|
JPH10503364A
(ja)
|
1994-05-10 |
1998-03-31 |
ザ ジェネラル ホスピタル コーポレーション |
C型肝炎ウイルスのアンチセンス阻害
|
|
TW520293B
(en)
|
1995-11-22 |
2003-02-11 |
Univ Johns Hopkins Med |
Delivery system to enhance cellular uptake of biomolecules
|
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
AU7406700A
(en)
|
1999-10-04 |
2001-05-10 |
Exiqon A/S |
Design of high affinity rnase h recruiting oligonucleotide
|
|
WO2001048190A2
(en)
|
1999-12-23 |
2001-07-05 |
Exiqon A/S |
Therapeutic uses of lna-modified oligonucleotides
|
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
CN100406065C
(zh)
|
2000-12-01 |
2008-07-30 |
细胞工厂治疗公司 |
糖基化/半乳糖基化肽、双官能接头和核苷酸单体/多聚体的缀合物以及相关的组合物和使用方法
|
|
CN1344803A
(zh)
|
2001-09-27 |
2002-04-17 |
吴昌 |
核酸靶分子选择及扩增方法
|
|
EP2669377A3
(en)
|
2003-04-17 |
2015-10-14 |
Alnylam Pharmaceuticals Inc. |
Modified iRNA agents
|
|
WO2005013901A2
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
JP4989225B2
(ja)
|
2003-09-25 |
2012-08-01 |
コーリー ファーマシューティカル グループ,インコーポレイテッド |
核酸親油性接合体
|
|
ES2344566T3
(es)
|
2003-12-23 |
2010-08-31 |
Santaris Pharma A/S |
Compuestos oligomericos para la modulacion de bcl-2.
|
|
AU2005325262B2
(en)
|
2004-04-27 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
|
|
PT1747023E
(pt)
|
2004-05-04 |
2011-04-11 |
Univ Leland Stanford Junior |
Métodos e composições para reduzir quantidades de genoma viral numa célula alvo
|
|
EP1913011B1
(en)
|
2004-08-04 |
2016-11-02 |
Alnylam Pharmaceuticals Inc. |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
|
|
WO2006031461A2
(en)
|
2004-09-09 |
2006-03-23 |
Isis Pharmaceuticals, Inc. |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
|
US20070099196A1
(en)
|
2004-12-29 |
2007-05-03 |
Sakari Kauppinen |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mRNAs
|
|
US20120122801A1
(en)
|
2005-01-05 |
2012-05-17 |
Prosensa B.V. |
Mannose-6-phosphate receptor mediated gene transfer into muscle cells
|
|
US20060148740A1
(en)
|
2005-01-05 |
2006-07-06 |
Prosensa B.V. |
Mannose-6-phosphate receptor mediated gene transfer into muscle cells
|
|
EP1841867A1
(en)
|
2005-01-24 |
2007-10-10 |
Avaris AB |
COMPLEX CONTAINING SiRNA, ShRNA OR ANTISENSE MOLECULE AND FUNCTIONAL ENTITY, FOR IMPROVED SPECIFICITY AND DELIVERY
|
|
AU2006279906B2
(en)
|
2005-08-10 |
2012-05-10 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
|
|
US20070213292A1
(en)
|
2005-08-10 |
2007-09-13 |
The Rockefeller University |
Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
|
|
WO2007027894A2
(en)
|
2005-08-29 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds having enhanced anti-microrna activity
|
|
ATE494372T1
(de)
|
2005-08-29 |
2011-01-15 |
Regulus Therapeutics Inc |
Verfahren für mir-122a-modulation
|
|
EP2388328A1
(en)
|
2006-01-27 |
2011-11-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
EA201100811A1
(ru)
|
2006-04-03 |
2012-06-29 |
Сантарис Фарма А/С |
Фармацевтическая композиция
|
|
CA3042781C
(en)
|
2006-04-03 |
2021-10-19 |
Roche Innovation Center Copenhagen A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
|
DK2152879T3
(da)
|
2007-05-01 |
2013-02-18 |
Santaris Pharma As |
RNA antagonistforbindelser til modulering af beta-catenin
|
|
DK2205737T3
(da)
|
2007-10-04 |
2013-05-21 |
Santaris Pharma As |
Mikromirer
|
|
NZ585327A
(en)
|
2007-11-26 |
2012-10-26 |
Santaris Pharma As |
Lna antagonists targeting the androgen receptor
|
|
EP2229186A2
(en)
|
2007-12-04 |
2010-09-22 |
Alnylam Pharmaceuticals Inc. |
Carbohydrate conjugates as delivery agents for oligonucleotides
|
|
WO2009091972A2
(en)
|
2008-01-18 |
