JP2021516222A5 - - Google Patents

Info

Publication number
JP2021516222A5
JP2021516222A5 JP2020542898A JP2020542898A JP2021516222A5 JP 2021516222 A5 JP2021516222 A5 JP 2021516222A5 JP 2020542898 A JP2020542898 A JP 2020542898A JP 2020542898 A JP2020542898 A JP 2020542898A JP 2021516222 A5 JP2021516222 A5 JP 2021516222A5
Authority
JP
Japan
Prior art keywords
leu
ala
trp
exist
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020542898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021516222A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/022439 external-priority patent/WO2019178462A1/en
Publication of JP2021516222A publication Critical patent/JP2021516222A/ja
Publication of JP2021516222A5 publication Critical patent/JP2021516222A5/ja
Pending legal-status Critical Current

Links

JP2020542898A 2018-03-16 2019-03-15 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法 Pending JP2021516222A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862644316P 2018-03-16 2018-03-16
US62/644,316 2018-03-16
PCT/US2019/022439 WO2019178462A1 (en) 2018-03-16 2019-03-15 Parathyroid hormone polypeptide conjugates and methods of their use

Publications (2)

Publication Number Publication Date
JP2021516222A JP2021516222A (ja) 2021-07-01
JP2021516222A5 true JP2021516222A5 (cg-RX-API-DMAC7.html) 2022-03-23

Family

ID=67908395

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020542898A Pending JP2021516222A (ja) 2018-03-16 2019-03-15 副甲状腺ホルモンポリペプチドコンジュゲートおよびその使用方法

Country Status (4)

Country Link
US (1) US11975050B2 (cg-RX-API-DMAC7.html)
EP (1) EP3765061A4 (cg-RX-API-DMAC7.html)
JP (1) JP2021516222A (cg-RX-API-DMAC7.html)
WO (1) WO2019178462A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230285578A1 (en) * 2020-05-26 2023-09-14 Indiana University Research And Technology Corporation Pth analogs for the treatment of hypoparathyroidism
KR20250075704A (ko) 2022-09-30 2025-05-28 익스텐드 바이오사이언시즈, 인크. 장기-지속형 부갑상선 호르몬
WO2025250793A1 (en) * 2024-05-29 2025-12-04 The General Hospital Corporation Parathyroid hormone polypeptide conjugates and methods of their use
WO2026067798A1 (zh) * 2024-09-30 2026-04-02 长春金赛药业有限责任公司 Pth复合物及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5261686A (en) 1992-04-06 1993-11-16 Buckler Clive E Semi-recumbent
US7150974B1 (en) 1991-04-05 2006-12-19 The General Hospital Corporation Parathyroid hormone receptor binding method
US7132260B2 (en) 1991-04-05 2006-11-07 The General Hospital Corporation DNA encoding parathyroid hormone receptor
DE69233472T2 (de) 1991-04-05 2006-02-09 The General Hospital Corp., Charlestown Parathormonrezeptor und dafür codierende DNA
JP4142743B2 (ja) 1996-07-31 2008-09-03 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモンに関連する新規ペプチド類似体
US6183974B1 (en) 1997-07-31 2001-02-06 The General Hospital Corporation Screening assays for G protein coupled receptor agonists and antagonists
JP4486256B2 (ja) 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
WO2000031266A1 (en) 1998-11-25 2000-06-02 The General Hospital Corporation Human parathyroid hormone modifications, preparation and use
DE69938064T2 (de) 1998-11-25 2009-01-15 The General Hospital Corp., Boston Aminoterminal modifizierte parathyroidhormon (pth) analoge
AU4217299A (en) 1998-11-30 2000-06-19 General Hospital Corporation, The Pth1r and pth3r receptors, methods and uses thereof
US7057012B1 (en) 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
ATE308609T1 (de) 1998-12-31 2005-11-15 Gen Hospital Corp Pth rezeptor und testverfahren unter verwendung desselben
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
WO2001023521A2 (en) 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
US7087229B2 (en) * 2003-05-30 2006-08-08 Enzon Pharmaceuticals, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers
WO2004067021A1 (en) 2003-01-24 2004-08-12 Gardella Thomas J Conformationally constrained parathyroid hormone (pth) analogs with lactam bridges
US7795220B2 (en) 2003-03-19 2010-09-14 The General Hospital Corporation Conformationally constrained parathyroid hormones with alpha-helix stabilizers
JP4871128B2 (ja) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション 高次構造的に制約された副甲状腺ホルモン（ｐｔｈ）アナログ
BR122019021416A2 (cg-RX-API-DMAC7.html) * 2003-09-19 2019-12-21
JP5324781B2 (ja) * 2004-06-14 2013-10-23 ビーエーエスエフ、ビューティー、ケア、ソルーションズ、フランス、エスエーエス Ｐｔｈ断片含有化粧品
WO2008019062A2 (en) 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
CN104072606B (zh) 2007-08-01 2017-09-22 总医院有限公司 利用g蛋白偶联受体和相关组合物的筛选方法
US20110294738A1 (en) * 2008-11-04 2011-12-01 Yong Ren Pthr1 receptor compounds
WO2010111617A2 (en) * 2009-03-27 2010-09-30 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
MX358161B (es) * 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.
MY208384A (en) * 2016-03-01 2025-05-05 Ascendis Pharma Bone Diseases As Pth prodrugs
WO2017173372A1 (en) * 2016-04-01 2017-10-05 The General Hospital Corporation Parathyroid hormone receptor 1 antagonist and inverse agonist polypeptides and methods of their use
HRP20230383T1 (hr) * 2016-09-29 2023-07-07 Ascendis Pharma Bone Diseases A/S Pth spojevi s malim omjerima maksimalne prema minimalnoj koncentraciji
KR101964376B1 (ko) * 2017-09-29 2019-04-01 주식회사 나이벡 부갑상선호르몬(parathyroid hormone, PTH)에 골조직 선택성 펩타이드가 결합되어 있는 융합 펩타이드를 포함하는 약학 조성물 및 생체재료

