JP2021509475A - 外傷性脳損傷を診断及び査定するための、新規のバイオマーカー及び方法 - Google Patents
外傷性脳損傷を診断及び査定するための、新規のバイオマーカー及び方法 Download PDFInfo
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Abstract
Description
本開示の複数の実施形態は、少なくとも1つのバイオマーカーを測定又は検出する方法を含む。これらの実施形態に従い、方法は、実際の頭部損傷又は推測される頭部損傷の後において、対象から試料を得るステップ;並びに試料中の、AL9A1、ATPG、C1RL、CAND1、EPIPL、GLO2、IGHA2、PZP、SYTC、SYYC若しくはこれらの任意の組合せからなる群から選択される少なくとも1つのバイオマーカー若しくはこの断片を測定若しくは検出するステップ;及び/又は試料中の、ABHEB、AL9A1、DNM1L、FCN2、INF2、K22E、M3K5、NCOR1、SBSN、SYEP、TPP2若しくはこれらの任意の組合せからなる群から選択される少なくとも1つのバイオマーカー若しくはこの断片を測定若しくは検出するステップを含む。一部の実施形態において、少なくとも1つのバイオマーカーの測定又は検出は、対象が外傷性脳損傷(TBI)を負った又は負った可能性があることを指し示す。
そうでないことが規定されない限りにおいて、本明細書において使用された、全ての技術用語及び科学用語は、当業者により一般に理解される意味と同じ意味を有する。齟齬が生じる場合は、定義を含む本文献に従う。本開示の実施又は試験において、本明細書において記載された方法及び材料と同様又は同等な方法及び材料も使用されうるが、下記において、好ましい方法及び材料について記載される。本明細書において言及された、全ての刊行物、特許出願、特許及び他の参考文献は、参照によりそれらの全体において組み込まれる。本明細書において開示された材料、方法及び例は、例示的なものであるに過ぎず、限定を意図するものではない。
本開示は、対象がTBI又は各種の軽度TBIを負ったのかどうかを含む、対象が頭部への損傷を負っている又はこれを負った可能性があるのかどうかについての診断、予後診断、危険性層別化及び査定の一助となる方法に関する。これらの方法は、推測される頭部への損傷を伴うヒト対象におけるTBIの程度及び/又は重症度を決定することであって、例えば、対象が軽度TBIを負っているのかどうかを決定することであり、そうである場合、負われた、軽度TBIのサブクラス、対象が中等度〜重度のTBIを負っているのかどうか又は対象がTBIを負っていないのかどうかを決定することを含む、決定することの一助となりうる。より具体的に、本開示のバイオマーカーは、診断検査において、脳損傷状態を決定、定量及び/又は評価する、例えば、個々の対象又は患者において、TBIを診断するのに使用されうる。一部の実施形態において、TBI状態は、患者の無症候性脳損傷状態又はSCI状態を決定して、例えば、個々の対象又は患者において、SCIを診断することを含みうる。本開示のバイオマーカーを検出又は測定することは、TBIを診断することの一助となることが可能であり、例えば、軽度TBIのサブクラスについて、TBIシグネチャーを生成することの一助となりうる。
本開示のバイオマーカーは、TBI状態など、患者における脳損傷状態を評価、決定及び/又は定量する(本明細書において互換的に使用された)診断検査において使用されうる。「脳損傷状態」という語句は、脳損傷を有さないことを含む、任意の識別可能な状態の顕示を含む。例えば、脳損傷状態は、限定せずに述べると、患者における脳損傷の存在又は非存在、脳損傷を発症する危険性、脳損傷の病期又は重症度、脳損傷の進行(例えば、脳損傷の時間経過にわたる進行)、脳損傷の処置の有効性又はこれに対する応答(例えば、処置の後における、脳損傷の臨床追跡及び臨床監視)及びTBI又はTBIのサブクラスなど、脳損傷の種類を含む。この状態に基づき、さらなる診断検査又は治療手順又はレジメンを含む、さらなる手順が指し示されうる。
一部の実施形態において、本開示は、1つ以上のTBIバイオマーカーの検出、非検出及び/又は検出レベルに基づき、TBIの重症度、異なる種類のTBIを特徴付けることなど、TBIを特徴付け、かつ/又は類別するための方法を提示する。TBIの各クラス又は各サブクラスは、特徴的レベルのバイオマーカー又は相対レベルのバイオマーカー(シグネチャー)のセットを有する可能性が高い。一実施形態において、本開示は、患者における、進行(増悪)及び退縮(改善)を含む、TBI状態の進行を、時間経過にわたり査定するための方法を提示する。時間経過にわたり、TBIバイオマーカーの量又は相対量(例えば、パターン又はシグネチャー)は変化しうる。例えば、バイオマーカー「X」が、脳損傷と共に増大しうるのに対し、バイオマーカー「Y」は、脳損傷と共に減少しうる。したがって、これらのバイオマーカーが、時間経過にわたり、増大又は減少して、脳損傷又は非脳損傷への傾向を示すことは、状態の経過を指し示す。したがって、この方法は、患者における、1つ以上のバイオマーカーのレベルを、少なくとも2つの異なる時点において測定するステップ(例えば、第1の時点及び第2の時点であり、変化があれば、これを比較するステップ)を伴う。
