilmethyl) -1- (1,2,4-triazole-1-ylmethyl) cyclopentanol (B.1.43); imidazoles: imidazoles (imazalil) (B.1.44), pefurazoate (B.1.45), prochloraz (B.1.46), triflumizol (B.1) 1.47); pyrimidines, pyridines, piperazines: fenarimol (B.1.49), pyrifenox (B.1.50), triforine (B) .1.51), [3- (4-Chloro-2-fluoro-phenyl) -5- (2,4-difluorophenyl) isooxazole-4-yl]-(3-pyridyl) methanol (B.1.52);

-Delta 14-Reductase Inhibitors: aldimorph (B.2.1), dodemorph (B.2.2), dodemorph-acetate acetate (B.2.3), fenpropimorph (B. 2.4), tridemorph (B.2.5), fenpropidin (B.2.6), piperalin (B.2.7), spiroxamine (B.2.8);

-3-Ketreductase inhibitor: fenhexamid (B.3.1);

-Other sterol biosynthesis inhibitors: chlorphenomizole (B.4.1);

C) Nucleic acid synthesis inhibitor
-Phenylamides or acyl amino acid fungicides: benaraxyl (C.1.1), benalaxyl-M (benalaxyl-M) (C.1.2), kiralaxyl (C. 1.3), metalaxyl (C.1.4), metalaxyl-M (C.1.5), offurace (C.1.6), oxadixyl (C.1.7);

-Other nucleic acid synthesis inhibitors: hymexazole (C.2.1), octhilinone (C.2.2), oxolinic acid (C.2.3), bupirimate (C.2.4), 5-fluorocytosine (C.2.5), 5-fluoro-2- (p-tolylmethoxy) pyrimidine-4-amine (C.2.6), 5-fluoro-2- (4-fluorophenylmethoxy) ) Pyrimidine-4-amine (C.2.7), 5-fluoro-2- (4-chlorophenylmethoxy) pyrimidine-4-amine (C.2.8);

D) Cell division and cytoskeletal inhibitors
--Tubulin inhibitors: benomyl (D.1.1), carbendazim (D.1.2), fuberidazole (D.1.3), thiabendazole (D.1.4), thiophanate-methyl (thiophanate-methyl) (D.1.5), pyridachlometyl (D.1.6), 3-chloro-6-methyl-5-phenyl-4-(2,4,6-trifluorophenyl) pyridazine ( D.1.7), N-ethyl-2-[(3-ethynyl-8-methyl-6-quinolyl) oxy] butaneamide (D.1.8), N-ethyl-2-[(3-ethynyl-8-methyl-) 6-quinolyl) oxy] -2-methylsulfanyl-acetamide (D.1.9), 2-[(3-ethynyl-8-methyl-6-quinol-yl) oxy] -N- (2-fluoroethyl) butaneamide ( D.1.10), 2-[(3-Ethynyl-8-methyl-6-quinolyl) oxy] -N- (2-fluoroethyl) -2-methoxy-acetamide (D.1.11), 2-[(3-3-quinolyl) oxy] Ethynyl-8-methyl-6-quinolyl) oxy] -N-propyl-butanamide (D.1.12), 2-[(3-ethynyl-8-methyl-6-quinolyl) oxy] -2-methoxy-N-propyl -Acetamide (D.1.13), 2-[(3-Ethynyl-8-methyl-6-quinolyl) oxy] -2-methylsulfanyl-N-propyl-acetamide (D.1.14), 2-[(3-Etinyl) -8-Methyl-6-quinolyl) oxy] -N- (2-fluoroethyl) -2-methylsulfanyl-acetamide (D.1.15), 4- (2-bromo-4-fluoro-phenyl) -N-( 2-Chloro-6-fluoro-phenyl) -2,5-dimethyl-pyrazol-3 amine (D.1.16);

-Other cell division inhibitors: diethofencarb (D.2.1), ethaboxam (D.2.2), peniccuron (D.2.3), fluopicolide (D.2.4), zoxamide (zoxamide) zoxamide (D.2.5), metrafenone (D.2.6), pyriofenone (D.2.7), phenamacril (D.2.8);

E) Amino acid and protein synthesis inhibitors
-Methionine synthesis inhibitors: cyprodinil (E.1.1), mepanipyrim (E.1.2), pyrimethanil (E.1.3);

-Protein synthesis inhibitors: blasticidin-S (E.2.1), kasugamycin (E.2.2), kasugamycin hydrochloride-hydrate (E.2.3), mill Diomycin (mildiomycin) (E.2.4), streptomycin (E.2.5), oxytetracyclin (E.2.6);

F) Signal transduction inhibitor
-MAP / histidine kinase inhibitors: fluoroimid (F.1.1), iprodione (F.1.2), procymidone (F.1.3), vinclozolin (F.1.4), fludioxonyl (fludioxonil) (F.1.5);
-G protein inhibitor: quinoxyfen (F.2.1);

G) Lipid and membrane synthesis inhibitors
-Phospholipid biosynthesis inhibitors: edifenphos (G.1.1), iprobenfos (G.1.2), pyrazophos (G.1.3), isoprothiolane (G.1.4);

-Lipid peroxidation: dichloran (G.2.1), quintozene (G.2.2), tecnazene (G.2.3), tolclofos-methyl (G) .2.4), biphenyl (G.2.5), chloroneb (G.2.6), etridiazole (G.2.7), zinc thiazole (G.2.8);

-Phospholipid biosynthesis and cell wall deposition: dimethomorph (G.3.1), flumorph (G.3.2), mandipropamid (G.3.3), pyrimorph (G.3.4), bench Benthia valicarb (G.3.5), iprovalicarb (G.3.6), valifenalate (G.3.7);

-Compounds that affect cell membrane permeability and fatty acids: propamocarb (G.4.1);

--Inhibitors of oxysterol binding proteins: oxathia piprolin (G.5.1), fluoxapiprolin (G.5.3), 4- [1- [2- [3- (difluoromethyl)) -5-Methyl-pyrazol-1-yl] acetyl] -4-piperidyl] -N-tetraline-1-yl-pyridine-2-carboxamide (G.5.4), 4- [1- [2- [3,5) -Bis (difluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetraline-1-yl-pyridine-2-carboxamide (G.5.5), 4- [1- [2- [3- [3- (Difluoromethyl) -5- (trifluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetralin-1-yl-pyridine-2-carboxamide (G.5.6), 4- [1- [2- [5-Cyclopropyl-3- (difluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetralin-1-yl-pyridine-2-carboxamide (G.5.7), 4- [1- [2- [5-Methyl-3- (trifluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetralin-1-yl-pyridine-2-carboxamide (G.5.8) , 4- [1- [2- [5- (difluoromethyl) -3- (trifluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetraline-1-yl-pyridine-2- Carboxamide (G.5.9), 4- [1- [2- [3,5-bis (trifluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetraline-1-yl-pyridine- 2-Carboxamide (G.5.10), (4- [1- [2- [5-Cyclopropyl-3- (trifluoromethyl) pyrazole-1-yl] acetyl] -4-piperidyl] -N-tetraline-1 -Il-pyridine-2-carboxamide (G.5.11);

H) Multisite inhibitor
-Inorganic active substance: Bordeaux mixture (H.1.1), copper (H.1.2), copper acetate (H.1.3), copper hydroxide (H.1.4), copper oxychloride (H.1.5) , Basic copper sulfate (H.1.6), Sulfur (H.1.7);

-Thio- and dithiocarbamates: ferbam (H.2.1), mancozeb (H.2.2), maneb (H.2.3), metam (metam) (H) .2.4), metiram (H.2.5), propineb (H.2.6), thiram (H.2.7), zineb (H.2.8), ziram (H.2.8) .2.9);

