JP2021510380A5 - - Google Patents
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- JP2021510380A5 JP2021510380A5 JP2020546284A JP2020546284A JP2021510380A5 JP 2021510380 A5 JP2021510380 A5 JP 2021510380A5 JP 2020546284 A JP2020546284 A JP 2020546284A JP 2020546284 A JP2020546284 A JP 2020546284A JP 2021510380 A5 JP2021510380 A5 JP 2021510380A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- radiation
- composition according
- tissue
- organ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000008194 pharmaceutical composition Substances 0.000 claims 28
- 230000005855 radiation Effects 0.000 claims 17
- 210000001519 tissue Anatomy 0.000 claims 14
- 210000000056 organ Anatomy 0.000 claims 12
- 230000001120 cytoprotective effect Effects 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 210000001198 duodenum Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- -1 3-aminopropylamino Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000001630 jejunum Anatomy 0.000 claims 2
- 208000037819 metastatic cancer Diseases 0.000 claims 2
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 2
- 210000000496 pancreas Anatomy 0.000 claims 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 206010073306 Exposure to radiation Diseases 0.000 claims 1
- 206010061203 Hepatobiliary neoplasm Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000004100 adrenal gland Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229940124569 cytoprotecting agent Drugs 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 210000000232 gallbladder Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000002429 large intestine Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000004846 retroperitoneal sarcoma Diseases 0.000 claims 1
- 210000000574 retroperitoneal space Anatomy 0.000 claims 1
- 210000000813 small intestine Anatomy 0.000 claims 1
- 238000011517 stereotactic body radiotherapy Methods 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
- 210000001635 urinary tract Anatomy 0.000 claims 1
- 210000004291 uterus Anatomy 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023204518A JP2024026262A (ja) | 2017-11-21 | 2023-12-04 | 放射線感受性組織における細胞保護薬の選択的堆積およびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762589155P | 2017-11-21 | 2017-11-21 | |
| US62/589,155 | 2017-11-21 | ||
| PCT/US2018/061888 WO2019103983A1 (en) | 2017-11-21 | 2018-11-19 | Selective accretion of cytoprotectant in radiation-sensitive tissues and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023204518A Division JP2024026262A (ja) | 2017-11-21 | 2023-12-04 | 放射線感受性組織における細胞保護薬の選択的堆積およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021510380A JP2021510380A (ja) | 2021-04-22 |
| JP2021510380A5 true JP2021510380A5 (https=) | 2022-01-04 |
Family
ID=66631627
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020546284A Pending JP2021510380A (ja) | 2017-11-21 | 2018-11-19 | 放射線感受性組織における細胞保護薬の選択的堆積およびその使用 |
| JP2023204518A Pending JP2024026262A (ja) | 2017-11-21 | 2023-12-04 | 放射線感受性組織における細胞保護薬の選択的堆積およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023204518A Pending JP2024026262A (ja) | 2017-11-21 | 2023-12-04 | 放射線感受性組織における細胞保護薬の選択的堆積およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11478489B2 (https=) |
| EP (1) | EP3713534A4 (https=) |
| JP (2) | JP2021510380A (https=) |
| KR (1) | KR20200121286A (https=) |
| CN (1) | CN111867599A (https=) |
| AU (2) | AU2018372917A1 (https=) |
| CA (1) | CA3083238C (https=) |
| WO (1) | WO2019103983A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9855445B2 (en) | 2016-04-01 | 2018-01-02 | Varian Medical Systems, Inc. | Radiation therapy systems and methods for delivering doses to a target volume |
| US10092774B1 (en) | 2017-07-21 | 2018-10-09 | Varian Medical Systems International, AG | Dose aspects of radiation therapy planning and treatment |
| US11712579B2 (en) | 2017-07-21 | 2023-08-01 | Varian Medical Systems, Inc. | Range compensators for radiation therapy |
| US11590364B2 (en) | 2017-07-21 | 2023-02-28 | Varian Medical Systems International Ag | Material inserts for radiation therapy |
| US10549117B2 (en) | 2017-07-21 | 2020-02-04 | Varian Medical Systems, Inc | Geometric aspects of radiation therapy planning and treatment |