TBIを有すると同定又は評価された対象は、多様なTBIバイオマーカーを検出又は測定することを含みうる評価に基づき、処置又はモニタリングされうる。一部の実施形態において、方法は、TBIを有すると評価されたヒト対象を、頭部への損傷の重症度に応じて、様々な形態を取りうる処置により処置するステップをさらに含む。例えば、軽度TBIを患う対象の場合、処置は、休息、スポーツなどの、身体活動の抑制、日向に出るときの、光線の回避又はサングラスの着用、頭痛又は偏頭痛を緩和するための薬物、抗悪心薬などのうちの1つ以上を含みうる。重度TBIを患う患者のための処置は、1つ以上の適切な薬物(例えば、利尿剤、抗痙攣薬物、個体を鎮静させ、薬物誘導性昏睡へと導く薬物など)又は他の医薬若しくは生物医薬(TBIの処置のために公知の医薬又は将来開発される医薬)の投与、1つ以上の手術手順(例えば、血腫の除去、頭蓋骨骨折の修復、減圧開頭術など)、1つ以上の治療(例えば、1つ以上のリハビリ、認知行動療法、アンガーマネージメント、心理カウンセリングなど)を含みうる。一部の実施形態において、方法は、外傷性脳損傷(例えば、軽度又は中等度〜重度の外傷性脳損傷)を有すると評価されたヒト対象をモニタリングするステップをさらに含む。一部の実施形態において、軽度外傷性脳損傷又は重度外傷性脳損傷などの外傷性脳損傷を有すると同定された対象は、CTスキャン又はMRIによりモニタリングされうる。
本明細書において記載された方法は、TBIを負った可能性がある対象の診断及び査定の一助となりうる、1つ以上のTBIバイオマーカー又は候補TBIバイオマーカーを同定するのに使用されうる。下記に、例示的なTBIバイオマーカーについて記載される。
下記において記載される、以下のTBIバイオマーカーは、単独又は組合せで検出された場合に、健常対象を、TBIを負っている対象から識別することが可能であると同定された。
ジナミン1様タンパク質(DNM1L)
SYEPは、2ステップの反応において、コグネイトアミノ酸の、対応するtRNAへの接合を触媒する:チロシンは、まず、ATPにより活性化して、共有結合中間体を形成し、次いで、コグネイトtRNAのアクセプター末端へと転移される。SYEPは、炎症過程において、インターフェロンガンマ誘導転写物選択的翻訳阻害を媒介する、GAIT(gamma interferon−activate inhibitor of translation)複合体の構成要素である。インターフェロンガンマの活性化及び後続のリン酸化がなされると、SYEPは、マルチシンセターゼ複合体から解離し、GAIT複合体へとアセンブルされ、これは、多様な炎症性mRNAの3’−UTR内の、ステムループ含有GAITエレメント(セルロプラスミンなど)に結合し、それらの翻訳を抑制する(UniProt基本受託番号:P07814)。
Aキナーゼアンカータンパク質12(AKA12又はAKAP12)
ミトコンドリアリンゴ酸デヒドロゲナーゼ(MDHM又はMDH2)
細胞質ジネイン軽鎖1(DYL1又はDYNLL1)
DYL1は、細胞質ジネイン1複合体の、いくつかの非触媒性アクセサリー構成要素のうちの1つとして作用し、ジネインを、カーゴ及びジネイン機能を調節するアダプタータンパク質へと連結することに関与すると考えられる。細胞質ジネイン1は、小胞及び細胞小器官の、微小管に沿った、細胞内の逆向き運動のためのモーターとして作用する。DYL1は、細胞骨格構造の空間的分布を変化させる又は維持することにおいて、役割を果たしうる。DYL1は、ニューロンの一酸化窒素シンターゼに結合し、この触媒活性を阻害する。DYL1は、ESR1のトランス活性化機能を促進し、ESR1の核内局在化において、役割を果たす。DYL1は、BCL2L11を、微小管へと封鎖することにより、BCL2L11のアポトーシス活性を調節する。アポトーシス刺激があると、BCL2L11−DYNLL1複合体は、細胞質ジネインから解離し、ミトコンドリアへと移行し、BCL2を封鎖し、これにより、その抗アポトーシス活性を中和する(UniProt基本受託番号:P63167)。
免疫グロブリン可変カッパ1−39(KV139又はIGKV1−39)
補体H因子関連タンパク質4(FHR4又はCFHR4)
FHR4は、補体の調節に関与している。FHR4は、リポタンパク質と会合することが可能であり、脂質代謝において、役割を果たしうる(UniProt基本受託番号:Q92496)。