-Organochlorine compounds: anilazine (H.3.1), chlorothalonil (H.3.2), captafol (H.3.3), captan (H.3.4), folpet (H.3.5), dichlofluanid (H.3.6), dichlorophen (H.3.7), hexachlorobenzene (H.3.8), pentachlorphenole (H.3.9) ) And its salts, phthalide (H.3.10), tolylfluanid (H.3.11);

-Guanidines and others: guanidine (H.4.1), dodine (H.4.2), dodine free base (H.4.3), guazatine (H. 4.4), guazatine-acetate (H.4.5), iminoctadine (H.4.6), iminoctadine-triacetate (H.4.7), iminoctadine-tris (iminoctadine-tris) Albesilate) (H.4.8), dithianon (H.4.9), 2,6-dimethyl-1H, 5H- [1,4] dithino [2,3-c: 5,6-c' ] Dipyrrole-1,3,5,7 (2H, 6H) -Tetraone (H.4.10);

I) Cell wall synthesis inhibitor
-Glucan synthesis inhibitors: validamycin (I.1.1), polyoxin B (I.1.2);

-Melanin synthesis inhibitors: pyroquilon (I.2.1), tricyclazole (I.2.2), carpropamid (I.2.3), dicyclomet (I.2.4), fenoxanil (I.2.5);

J) Plant defense inducer
-Acibenzolar-S-methyl (J.1.1), probenazole (J.1.2), isotianil (J.1.3), tiadinil (J.1.4), pro Hexadione-calcium (J.1.5); Phosphonates: fosetyl (J.1.6), fosetyl-aluminum (J.1.7), phosphorous acid (phosphorous) acid) and its salts (J.1.8), calcium phosphate (J.1.11), potassium phosphate (J.1.12), potassium bicarbonate or sodium (J.1.9), 4-cyclopropyl-N- (2,4-) Dimethoxyphenyl) thiazizol-5-carboxamide (J.1.10);

K) The mechanism of action is unknown
-Bronopol (K.1.1), chinomethionat (K.1.2), cyflufenamid (K.1.3), cymoxanil (K.1.4), dazomet (K.1.5) , Debacarb (K.1.6), diclocymet (K.1.7), diclomezine (K.1.8), difenzoquat (K.1.9), difenzoquat-methylsulfate ) (K.1.10), diphenylamin (K.1.11), fenitropan (K.1.12), fenpyrazamine (K.1.13), flumetover (K.1.14), flusulfamide (K.1.14) flusulfamide (K.1.15), flutianil (K.1.16), harpin (K.1.17), methasulfocarb (K.1.18), nitrapyrin (K.1.19), Nitrothal-isopropyl (K.1.20), tolprocarb (K.1.21), oxin-copper (K.1.22), proquinazid (K.1.23), tebufloquin ) (K.1.24), tecloftalam (K.1.25), triazoxide (K.1.26), N'-(4- (4-chloro-3-trifluoromethyl-phenoxy) -2,5 -Dimethyl-phenyl) -N-ethyl-N-methylformamidine (K.1.27), N'-(4- (4-fluoro-3-trifluoromethyl-phenoxy) -2,5-dimethyl-phenyl)- N-Ethyl-N-Methylformamidine (K.1.28), N'-[4-[[3-[(4-Chlorophenyl) Methyl] -1,2,4-thiazazole-5-yl] oxy] -2 , 5-Dimethyl-phenyl] -N-ethyl-N-methyl-formamidine (K.1.29) , N'-(5-Bromo-6-indan-2-yloxy-2-methyl-3-pyridyl) -N-ethyl-N-methyl-formamamiden (K.1.30), N'-[5-Bromo- 6- [1- (3,5-difluorophenyl) ethoxy] -2-methyl-3-pyridyl] -N-ethyl-N-methyl-formamidine (K.1.31), N'-[5-bromo-6 -(4-Isopropylcyclohexoxy) -2-methyl-3-pyridyl] -N-ethyl-N-methyl-formamidine (K.1.32), N'-[5-bromo-2-methyl-6- (1) -Phenyl-ethoxy) -3-pyridyl] -N-ethyl-N-methyl-formamidine (K.1.33), N'-(2-methyl-5-trifluoromethyl-4- (3-trimethylsilanyl-) Propoxy) -phenyl) -N-ethyl-N-methylformamidine (K.1.34), N'-(5-difluoromethyl-2-methyl-4- (3-trimethylsilanyl-propoxy) -phenyl) -N -Ethyl-N-Methylformamidine (K.1.35), 2- (4-Chloro-phenyl) -N- [4- (3,4-dimethoxy-phenyl) -isoxazole-5-yl] -2-propa -2-Inyloxy-acetamide (K.1.36), 3- [5- (4-chloro-phenyl) -2,3-dimethyl-isooxazolidine-3-yl] -pyridine (pyrisoxazole) (K.1.37), 3 -[5- (4-Methylphenyl) -2,3-dimethyl-isooxazolidin-3-yl] -pyridine (K.1.38), 5-chloro-1 (4,6-dimethoxy-pyrimidine-2-yl) -2-Methyl-1H-benzoimidazole (K.1.39), ethyl (Z) 3-amino-2-cyano-3-phenyl-propa-2-enoate (K.1.40), picarbutrazox (picarbutrazox) ( K.1.41), Pentyl-N- [6-[[(Z)-[(1-Methyltetrazole-5-yl) -phenyl-methylene] amino] oxymethyl] -2-pyridyl] carbamate (K.1.42) , Buta-3-inyl N- [6-[[(Z)-[(1-methyltetrazole-5-yl) -phenyl-methylene] amino] oxymethyl] -2-pyridyl] carbamate (K.1.43), Ipflufenoquin (K.1.44), quinofumelin (K.1) .47), benzoisothiazolinone (K.1.48), bromothalonil (K.1.49), 2- (6-benzyl-2-pyridyl) quinazoline (K.1.50), 2- [6- (3-Fluoro-4-methoxy-phenyl) -5-methyl-2-pyridyl] quinazoline (K.1.51), dichlobentiazox (K.1.52), N'-(2,5-dimethyl- 4-Phenoxy-phenyl) -N-ethyl-N-methyl-formamidine (K.1.53), pyrifenamine (K.1.54), fluopimomide (K.1.55), N'-[5-bromo -2-Methyl-6- (1-Methyl-2-propoxy-ethoxy) -3-pyridyl] -N-ethyl-N-methyl-formamidine (K.1.56).

The fungicides described by generic names, their preparation and their activity against harmful fungi are known (http://www.alanwood.net/pesticides/) and these substances are commercially available. The fungicides described by the IUPAC nomenclature, their preparation and their pesticidal activity are also known (Can. J. Plant Sci. 48 (6), 587-94, 1968; EP-A 141 317; EP-A 152 031; EP-A 226 917; EP-A 243 970; EP-A 256 503; EP-A 428 941; EP-A 532 022; EP-A 1 028 125; EP-A 1 035 122; EP-A 1 201 648; EP-A 1 122 244, JP 2002316902; DE 19650197; DE 10021412; DE 102005009458; US 3,296,272; US 3,325,503; WO 98/46608; WO 99/14187; WO 99/24413; WO 99 / 27783; WO 00/29404; WO 00/46148; WO 00/65913; WO 01/54501; WO 01/56358; WO 02/22583; WO 02/40431; WO 03/10149; WO 03/11853; WO 03 / 14103; WO 03/16286; WO 03/53145; WO 03/61388; WO 03/66609; WO 03/74491; WO 04/49804; WO 04/83193; WO 05/120234; WO 05/123689; WO 05 / 123690; WO 05/63721; WO 05/87772; WO 05/87773; WO 06/15866; WO 06/87325; WO 06/87343; WO 07/82098; WO 07/90624, WO 10/139271, WO 11 / 028657, WO12 / 168188, WO07 / 006670, WO11 / 77514; WO13 / 047749, WO 10/069882, WO 13/047441, WO 03/16303, WO 09/90181, WO 13/007767, WO 13/010862, WO 13 / 127704, WO 13/024009, WO 13/024010, WO 13/047441, WO 13/162072, WO 13/092224, WO 11/135833), CN 1907024, CN 1456054, CN 103387541, CN 1309897, WO 12/8481 2, CN 1907024, WO 09094442, WO 14/60177, WO 13/116251, WO 08/013622, WO 15/65922, WO 94/01546, EP 2865265, WO 07/129454, WO 12/165511, WO 11/081174 , WO 13/47441 WO 16/156241, WO 16/162265)). Some compounds are identified by their CAS Registry Number, which is divided by a hyphen into three parts (first consisting of 2-7 digits, 2nd consisting of 2 digits, and 3rd consisting of 1 digit).