| US10843011B2 (en) | 2017-07-21 | 2020-11-24 | Varian Medical Systems, Inc. | Particle beam gun control systems and methods |
| US10183179B1 (en) | 2017-07-21 | 2019-01-22 | Varian Medical Systems, Inc. | Triggered treatment systems and methods |
| EP3654976A1 (en) | 2017-07-21 | 2020-05-27 | Varian Medical Systems, Inc. | Methods of use of ultra-high dose rate radiation and therapeutic agents |
| US11007381B2 (en) | 2017-11-16 | 2021-05-18 | Varian Medical Systems, Inc | Increased beam output and dynamic field shaping for radiotherapy system |
| US10910188B2 (en) | 2018-07-25 | 2021-02-02 | Varian Medical Systems, Inc. | Radiation anode target systems and methods |
| US10814144B2 (en) | 2019-03-06 | 2020-10-27 | Varian Medical Systems, Inc. | Radiation treatment based on dose rate |
| US11116995B2 (en) | 2019-03-06 | 2021-09-14 | Varian Medical Systems, Inc. | Radiation treatment planning based on dose rate |
| US11103727B2 (en) | 2019-03-08 | 2021-08-31 | Varian Medical Systems International Ag | Model based PBS optimization for flash therapy treatment planning and oncology information system |
| US11090508B2 (en) | 2019-03-08 | 2021-08-17 | Varian Medical Systems Particle Therapy Gmbh & Co. Kg | System and method for biological treatment planning and decision support |
| US10918886B2 (en) | 2019-06-10 | 2021-02-16 | Varian Medical Systems, Inc. | Flash therapy treatment planning and oncology information system having dose rate prescription and dose rate mapping |
| US11291859B2 (en) | 2019-10-03 | 2022-04-05 | Varian Medical Systems, Inc. | Radiation treatment planning for delivering high dose rates to spots in a target |
| US12390662B2 (en) | 2020-04-02 | 2025-08-19 | Siemens Healthineers International Ag | System and method for proton therapy treatment planning with proton energy and spot optimization |
| US11865361B2 (en) | 2020-04-03 | 2024-01-09 | Varian Medical Systems, Inc. | System and method for scanning pattern optimization for flash therapy treatment planning |
| US11541252B2 (en) | 2020-06-23 | 2023-01-03 | Varian Medical Systems, Inc. | Defining dose rate for pencil beam scanning |
| US11957934B2 (en) | 2020-07-01 | 2024-04-16 | Siemens Healthineers International Ag | Methods and systems using modeling of crystalline materials for spot placement for radiation therapy |
| US12064645B2 (en) | 2020-07-02 | 2024-08-20 | Siemens Healthineers International Ag | Methods and systems used for planning radiation treatment |
| CN113768940A (zh) * | 2021-08-25 | 2021-12-10 | 中国辐射防护研究院 | 一种放射性肺损伤的防护方法 |
| WO2025075691A1 (en) * | 2023-10-07 | 2025-04-10 | Xerient Pharma Ltd. | Irradiation protection methods uses and compositions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573253B2 (en) * | 1997-02-12 | 2003-06-03 | Medimmune Oncology Inc. | Methods for the administration of amifostine and related compounds |
| US6239119B1 (en) * | 1998-04-27 | 2001-05-29 | Medimmune Oncology, Inc. | Topical administration of amifostine and related compounds |
| WO2007047315A1 (en) | 2005-10-20 | 2007-04-26 | Albemarle Corporation | Amifostine dihydrate crystalline composition |
| US9393439B2 (en) | 2010-03-01 | 2016-07-19 | Intraop Medical Corporation | Radiotherapy combined with hypoxic cell sensitizers |
| US9408882B2 (en) | 2011-03-18 | 2016-08-09 | Albert Einstein College Of Medicine, Inc. | Oral administration of melanin for protection against radiation |
| CN102210694A (zh) * | 2011-04-12 | 2011-10-12 | 上海长征医院 | 一种氨磷汀口服制剂及其制备方法 |
-
2018
- 2018-11-19 WO PCT/US2018/061888 patent/WO2019103983A1/en not_active Ceased
- 2018-11-19 CA CA3083238A patent/CA3083238C/en active Active
- 2018-11-19 JP JP2020546284A patent/JP2021510380A/ja active Pending
- 2018-11-19 EP EP18880730.9A patent/EP3713534A4/en active Pending
- 2018-11-19 US US16/766,025 patent/US11478489B2/en active Active
- 2018-11-19 CN CN201880082136.8A patent/CN111867599A/zh active Pending
- 2018-11-19 KR KR1020207017925A patent/KR20200121286A/ko not_active Ceased
- 2018-11-19 AU AU2018372917A patent/AU2018372917A1/en not_active Abandoned
-
2023
- 2023-12-04 JP JP2023204518A patent/JP2024026262A/ja active Pending
-
2024
- 2024-10-04 AU AU2024227095A patent/AU2024227095A1/en active Pending
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