JP2021509084A - 音響定在波プロセスに用いるための粒子 - Google Patents
音響定在波プロセスに用いるための粒子 Download PDFInfo
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Abstract
Description
Claims (23)
- 第1の位置で一次流体中の粒子を濃縮するための方法であって、
前記粒子及び前記一次流体を含む流体混合物が流れる音響チャンバと前記音響チャンバ内に音響波を発生させるために駆動可能な圧電材料を含む超音波トランスデューサとを備える音響泳動デバイスに、前記流体混合物を流すことと、
前記超音波トランスデューサを駆動して前記音響波を発生させることと、を含み、
前記音響波は、前記第1の位置で前記粒子を濃縮する、方法。 - 請求項1の方法において、
前記音響波は、複数次元音響定在波、平面音響定在波、複数次元音響定在波と平面音響定在波との組み合わせ、又は、音響進行波である、方法。 - 請求項1の方法において、
前記粒子はペイロードを含む、方法。 - 請求項3の方法において、
前記ペイロードは、ウイルス、核酸、サイトカイン、医薬分子、液体、気体、又は、それらの混合物である、方法。 - 請求項3の方法において、
前記第1の位置にある前記粒子から前記ペイロードを放出させることを更に含む、方法。 - 請求項1の方法において、
前記粒子は、中実状、細胞状、中空状、又は、発泡体である、方法。 - 請求項1の方法において、
前記粒子は、高分子材料、アイオノマー、セラミック及びガラスの1又は2以上で作製されている、方法。 - 請求項7の方法において、
前記1又は2以上の高分子材料は、ポリエチレン、ポリプロピレン、ポリスチレン、ジビニルベンゼン、ポリメチルメタクリレート、多糖類、ポリ乳酸(PLA)及びポリ(乳酸−コ−グリコール酸)(PLGA)からなる群から選択される、方法。 - 請求項1の方法において、
前記粒子は、高分子材料の複数の層から形成されている、方法。 - 請求項1の方法において、
前記粒子は、中空であり、ガラスで作られ、前記ガラスの外面をコーティングするアブレーションポリマーを有する、方法。 - 請求項10の方法において、
前記アブレーションポリマーは、抗原、抗体、又は、タンパク質で機能化された多糖類である、方法。 - 請求項1の方法において、
前記粒子は、液体コアと、前記液体コアをカプセル化する脂質シェルとを有する、方法。 - 請求項12の方法において、
前記液体コアの液体はパーフルオロカーボンを含む、方法。 - 請求項13の方法において、
前記パーフルオロカーボンは、パーフルオロペンタン、パーフルオロヘキサン、パーフルオロオクタン、臭化パーフルオロオクチル、パーフルオロジクロロオクタン、又は、パーフルオロデカリンである、方法。 - 請求項12の方法において、
前記脂質シェルは、ジパルミトイルホスファチジルコリン(DPPC)、1,2−パルミトイルホスファチジン酸(DPPA)、脂質−ポリエチレングリコール結合体、又は、脂質とアルブミンとの複合体から形成されている、方法。 - 請求項12の方法において、
前記脂質シェルは、ストレプトアビジン、ビオチン、アビジン又は抗体で機能化されている、方法。 - 液体コアと、前記液体コアをカプセル化する脂質シェルと、を含む粒子。
- 請求項17の粒子において、
前記液体コアの液体はパーフルオロカーボンを有する、粒子。 - 請求項18の粒子において、
前記パーフルオロカーボンは、パーフルオロペンタン、パーフルオロヘキサン、パーフルオロオクタン、臭化パーフルオロオクチル、パーフルオロジクロロオクタン、又は、パーフルオロデカリンである、粒子。 - 請求項17の粒子において、
前記脂質シェルは、ジパルミトイルホスファチジルコリン(DPPC)、1,2−パルミトイルホスファチジン酸(DPPA)、脂質−ポリエチレングリコール結合体、又は、脂質とアルブミンとの複合体から形成されている、粒子。 - 請求項17の粒子において、
前記脂質シェルは、ストレプトアビジン、ビオチン、アビジン又は抗体で機能化されている、粒子。 - 流体からターゲット粒子を分離する方法であって、
流体中の機能化粒子をチャンバ内に受け取ることと、
ターゲット粒子を前記チャンバ内に受け取ることと、
前記ターゲット粒子が前記機能化粒子と結合できるようにすることと、
前記チャンバ内に音響波を印加して、前記音響波によって捕集又はブロックされる前記機能化粒子に影響を与えることと、を含む方法。 - 請求項22の方法において、
前記機能化粒子は、パーフルオロペンタン、パーフルオロヘキサン、パーフルオロオクタン、臭化パーフルオロオクチル、パーフルオロジクロロオクタン及びパーフルオロデカリンのうちの1又は2以上であるパーフルオロカーボンを含む、方法。
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US62/621,585 | 2018-01-24 | ||
PCT/US2018/063698 WO2019135843A1 (en) | 2018-01-02 | 2018-12-03 | Particles for use in acoustic standing wave processes |
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US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
BR112022000468A2 (pt) * | 2019-10-28 | 2022-07-12 | Flodesign Sonics Inc | Partículas para uso em processos acústicos |
CN111646655B (zh) * | 2020-06-30 | 2021-08-20 | 广东源控环保科技有限公司 | 一种水力空化减泥的aa/o处理工艺 |
EP4036580A1 (en) * | 2021-02-01 | 2022-08-03 | Oxford University Innovation Limited | Drug loaded cavitation agent |
EP4035655A1 (en) * | 2021-02-01 | 2022-08-03 | Oxford University Innovation Limited | Immune modulating particles |
