JP7125725B2 - ポリ3,4-ジヒドロキシ-l-フェニルアラニンキレート第二鉄イオンを含有する両親媒性ポリマーナノミセル及びその使用 - Google Patents
ポリ3,4-ジヒドロキシ-l-フェニルアラニンキレート第二鉄イオンを含有する両親媒性ポリマーナノミセル及びその使用 Download PDFInfo
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Description
従って、低毒性又は無毒性の磁気共鳴造影剤の開発は、現在、早急に解決すべき課題である。
上記ポリ3,4-ジヒドロキシ-L-フェニルアラニンを含有する両親媒性ポリマーの代表的な例は、以下の構造を含む。
本発明の実施例における特性評価方法は、以下のとおりである。
ナノミセルの粒径と形状はHITACHI HT7700透過型電子顕微鏡を用いて観察した。加速電圧は100KVとした。
実施例1
(1)ポリ3,4-ジヒドロキシ-L-フェニルアラニン-ポリサルコシンブロック共重合体(PDOPA-b-PSar)の構造式は以下のとおりである。
ここで、R1はベンジル基であり、m=5~200であり、n=5~50である。
具体的な合成ステップは、以下の工程を含む。
実施例2
ここで、R2はメチル基であり、m=5~200であり、n=5~50である。
性能試験条件は、実施例1と同様とした。ミセルの平均粒径は30nmで、MRIにおける体外増強作用を有した。
実施例3
ここで、R1はn-ブチル基であり、m=5~200であり、n1=5~50であり、
具体的な合成ステップは、以下の工程を含む。
実施例4
ここで、m=5~200であり、n=5~50である。
他の性能試験条件は実施例1と同様とした。ミセルの平均粒径は35nmで、MRIにおける体外増強作用を有した。
Claims (4)
- ポリ3,4-ジヒドロキシ-L-フェニルアラニンキレート第二鉄イオンを含有する両親媒性ポリマーナノミセルの磁気共鳴イメージング分野における使用であって、
前記両親媒性ポリマーナノミセル中の疎水性ブロックは、ポリ3,4-ジヒドロキシ-L-フェニルアラニンブロックであり、
ポリ3,4-ジヒドロキシ-L-フェニルアラニンブロック側鎖のカテコール基は、第二鉄イオンをキレート化し、以下の構造式で示すキレート結合を有し、
両親媒性ポリマーの構造式が式(1)~(5)に示すうちのいずれか一種であり、
R 1 は、アルキル基、ベンジル基、シリル基から独立して選択され、R 2 は、アルキル基から独立して選択され、mは1~1500の整数であり、nは1~500の整数であり、n 1 は1~200の整数であることを特徴とするポリ3,4-ジヒドロキシ-L-フェニルアラニンキレート第二鉄イオンを含有する両親媒性ポリマーナノミセルの磁気共鳴T1イメージング造影剤としての使用。 - 前記ポリ3,4-ジヒドロキシ-L-フェニルアラニンのセグメントの長さは5~50の範囲であり、ポリサルコシン又はポリエチレングリコールのセグメントの長さは5~200の範囲にあることを特徴とする請求項1に記載の使用。
- 前記磁気共鳴T1イメージング造影剤は、ポリ3,4-ジヒドロキシ-L-フェニルアラニンキレート第二鉄イオンを含有する両親媒性ポリマーナノミセル、薬学用賦形剤、希釈剤及び補助材料を含むことを特徴とする請求項1又は2に記載の使用。
- 前記磁気共鳴T1イメージング造影剤は、平均粒径が20~200nmで、キレート化鉄イオンの含有量が10~1000ppmであることを特徴とする請求項3に記載の使用。
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CN201810468018.2A CN110496231B (zh) | 2018-05-16 | 2018-05-16 | 一种含有聚多巴氨基酸螯合三价铁离子的两亲性聚合物纳米胶束及应用 |
PCT/CN2019/086586 WO2019218960A1 (zh) | 2018-05-16 | 2019-05-13 | 一种含有聚多巴氨基酸螯合三价铁离子的两亲性聚合物纳米胶束及应用 |
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JP2014514301A (ja) | 2011-06-22 | 2014-06-19 | ハンファ ケミカル コーポレーション | 酸化鉄ナノ粒子に基づくリンパ系造影用mri造影剤およびこれを用いてリンパ節を造影する方法 |
JP2016069358A (ja) | 2014-09-26 | 2016-05-09 | ソウル大学校産学協力団 | 癌細胞の造影用mri造影剤組成物 |
CN106916301A (zh) | 2017-04-14 | 2017-07-04 | 四川大学 | 高载铁量聚多巴胺纳米粒子的制备方法 |
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JP2014514301A (ja) | 2011-06-22 | 2014-06-19 | ハンファ ケミカル コーポレーション | 酸化鉄ナノ粒子に基づくリンパ系造影用mri造影剤およびこれを用いてリンパ節を造影する方法 |
JP2016069358A (ja) | 2014-09-26 | 2016-05-09 | ソウル大学校産学協力団 | 癌細胞の造影用mri造影剤組成物 |
CN106916301A (zh) | 2017-04-14 | 2017-07-04 | 四川大学 | 高载铁量聚多巴胺纳米粒子的制备方法 |
Non-Patent Citations (2)
Title |
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Gyu Ha Hwang et al.,pH-Responsive robust polymer micelles with metal-ligand coordinated core cross-links,Chem. Commun.,2014年03月18日,Volume 50, Issue 33,4351-4353 |
Yiwen Li et al.,Polycatechol Nanoparticle MRI Contrast Agents,Small,2016年02月03日,vol. 12, issue 5,p. 668-677 |
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US20210052749A1 (en) | 2021-02-25 |
CN110496231B (zh) | 2020-09-18 |
WO2019218960A1 (zh) | 2019-11-21 |
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