When the mixture of the present invention is mixed with one or more bactericides, the mixture is also suitable for the control or control of plant diseases caused by phytopathogenic fungi. Examples of phytopathogenic fungi in rice are: Alternaria species in rice, Bipolaris (eg, Bipolaris oryzae), and Drechslera in rice. species), Cercospora oryzae, Cochliobolus miyabeanus, Curvularia lunata, Sarocladium oryzae, S. attenuatum oren , Fusarium spp, eg Fusarium semitectum (and / or moniliforme), Gibberella fujikuroi (bakanae), grain-staining complex (Grainstaining complex) (various pathogens) and / or species of the genus Pythium ssp, species of the genus Helminthosporium. Spp, such as Helminthosporium oryzae. , Microdochium oryzae, Pyricularia grisea (syn. Pyricularia oryzae), Rhizoctonia species, for example, in Rhizoctonia solani (syn rice) Sasakii (Pellicularia sasakii), Corticium sasakii and Ustilaginoidea virens.

Formulation The present invention also relates to a method in which a compound of a mixture according to the present invention is provided and applied in an agrochemical composition containing an auxiliary agent and the mixture according to the present invention. The compounds may be present together in one formulation (for simultaneous use and) or in two separate formulations (for mixing immediately prior to simultaneous application or for separate application). You may.

Agricultural chemical compositions include effective amounts of pesticides of the compounds of the invention or mixtures thereof. The term "effective amount of pesticide" is defined below.

Mixtures of the invention are, for example, solutions, emulsions, suspensions, dusts, powders, pastes, gramules, compressors. It can be converted to conventional types of pesticide compositions such as (pressings), capsules and mixtures thereof. Examples of composition types are suspensions (eg SC, OD, FS), emulsifier concentrates (eg EC), emulsions (eg EW, EO, ES, ME), capsules (eg EW, EO, ES, ME). , CS, ZC), pastes, pastelles, wettable powders or wettable dusts (eg WP, SP, WS, DP, DS), compressors (eg BR) , TB, DT), granules (eg, WG, SG, GR, FG, GG, MG), insecticidal articles (eg, LN), and gels for the treatment of plant breeding materials, eg seeds. It is a gel emulsion (eg, GF). The types of these and additional compositions are defined in "Catalogue of pesticide formulation types and international coding system", Technical Monograph No. 2, 6th Edition May 2008, CropLife International.

The compositions are prepared, for example, by the known methods described in Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001, or Knowles, New developments in crop protection product formulation, Agrow Reports DS243, T & F Informa, London, 2005. Will be done.

Examples of suitable auxiliaries are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetters, auxiliaries, solubilizers, penetration enhancers, protective colloids, binders. (Adhesion agent), thickener, moisturizer, repellent, attractant, feeding promoter, compatibilizer, antibacterial agent, antifreeze, antifoaming agent, colorant, adhesive and binder.

Suitable solvents and liquid carriers are water and organic solvents such as medium to high boiling mineral oil fractions such as kerosine, diesel oil, plant or animal derived oils, toluene, paraffin, tetrahydronaphthalene, alkylated naphthalene and other fats. Group, cyclic and aromatic hydrocarbons, ethanol, propanol, butanol, benzyl alcohol, alcohols such as cyclohexanol, glycols, DMSO, ketones such as cyclohexanone, lactic acid ester, carbonate ester, fatty acid ester, gamma-butyrolactone, etc. Esters, fatty acids, phosphonates, amines, amides such as N-methylpyrrolidone, fatty acid dimethylamide, and mixtures thereof.

Suitable solid carriers or fillers include, for example, silicate, silica gel, talc, kaolin, limestone, lime, flour, clay, dolomite, diatomaceous soil, bentonite, calcium sulfate, magnesium sulfate, magnesium oxide and other mineral soils, cellulose, starch and the like. Polysaccharide powder, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate and urea, plant-derived products such as cereal flour, bark flour, wood flour and fruit husk flour, and mixtures thereof.

Suitable surfactants are surfactants such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifiers, dispersants, solubilizers, wetting agents, penetration enhancers, protective colloids or auxiliary agents. Examples of surfactants are listed in McCutcheon's, Vol.1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International Ed. Or North American Ed.).

Suitable anionic surfactants are sulfonates, sulfates, phosphates, alkalis of carboxylates, alkaline earth or ammonium salts, and mixtures thereof. Examples of sulfonates are alkylaryl sulphonates, diphenyl sulphonates, alpha-olefin sulphonates, lignin sulphonates, fatty acid and fatty oil sulphonates, ethoxylated alkylphenol sulphonates, alkoxylated arylphenol sulphonates, condensed naphthalene sulphonates, dodecyl- and tridecyl. Benzene sulfonate, naphthalene and alkylnaphthalene sulfonate, sulfosuccinate or sulfosuccinamate. Examples of sulphates are fatty acid and fatty oil sulphates, ethoxylated alkylphenol sulphates, alcohol sulphates, ethoxylated alcohol sulphates or fatty acid ester sulphates. An example of phosphate is a phosphate ester. Examples of carboxylates are alkyl carboxylates and alcohols carboxylated or alkylphenol ethoxylates.

Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters, which are alkoxylated with 1 to 50 equivalents. Ethylene oxide and / or propylene oxide, preferably ethylene oxide, can be used for the alkoxylation. Examples of N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides. Examples of esters are fatty acid esters, glycerol esters or monoglycerides. Examples of sugar-based surfactants are sorbitan, sorbitan ethoxylated, sucrose and glucose esters, or alkyl polyglucosides. Examples of polymeric surfactants are homo or copolymers of vinylpyrrolidone, vinyl alcohol or vinyl acetate.

Suitable cationic surfactants are, for example, quaternary surfactants such as quaternary ammonium compounds having one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are alkyl betaine and imidazoline. Suitable block polymers are A-B or A-B-A type block polymers containing blocks of polyethylene oxide and polypropylene oxide, or A-B-C type block polymers containing alkanol, polyethylene oxide and polypropylene oxide. Suitable polymeric electrolytes are polyacids or polybases. Examples of polyacids are polyacrylic acid or alkali salts of polyacid comb polymers. Examples of polybases are polyvinylamine or polyethyleneamine.

Suitable auxiliaries are compounds that themselves have negligible or no pesticidal activity and improve the biological action of the mixture of the invention on the target. .. Examples are surfactants, mineral or vegetable oils, and other auxiliaries. Further examples are listed in Knowles, Adjuvants and salts, Agrow Reports DS256, T & F Informa UK, 2006, chapter 5.

Suitable thickeners are polysaccharides (eg, xanthan gum, carboxymethyl cellulose), inorganic clays (organically modified or unmodified clays), polycarboxylates, and silicates.

Suitable bacterial killers are bronopol and isothiazolinone derivatives such as alkylisothiazolinone and benzisothiazolinone.

Suitable antifreeze agents are ethylene glycol, propylene glycol, urea and glycerin.

