JP2021520207A5 - - Google Patents
Info
- Publication number
- JP2021520207A5 JP2021520207A5 JP2020554254A JP2020554254A JP2021520207A5 JP 2021520207 A5 JP2021520207 A5 JP 2021520207A5 JP 2020554254 A JP2020554254 A JP 2020554254A JP 2020554254 A JP2020554254 A JP 2020554254A JP 2021520207 A5 JP2021520207 A5 JP 2021520207A5
- Authority
- JP
- Japan
- Prior art keywords
- chain
- nucleic acid
- nucleotides
- strand
- acid according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024001366A JP2024036347A (ja) | 2017-04-05 | 2024-01-09 | アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17165007.0A EP3385380A1 (en) | 2017-04-05 | 2017-04-05 | Products and compositions |
| EP17201405 | 2017-11-13 | ||
| EPPCT/EP2018/058764 | 2018-04-05 | ||
| PCT/EP2018/058764 WO2018185240A1 (en) | 2017-04-05 | 2018-04-05 | Products and compositions |
| EP18197795.0A EP3550022A1 (en) | 2018-04-05 | 2018-09-28 | Products and compositions |
| EP18197795.0 | 2018-09-28 | ||
| PCT/EP2019/058615 WO2019193144A1 (en) | 2018-04-05 | 2019-04-05 | siRNAs WITH VINYLPHOSPHONATE AT THE 5' END OF THE ANTISENSE STRAND |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024001366A Division JP2024036347A (ja) | 2017-04-05 | 2024-01-09 | アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021520207A JP2021520207A (ja) | 2021-08-19 |
| JP2021520207A5 true JP2021520207A5 (enExample) | 2023-11-15 |
| JP7419252B2 JP7419252B2 (ja) | 2024-01-22 |
Family
ID=61899310
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020504435A Active JP7247167B2 (ja) | 2017-04-05 | 2018-04-05 | 産物及び組成物 |
| JP2020554254A Active JP7419252B2 (ja) | 2017-04-05 | 2019-04-05 | アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ |
| JP2023039774A Active JP7495544B2 (ja) | 2017-04-05 | 2023-03-14 | 産物及び組成物 |
| JP2024001366A Pending JP2024036347A (ja) | 2017-04-05 | 2024-01-09 | アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020504435A Active JP7247167B2 (ja) | 2017-04-05 | 2018-04-05 | 産物及び組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023039774A Active JP7495544B2 (ja) | 2017-04-05 | 2023-03-14 | 産物及び組成物 |
| JP2024001366A Pending JP2024036347A (ja) | 2017-04-05 | 2024-01-09 | アンチセンス鎖の５’末端でビニルホスホネートを有するｓｉＲＮＡ |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11174483B2 (enExample) |
| EP (2) | EP4219714A3 (enExample) |
| JP (4) | JP7247167B2 (enExample) |
| KR (1) | KR102589803B1 (enExample) |
| CN (2) | CN110573619B (enExample) |
| AU (2) | AU2018247924B2 (enExample) |
| CA (2) | CA3057561C (enExample) |
| DK (1) | DK3607068T3 (enExample) |
| ES (1) | ES2936109T3 (enExample) |
| FI (1) | FI3607068T3 (enExample) |
| HR (1) | HRP20221547T1 (enExample) |
| HU (1) | HUE061894T2 (enExample) |
| IL (2) | IL269576B2 (enExample) |
| LT (1) | LT3607068T (enExample) |
| PL (1) | PL3607068T3 (enExample) |
| RS (1) | RS63887B1 (enExample) |
| SI (1) | SI3607068T1 (enExample) |
| WO (1) | WO2018185240A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013501969B1 (en) | 2011-03-29 | 2018-08-31 | Alnylam Pharmaceuticals Inc | Compositions and methods for inhibiting expression of tmprss6 gene |
| DK3607069T3 (da) * | 2017-04-05 | 2022-11-21 | Silence Therapeutics Gmbh | Produkter og sammensætninger |
| IL269517B2 (en) | 2017-04-05 | 2025-01-01 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of a target gene in a cell, conjugates thereof, compositions containing them, and medical uses thereof |
| EP3598995A1 (en) * | 2018-07-26 | 2020-01-29 | Silence Therapeutics GmbH | Products and compositions |
| CN111973619B (zh) * | 2019-05-23 | 2024-01-30 | 苏州瑞博生物技术股份有限公司 | 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途 |
| AU2022265493A1 (en) | 2021-04-27 | 2023-09-21 | Silence Therapeutics Gmbh | Sirna targeting tmprss6 for the treatment of myeloproliferative disorders |
| TWI868755B (zh) | 2022-06-24 | 2025-01-01 | 丹麥商諾佛 儂迪克股份有限公司 | 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法 |
| WO2024060649A1 (zh) * | 2022-09-29 | 2024-03-28 | 广州必贝特医药股份有限公司 | 用于抑制TMPRSS6基因表达的siRNA或其盐、药物及其应用 |
