JP2021505190A - 新規γδ Ｔ細胞受容体及びそのリガンド - Google Patents

新規γδ Ｔ細胞受容体及びそのリガンド Download PDF

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JP2021505190A
JP2021505190A JP2020544990A JP2020544990A JP2021505190A JP 2021505190 A JP2021505190 A JP 2021505190A JP 2020544990 A JP2020544990 A JP 2020544990A JP 2020544990 A JP2020544990 A JP 2020544990A JP 2021505190 A JP2021505190 A JP 2021505190A
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cancer
tcr
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セウェル アンドリュー
セウェル アンドリュー
ドルトン ギャリー
ドルトン ギャリー
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ユニバーシティ カレッジ カーディフ コンサルタンツ エルティーディー
ユニバーシティ カレッジ カーディフ コンサルタンツ エルティーディー
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hematology (AREA)
JP2020544990A 2017-11-20 2018-11-16 新規γδ Ｔ細胞受容体及びそのリガンド Pending JP2021505190A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1719169.3 2017-11-20
GBGB1719169.3A GB201719169D0 (en) 2017-11-20 2017-11-20 Novel T-cell receptor and ligand
PCT/GB2018/053321 WO2019097244A1 (en) 2017-11-20 2018-11-16 Novel gamma delta t-cell receptor and its ligand

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Publication Number Publication Date
JP2021505190A true JP2021505190A (ja) 2021-02-18
JP2021505190A5 JP2021505190A5 (https=) 2022-01-04

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JP2020544990A Pending JP2021505190A (ja) 2017-11-20 2018-11-16 新規γδ Ｔ細胞受容体及びそのリガンド

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US (1) US11850264B2 (https=)
EP (1) EP3713954A1 (https=)
JP (1) JP2021505190A (https=)
KR (1) KR20200085776A (https=)
CN (1) CN111372944A (https=)
AU (1) AU2018369698A1 (https=)
BR (1) BR112020007469A2 (https=)
CA (1) CA3079156A1 (https=)
EA (1) EA202091276A1 (https=)
GB (1) GB201719169D0 (https=)
IL (1) IL274482A (https=)
MX (1) MX2020005200A (https=)
SG (1) SG11202002993UA (https=)
WO (1) WO2019097244A1 (https=)
ZA (1) ZA202002417B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230226183A1 (en) * 2020-01-15 2023-07-20 The Regents Of The University Of California Compositions and methods for altering gamma delta t cell activity
EP4059955A1 (en) 2021-03-19 2022-09-21 Medizinische Hochschule Hannover Hla-dr-specific gamma delta tcr constructs and use thereof
EP4472742A1 (en) 2022-02-03 2024-12-11 University College Cardiff Consultants Limited Novel t-cell receptor
US20240043496A1 (en) * 2022-07-26 2024-02-08 Gadeta B.V. Delta t-cell or gamma receptor chains or parts thereof for treating ovarian cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072254A1 (en) * 2001-05-01 2004-04-15 Senomyx, Inc. High throughput cell-based assay for monitoring sodium channel activity and discovery of salty taste modulating compounds
JP2007528712A (ja) * 2003-07-10 2007-10-18 セノミックス、インコーポレイテッド ヒトＥＮａＣを発現する卵母細胞を用いた改良された電気生理学的アッセイ及び膜電位リポーター色素を用いたアッセイにおけるＥＮａＣ相乗剤の効果を向上させるためのフェナミルの使用
WO2013155406A1 (en) * 2012-04-12 2013-10-17 The Chinese University Of Hong Kong Contragestion and treating inflammation by modulating sodium channel activity in the epithelium

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260223A (en) * 1986-07-03 1993-11-09 President & Fellows Of Harvard College Methods for detection of human gamma, γ T cell receptor
WO1996013593A2 (en) * 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1999060120A2 (en) 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
AU2002359666A1 (en) * 2001-12-10 2003-06-23 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
PL3119807T3 (pl) * 2014-03-19 2019-09-30 Cellectis Specyficzne wobec cd123 chimeryczne receptory antygenowe do immunoterapii nowotworów
MX2016014434A (es) 2014-05-13 2017-02-23 Chugai Pharmaceutical Co Ltd Molecula de union a antigeno redirigida a celulas t para celulas que tienen funcion de inmunosupresion.
WO2016016344A1 (en) 2014-07-29 2016-02-04 Cellectis Ror1(ntrkr1)specific chimeric antigen receptors for cancer immunotherapy
DK3271382T3 (da) * 2015-03-16 2020-05-04 Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072254A1 (en) * 2001-05-01 2004-04-15 Senomyx, Inc. High throughput cell-based assay for monitoring sodium channel activity and discovery of salty taste modulating compounds
JP2007528712A (ja) * 2003-07-10 2007-10-18 セノミックス、インコーポレイテッド ヒトＥＮａＣを発現する卵母細胞を用いた改良された電気生理学的アッセイ及び膜電位リポーター色素を用いたアッセイにおけるＥＮａＣ相乗剤の効果を向上させるためのフェナミルの使用
WO2013155406A1 (en) * 2012-04-12 2013-10-17 The Chinese University Of Hong Kong Contragestion and treating inflammation by modulating sodium channel activity in the epithelium

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LEGUT M, ET AL.: "The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy", CELL MOL IMMUNOL, vol. 12(6), JPN6022040795, December 2015 (2015-12-01), pages 656 - 668, ISSN: 0005092007 *

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Publication number Publication date
ZA202002417B (en) 2021-07-28
US11850264B2 (en) 2023-12-26
US20200316124A1 (en) 2020-10-08
CA3079156A1 (en) 2019-05-23
AU2018369698A1 (en) 2020-04-30
MX2020005200A (es) 2020-08-20
SG11202002993UA (en) 2020-06-29
BR112020007469A2 (pt) 2020-11-03
EA202091276A1 (ru) 2020-09-04
WO2019097244A1 (en) 2019-05-23
IL274482A (en) 2020-06-30
EP3713954A1 (en) 2020-09-30
KR20200085776A (ko) 2020-07-15
CN111372944A (zh) 2020-07-03
GB201719169D0 (en) 2018-01-03

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