JP2021513998A - 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形 - Google Patents

鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形 Download PDF

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Publication number
JP2021513998A
JP2021513998A JP2020544420A JP2020544420A JP2021513998A JP 2021513998 A JP2021513998 A JP 2021513998A JP 2020544420 A JP2020544420 A JP 2020544420A JP 2020544420 A JP2020544420 A JP 2020544420A JP 2021513998 A JP2021513998 A JP 2021513998A
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Prior art keywords
bupropion
dosage form
administered
dextromethorphan
human
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JP2020544420A
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English (en)
Japanese (ja)
Inventor
タビュトー、ヘリオット
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アクスサム セラピューティクス インコーポレイテッド
アクスサム セラピューティクス インコーポレイテッド
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Publication of JP2021513998A publication Critical patent/JP2021513998A/ja
Priority to JP2022124557A priority Critical patent/JP2022153638A/ja
Priority to JP2024041381A priority patent/JP2024075655A/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020544420A 2018-02-23 2019-02-25 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形 Pending JP2021513998A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022124557A JP2022153638A (ja) 2018-02-23 2022-08-04 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法
JP2024041381A JP2024075655A (ja) 2018-02-23 2024-03-15 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862634718P 2018-02-23 2018-02-23
US62/634,718 2018-02-23
US201962794469P 2019-01-18 2019-01-18
US62/794,469 2019-01-18
US201962809480P 2019-02-22 2019-02-22
US62/809,480 2019-02-22
PCT/US2019/019445 WO2019165379A1 (en) 2018-02-23 2019-02-25 Dosage forms and methods for enantiomerically enriched or pure bupropion

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2022124557A Division JP2022153638A (ja) 2018-02-23 2022-08-04 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法
JP2024041381A Division JP2024075655A (ja) 2018-02-23 2024-03-15 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法

Publications (1)

Publication Number Publication Date
JP2021513998A true JP2021513998A (ja) 2021-06-03

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JP2020544420A Pending JP2021513998A (ja) 2018-02-23 2019-02-25 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形
JP2022124557A Pending JP2022153638A (ja) 2018-02-23 2022-08-04 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法
JP2024041381A Pending JP2024075655A (ja) 2018-02-23 2024-03-15 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法

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JP2022124557A Pending JP2022153638A (ja) 2018-02-23 2022-08-04 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法
JP2024041381A Pending JP2024075655A (ja) 2018-02-23 2024-03-15 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法

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EP (1) EP3755312A4 (https=)
JP (3) JP2021513998A (https=)
KR (3) KR20230075531A (https=)
CN (2) CN112087999A (https=)
AU (3) AU2019223187B2 (https=)
BR (1) BR112020017179A2 (https=)
CA (1) CA3092076A1 (https=)
CL (1) CL2020002166A1 (https=)
CR (1) CR20200415A (https=)
EC (1) ECSP20060179A (https=)
IL (2) IL276871B2 (https=)
MA (1) MA51914A (https=)
MX (2) MX2020008704A (https=)
MY (1) MY202993A (https=)
NI (1) NI202000056A (https=)
NZ (1) NZ767378A (https=)
PE (1) PE20211752A1 (https=)
SG (1) SG11202008056SA (https=)
WO (1) WO2019165379A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022153638A (ja) * 2018-02-23 2022-10-12 アクスサム セラピューティクス インコーポレイテッド 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660274B2 (en) 2018-09-20 2023-05-30 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US11291639B2 (en) 2018-09-20 2022-04-05 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
US11660273B2 (en) 2018-09-20 2023-05-30 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion
KR20220066930A (ko) * 2019-09-20 2022-05-24 액섬 테라퓨틱스, 인크. 에난티오머적으로 풍부한 또는 순수한 부프로피온을 위한 제형 및 방법
US20250073188A1 (en) 2020-06-05 2025-03-06 Antecip Bioventures Ii Llc Compounds and combinations thereof for treating neurological and psychiatric conditions
US12036191B1 (en) 2022-06-30 2024-07-16 Antecip Bioventures Ii Llc Treatment of poor metabolizers of dextromethorphan with a combination of bupropion and dextromethorphan
US11717518B1 (en) 2022-06-30 2023-08-08 Antecip Bioventures Ii Llc Bupropion dosage forms with reduced food and alcohol dosing effects
US12156914B2 (en) * 2022-06-30 2024-12-03 Axsome Therapeutics, Inc. Pharmaceutical compositions comprising bupropion and cysteine
US11730706B1 (en) 2022-07-07 2023-08-22 Antecip Bioventures Ii Llc Treatment of depression in certain patient populations
WO2025259728A1 (en) * 2024-06-13 2025-12-18 Antecip Bioventures Ii Llc Compounds and combinations thereof for treating neurological and psychiatric conditions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003529563A (ja) * 2000-02-22 2003-10-07 セプラコア インコーポレーテッド ビュープロピオン代謝産物並びにその合成および使用方法
WO2012118562A1 (en) * 2011-03-02 2012-09-07 Rhine Pharmaceuticals, Llc Compositions and methods for treating depression, adhd and other central nervous system disorders employing novel bupropion compounds, and methods for production and use of novel bupropion compounds and formulations