| CN120981247A (zh) | 2023-03-27 | 2025-11-18 | 赛伦斯治疗有限责任公司 | 用于干细胞移植的化合物和组合物 |
| WO2025132845A1 (en) | 2023-12-21 | 2025-06-26 | Silence Therapeutics Gmbh | Galnac phosphoramidites and their uses |
| WO2025163186A1 (en) * | 2024-02-01 | 2025-08-07 | Silence Therapeutics Gmbh | Conjugated nucleic acids and nucleic acids comprising locked nucleosides and inverted nucleotides for inhibiting gene expression in a cell |
| WO2026003163A1 (en) | 2024-06-26 | 2026-01-02 | Silence Therapeutics Gmbh | Sirna against tmprss6 for treating polycythemia vera |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9201440A (nl) | 1992-08-11 | 1994-03-01 | Univ Leiden | Triantennaire clusterglycosiden, hun bereiding en toepassing. |
| AU2003295600A1 (en) * | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| EP2601204B1 (en) * | 2010-04-28 | 2016-09-07 | Ionis Pharmaceuticals, Inc. | Modified nucleosides and oligomeric compounds prepared therefrom |
| PH12013501969B1 (en) * | 2011-03-29 | 2018-08-31 | Alnylam Pharmaceuticals Inc | Compositions and methods for inhibiting expression of tmprss6 gene |
| HRP20191883T1 (hr) * | 2011-11-07 | 2019-12-27 | Ionis Pharmaceuticals, Inc. | Modulacija ekspresije tmprss6 |
| KR102234623B1 (ko) * | 2013-05-22 | 2021-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | Ｔｍｐｒｓｓ6 조성물 및 이의 사용 방법 |
| IL316808A (en) * | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| CN106795200B (zh) * | 2014-10-10 | 2020-06-19 | 豪夫迈·罗氏有限公司 | Galnac亚磷酰胺、其核酸缀合物及其用途 |
| WO2016085852A1 (en) * | 2014-11-24 | 2016-06-02 | Alnylam Pharmaceuticals, Inc. | Tmprss6 irna compositions and methods of use thereof |
| WO2016149020A1 (en) * | 2015-03-17 | 2016-09-22 | Arrowhead Research Corporation | Rna interference agents |
| EP3228326A1 (en) | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Nucleic acid linked to a trivalent glycoconjugate |
| IL269517B2 (en) * | 2017-04-05 | 2025-01-01 | Silence Therapeutics Gmbh | Nucleic acids for inhibiting expression of a target gene in a cell, conjugates thereof, compositions containing them, and medical uses thereof |
| DK3607069T3 (da) * | 2017-04-05 | 2022-11-21 | Silence Therapeutics Gmbh | Produkter og sammensætninger |
-
2018
- 2018-04-05 SI SI201830837T patent/SI3607068T1/sl unknown
- 2018-04-05 RS RS20230024A patent/RS63887B1/sr unknown
- 2018-04-05 CA CA3057561A patent/CA3057561C/en active Active
- 2018-04-05 DK DK18715705.2T patent/DK3607068T3/da active
- 2018-04-05 IL IL269576A patent/IL269576B2/en unknown
- 2018-04-05 ES ES18715705T patent/ES2936109T3/es active Active
- 2018-04-05 WO PCT/EP2018/058764 patent/WO2018185240A1/en not_active Ceased
- 2018-04-05 HR HRP20221547TT patent/HRP20221547T1/hr unknown
- 2018-04-05 US US16/500,703 patent/US11174483B2/en active Active
- 2018-04-05 EP EP22202522.3A patent/EP4219714A3/en active Pending
- 2018-04-05 CN CN201880021535.3A patent/CN110573619B/zh active Active
- 2018-04-05 JP JP2020504435A patent/JP7247167B2/ja active Active
- 2018-04-05 AU AU2018247924A patent/AU2018247924B2/en active Active
- 2018-04-05 EP EP18715705.2A patent/EP3607068B1/en active Active
- 2018-04-05 PL PL18715705.2T patent/PL3607068T3/pl unknown
- 2018-04-05 LT LTEPPCT/EP2018/058764T patent/LT3607068T/lt unknown
- 2018-04-05 HU HUE18715705A patent/HUE061894T2/hu unknown
- 2018-04-05 FI FIEP18715705.2T patent/FI3607068T3/fi active
- 2018-04-05 KR KR1020197032297A patent/KR102589803B1/ko active Active
-
2019
- 2019-04-05 CN CN201980037644.9A patent/CN112424354A/zh active Pending
- 2019-04-05 AU AU2019247637A patent/AU2019247637B2/en active Active
- 2019-04-05 JP JP2020554254A patent/JP7419252B2/ja active Active
- 2019-04-05 IL IL277636A patent/IL277636B2/en unknown
- 2019-04-05 CA CA3095523A patent/CA3095523A1/en active Pending
-
2021
- 2021-10-05 US US17/450,064 patent/US20220025377A1/en active Pending
-
2023
- 2023-03-14 JP JP2023039774A patent/JP7495544B2/ja active Active
-
2024
- 2024-01-09 JP JP2024001366A patent/JP2024036347A/ja active Pending
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