EP4036581A1 (en) * | 2021-02-01 | 2022-08-03 | Oxford University Innovation Limited | Cavitation agent |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09122480A (ja) * | 1995-11-08 | 1997-05-13 | Hitachi Ltd | 超音波処理方法および装置 |
JP2005521704A (ja) * | 2002-03-26 | 2005-07-21 | バーンズ−ジューイッシュ ホスピタル | 改善された緩和度を供する常磁性パーティクル |
US20080245709A1 (en) * | 2007-04-09 | 2008-10-09 | Gregory Kaduchak | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
JP2012503776A (ja) * | 2008-09-26 | 2012-02-09 | アボット・ラボラトリーズ | 定在超音波により懸濁液から粒子を分離するための装置と方法 |
JP2014509311A (ja) * | 2011-01-05 | 2014-04-17 | ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | 低キャビテーション閾値の音響応答性粒子 |
US20160279540A1 (en) * | 2015-03-24 | 2016-09-29 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
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US7220401B2 (en) * | 1999-09-24 | 2007-05-22 | Barnes-Jewish Hospital | Blood clot-targeted nanoparticles |
GB0410015D0 (en) * | 2004-05-05 | 2004-06-09 | Univ Coventry | Use |
US20110045095A1 (en) * | 2008-10-08 | 2011-02-24 | The Regents Of The University Of California | Polymer-phospholipid shelled microbubbles |
CN102138889A (zh) | 2011-03-25 | 2011-08-03 | 中国科学院深圳先进技术研究院 | 靶向载药超声微泡及其制备方法 |
US10279053B2 (en) * | 2011-07-19 | 2019-05-07 | Nuvox Pharma Llc | Microbubble compositions, method of making same, and method using same |
WO2013049623A1 (en) * | 2011-09-30 | 2013-04-04 | Brian David Warner | Fluid exchange methods and devices |
US9950282B2 (en) * | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
EP4005604B8 (en) * | 2013-09-27 | 2023-07-19 | Exact Therapeutics As | Delivery of drugs |
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09122480A (ja) * | 1995-11-08 | 1997-05-13 | Hitachi Ltd | 超音波処理方法および装置 |
JP2005521704A (ja) * | 2002-03-26 | 2005-07-21 | バーンズ−ジューイッシュ ホスピタル | 改善された緩和度を供する常磁性パーティクル |
US20080245709A1 (en) * | 2007-04-09 | 2008-10-09 | Gregory Kaduchak | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
JP2012503776A (ja) * | 2008-09-26 | 2012-02-09 | アボット・ラボラトリーズ | 定在超音波により懸濁液から粒子を分離するための装置と方法 |
JP2014509311A (ja) * | 2011-01-05 | 2014-04-17 | ザ レジェンツ オブ ザ ユニヴァーシティー オブ カリフォルニア | 低キャビテーション閾値の音響応答性粒子 |
US20160279540A1 (en) * | 2015-03-24 | 2016-09-29 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
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BR112020009373A2 (pt) | 2020-11-03 |
CA3167887A1 (en) | 2019-07-11 |
EP3735308A1 (en) | 2020-11-11 |
IL274181A (en) | 2020-06-30 |
CA3087498C (en) | 2022-09-27 |
AU2018399435A1 (en) | 2020-05-14 |
SG11202004025WA (en) | 2020-05-28 |
EP3735308A4 (en) | 2021-09-01 |
CA3087498A1 (en) | 2019-07-11 |
KR20200063252A (ko) | 2020-06-04 |
WO2019135843A1 (en) | 2019-07-11 |
CN111587140A (zh) | 2020-08-25 |
AU2022201253A1 (en) | 2022-03-17 |
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