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002501890A (ja) * 1998-01-29 2002-01-22 セプラコア インコーポレーテッド 光学的に純粋な（＋）−ビュープロピオンの薬学的使用
ME00391B (me) * 2003-08-08 2011-10-10 Biovail Laboratories Int Srl Tableta bupropion hidrohlorida sa modifikovanim otpuštanjem
US9474731B1 (en) * 2013-11-05 2016-10-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
US9198905B2 (en) * 2013-11-05 2015-12-01 Antecip Bioventures Ii Llc Compositions and methods for reducing dextrorphan plasma levels and related pharmacodynamic effects
US10080727B2 (en) * 2013-11-05 2018-09-25 Antecip Bioventures Ii Llc Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects
WO2015095713A1 (en) * 2013-12-20 2015-06-25 Deuterx, Llc Methods of treating neurological and other disorders using enantiopure deuterium-enriched bupropion
CA3092076A1 (en) * 2018-02-23 2019-08-29 Axsome Therapeutics, Inc. Dosage forms and methods for enantiomerically enriched or pure bupropion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003529563A (ja) * 2000-02-22 2003-10-07 セプラコア インコーポレーテッド ビュープロピオン代謝産物並びにその合成および使用方法
WO2012118562A1 (en) * 2011-03-02 2012-09-07 Rhine Pharmaceuticals, Llc Compositions and methods for treating depression, adhd and other central nervous system disorders employing novel bupropion compounds, and methods for production and use of novel bupropion compounds and formulations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J CLIN PHARMACOL, vol. 48, JPN6021032200, 2008, pages 464 - 474, ISSN: 0004744663 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022153638A (ja) * 2018-02-23 2022-10-12 アクスサム セラピューティクス インコーポレイテッド 鏡像異性体的に濃縮された、または鏡像異性体的に純粋なブプロピオンの剤形および方法

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Publication number Publication date
MX2023009281A (es) 2023-08-17
CR20200415A (es) 2021-02-03
NZ767378A (en) 2024-03-22
WO2019165379A1 (en) 2019-08-29
KR20230075531A (ko) 2023-05-31
KR20240091043A (ko) 2024-06-21
ECSP20060179A (es) 2020-12-31
MA51914A (fr) 2020-12-30
NI202000056A (es) 2021-01-11
IL276871A (en) 2020-10-29
AU2022204521A1 (en) 2022-07-21
EP3755312A1 (en) 2020-12-30
EP3755312A4 (en) 2022-03-16
CA3092076A1 (en) 2019-08-29
AU2019223187B2 (en) 2022-07-28
CL2020002166A1 (es) 2020-10-23
AU2019223187A1 (en) 2020-09-17
BR112020017179A2 (pt) 2020-12-22
JP2024075655A (ja) 2024-06-04
MX2020008704A (es) 2020-12-07
IL276871B2 (en) 2024-11-01
AU2022204521B2 (en) 2024-09-05
MY202993A (en) 2024-05-31
IL313368A (en) 2024-08-01
JP2022153638A (ja) 2022-10-12
CN112087999A (zh) 2020-12-15
PE20211752A1 (es) 2021-09-06
SG11202008056SA (en) 2020-09-29
IL276871B1 (en) 2024-07-01
CN120827545A (zh) 2025-10-24
KR20210003091A (ko) 2021-01-11
AU2024205858A1 (en) 2024-09-05

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