本明細書において記載された方法は、「TBIバイオマーカー抗体」と称される、TBIバイオマーカー又はこの断片に特異的に結合する単離抗体を使用しうる。TBIバイオマーカー抗体は、TBIバイオマーカー状態を、外傷性脳損傷の尺度として評価する、TBIバイオマーカーの、生体試料中の存在を検出する、TBIバイオマーカーの、生体試料中に存在する量を定量する又はTBIバイオマーカーの、生体試料中の存在を検出し、かつ、TBIバイオマーカーの、生体試料中量を定量するのに使用されうる。
本開示の方法は、1つ以上のTBIバイオマーカーを検出又は同定するアプタマーの使用を含む。アプタマーは、TBIペプチドバイオマーカーなどの標的分子に対する高アフィニティー及び選択性を有するプローブの開発における使用に適する。アプタマーは、有機低分子〜タンパク質及びペプチドの範囲にわたる、それらの標的に特異的に結合する能力を有する、一本鎖DNA(ssDNA)、RNA又は修飾核酸を含む。標的認識のためのベースは、当技術分野において公知の、一本鎖オリゴヌクレオチドにより形成された三次構造である。一部の実施形態において、1つ以上のTBIバイオマーカーを検出又は同定するのに使用されるアプタマーは、アプタマーが、オリゴヌクレオチドの、標的分子への反復的結合による、合成のDNA又はRNAのランダム配列のライブラリーから選択されるSELEXとして公知の、インビトロにおける選択工程を介して得られうる。
試料中に存在する目的の解析物(例えば、TBIバイオマーカー)の存在又は量を決定する、開示された方法は、本明細書において記載された通りでありうる。方法はまた、解析物を解析するための他の方法を念頭に置いて、適合させる場合もある。周知の変化形の例は、酵素による検出(酵素イムノアッセイ(EIA)又は酵素免疫測定アッセイ(ELISA))を含む、サンドイッチイムノアッセイ(例えば、モノクローナル−モノクローナルサンドイッチイムノアッセイ、モノクローナル−ポリクローナルサンドイッチイムノアッセイ)、競合阻害イムノアッセイ(例えば、フォワード競合阻害イムノアッセイ及びリバース競合阻害イムノアッセイ)、酵素多重化イムノアッセイ法(EMIT)、競合結合アッセイなどのイムノアッセイ、生物発光エネルギー移動(BRET)、ワンステップ抗体検出アッセイ、同種アッセイ、異種アッセイ、キャプチャーオンザフライアッセイなどを含むがこれらに限定されない。
目的の解析物及び/又はこのペプチド若しくは断片(例えば、TBIバイオマーカー及び/又はこのペプチド若しくは断片)は、TBIバイオマーカー抗体を、イムノアッセイにおいて使用して解析されうる。解析物(例えば、TBIバイオマーカー)の存在又は量は、抗体を使用し、解析物への特異的結合を検出して決定されうる。例えば、抗体又はこの抗体断片は、解析物に特異的に結合しうる。所望の場合、抗体のうちの1つ以上は、1つ以上の、市販のモノクローナル/ポリクローナル抗体と組み合わせて使用されうる。このような抗体は、R&D Systems,Inc.(Minneapolis、MN)及びEnzo Life Sciences International,Inc.(Plymouth Meeting、PA)などの企業から市販されている。
サンドイッチイムノアッセイは、抗体(すなわち、少なくとも1つの捕捉抗体)と、検出抗体(すなわち、少なくとも1つの検出抗体)とからなる、2つの層の間の抗原の量を測定する。捕捉抗体及び検出抗体は、抗原、例えば、TBIバイオマーカーなど、目的の解析物上の、異なるエピトープに結合する。捕捉抗体の、エピトープへの結合は、検出抗体の、エピトープへの結合に干渉しないことが所望される。モノクローナル抗体又はポリクローナル抗体のいずれも、サンドイッチイムノアッセイにおける、捕捉抗体及び検出抗体として使用されうる。
任意選択的に、被験試料を、少なくとも1つの、第1の捕捉抗体と接触させる前に、少なくとも1つの、第1の捕捉抗体は、第1の抗体−解析物(例えば、TBIバイオマーカー)複合体の、被験試料からの分離を容易とする固体支持体に結合しうる。当技術分野において公知である、任意の固体支持体であって、ウェル、チューブ又はビーズ(マイクロ粒子など)の形態のポリマー材料から作られた固体支持体を含むがこれらに限定されない固体支持体が使用されうる。抗体(antibody(又はantibodies))は、そのような結合が、解析物に結合する抗体の能力に干渉しないことを条件として、吸着により、化学的カップリング剤を使用する共有結合により又は当技術分野において公知である他の手段により、固体支持体に結合しうる。さらに、必要な場合、固体支持体は、抗体上の多様な官能基との反応性を可能とするように、誘導体化されうる。このような誘導体化は、無水マレイン酸、N−ヒドロキシスクシンイミド及び1−エチル−3−(3−ジメチルアミノプロピル)カルボジイミドなどであるがこれらに限定されない、ある特定のカップリング剤の使用を要求する。