Suitable antifoaming agents are salts of silicones, long chain alcohols and fatty acids.

Suitable colorants (eg, red, blue or green) are low water-soluble pigments and water-soluble dyes. Examples are inorganic colorants (eg iron oxide, titanium oxide, iron hexacyanoferrate) and organic colorants (eg alizarin-, azo-, and phthalocyanine colorants).

Suitable pressure-sensitive adhesives or binders are polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol, polyacrylates, biological or synthetic waxes, and cellulose ethers.

Examples of composition types and their preparation are as follows.

i) water-soluble concentrate (SL, LS)
10-60% by weight of Compound I or II or a mixture according to the invention and 5-15% by weight of a wetting agent (eg, alcohol alkoxylate) are dissolved in water and / or a water-soluble solvent (eg, alcohol). Make it 100% by weight. The active substance dissolves when diluted with water.

ii) Dispersible concentrate (DC)
100% by weight of 5 to 25% by weight of Compound I or II according to the invention or a mixture according to the present invention and 1 to 10% by weight of a dispersant (eg, polyvinylpyrrolidone) dissolved in an organic solvent (eg, cyclohexanone). To. A dispersion is obtained by diluting with water.

iii) Emulsifiable concentrate (EC)
15-70% by weight of Compound I or II or mixture according to the invention, and 5-10% by weight of emulsifier (eg, calcium dodecylbenzenesulfonate and castor oil ethoxylate) in a water-insoluble organic solvent (eg, aromatic). Dissolve in (hydrocarbon) to 100% by weight. Dilution with water gives an emulsion.

iv) Emulsion agent (EW, EO, ES)
5-40% by weight of Compound I or II according to the invention or a mixture according to the present invention, and 1-10% by weight of emulsifier (eg, calcium dodecylbenzenesulfonate and castor oil ethoxylate), 20-40% by weight non-. It dissolves in water-soluble organic solvents (eg, aromatic hydrocarbons). This mixture is introduced into water by an emulsifying device to 100% by weight to form a uniform emulsion. Dilution with water gives an emulsion.

v) Suspension (SC, OD, FS)
In a stirred ball mill, add 20-60% by weight of Compound I or II or mixture according to the invention to 2-10% by weight of dispersant and wetting agent (eg, sodium lignosulfonate and alcohol ethoxylate), 0.1-2. Addition of a thickening agent (eg, xanthan gum) by weight and 100% by weight of water and grinding to obtain a fine suspension of the active substance. Dilution with water gives a stable suspension of the active material. For FS type compositions, up to 40% by weight of binder (eg, polyvinyl alcohol) is added.

vi) Water-dispersible granules and water-soluble granules (WG, SG)
50-80% by weight of Compound I or II or a mixture according to the present invention is finely ground by adding up to 100% by weight of a dispersant and a wetting agent (for example, sodium lignosulfonate and alcohol ethoxylate), and a dedicated apparatus (for example). For example, an extruder, a spray tower, a fluidized bed) are used to prepare water-dispersible granules or water-soluble granules. Dilution with water gives a stable dispersion or solution of the active substance.

vii) Water-dispersible powder and water-soluble powder (WP, SP, WS)
In a rotor stator mill, 50-80% by weight of compound I or II or mixture according to the invention 1-5% by weight dispersant (eg, sodium lignosulfonate), 1-3% by weight wetting agent (eg, eg). Alchol ethoxylate) and up to 100% by weight solid support (eg silica gel) are added and ground. Dilution with water gives a stable dispersion or solution of the active substance.

viii) Gel (GW, GF)
In a stirred ball mill, 5-25% by weight of Compound I or II or mixture according to the invention, 3-10% by weight dispersant (eg, sodium lignosulfonate), 1-5% by weight thickener (eg, sodium lignosulfonate). For example, carboxymethyl cellulose) and up to 100% by weight of water are added and pulverized to obtain a fine suspension of the active substance. Dilution with water gives a stable suspension of the active material.

ix) Microemulsion (ME) or nanoemulsion
5-20% by weight of Compound I or II or a mixture according to the invention in a 5-30% by weight organic solvent blend (eg fatty acid dimethylamide and cyclohexanone), 10-25% by weight surfactant blend (eg alcohol ethoxy). Rate and arylphenol ethoxylates), and add up to 100% by weight water. Stirring this mixture for 1 hour naturally produces thermodynamically stable microemulsions.

x) Microcapsule (CS)
5-50% by weight of Compound I or II or mixture according to the invention, 0-40% by weight water-insoluble organic solvent (eg, aromatic hydrocarbons), 2-15% by weight acrylic monomer (eg, methyl methacrylate). , Methacrylic acid, and di or triacrylate) are dispersed in an aqueous solution of a protective colloid (eg, polyvinyl alcohol). Radical polymerization initiated by a radical initiator forms poly (meth) acrylate microcapsules. Alternatively, 5-50% by weight of Compound I or II or a mixture according to the invention, 0-40% by weight of a water-insoluble organic solvent (eg, aromatic hydrocarbon), and isocyanate monomer (eg, diphenylmethene-4,4). The oil phase containing'-diisocyanate) is dispersed in an aqueous solution of a protective colloid (eg, polyvinyl alcohol). Addition of polyamines (eg hexamethylenediamine) forms microcapsules of polyurea. Monomers total 1-10% by weight. % By weight is related to the total amount of CS composition.

xi) dustable powder (DP, DS)
Milling 1-10% by weight of Compound I or II or a mixture according to the invention and mixing well with up to 100% by weight of a solid support (eg, milled kaolin).

xii) Granule (GR, FG)
0.5-30% by weight of Compound I or II or mixture according to the invention is milled and combined with up to 100% by weight of solid support (eg, silicate). Granules are obtained by extrusion, spray drying, or fluidized bed.

xiii) Ultra-low volume liquid (UL)
1 to 50% by weight of Compound I or II or a mixture according to the invention is dissolved in an organic solvent (eg, aromatic hydrocarbon) to 100% by weight.

Composition types i) to xiii) include 0.1 to 1% by weight antibacterial agent, 5 to 15% by weight antifreeze, 0.1 to 1% by weight antifoaming agent, 0.1 to 1% by weight colorant, etc. Additional auxiliaries may optionally be included.

Agricultural chemical compositions generally contain the active substance in an amount of 0.01-95% by weight, preferably 0.1-90% by weight, most preferably 0.5-75% by weight. The active material is used with a purity of 90% to 100%, preferably 95% to 100% (according to NMR spectrum).

Various types of oils, wetting agents, auxiliaries, fertilizers or micronutrients, and other pesticides (eg, herbicides, pesticides, fungicides, growth regulators, toxicity mitigating agents) as a premix or If appropriate, it can be added to the active substance, or composition containing them, immediately prior to use (tank mixing). These agents can be mixed with the compositions according to the invention in a weight ratio of 1: 100 to 100: 1, preferably 1: 10 to 10: 1.

In one embodiment, the SC formulation (suspoconcentration (SC)) is preferred for application in crop protection. In one sub-embodiment, the SC pesticide composition is 50-500 g / L (grams / liter), or 100-250 g / L, or 100 g / L or 150 g / L or 200 g / L or 250 g /. Including L.

In a further embodiment, granules according to formulation type xii) are used for application in rice according to the present invention.

In a further embodiment, a Dispersible concentrate (DC) according to formulation type ii) is used for application in rice according to the present invention.

In a further embodiment, an emulsion concentrate (EC) according to formulation type iii) is used for application in rice according to the present invention. ix. ME).

In a further embodiment, a microemulsion (ME) according to the formulation type ix) is used for application in rice according to the present invention.

In a further embodiment, the nanoemulsion agent is used for application in rice according to the present invention.

