JP2021511042A - Ａｌｄｈ２発現を阻害するための組成物及び方法 - Google Patents

Ａｌｄｈ２発現を阻害するための組成物及び方法 Download PDF

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JP2021511042A
JP2021511042A JP2020539274A JP2020539274A JP2021511042A JP 2021511042 A JP2021511042 A JP 2021511042A JP 2020539274 A JP2020539274 A JP 2020539274A JP 2020539274 A JP2020539274 A JP 2020539274A JP 2021511042 A JP2021511042 A JP 2021511042A
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oligonucleotide
nucleotides
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aldh2
antisense strand
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JP2021511042A5 (https=
JPWO2019143621A5 (https=
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ユトサフ サクセナ
ユトサフ サクセナ
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Dicerna Pharmaceuticals Inc
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JP2020539274A 2018-01-16 2019-01-15 Ａｌｄｈ２発現を阻害するための組成物及び方法 Pending JP2021511042A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862617692P 2018-01-16 2018-01-16
US62/617,692 2018-01-16
PCT/US2019/013672 WO2019143621A1 (en) 2018-01-16 2019-01-15 Compositions and methods for inhibiting aldh2 expression

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JP2021511042A true JP2021511042A (ja) 2021-05-06
JP2021511042A5 JP2021511042A5 (https=) 2022-01-20
JPWO2019143621A5 JPWO2019143621A5 (https=) 2022-01-20

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US (1) US11661603B2 (https=)
EP (1) EP3710588A4 (https=)
JP (1) JP2021511042A (https=)
KR (1) KR20200109311A (https=)
CN (1) CN111601891A (https=)
AU (1) AU2019209324A1 (https=)
CA (1) CA3086409A1 (https=)
IL (1) IL275539A (https=)
MX (1) MX2020007582A (https=)
WO (1) WO2019143621A1 (https=)

Families Citing this family (10)

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WO2019143621A1 (en) 2018-01-16 2019-07-25 Dicerna Pharmaceuticals, Inc. Compositions and methods for inhibiting aldh2 expression
CA3135402A1 (en) * 2019-04-04 2020-10-08 Dicerna Pharmaceuticals, Inc. Compositions and methods for inhibiting gene expression in the central nervous system
WO2020226960A1 (en) 2019-05-03 2020-11-12 Dicerna Pharmaceuticals, Inc. Double-stranded nucleic acid inhibitor molecules with shortened sense strands
EP4244356A1 (en) 2020-11-13 2023-09-20 Dicerna Pharmaceuticals, Inc. Chemical modifications for inhibiting expression of aldh2
CN113174438B (zh) * 2021-06-01 2022-07-26 中国科学院城市环境研究所 Aldh2基因多态性检测试剂盒及检测方法
CN114891808B (zh) * 2022-06-21 2023-10-27 珠海丽凡达生物技术有限公司 编码ALDH2多肽的mRNA分子、应用及mRNA药物
WO2024000237A1 (zh) * 2022-06-29 2024-01-04 河南省农业科学院植物营养与资源环境研究所 Iaa-po1基因在诱导平菇原基形成和平菇生长发育抗逆中的应用
GB202218090D0 (en) 2022-12-01 2023-01-18 Proqr Therapeutics Ii Bv Antisense oligonucleotides for the treatment of aldehyde dehydrogenase 2 deficiency
AU2023408479A1 (en) * 2022-12-19 2025-05-01 Arnatar Therapeutics, Inc Advanced rna targeting (arnatar)
CN119082043A (zh) * 2024-10-10 2024-12-06 张家界学院 Aldh2稳定表达的细胞系、构建方法及应用

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US20030032788A1 (en) * 1997-07-03 2003-02-13 Thomas Jefferson University Methods of inhibiting alcohol consumption
WO2001016346A1 (en) * 1999-08-30 2001-03-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
WO2005116265A2 (en) * 2004-05-26 2005-12-08 Wyeth Probe arrays for expression profiling of rat genes
JP2012504389A (ja) * 2008-09-22 2012-02-23 ダイセルナ ファーマシューティカルズ， インコーポレイテッド 修飾を有するｄｓＲＮＡによる遺伝子発現の特異的な阻害のための組成物および方法
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JP2014530602A (ja) * 2011-10-05 2014-11-20 プロティバ バイオセラピューティクス インコーポレイテッド アルデヒドデヒドロゲナーゼをサイレンシングするための組成物および方法
JP2018500027A (ja) * 2014-12-15 2018-01-11 ダイセルナ ファーマシューティカルズ， インコーポレイテッドＤｉｃｅｒｎａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． リガンド修飾二本鎖核酸
WO2016183009A2 (en) * 2015-05-08 2016-11-17 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of antithrombin 3 (at3) by double-stranded rna

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EP3710588A4 (en) 2021-08-18
IL275539A (en) 2020-08-31
EP3710588A1 (en) 2020-09-23
US11661603B2 (en) 2023-05-30
MX2020007582A (es) 2020-09-03
CN111601891A (zh) 2020-08-28
WO2019143621A1 (en) 2019-07-25
KR20200109311A (ko) 2020-09-22
US20210380984A1 (en) 2021-12-09
AU2019209324A1 (en) 2020-07-09
CA3086409A1 (en) 2019-07-25

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