次いで、第1の/複数の捕捉抗体−解析物(例えば、TBIバイオマーカー)複合体の形成後、複合体は、少なくとも1つの、第2の検出抗体と接触させる(第1の/複数の抗体−解析物抗原−第2の抗体複合体の形成を可能とする条件下において)。一部の実施形態において、被験試料は、捕捉抗体と同時に、検出抗体と接触させる。第1の抗体−解析物複合体が、1つを超える検出抗体と接触させる場合、第1の/複数の捕捉抗体−解析物−複数の検出抗体複合体が形成される。少なくとも第2の(及び後続の)抗体が、第1の抗体−解析物複合体と接触させる場合、第1の抗体と同様に、上記された条件と同様の条件下におけるインキュベーション時間が、第1の/複数の抗体−解析物−第2の/複数の抗体複合体の形成に要求される。好ましくは、少なくとも1つの、第2の抗体は、検出可能な標識を含有する。検出可能な標識は、第1の/複数の抗体−解析物−第2の/複数の抗体複合体の形成の前に、これと同時に又はこの後に、少なくとも1つの、第2の抗体に結合しうる。当技術分野において公知である、任意の検出可能な標識が使用されうる。
フォワード競合フォーマットにおいて、公知の濃度の、蛍光標識、切断可能なリンカーと接合されたタグなどを有する、標識された目的の解析物(例えば、TBIバイオマーカー)のアリコートが、被験試料中の目的の解析物と、目的の解析物抗体(例えば、TBIバイオマーカー抗体)への結合について競合するように使用される。
リバース競合アッセイにおいて、固定化された目的の解析物(例えば、TBIバイオマーカー)は、被験試料及び少なくとも1つの標識された抗体と、逐次的に又は同時に接触させうる。
キャプチャーオンザフライイムノアッセイにおいて、固体基質は、固定化剤によりあらかじめコーティングされている。捕捉剤、解析物(例えば、TBIバイオマーカー)及び検出剤が、固体基質へと併せて添加されるのに続き、検出の前に、洗浄ステップがなされる。捕捉剤は、解析物に結合することが可能であり、固定化剤のためのリガンドを含む。捕捉剤及び検出剤は、本明細書において記載された又は当技術分野において公知である、捕捉又は検出が可能な、抗体又は他の任意の部分でありうる。リガンドは、ペプチドタグを含むことが可能であり、固定化剤は、抗ペプチドタグ抗体を含みうる。代替的に、リガンド及び固定化剤は、キャプチャーオンザフライアッセイのために利用されるように、併せて結合することが可能な薬剤の任意の対(例えば、特異的結合対及び当技術分野において公知である対など、他の対)でありうる。1つを超える解析物が測定されうる。一部の実施形態において、固体基質は、抗原によりコーティングされる場合があり、解析される解析物は、抗体である。この方法はまた、MSによる検出及び定量ともカップリングさせうる。
上記された、診断法、予後診断法、危険性層別化法及び/又は評価法は、診断、予後診断及び評価のための他の因子の使用をさらに含みうる。一部の実施形態において、外傷性脳損傷は、Glasgow昏睡スケール又は拡張版Glasgow転帰スケール(GOSE)を使用して診断されうる。他の検査、スケール又は指標もまた、単独で又はGlasgow昏睡スケールと組み合わせて使用されうる。例は、Ranchos Los Amigosスケールである。Ranchos Los Amigosスケールは、意識、認知、行動及び環境との相互作用のレベルを測定する。Ranchos Los Amigosスケールは、レベルI:応答なし;レベルII:一般的な応答;レベルIII:局所的応答;レベルIV:混乱(興奮);レベルV:混乱(不適切);レベルVI:混乱(適切);レベルVII:自動的(適切)及びレベルVIII:意図的(適切)を含む。
一部の実施形態において、試料は、ヒト対象が、物理的振盪、閉鎖性頭部外傷若しくは開放性頭部外傷を結果としてもたらす外部の機械的力若しくは他の力、1回以上の転倒、爆発若しくは爆破による鈍的衝撃により引き起こされた頭部損傷又は他の種類の鈍力外傷を負った後において得られる。一部の実施形態において、ヒト対象が、化学物質、毒素又は化学物質と毒素との組合せを摂取した後又はこれらへと曝露された後において、試料が得られる。このような化学物質及び/又は毒素の例は、火、カビ、アスベスト、害虫駆除剤、殺虫剤、有機溶剤、塗料、糊、ガス(一酸化炭素、硫化水素及びシアン化物など)、有機金属(メチル水銀、テトラエチル鉛及び有機スズなど)及び/又は1つ以上の乱用薬物を含む。一部の実施形態において、試料は、自己免疫疾患、代謝性障害、脳腫瘍、低酸素症、1つ以上のウイルス、髄膜炎、水頭症又はこれらの組合せを患うヒト対象から得られる。