The user typically applies the composition according to the invention from a pre-administration device, a backpack sprayer, a spray tank, a spray plane or an irrigation system. Usually, the pesticide composition is prepared to the desired application concentration with water, buffer and / or additional auxiliaries, thus obtaining a ready-to-use spray or pesticide composition according to the invention. Usually, 20-2000 liters, preferably 50-400 liters of ready-to-use spray liquid is applied per hectare of agricultural land.

According to one embodiment, the individual components of the composition according to the invention, eg, part of the kit or part of a mixture of two or three components, can be mixed by the user himself in the spray tank, which is suitable. If so, additional auxiliaries can be added.

In a further embodiment, each component of the composition according to the invention, or a component partially premixed, eg, a compound or mixture of the invention and / or a component comprising an additional mixing partner as defined above, is used by the user. May be mixed in a spray tank, and additional auxiliaries and additives may be added as appropriate.

In a further embodiment, each component of the composition according to the invention, or a component partially premixed, eg, a compound or mixture of the invention and / or a component comprising an additional mixing partner as defined above (eg,). May be applied together or continuously (after mixing the tanks).

Method of application The present invention also indicates that the mixture according to the present invention is a crop and a plant breeding material thereof, for example, seeds, particularly rice, rice plants, rice plant breeding materials, for example, seeds, or soil in which a plant or rice plant grows. Or related to methods suitable for use to protect water from attack or harm by pests or rice pests, especially rice pest invertebrates. Accordingly, the present invention also allows the growth of crops or plant breeding materials, rice, rice plants, rice plant breeding materials such as seeds, or plants that should be protected from attack or harm by rice pests, especially rice pest vertebrates. It also relates to methods of protecting plants, including the step of contacting the soil or water with the effective amount of pesticides according to the present invention.

The present invention is also a method of exterminating or controlling pests, especially rice pests, especially rice pests, and pests, especially rice pests, especially rice pests, their habitats, breeding. Crop and its plant reproductive materials, such as seeds, especially rice, rice plants, rice plants, where the land, or food source, or pests or rice pests, especially rice harmful invertebrates, grow or can grow. It also relates to a method comprising contacting a breeding material, such as seed, or soil or water, or an area, material or environment with an effective amount of a pesticide of the compound of the invention.

The mixtures of the present invention are effective in both contact and ingestion. In addition, the mixtures of the invention can be applied to any and all developmental stages, such as eggs, nymphs, pupae, and adults.

The mixtures of the present invention can be applied on their own or in the form of compositions containing them as defined above. In addition, the mixtures of the invention can be applied with additional mixing partners as defined above or in the form of compositions containing said mixtures as defined above. The components of the mixture can be applied simultaneously, together, separately or sequentially (which can be applied immediately one after the other so that the mixture is "in situ" in a desired location, eg, a plant. (Generated), can be applied, and the order in the case of separate applications generally has no effect on the results of the control measures.

The application is carried out both before and after the crop and its plant propagation materials, such as seeds, especially rice, rice plants, rice plant propagation materials, such as seeds, soil, or areas, materials or environmental pests. be able to.

Suitable application methods include, in particular, soil treatment, seed treatment, in-furrow application, water inlet application and foliar application. Soil treatment methods include soil irrigation, root immersion, or soil injection. Seed processing techniques include a seed powder coating method, a seed coating method, a seed powdering method, a seed dipping method, and a seed pelleting method. Ridge application usually involves the steps of creating furrows in the cultivated land, sowing seeds in the ridges, applying a pesticide-active compound to the ridges, and closing the ridges. Foliar application refers, for example, to the application of a pesticide-active compound to the foliage of a plant by a spraying device. For foliar application, it may be advantageous to alter the behavior of pests by using pheromones in combination with the mixtures of the invention. Suitable pheromones for specific crops and pests are known to those of skill in the art and are publicly available from databases of pheromones and semiochemicals (eg http://www.pherobase.com).

In the context of rice cultivation and rice crops, the following application types are particularly relevant:
--A "Granular application" is a direct application of an insecticidal granule or a mixture of an insecticide / fungicide and a nematode to a field or nursery box (either on the soil surface or on stored water). Includes manual or mechanical spraying or throwing. The granule preparation may be mixed with a filler, carrier or fertilizer to allow uniform distribution in the field.

―― “Floating packet application” refers to the application of a water-soluble sachet / packet of insecticide, or a mixture of insecticide / fungicide and nematode, by throwing it into the stored water of a paddy field. ..

—— “Seedling box application” refers to manual or mechanical incorporation of pesticides (eg granules, liquids) in seedling boxes or seedling boxes containing rice seedlings before they are transplanted to major fields. Point to.

—— “Seed treatment” includes the immersion / mixing of rice seeds in a solution of an insecticide or an insecticide / nematode / fungicide mixture. This application is performed either before sowing, before or after seed germination.

--"Foliar application" is an insecticide in water or oil, or an insecticide / fungicide / for spraying with various application devices (eg, knapsacks, power sprayers, boom sprayers, etc.) Refers to the application of nematodes / selective herbicides.

—— “Soil application” is the application of an insecticide or a mixture of insecticides / fungicides / nematodes / selective herbicides into the soil as an irrigation application, a water outlet application or a granule application. Point to.

―― “Aerial application” is the application of granules or liquids of pesticides or a mixture of pesticides / fungicides / nematodes / selective herbicides to fields using airplanes, helicopters or drones. Point to.

—— “Dust application” is a pesticide as a dust formulation, or a mixture of pesticides / fungicides / nematodes / selective herbicides, using a special applicator (eg power duster). Includes directed application of.

--A "Water inlet application" is a liquid of an insecticide or a mixture of an insecticide / fungicide / nematode / selective herbicide at the point where the irrigation water is discharged into the paddy field. The application of the drug.

―― “Encircling application” is a liquid or granular formulation of an insecticide or a mixture of an insecticide / fungicide / nematode / selective herbicide, clockwise or counterclockwise to the inner boundary of the paddy field. This type of application is applied to stored water in the clockwise direction.

Preferred applications are granule application, seedling box application and foliar application.

In one embodiment, the present invention relates to a method of applying a pesticide by applying granules.

In one embodiment, the present invention relates to a method of applying a pesticide by applying a seedling box.

In one embodiment, the present invention relates to a method of applying a pesticide by foliar application.

As used herein, the term "contact" refers to direct contact (the compound / composition is applied directly to an animal pest or plant (typically a plant leaf, stem or root)), and Indirect contact (compound / composition applied to the location of an animal pest or plant, i.e. a habitat, breeding ground, plant, seed, soil, area, material or environment in which the pest grows or can grow. ) Included.

In the context of the present invention, the term "animal pest" includes pests, especially rice pests (particularly rice pest invertebrates), especially the above-mentioned rice pests such as arthropods, abdominal feet, and nematodes. Arthropods are preferably insects and arachnids, especially insects. Insects, especially related insects, are typically referred to as crop insect pests or rice pests.

The term "crop" refers to both growing and harvested rice.

In the context of the present invention, the term "plant" preferably means a rice plant (Oryza species, preferably Oryza sativa). Two types of rice, Oryza sativa and Oryza glaberrima, are most frequently cultivated. Numerous variants of Oryza sativa are of commercial importance, such as Oryza sativa subsp. Indica, Oryza sativa subsp. Japonica, Oryza sativa subsp. Japonica, Oryza sativa subsp. Glutinosa (rice cake), Oryza sativa Aromatica group (eg bastati) ), And Oryza sativa (floating rice group). The term "plant" is understood to include wild-type plants and plants that have been modified by either conventional breeding or mutagenesis or genetic engineering, or a combination thereof.

