JP2021518479A5 - - Google Patents
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- Publication number
- JP2021518479A5 JP2021518479A5 JP2020564078A JP2020564078A JP2021518479A5 JP 2021518479 A5 JP2021518479 A5 JP 2021518479A5 JP 2020564078 A JP2020564078 A JP 2020564078A JP 2020564078 A JP2020564078 A JP 2020564078A JP 2021518479 A5 JP2021518479 A5 JP 2021518479A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- phenylalanine
- dihydroxy
- block
- ferric ion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 13
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 13
- 229920000642 polymer Polymers 0.000 claims 12
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 9
- 229910001447 ferric ion Inorganic materials 0.000 claims 9
- 239000013522 chelant Substances 0.000 claims 4
- 239000002872 contrast media Substances 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 108010082974 polysarcosine Proteins 0.000 claims 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229920000578 graft copolymer Polymers 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- -1 iron ion Chemical class 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000000693 micelle Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810468018.2A CN110496231B (zh) | 2018-05-16 | 2018-05-16 | 一种含有聚多巴氨基酸螯合三价铁离子的两亲性聚合物纳米胶束及应用 |
| CN201810468018.2 | 2018-05-16 | ||
| PCT/CN2019/086586 WO2019218960A1 (zh) | 2018-05-16 | 2019-05-13 | 一种含有聚多巴氨基酸螯合三价铁离子的两亲性聚合物纳米胶束及应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021518479A JP2021518479A (ja) | 2021-08-02 |
| JP2021518479A5 true JP2021518479A5 (https=) | 2022-01-06 |
| JP7125725B2 JP7125725B2 (ja) | 2022-08-25 |
Family
ID=68539457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020564078A Active JP7125725B2 (ja) | 2018-05-16 | 2019-05-13 | ポリ３，４－ジヒドロキシ－ｌ－フェニルアラニンキレート第二鉄イオンを含有する両親媒性ポリマーナノミセル及びその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20210052749A1 (https=) |
| JP (1) | JP7125725B2 (https=) |
| CN (1) | CN110496231B (https=) |
| WO (1) | WO2019218960A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114306650B (zh) * | 2022-01-21 | 2022-12-06 | 南方医科大学 | 一种磁性四氧化三铁纳米粒及其制备方法和应用 |
| CN118987283A (zh) * | 2024-10-25 | 2024-11-22 | 杭州奥赛瑞生物医药科技有限责任公司 | 基于聚氨基酸纳米胶束的多模态对比剂及制备方法和应用 |
| CN118987284A (zh) * | 2024-10-25 | 2024-11-22 | 杭州奥赛瑞生物医药科技有限责任公司 | 一种聚合物纳米胶束及其在增强ct成像中的应用 |
| CN119033973A (zh) * | 2024-10-30 | 2024-11-29 | 杭州奥赛瑞生物医药科技有限责任公司 | 一种透明质酸修饰的铁基聚多巴氨基酸纳米探针及其制备方法与应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2161020A1 (en) * | 2008-09-09 | 2010-03-10 | Koninklijke Philips Electronics N.V. | Chelating amphiphilic polymers |
| KR101721570B1 (ko) * | 2011-06-22 | 2017-03-30 | 한화케미칼 주식회사 | 산화철 나노입자 기반 림프절 이미징용 ｍｒｉ 조영제 및 이를 이용하여 림프절을 조영하는 방법 |
| CN104140546B (zh) * | 2014-06-27 | 2017-02-15 | 江南大学 | 一种类碳纳米管状可降解聚合物的制备方法 |
| KR101765335B1 (ko) * | 2014-09-26 | 2017-08-22 | 서울대학교산학협력단 | 암 세포 조영용 ｍｒｉ 조영제 조성물 |
| CN105524271B (zh) * | 2014-10-24 | 2018-07-03 | 江苏师范大学 | 胆酸修饰的聚氨基酸嵌段共聚物的合成及应用 |
| CN106916301A (zh) * | 2017-04-14 | 2017-07-04 | 四川大学 | 高载铁量聚多巴胺纳米粒子的制备方法 |
-
2018
- 2018-05-16 CN CN201810468018.2A patent/CN110496231B/zh active Active
-
2019
- 2019-05-13 WO PCT/CN2019/086586 patent/WO2019218960A1/zh not_active Ceased
- 2019-05-13 JP JP2020564078A patent/JP7125725B2/ja active Active
-
2020
- 2020-11-03 US US17/088,566 patent/US20210052749A1/en active Pending
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