本明細書において使用された「試料」、「被験試料」、「生物学的試料」とは、TBIバイオマーカーを含有する又はこれを含有することが推測される体液試料を指す。試料は、任意の適切な供給源に由来しうる。場合によって、試料は、液体、流動性の粒子状固体又は固体粒子の懸濁流体を含みうる。場合によって、試料は、本明細書において記載された解析の前に処理されうる。例えば、試料は、解析の前に、その供給源から、分離又は精製されうるが、ある特定の実施形態において、TBIバイオマーカーを含有する非処理試料が、直接的にアッセイされうる。特定の例において、TBIバイオマーカーを含有する供給源は、ヒト体内物質(例えば、体液、全血、血清、血漿などの血液、尿、唾液、汗、痰、精液、粘液、涙液、リンパ液、羊水、間質液、肺洗浄液、脳脊髄液、糞便、組織、臓器など)である。組織は、骨格筋組織、肝臓組織、肺組織、腎臓組織、心筋組織、脳組織、骨髄、子宮頸部組織、皮膚などを含みうるがこれらに限定されない。試料は、液体試料又は固体試料の液体抽出物でありうる。ある特定の場合、試料の供給源は、組織の分解/細胞の溶解により可溶化されうる、臓器又は生検試料などの組織でありうる。
対照試料を含むことが所望でありうる。対照は、上記された通り、対象に由来する試料と共時的に解析されうる。対象試料から得られた結果は、対照試料から得られた結果と比較されうる。試料についてのアッセイ結果が比較されうる、検量線が用意されうる。このような検量線は、マーカーのレベルを、アッセイ単位、すなわち、蛍光標識が使用される場合なら、蛍光のシグナル強度の関数として提示する。複数のドナーから採取された試料を使用して、正常健常組織内のTBIバイオマーカーの基準レベル並びに上記において明示された特徴のうちの1つ以上を有しうるドナーから採取された組織内の、「危険性がある」TBIバイオマーカーのレベルについての検量線が用意されうる。
本明細書において、被験試料を、1つ以上のTBIバイオマーカー及び/又はこれらの断片についてアッセイ又は評価するために使用されうるキットが提示される。キットは、被験試料を、TBIバイオマーカーについてアッセイするための、少なくとも1つの構成要素及び被験試料を、TBIバイオマーカーについてアッセイするための指示書を含む。例えば、キットは、被験試料を、TBIバイオマーカーについて、イムノアッセイ(例えば、化学発光マイクロ粒子イムノアッセイ)により又は質量分析アッセイ(例えば、PRM−MS又はMRM/SRM−MS)によりアッセイするための指示書を含みうる。キット内に含まれる指示書は、パッケージング材料に貼付されうる又はパッケージの添付文書として含まれうる。指示書は、典型的に、文書又は印刷物でありうるが、このようなものに限定されない。このような指示書を保存し、これらを末端使用者へと通信することが可能な、任意のメディアが、本開示により想定される。このようなメディアは、電子保存メディア(例えば、磁気ディスク、テープ、カートリッジ、チップ)、光学メディア(例えば、CD ROM)などを含むがこれらに限定されない。本明細書において使用された「指示書」という用語は、指示書を提供するインターネットサイトのアドレスを含みうる。
本明細書において記載されたイムノアッセイにより、TBIバイオマーカーの、被験試料中濃度を評価又は決定するためのキット(又はこの構成要素)並びに方法は、例えば、米国特許第5,063,081号、米国特許出願公開第2003/0170881号、同第2004/0018577号、同第2005/0054078号及び同第2006/0160164号において記載されており、例えば、Abbott Laboratories(Abbott Park、IL)により、Abbott Point of Care(i−STAT(登録商標)又はi−STAT Alinity、Abbott Laboratories)として市販されている、様々な自動式システム及び半自動式システム(固相がマイクロ粒子を含むシステムを含む)のほか、米国特許第5,089,424号及び同第5,006,309号において記載されており、例えば、Abbott Laboratories(Abbott Park、IL)により、ARCHITECT(登録商標)又はAbbott Alinityデバイスのシリーズとして市販されているシステムにおける使用に適合させうる。
当業者に、本明細書において記載された、本開示の方法の、他の適切な改変及び適合は、容易に適用可能かつ認識可能であり、本開示の範囲又は本明細書において開示された態様及び実施形態から逸脱しない限りにおいて、適切な同等物を使用してなされうることが容易に明らかとなる。さて、本開示について詳細に記載してきたが、これは、本開示の一部の態様及び実施形態を例示することだけを意図するものであり、本開示の範囲に対して限定的であると考えられるべきではない、以下の例を参照することにより、より明確に理解される。本明細書において言及された、全ての雑誌の参考文献、米国特許及び刊行物の開示は、参照によりそれらの全体において本明細書に組み込まれている。
外傷性脳損傷についての、マルチモダリティー分類スキームの開発
DIA−MS解析
[実施例3]
TBIバイオマーカーの、タンパク質及びペプチド断片