Rice is a particularly commercially important plant that has been modified by mutagenesis or genetic engineering. In plants that have been mutagenic or genetically engineered, one or more genes have been mutated in the plant's genetic material or integrated into the plant's genetic material. One or more mutagenic or integrated genes are preferably pat, epsps, cry1Ab, bar, cry1Fa2, cry1Ac, cry34Ab1, cry35AB1, cry3A, cryF, cry1F, mcry3a, cry2Ab2, cry3Bb1, cry1A.105, It is selected from dfr, barnase, vip3Aa20, barstar, als, bxn, bp40, asn1 and ppo5. Mutation induction or integration of one or more genes is performed to improve certain properties of the plant. Such properties, also known as traits, include, for example, abiotic stress resistance, altered growth / yield, disease resistance, herbicide resistance, insect resistance, modified product quality, and pollination control. And so on. Of these properties, herbicide resistance, such as imidazolinone resistance, glyphosate resistance, or glufosinate resistance, is of particular importance.

Surprisingly, it has been found that the pesticidal activity of the mixtures of the invention can be enhanced by the modified plant insecticidal traits. In addition, the mixtures of the invention prevent pests that are already resistant to the insecticidal traits of the modified plant or to prevent insects from becoming resistant to the insecticidal traits. It has been found to be suitable for use. In addition, the mixture of the present invention is suitable for exterminating pests for which the insecticidal trait is not effective, so that complementary insecticidal activity can be advantageously used.

The term "plant propagation material" refers to all generative parts of a plant, such as seeds, germinated seeds, seedlings and seedlings. Seedlings and juveniles that are transplanted after germination or after germination from soil may also be included. These plant breeding materials can be prophylactically treated with phytoprotective compounds at or before planting or transplantation.

The term "seed" refers to seeds and phytotrophic breeders of all kinds (eg, but not limited to, genuine seeds, seed pieces, propagules, corms, fruits, grains, cuttings, cut shoots, etc.). In a preferred embodiment, it means a genuine seed.

In general, an "effective amount of pesticide" has an observable effect on growth (eg, necrosis, death, delay, prevention, and elimination, destruction of the target organism, or an effect of reducing the development and activity of the target organism). It means the amount of active ingredient needed to obtain. Effective amounts of pesticides can vary for the various compounds / compositions used in the present invention. The effective amount of pesticide of the composition will also vary depending on general conditions such as desired pesticide action and duration, weather, target species, whereabouts, mode of application.

For soil treatment, furrow application or application to the residence or nest of pests, the amount of active ingredient ranges from 0.0001 to 500 g per ^{100 m 2} and preferably 0.001 to 20 ^{g per 100 m 2.}

For use in the treatment of rice plants (eg by foliar application), the application dose of the active ingredient of the present invention is 0.0001 g to 4000 g per hectare, eg 1 g to 2 kg per hectare, or 1 g to 750 g per hectare. , Desirably 1 g-100 g per hectare, more preferably 10 g-50 g per hectare, eg 10-20 g per hectare, 20-30 g per hectare, 30-40 g per hectare, or 40-50 g per hectare. Can be within range.

The mixtures of the present invention are used in the treatment of seeds to protect seeds from insect pests, especially soil-dwelling insect pests, and the resulting seedling roots and streaks from soil pests and foliar insects. Especially suitable. Accordingly, the present invention is also a method for protecting seeds from insects, especially soil insects, and seedling roots and streaks from insects, especially soil insects and foliar insects. Also related to the above methods, which comprises treating the seeds before sowing and / or after pre-germination treatment with the compounds of the present invention. Protection of seedling roots and shoots is preferred. More preferred is the protection of seedling shoots from piercing and sucking insects, chewing insects and nematodes.

The term "seed treatment" refers to all suitable seed treatment techniques known in the art, such as seed flour coating, seed coating, seed flouring, seed dipping, seed pelleting, and furrow application. include. Preferably, the seed treatment application of the active compound is carried out by spraying or dusting the seeds before sowing the plant and before the emergence of the plant.

The present invention also includes seeds coated with an active compound or seeds containing an active compound. The term "coated with and / or contains" generally means that most of the active ingredient is on the surface of the breeding product at the time of application, but depending on the method of application, of the ingredients. Some may be more or less infiltrated into breeding products. When the breeding product is (re) planted, the breeding product can absorb the active ingredient.

In the context of the present invention, seeds are rice seeds. The active compounds of the present invention can also be used in the treatment of plant-derived seeds that have been mutagenic or genetically engineered and are resistant to the effects of, for example, herbicides or fungicides or pesticides. Such modified plants are described in detail above.

Conventional seed treatment preparations include, for example, flowable concentrates FS, solutions LS, suspoemulsions (SE), powders for dry treatment DS, and slurry treatment. Examples thereof include water dispersible powders for slurry treatment WS, water-soluble powders SS, emulsions ES and EC, and gel formulation GF. These formulations can be applied to seeds with or without dilution. Application to seeds is carried out either directly on the seeds before sowing or after pre-germination of the seeds. Preferably, the formulation is applied so that germination is not included.

The concentration of the active substance in the ready-to-use formulation, which can be obtained after diluting 2 to 10 times, is preferably 0.01 to 60% by weight, more preferably 0.1 to 40% by weight.

In a preferred embodiment, the FS formulation is used for seed treatment. Typically, the FS formulation is 1 to 800 g / L of active ingredient, 1 to 200 g / L of surfactant, 0 to 200 g / L of antifreeze, 0 to 400 g / L of binder, 0 to 200 g. It may contain up to 1 liter of pigment, preferably water.

A particularly preferred FS formulation of the mixture of the invention for seed treatment is typically at least one of 0.1-80% by weight (1-800 g / L) of active ingredient and 0.1-20% by weight (1-200 g / L). Surfactants such as 0.05-5% by weight wetting agent and 0.5-15% by weight dispersant, up to 20% by weight (eg 5-20%) antifreeze, 0-15% by weight (eg 1-15% by weight) %) Pigment and / or dye, 0-40% by weight (eg 1-40% by weight) binder (spreading agent / adhesive), optionally up to 5% by weight (eg 0.1-5% by weight) increase. It contains a viscous agent, optionally 0.1-2% antifoaming agent, and optionally a preservative (eg, biopathicide, antioxidant, etc.) in an amount of, eg 0.01-1 wt%, plus 100 fillers / vehicles. Includes up to% by weight.

In the treatment of seeds, the application rate of the compounds of the present invention is generally 0.1 g to 10 kg per 100 kg of seeds, preferably 1 g to 5 kg per 100 kg of seeds, more preferably 1 g to 1000 g per 100 kg of seeds, and particularly per 100 kg of seeds. 1 g to 200 g, for example 1 g to 100 g per 100 kg of seeds, or 5 g to 100 g.

Accordingly, the present invention also relates to seeds containing the compounds of the present invention as defined herein, or agriculturally useful salts thereof. The amount of the compound of the invention or an agriculturally useful salt thereof will generally vary from 0.1 g to 10 kg per 100 kg of seeds, preferably 1 g to 5 kg per 100 kg of seeds, particularly 1 g to 1000 g per 100 kg of seeds.

In the present invention, the mixture of the present invention can also be used to improve the health of plants. Therefore, the present invention also uses an effective amount and a non-phytotoxic amount of the compound of the present invention in an effective amount and a non-phytotoxic amount of the rice plant, the rice plant breeding material and / or the place where the rice plant grows or is intended to grow. It also concerns how to improve the health of plants by treatment.

As used herein, "effective and non-phytotoxic" means that the compound has the desired effect in treated plants, or in plants grown from treated propagules or treated soil. It means that it is used in an amount that allows it to be obtained but not cause any phytotoxic symptoms.

The terms "plant" and "plant propagation material" are defined above.

