CA3083238C - Selective accretion of cytoprotectant in radiation-sensitive tissues and uses thereof - Google Patents

Selective accretion of cytoprotectant in radiation-sensitive tissues and uses thereof Download PDF

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Publication number
CA3083238C
CA3083238C CA3083238A CA3083238A CA3083238C CA 3083238 C CA3083238 C CA 3083238C CA 3083238 A CA3083238 A CA 3083238A CA 3083238 A CA3083238 A CA 3083238A CA 3083238 C CA3083238 C CA 3083238C
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Canada
Prior art keywords
radiation
dose
tissue
oral
administration
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Active
Application number
CA3083238A
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English (en)
French (fr)
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CA3083238A1 (en
Inventor
James Tour
Cullen Taniguchi
Kathy Mason
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
University of Texas System
Leland Stanford Junior University
Original Assignee
William Marsh Rice University
University of Texas System
Leland Stanford Junior University
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Publication of CA3083238A1 publication Critical patent/CA3083238A1/en
Application granted granted Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1094—Shielding, protecting against radiation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3083238A 2017-11-21 2018-11-19 Selective accretion of cytoprotectant in radiation-sensitive tissues and uses thereof Active CA3083238C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762589155P 2017-11-21 2017-11-21
US62/589,155 2017-11-21
PCT/US2018/061888 WO2019103983A1 (en) 2017-11-21 2018-11-19 Selective accretion of cytoprotectant in radiation-sensitive tissues and uses thereof

Publications (2)

Publication Number Publication Date
CA3083238A1 CA3083238A1 (en) 2019-05-31
CA3083238C true CA3083238C (en) 2024-02-13

Family

ID=66631627

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3083238A Active CA3083238C (en) 2017-11-21 2018-11-19 Selective accretion of cytoprotectant in radiation-sensitive tissues and uses thereof

Country Status (8)

Country Link
US (1) US11478489B2 (https=)
EP (1) EP3713534A4 (https=)
JP (2) JP2021510380A (https=)
KR (1) KR20200121286A (https=)
CN (1) CN111867599A (https=)
AU (2) AU2018372917A1 (https=)
CA (1) CA3083238C (https=)
WO (1) WO2019103983A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9855445B2 (en) 2016-04-01 2018-01-02 Varian Medical Systems, Inc. Radiation therapy systems and methods for delivering doses to a target volume
US10092774B1 (en) 2017-07-21 2018-10-09 Varian Medical Systems International, AG Dose aspects of radiation therapy planning and treatment
US11712579B2 (en) 2017-07-21 2023-08-01 Varian Medical Systems, Inc. Range compensators for radiation therapy
US11590364B2 (en) 2017-07-21 2023-02-28 Varian Medical Systems International Ag Material inserts for radiation therapy
US10549117B2 (en) 2017-07-21 2020-02-04 Varian Medical Systems, Inc Geometric aspects of radiation therapy planning and treatment
US10843011B2 (en) 2017-07-21 2020-11-24 Varian Medical Systems, Inc. Particle beam gun control systems and methods
US10183179B1 (en) 2017-07-21 2019-01-22 Varian Medical Systems, Inc. Triggered treatment systems and methods
EP3654976A1 (en) 2017-07-21 2020-05-27 Varian Medical Systems, Inc. Methods of use of ultra-high dose rate radiation and therapeutic agents
US11007381B2 (en) 2017-11-16 2021-05-18 Varian Medical Systems, Inc Increased beam output and dynamic field shaping for radiotherapy system
US10910188B2 (en) 2018-07-25 2021-02-02 Varian Medical Systems, Inc. Radiation anode target systems and methods
US10814144B2 (en) 2019-03-06 2020-10-27 Varian Medical Systems, Inc. Radiation treatment based on dose rate
US11116995B2 (en) 2019-03-06 2021-09-14 Varian Medical Systems, Inc. Radiation treatment planning based on dose rate
US11103727B2 (en) 2019-03-08 2021-08-31 Varian Medical Systems International Ag Model based PBS optimization for flash therapy treatment planning and oncology information system
US11090508B2 (en) 2019-03-08 2021-08-17 Varian Medical Systems Particle Therapy Gmbh & Co. Kg System and method for biological treatment planning and decision support
US10918886B2 (en) 2019-06-10 2021-02-16 Varian Medical Systems, Inc. Flash therapy treatment planning and oncology information system having dose rate prescription and dose rate mapping
US11291859B2 (en) 2019-10-03 2022-04-05 Varian Medical Systems, Inc. Radiation treatment planning for delivering high dose rates to spots in a target
US12390662B2 (en) 2020-04-02 2025-08-19 Siemens Healthineers International Ag System and method for proton therapy treatment planning with proton energy and spot optimization
US11865361B2 (en) 2020-04-03 2024-01-09 Varian Medical Systems, Inc. System and method for scanning pattern optimization for flash therapy treatment planning
US11541252B2 (en) 2020-06-23 2023-01-03 Varian Medical Systems, Inc. Defining dose rate for pencil beam scanning
US11957934B2 (en) 2020-07-01 2024-04-16 Siemens Healthineers International Ag Methods and systems using modeling of crystalline materials for spot placement for radiation therapy
US12064645B2 (en) 2020-07-02 2024-08-20 Siemens Healthineers International Ag Methods and systems used for planning radiation treatment
CN113768940A (zh) * 2021-08-25 2021-12-10 中国辐射防护研究院 一种放射性肺损伤的防护方法
WO2025075691A1 (en) * 2023-10-07 2025-04-10 Xerient Pharma Ltd. Irradiation protection methods uses and compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6573253B2 (en) * 1997-02-12 2003-06-03 Medimmune Oncology Inc. Methods for the administration of amifostine and related compounds
US6239119B1 (en) * 1998-04-27 2001-05-29 Medimmune Oncology, Inc. Topical administration of amifostine and related compounds
WO2007047315A1 (en) 2005-10-20 2007-04-26 Albemarle Corporation Amifostine dihydrate crystalline composition
US9393439B2 (en) 2010-03-01 2016-07-19 Intraop Medical Corporation Radiotherapy combined with hypoxic cell sensitizers
US9408882B2 (en) 2011-03-18 2016-08-09 Albert Einstein College Of Medicine, Inc. Oral administration of melanin for protection against radiation
CN102210694A (zh) * 2011-04-12 2011-10-12 上海长征医院 一种氨磷汀口服制剂及其制备方法

Also Published As

Publication number Publication date
JP2021510380A (ja) 2021-04-22
AU2024227095A1 (en) 2024-10-24
WO2019103983A1 (en) 2019-05-31
CA3083238A1 (en) 2019-05-31
EP3713534A1 (en) 2020-09-30
EP3713534A4 (en) 2021-08-25
AU2018372917A1 (en) 2020-06-18
JP2024026262A (ja) 2024-02-28
KR20200121286A (ko) 2020-10-23
US11478489B2 (en) 2022-10-25
US20200360406A1 (en) 2020-11-19
CN111867599A (zh) 2020-10-30

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