質量分析法は、典型的に、質量分析計における、物理的変化を経たイオンの検出を伴う。しばしば、物理的変化は、選択された前駆体イオンをフラグメント化すること及び結果として得られるフラグメントイオンの質量スペクトルを記録することを伴う。フラグメントイオンの質量スペクトル中の情報は、前駆体イオンの構造の解明における、有用な一助となることが多い。質量分析/質量分析(MS/MS又はMS2)スペクトルを得るのに使用された、一般的な手法は、適切なm/z解析器により、選択された前駆体イオンを単離し、解離を誘導するために、前駆体イオンを、中性ガスとのエネルギー衝突下に置き、最後に、質量スペクトルを生成するために、フラグメントイオンを質量分析にかけることである。
条項60.対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:NCOR1、HV103、IGHD、ABHEB、DNM1L、ALBU、THIM、IGHA2、KV139又はこれらの任意の組合せのうちの少なくとも1つを含み、健常対象における少なくとも1つのバイオマーカーのレベルと比較した、対象における少なくとも1つのバイオマーカーの高レベルの測定又は検出が、対象がサブクラス3の軽度TBIを負っていることを指し示すパネル。
Claims (32)
- 少なくとも1つのバイオマーカーを測定又は検出する方法であって、
実際の頭部損傷又は推測される頭部損傷の後において、対象から試料を得るステップ;並びに
前記試料中の、AL9A1、ATPG、C1RL、CAND1、EPIPL、GLO2、IGHA2、PZP、SYTC、SYYC若しくはこれらの任意の組合せからなる群から選択される少なくとも1つのバイオマーカー若しくはこの断片を測定若しくは検出するステップ;及び/又は
前記試料中の、ABHEB、AL9A1、DNM1L、FCN2、INF2、K22E、M3K5、NCOR1、SBSN、SYEP、TPP2若しくはこれらの任意の組合せからなる群から選択される少なくとも1つのバイオマーカー若しくはこの断片を測定若しくは検出するステップ
を含む方法。 - 前記少なくとも1つのバイオマーカーの前記測定又は検出が、前記対象が外傷性脳損傷(TBI)を負っていることを指し示す、請求項1に記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、AL9A1、ATPG、C1RL、EPIPL、IGHA2、PZP、SYTC、SYYC又はこれらの任意の組合せからなる群から選択され;前記少なくとも1つのバイオマーカーが、健常対象から得られた試料中において、検出可能ではない、請求項1又は請求項2に記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、ATPG、C1RL、SYYC又はこれらの任意の組合せからなる群から選択される、請求項1〜3のいずれかに記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、CAND1、GLO2又はこれらの組合せからなる群から選択され;CAND1及びGLO2のレベルが、健常対象から得られた試料中のCAND1及びGLO2のレベルと比較して高い、請求項1又は請求項2に記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、ABHEB、AL9A1、DNM1L又はこれらの組合せからなる群から選択され;
ABHEBのレベルが、健常対象から得られた試料中のABHEBのレベルと比較して高く、かつ/又は
AL9A1及びDNM1Lのレベルが、健常対象から得られた試料中のAL9A1及びDNM1Lのレベルと比較して低い、請求項1又は請求項2に記載の方法。 - 前記少なくとも1つのバイオマーカー又はこれらの断片が、M3K5、SBSN、SYEP又はこれらの組合せからなる群から選択され;
SBSN及びSYEPのレベルが、健常対象から得られた試料中のSBSN及びSYEPのレベルと比較して高く、かつ/又は
M3K5のレベルが、健常対象から得られた試料中のM3K5のレベルと比較して低い、請求項1又は請求項2に記載の方法。 - 前記少なくとも1つのバイオマーカー又はこれらの断片が、INF2、SYEP又はこれらの組合せからなる群から選択される、請求項1又は請求項2に記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、ANXA6、ERAP1、EZRI、FA5、G6PI、MYLK、SAMP又はこれらの組合せからなる群から選択される少なくとも1つのバイオマーカーをさらに含む、請求項1〜8のいずれかに記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、MYLK、SAMP又はこれらの組合せからなる群から選択される少なくとも1つのバイオマーカーをさらに含む、請求項1〜8のいずれかに記載の方法。