2009-07-23 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides and small molecules for use in reducing micro rna activity levels and uses thereof
|
|
EP2268811A1
(en)
|
2008-03-07 |
2011-01-05 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
|
WO2010076248A1
(en)
|
2008-12-31 |
2010-07-08 |
Santaris Pharma A/S |
Use of lna apob antisense oligomers for the treatment of acute coronary syndromes
|
|
US9034837B2
(en)
|
2009-04-24 |
2015-05-19 |
Roche Innovation Center Copenhagen A/S |
Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon
|
|
MA33488B1
(fr)
|
2009-06-08 |
2012-08-01 |
Miragen Therapeutics |
Motifs de modification chimique pour des inhibiteurs et mimétiques de miarn
|
|
ES2651308T3
(es)
|
2009-10-16 |
2018-01-25 |
Glaxo Group Limited |
Inhibidores antisentido de HBV
|
|
PH12012501596A1
(en)
|
2010-02-24 |
2017-02-03 |
Arrowhead Res Corporation |
Compositions for targeted delivery of sirna
|
|
US8349308B2
(en)
|
2010-03-26 |
2013-01-08 |
Mersana Therapeutics, Inc. |
Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof
|
|
WO2011130458A2
(en)
|
2010-04-13 |
2011-10-20 |
John Rossi |
Rna aptamers against baff-r as cell-type specific delivery agents and methods for their use
|
|
WO2012007477A1
(en)
|
2010-07-12 |
2012-01-19 |
Santaris Pharma A/S |
Anti hcv oligomers
|
|
US9290760B2
(en)
|
2010-09-15 |
2016-03-22 |
Alnylam Pharmaceuticals, Inc. |
Modified iRNA agents
|
|
RU2013117288A
(ru)
|
2010-12-17 |
2015-01-27 |
Эрроухэд Рисерч Корпорейшн |
СОДЕРЖАЩАЯ ГАЛАКТОЗНЫЙ КЛАСТЕР НАЦЕЛИВАЮЩАЯ ГРУППА ДЛЯ миРНК, МОДУЛИРУЮЩАЯ ФОРМАКОКИНЕТИЧЕСКИЕ СВОЙСТВА
|
|
RU2582235C2
(ru)
|
2010-12-29 |
2016-04-20 |
Ф.Хоффманн-Ля Рош Аг |
Низкомолекулярные конъюгаты для внутриклеточной доставки нуклеиновых кислот
|
|
MX393138B
(es)
|
2011-04-25 |
2025-03-24 |
Sanofi Sa |
Compuestos de microarn y metodos para modular la actividad de mir-21.
|
|
US20140248611A1
(en)
|
2011-06-16 |
2014-09-04 |
Nippon Steel & Sumikin Eco-Tech Corporation |
Nucleic acid probe for assaying nucleic acids
|
|
WO2012175733A1
(en)
|
2011-06-23 |
2012-12-27 |
Santaris Pharma A/S |
Hcv combination therapy
|
|
KR20140058536A
(ko)
|
2011-06-30 |
2014-05-14 |
스텔라 에이피에스 |
Hcv 조합 치료
|
|
EP2726610A1
(en)
|
2011-06-30 |
2014-05-07 |
Stella ApS |
Hcv combination therapy
|
|
US10023861B2
(en)
*
|
2011-08-29 |
2018-07-17 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
WO2013068348A1
(en)
|
2011-11-07 |
2013-05-16 |
Santaris Pharma A/S |
Lna oligomers for improvement in hepatic function
|
|
EP2776590B1
(en)
|
2011-11-07 |
2016-10-26 |
Roche Innovation Center Copenhagen A/S |
Prognostic method for checking efficacy of micro rna-122 inhibitors in hcv+ patients
|
|
EP2864482A4
(en)
|
2012-06-21 |
2016-02-10 |
Miragen Therapeutics Inc |
OLIGONUCLEOTIDE INHIBITORS COMPRISING A BLOCKED NUCLEIC ACID PATTERN
|
|
CN104955950B
(zh)
|
2012-09-26 |
2019-04-26 |
米尔克斯治疗学公司 |
具有改善的脱靶特征谱的寡核苷酸
|
|
CA2889044A1
(en)
|
2012-11-15 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Anti apob antisense conjugate compounds
|
|
CA2893801A1
(en)
|
2013-01-30 |
2014-08-07 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotide carbohydrate conjugates
|
|
WO2014118272A1
(en)
*
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
|
PL2992098T3
(pl)
|
2013-05-01 |
2019-09-30 |
Ionis Pharmaceuticals, Inc. |
Kompozycje i sposoby modulowania ekspresji hbv i ttr
|
|
EP2992096B1
(en)
|
2013-05-01 |
2021-03-03 |
Regulus Therapeutics Inc. |
Compounds and methods for enhanced cellular uptake
|
|
JP2016518842A
(ja)
*
|
2013-05-01 |
2016-06-30 |
レグルス セラピューティクス インコーポレイテッド |
マイクロRNA化合物およびmiR−122をモジュレートする方法
|