"Plant health" refers to yield (eg, increased biomass and / or increased content of useful ingredients), quality (eg, improved content or composition of specific ingredients, or improved shelf life), plant vitality (eg, increased shelf life). Improved plant growth and / or resistance to darker green leaves (“greening effect”)), abiotic stress (eg, drought) and / or biological stress (eg, disease), and production efficiency (eg, disease). , Yield rate, processability), etc., are defined as the condition of the plant and / or its product, determined alone or in combination with each other.

The indicators of plant health identified above are interdependent and they can arise from each other. Each indicator can be determined by methods defined in the art and known to those of skill in the art.

Examples Compounds benzpyrimoxane and oxazosulfyl are described in the Pesticide Manual and are commercially available or known for their synthesis.

Biological test Synergy can be described as an interaction in which the combined effect of two or more compounds is greater than the sum of the individual effects of each compound (zero interaction). Highest single agent model (HSA, or Gaddum additive) (Berenbaum, 1989), Loewe additive model (Loewe, 1953), and Bliss independent model to quantify the degree of drug synergy. Several models have been proposed, including a model based on (Bliss, 1939).
In this case, the two mixed partners are considered to be non-exclusively active to each other, i.e., the Bliss independent model is most suitable for describing the zero interaction effect (Greco et al., 1992), where , YBLISS is the expected effect based on the single agent effects y1 and y2 of the compound, respectively (1).

A reference model is used that is particularly useful for analyzing matrix data from plate-based high-throughput experiments (Yadav et al., 2015). This model is called Zero Interaction Efficacy (ZIP), which overcomes many of the limitations of existing models and is based on an independent dose response curve for each of the two mixed partners. By combining the advantages of both the Loewe and Bliss models, the ZIP model assumes that the two non-interacting drugs are expected to produce minimal changes in their dose-response curve. In the ZIP model (Yadav et al., 2015, Equation 16), the zero interaction situation (yZIP) is defined according to Equation (2), where X1 and X2 are the doses of compounds 1 and 2, and m1 and m2 are compounds. A dose that produces a midpoint effect, also known as the relative EC50 or IC50 of 1 and 2, λ1 and λ2 (λ> 0) are shape parameters that indicate the sigmoid properties or gradient of the curves for compounds 1 and 2.

The mean delta score is calculated from the expected and observed ZIP (δ) values for each dose combination in the matrix. This is intended to allow surface plots of delta scores to visualize the interaction landscape for drug combinations and to identify synergistic and antagonistic dose regions for further dose optimization in validation screening. do. The delta score has a unit of percent inhibition and is directly comparable within and between drug combinations. Finally, the average of all dose combination delta scores in the matrix can be calculated. The average score (percentage) is called the "ZIP synergistic score" for the ZIP model and the "Bliss synergistic score" for the Bliss model.

He, L. et al. (2018) published an R script called "syngergyfinder" based on the above model. Bioconductor. You can also download it from org:
http://bioconductor.org/packages/release/bioc/html/synergyfinder.html

The following tests demonstrate the control efficacy of the compounds, mixtures or compositions of the invention against specific pests. However, the pest control protection obtained by compounds, mixtures or compositions is not limited to these species. In certain examples, combinations of the compounds of the invention with other invertebrate pest control compounds or agents have been found to have a synergistic effect on certain important invertebrate pests.

The mixture tested consists of two components, benzpyrimoxane and oxazosulfyl, which belong to two different mechanisms of action (IRAC classification).

Exam 1: Tobacco budworm (Heliothis virescens)
A test unit was constructed with 96-well microtiter plates containing insect bait and 15-25 H. bilescens eggs to assess control of fake corn earworms (Tobacco budworm) (Heliothis virescens). ..
Compounds or mixtures were formulated using solutions containing 75% water and 25% DMSO. Different concentrations of pharmaceutical compounds or mixtures were sprayed onto the insect bait in 10 μL using a custom microatomizer.
For the experimental mixture in these tests, both mixing partners of the same volume were mixed together at the desired concentrations. Mixture application was repeated 4 times on 4 separate microtiter plates.
After application, microtiter plates were incubated at 28 ± 1 ° C. and 80 ± 5% RH for 5 days. The mortality rates of both eggs and larvae were then visually assessed and scored (0, 50, or 100% control effect).

Exam 2: Greenhouse Whitefly (Trialeurodes vaporariorum)
To evaluate the control of Greenhouse Whitefly (Trialeurodes vaporariorum), a test unit was constructed with 96-well microtiter plates containing eggplant leaf discs containing whitefly eggs. The compound or mixture was formulated with a solution containing 75% water and 25% DMSO. Using a custom microatomizer, various concentrations of pharmaceutical compounds or mixtures were sprayed onto the insect bait in 2.5 μL. For the experimental mixture in these tests, both mixing partners of the same volume were mixed together at the desired concentration. Mixture application was repeated 4 times on 4 separate microtiter plates. For the experimental mixture in these tests, both mixing partners of the same volume were mixed together at the desired concentration.

After application, microtiter plates were incubated at 23 + 1 ° C. and 65 + 5% RH for 6 days. The mortality rate of the first-instar larvae that hatched was then visually evaluated and scored (0, 50, or 100% control effect).

For H. billessens, a synergistic effect was added between the Bliss model mortality rate of 40% and the ZIP model control mortality rate of 18% for a particular dose combination of oxazosulfyl and benzpyrimoxane. It was found (Tables 1.2b and 1.3b).

Synergistic effect of T. vaporoliolm on a particular dose combination between oxazosulfil and benzpyrimoxane, in addition to the 65% mortality rate from the Bliss model and the 51% mortality rate from ZIP model control. Was observed (Tables 2.2b and 2.3b).

References:
Berenbaum, M., C. (1989). What is synergy. Pharmacol Rev 41: 93-141
Loewe, S. (1953). The problem of synergism and antagonism of combined
drugs. Arzneimittelforschung 3: 285-290
Bliss, C., I. (1939). The toxicity of poisons applied jointly. Ann Appl Biol 26: 585-615
Yadav, B .; Wennerberg, K .; Aittokallio, T .; Tang, J. (2015). Computational Searching for drug synergy in complex dose-response landscapes using an inter-action potency model. Structural Biotechnology Journal 13: 504-513
Greco, W .; Unkelbach, H. -D .; Poech, G .; Suehnel, J .; Kundi, M .; Boedeker, W. (1992) Consensus on concepts and terminology for combined-action assessment: The Saariselkae agreement. Archives of Complex Environmental Studies. 4: 65-69
He, L .; Kulesskiy, E .; Saarela, J .; Turunen, L .; Wennerberg, K .; Aittokallio, T .; Tang, J. (2018). Methods for High-Throughput Drug Combination Screening and Synergy Scoring. In von Stechow, L. (ed.), Cancer Systems Biology: Methods and Protocols, chapter 17, 351-398. Springer New York.