- 少なくとも1つのバイオマーカーを測定又は検出する方法であって、
実際の頭部損傷又は推測される頭部損傷の後において、対象から試料を得るステップ;及び
前記試料中の、1433G、ACK1、ACY1、AKA12、ARGI1、CADH5、CLH1、COPG2、DPOD2、DSG2、HV307、IQGA2、K1C14、K1C19、KV105、LAMC1、MDHM、NQO2、PERM、PLST、PNCB、PTPRC、SEPT7、SYRC、TRXR2、TXNL1、UGGG1、WDR1又はこれらの任意の組合せからなる群から選択される少なくとも1つのバイオマーカー又はこの断片を測定又は検出するステップ
を含む方法。 - 前記少なくとも1つのバイオマーカーの前記測定又は検出が、前記対象が外傷性脳損傷(TBI)を負っていることを指し示す、請求項11に記載の方法。
- 前記少なくとも1つのバイオマーカーが、健常対象から得られた試料中において、検出可能ではない、請求項11又は請求項12に記載の方法。
- 前記少なくとも1つのバイオマーカーが、重度TBIを負っている対象から得られた試料中において、検出可能ではない、請求項11〜13のいずれかに記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、前記試料中の、ACK1、ACY1、PLST、PNCB、PTPRC、UGGG1又はこれらの任意の組合せからなる群から選択され;
前記少なくとも1つのバイオマーカーの前記測定又は検出が、前記対象がサブクラス1の軽度TBIを負っていることを指し示す、請求項11〜13のいずれかに記載の方法。 - 前記少なくとも1つのバイオマーカー又はこれらの断片が、前記試料中の、AKA12、HV307、PERM、KV105、NQO2、SEPT7、SYRC、TRXR2又はこれらの任意の組合せからなる群から選択され;
前記少なくとも1つのバイオマーカーの前記測定又は検出が、前記対象がサブクラス2の軽度TBIを負っていることを指し示す、請求項11〜13のいずれかに記載の方法。 - 前記少なくとも1つのバイオマーカー又はこれらの断片が、前記試料中の、1433B、ARGI1、CADH5、CLH1、COPG2、DPOD2、DSG2、IQGA2、K1C14、LAMC1、MDHM、TXNL1又はこれらの任意の組合せからなる群から選択され;
前記少なくとも1つのバイオマーカーの前記測定又は検出が、前記対象がサブクラス3の軽度TBIを負っていることを指し示す、請求項11〜13のいずれかに記載の方法。 - 前記少なくとも1つのバイオマーカー又はこれらの断片が、AHNK、AL1A1、AMPN、CAPZB、CATD、CLIP2、CMGA、FSCN1、GMPR2、GRP78、GSH1、IDHC、K1C20、KRR1、MBL2、NTF2、PCBP2、PGK1、SAA1、TFR1又はこれらの組合せからなる群から選択される少なくとも1つのバイオマーカーをさらに含む、請求項11〜17のいずれかに記載の方法。
- 前記少なくとも1つのバイオマーカー又はこれらの断片が、ANXA6、MASP2、MYLK、SAMP又はこれらの組合せからなる群から選択される少なくとも1つのバイオマーカーをさらに含む、請求項11〜17のいずれかに記載の方法。
- 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:TPP2、CAND1、NCOR1、K22E、AL9A1、ABHEB、DNM1L、INF2又はこれらの任意の組合せのうちの少なくとも1つを含み、
前記少なくとも1つのバイオマーカーの測定又は検出が、前記対象がサブクラス4の軽度TBIを負っていることを指し示す
パネル。 - CAND1、NCOR1、K22E、ABHEB及びDNM1Lのレベルが、健常対象から得られた試料中のCAND1、NCOR1、K22E、ABHEB及びDNM1Lのレベルと比較して高く;かつ/又は
TPP2、AL9A1及びINF2のレベルが、健常対象から得られた試料中のTPP2、AL9A1及びINF2のレベルと比較して低い、請求項20に記載のバイオマーカーパネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:TPP2、NCOR1、HV103、INF2、IGHD、CK054、M3K5、ABHEB、AL9A1、DNM1L又はこれらの任意の組合せのうちの少なくとも1つを含み、
前記少なくとも1つのバイオマーカーの測定又は検出が、前記対象がサブクラス3の軽度TBIを負っていることを指し示す
パネル。 - NCOR1、HV103、IGHD、ABHEB及びDNM1Lのレベルが、健常対象から得られた試料中のNCOR1、HV103、IGHD、ABHEB及びDNM1Lのレベルと比較して高く;かつ/又は