Similar Documents

Publication Publication Date Title
CN100506844C (zh) 新的肽
JP2021516222A5 (cg-RX-API-DMAC7.html)
RU2485135C2 (ru) Соединения оксинтомодулина (варианты), фармацевтическая композиция на их основе, способы лечения и профилактики ожирения и сопутствующих заболеваний (варианты) и лекарственное средство (варианты)
US11911443B2 (en) Fusion proteins with extended serum half life
US20180327454A1 (en) Peptide pharmaceuticals
IL101452A (en) Analogs of the factor that releases the growth hormone, their preparation and the pharmaceutical preparations that contain them
JPH11505807A (ja) 生物学的活性が増加したキメラ脂肪体プロｇｒｆ類似体
JP2014051505A (ja) グルコース依存性インスリン分泌刺激ポリペプチドの切り詰められたアナログ
IL98638A (en) Analogs of the factor that releases human growth hormone, their preparation and pharmaceutical preparations that contain them
JP2013526864A5 (cg-RX-API-DMAC7.html)
JPS63313800A (ja) 副甲状腺ホルモン拮抗剤
KR102117216B1 (ko) 강력한 작용제 효과를 지닌 신규한 ｇｈ-ｒｈ 유사체
CN103501801A (zh) 甲状旁腺激素类似物、其组合物和用途
CN109153712B (zh) Peg化生物活性肽及其用途
JP6113144B2 (ja) 成長ホルモン放出因子（ｇｒｆ）類似体およびその使用
RU2096416C1 (ru) Производные пептидов - аналоги grf или их нетоксичные соли
JPH09157294A (ja) 副甲状腺ホルモン誘導体
JP2004002378A (ja) 修飾ペプチドの製造方法
AU655791B2 (en) Stabilized, potent GRF analogs
EP0405763A1 (en) GRF peptides
HK40002026A (en) Fusion proteins with extended serum half life
HK1026215A1 (en) Analogs of parathyroid hormone