Claims (15)

A pesticide mixture containing benzpyrimoxane and oxazosulfyl. The mixture according to claim 1, wherein benzpyrimoxane and oxazosulfyl are the only active ingredients. The ratio of the mixed partners is 1000: 1 to 1: 1000; preferably 100: 1 to 1: 100, 50: 1 to 1:50, 20: 1 to 1:20, according to claim 1 or 2. mixture. A pesticidal composition comprising a liquid or solid carrier and a mixture according to any one of claims 1-3. A method for exterminating or controlling an invertent pest, according to any one of claims 1 to 3, wherein the pest or its food supply, habitat or breeding ground and an effective amount of the pest are killed. A method comprising contacting with a pesticide mixture. A method for protecting a growing plant or plant-growing material from attack or harm by an invertent pest, the plant, the plant-growing material, or the soil or water in which the plant is growing, and the effective amount of the pesticide. A method comprising contacting with the pesticide mixture according to any one of claims 1 to 3. A plant-growing material comprising the pest mixture according to any one of claims 1 to 3, in an amount of 0.1 g to 10 kg per 100 kg of seed. A method for protecting a plant breeding material, in which the plant breeding material is contacted with an amount of 0.1 g to 10 kg per 100 kg of the plant breeding material, according to any one of claims 1 to 3. Including that, how; A method for controlling a rice-harmful invertebrate in rice, which comprises applying the pest-killing organism mixture according to any one of claims 1 to 3 to the rice-harmful invertebrate. The method of claim 9, wherein the rice-harmful invertebrates are selected from the following groups:
Hemiptera:
Brown planthopper (brown planthopper)-Nilaparvata lugens
Himetobiunka (small brown planthopper)-Laodelphax striatellus
Segatella furcifera (white-backed planthopper)-Sogatella furcifera
Leafhopper (white leafhopper)-Cofana spectra
Nephotettix virescens, N. nigriceps, N. cincticeps, N. malayanus
Leafhopper (zig zag leafhopper)-Recilia dorsalis
Leafhopper (maize orange leafhopper) --Cicadulina bipunctata
Leafhopper (aster leafhopper)-Macrosteles fascifrons
Taiwan spider helicopter bug (rice earhead bug), Leptocorisa oratorius, L. acuta
Rice stink bugs-Nezara viridula, Pygomenida varipennis, Eysarcoris, Tibraca limbatriventris, Esarcoris ventralis ventris
Brown marmorated stink bug (small stink bug)-Oebalus poecilus, O. pugnax
Helicopter bug (coreid bug)-Eysarcoris sp
Chinch bug-Chinch bug-Blissus leucopterus, leucopterus
Rice mealybug, Brevennia rehi, Pseudococcus saccharicola
Rice aphids, Rhopalosiphum rufiabdominalis, Macrosiphum avenae, Hysteroneura setariae, Tetraneulo nigriabdominalis
Kebukachichuwatamushi (bean root aphid) --Smynthurodes betae
Lepidoptera:
Parnara guttata (rice skipper)-Parnara guttata, Melanitis Ieda ismene
Chilo suppressalis (rice stem borer / striped stem borer)-Chilo suppressalis, Chilo polychrusus, Chilo partellus, Kilo Pleasure Dels (Chilo plejadellus)
Rice stalk borer-Chilotraea polychrysa
Sesamia inferens (pink rice borer)-Sesamia inferens
Sankameiga (yellow rice borer)-Triporyza (= Scirpophaga) incertulas
Shiromeichu (white rice borer)-Tryporyza innotata
Covenomeiga (rice leaf roller / rice leaf folder)-Cnaphalocrocis medinalis, Marasmia patnalis, M. exigua
Mythimna separata (rice ear-cutting caterpillar / armyworm) --Pseudaletia separata
Xanthodes transversa (green caterpillar)-Xanthodes transversa
Futaobikoyaga (green rice caterpillar) --Narnaga aenescens
Green horned caterpillars-Melanitis Ieda ismene, Mycalesis sp
Fall armyworm (fall army worm)-Spodoptera frugiperda
Nekirimushi (cutworm)-Mythimna separata
Rice case worm (rice case worm)-Nymphula depunctalis
Black hairy caterpillar, Amata sp.
Hairy caterpillar-Mocis frugalis
Obiga (yellow caterpillar), Psalis pennatula
Rice semi-brown looper, Mocis frugalis
Rice semi-looper, Chrysodeixis chalcites
Kuroobi Chronomeiga (grass webworm)-Herpetogramma licarsisalis
Sugar cane borer-Diatraea saccharalis
Corn stalk borer-Elasmopalpus lignosellus
Striped grass looper-Mocis latipes
European corn borer-Ostrinia nubilalis
Mexican rice borer-Eoreuma loftini
Coleoptera:
Lissorhoptrus (water weevil)-Lissorhopterus oryzophilus
Rice plant weevil-Echinocnemus squamous
Rice weevil (rice weevil) --Oryzophagus oryzae
Rice hispa --Diclodispa armigera Rice leaf beetle --Oulema oryzae
Rice blackbug-Scotinophora vermidulate, S. vermidulate, S. lurida, S. latiuscula
Rice flea beetle-Chaetocnima basalis
Grubs-Leucopholis irrorata, Leucopholis irrorata, Phyllophaga sp, Heteronychus sp
Scarab beetle (bicho torito)-Diloboderus abderus
Weevils (billbugs)-Sphenophorus spp
Grape colaspis-Colaspis brunnea, C. louisianae
Rice pollen beetle, Chilolaba acuta Diptera:
Stem maggot-Chlorops oryzae
Leafminer-Agromyza oryzae
Rice whorl maggot / rice stem maggot --Hydrellia sasakii
Rice whorl maggot / small rice leaf miner --Hydrellia griseola
Rice gall midge-Orseolia (= Pachydiplosis) oryzae
Rice shoot fly-Atherigona oryzae
Rice seed midge-Chironomus cavazzai, Chironomus spp, Cricotopus spp
Thrips (Thysanoptera):
Rice thrips-Chloethrips oryzae, Stenochaetothrips biformis, Perrisothrips sp., Hoplothrips sp.,
Orthoptera:
Locusts (rice grasshoppers), Hieroglyphus banian, Hieroglyphus nigrorepletus, Catantops pinguis, Attractomorpha burri, A. A. crenulate, A. psittacina, A. Bedeli, Oxya adenttata, Oxya ebneri, Oxya hyla intricata, Acrida turricata
Grasshoppers (locusts)-Locusta migratoria manilensis
Mole cricket, Grylotalpa africana
Crickets (field crickets): Gryllus bimaculatus, Teleogryllus occipitalis, Euscyrtus concinus
Grasshopper (katydid) --Conocephalus longipennis (Isoptera):
Termites-Macrotermes gilvus, Syntermes molestans
Hymenoptera:
Ants-Akakami ants (Solenopsis geminata)
Rice white tip nematode (rice white tip nematode) --Aphelenchoides besseyi
Mites (Acari):
Rice panicle mite --Steotarsonemus pinki
Crustacea:
Triops longicauda (tadpole shrimp)-Triops longicauda (Triops longicaudatus), Triops longicauda (T. cancriformis)
Rice crayfish-Crayfish (Procambarus clarkii), Orconectes virilis. Rice-harmful invertebrates are selected from Hemiptera, Lepidoptera or Coleoptera orders, preferably from hoppers, or preferably from brown planthoppers (Brown). Plant hopper (brown plant hopper) (Nilaparvata lugens), Himetobiunka (small brown planthopper) (Laodelphax striatellus), Sedirounka (whitebacked planthopper) (white-backed planthopper)) (Sogatella furcifera), Brown planthopper (green leafhopper) (Nephotettix virescens), Hemiptera (rice stink bugs) (Nezara biridura) viridula)), Pygomenida varipennis, Eysarcoris, Tibraca limbatriventris, Eysarcoris ventralis, or small stink bug (small stink bug) )) (Oebalus poecilus, O. pugnax), Nikameiga (rice stem borer) (Chilo suppressalis), Sankameiga (yellow rice) borer)) (Triporyza (= Scirpophaga) incertulas), Covenomeiga (rice leaf roller / rice leaf folder) (Cnaphalocrocis medinalis) )), Malasmia・ Patnalis (Marasmia patnalis), M. exigua), Lissorhoptrus chinensis (water weevil) (Lissorhopterus oryzophilus), Rice weevil (rice weevil) (rice weevil) The method according to claim 9 or 10, which is selected from Oryzae (Oryzophagus oryzae). The method according to any one of claims 9, 10 or 11, which comprises granule application, seedling box application or foliar application. A method for increasing the health of plants, especially rice plants in paddy fields, comprising treatment with the mixture according to any one of claims 1-3. A method for increasing the yield of a plant, particularly a rice plant, comprising treatment with the mixture according to any one of claims 1-3. A method for protecting rice plants using the mixture according to any one of claims 1 to 3.