TPP2、IGHD、CK054、M3K5及びAL9A1のレベルが、健常対象から得られた試料中のTPP2、IGHD、CK054、M3K5及びAL9A1のレベルと比較して低い、請求項22に記載のバイオマーカーパネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:NCOR1、TPP2、K22E、ABHEB、INF2、SBSN、AL9A1、MA2B2又はこれらの任意の組合せのうちの少なくとも1つを含み、
前記少なくとも1つのバイオマーカーの測定又は検出が、前記対象がサブクラス2の軽度TBIを負っていることを指し示す
パネル。 - NCOR1、K22E、ABHEB及びSBSNのレベルが、健常対象から得られた試料中のNCOR1、K22E、ABHEB及びSBSNのレベルと比較して高く;かつ/又は
TPP2、INF2、AL9A1及びMA2B2のレベルが、健常対象から得られた試料中のTPP2、INF2、AL9A1及びMA2B2のレベルと比較して低い、請求項24に記載のバイオマーカーパネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:K22E、DNM1L、DIAP1、ABHEB、PLOD1、SYEP、KV133、AL9A1、EPHB4又はこれらの任意の組合せのうちの少なくとも1つを含み、
前記少なくとも1つのバイオマーカーの測定又は検出が、前記対象がサブクラス1の軽度TBIを負っていることを指し示す
パネル。 - K22E、DNM1L、DIAP1、ABHEB、PLOD1、SYEP及びEPHB4のレベルが、健常対象から得られた試料中のK22E、DNM1L、DIAP1、ABHEB、PLOD1、SYEP及びEPHB4のレベルと比較して高く;かつ/又は
KV133及びAL9A1のレベルが、健常対象から得られた試料中のKV133及びAL9A1のレベルと比較して低い、請求項26に記載のバイオマーカーパネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:CAND1、NCOR1、K22E、ABHEB、DNM1L、SBSN、GLO2、SYEP又はこれらの任意の組合せのうちの少なくとも1つを含み、
健常対象における前記少なくとも1つのバイオマーカーのレベルと比較した、前記対象における前記少なくとも1つのバイオマーカーの高レベルの測定又は検出が、前記対象がサブクラス4の軽度TBIを負っていることを指し示す
パネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:NCOR1、HV103、IGHD、ABHEB、DNM1L、ALBU、THIM、IGHA2、KV139又はこれらの任意の組合せのうちの少なくとも1つを含み、
健常対象における前記少なくとも1つのバイオマーカーのレベルと比較した、前記対象における前記少なくとも1つのバイオマーカーの高レベルの測定又は検出が、前記対象がサブクラス3の軽度TBIを負っていることを指し示す
パネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:NCOR1、K22E、ABHEB、SBSN、DNM1L、DIAP1、DYL1、PSA、EPHB4又はこれらの任意の組合せのうちの少なくとも1つを含み、
健常対象における前記少なくとも1つのバイオマーカーのレベルと比較した、前記対象における前記少なくとも1つのバイオマーカーの高レベルの測定又は検出が、前記対象がサブクラス2の軽度TBIを負っていることを指し示す
パネル。 - 対象の外傷性脳損傷(TBI)状態を決定するためのバイオマーカーパネルであって、以下のバイオマーカー:K22E、DNM1L、DIAP1、ABHEB、PLOD1、SYEP、EPHB4、FBLN3又はこれらの任意の組合せのうちの少なくとも1つを含み、
健常対象における前記少なくとも1つのバイオマーカーのレベルと比較した、前記対象における前記少なくとも1つのバイオマーカーの高レベルの測定又は検出が、前記対象がサブクラス1の軽度TBIを負っていることを指し示す
パネル。 - 対象が外傷性脳損傷(TBI)を負っていないことを決定するためのバイオマーカーパネルであって、以下のバイオマーカー:ACTBL、ALDH2、ANXA5、CAMP、CPNE3、CRAC1、CYTC、DNPEP、EIF3I、GSHB、ICAM1、HV323、HNRPD、KVD33、FA9、FHR4、FRPD1、HS90B、MA2A1、PCYOX、PNPH、PROC、RL3、SH3L3、SRRM2、TBB1、TENA、TRAP1又はこれらの任意の組合せのうちの少なくとも1つを含み、
前記対象における前記少なくとも1つのバイオマーカーの測定又は検出が、前記対象がTBIを負っていないことを指し示す
パネル。
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