JP2021505136A5 - - Google Patents
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- JP2021505136A5 JP2021505136A5 JP2020530325A JP2020530325A JP2021505136A5 JP 2021505136 A5 JP2021505136 A5 JP 2021505136A5 JP 2020530325 A JP2020530325 A JP 2020530325A JP 2020530325 A JP2020530325 A JP 2020530325A JP 2021505136 A5 JP2021505136 A5 JP 2021505136A5
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- JP
- Japan
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023133670A JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2025003895A JP2025072378A (ja) | 2017-12-04 | 2025-01-10 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762594244P | 2017-12-04 | 2017-12-04 | |
| US62/594,244 | 2017-12-04 | ||
| PCT/US2018/063581 WO2019112941A1 (en) | 2017-12-04 | 2018-12-03 | Hla class i-restricted t cell receptors against mutated ras |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023133670A Division JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021505136A JP2021505136A (ja) | 2021-02-18 |
| JP2021505136A5 true JP2021505136A5 (enExample) | 2022-01-11 |
| JP7385566B2 JP7385566B2 (ja) | 2023-11-22 |
Family
ID=64949411
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020530325A Active JP7385566B2 (ja) | 2017-12-04 | 2018-12-03 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2023133670A Active JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2025003895A Pending JP2025072378A (ja) | 2017-12-04 | 2025-01-10 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023133670A Active JP7620676B2 (ja) | 2017-12-04 | 2023-08-18 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
| JP2025003895A Pending JP2025072378A (ja) | 2017-12-04 | 2025-01-10 | 突然変異ｒａｓに対するｈｌａクラスｉ拘束性ｔ細胞受容体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11466071B2 (enExample) |
| EP (1) | EP3720478A1 (enExample) |
| JP (3) | JP7385566B2 (enExample) |
| KR (1) | KR20200115484A (enExample) |
| CN (2) | CN111836638B (enExample) |
| AU (2) | AU2018378200B2 (enExample) |
| BR (1) | BR112020011111A2 (enExample) |
| CA (1) | CA3084246A1 (enExample) |
| CR (1) | CR20200287A (enExample) |
| EA (1) | EA202091335A1 (enExample) |
| IL (1) | IL275031A (enExample) |
| MA (2) | MA51043A (enExample) |
| MX (1) | MX2020005765A (enExample) |
| SG (1) | SG11202005236QA (enExample) |
| WO (1) | WO2019112941A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3635000A4 (en) * | 2017-05-16 | 2021-04-14 | The Johns Hopkins University | Manabodies and methods of using |
| US20220088190A1 (en) * | 2019-01-25 | 2022-03-24 | The Trustees Of The University Of Pennsylvania | Compositions and Methods for Targeting Mutant RAS |
| GB2596461B (en) | 2019-02-20 | 2023-09-27 | Fred Hutchinson Cancer Center | Binding proteins specific for RAS neoantigens and uses thereof |
| EP3760217A1 (en) * | 2019-07-01 | 2021-01-06 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Cd5 specific t cell receptor cell or gene therapy |
| CN112646024B (zh) * | 2019-10-10 | 2023-03-24 | 香雪生命科学技术（广东）有限公司 | 一种识别kras突变的t细胞受体及其编码序列 |
| CN112759641B (zh) * | 2019-11-01 | 2023-01-20 | 香雪生命科学技术（广东）有限公司 | 一种识别Kras G12V的高亲和力TCR |
| GB2609760A (en) * | 2020-02-12 | 2023-02-15 | Us Health | HLA Class I-restricted T cell receptors against RAS with G12D mutation |
| WO2021163477A1 (en) * | 2020-02-14 | 2021-08-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla class i-restricted t cell receptors against ras with g12v mutation |
| CN115244075A (zh) * | 2020-02-26 | 2022-10-25 | 美国卫生和人力服务部 | 针对含有g12v突变的ras的hla ii类限制性t细胞受体 |
| EP4182029A1 (en) * | 2020-07-16 | 2023-05-24 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Hla class ii-restricted drb t cell receptors against ras with g12v mutation |
| AU2021351710A1 (en) * | 2020-10-02 | 2023-06-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla class ii-restricted dq t cell receptors against ras with g13d mutation |
| KR102488353B1 (ko) * | 2020-10-08 | 2023-01-12 | 부산대학교 산학협력단 | 돌연변이 kras를 표적하는 펩타이드 및 이의 용도 |
| JP2023550515A (ja) * | 2020-11-24 | 2023-12-01 | シャンハイ、ケンパーソー、バイオテクノロジー、カンパニー、リミテッド | Ｒａｓ突然変異体エピトープペプチドおよびｒａｓ突然変異体を認識するｔ細胞受容体 |
| US20240175047A1 (en) | 2021-02-25 | 2024-05-30 | Alaunos Therapeutics, Inc. | Recombinant Vectors Comprising Polycistronic Expression Cassettes and Methods of Use Thereof |
| WO2022251283A1 (en) * | 2021-05-25 | 2022-12-01 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting ras mutations and uses thereof |
| US20250101078A1 (en) | 2022-01-21 | 2025-03-27 | T-Knife Gmbh | Antigen recognizing construct that binds specific peptide with determinable affinity and t cell receptor having antigenic specificity for kras as well as corresponding nucleic acid sequence, vector, host cell, pharmaceutical composition and kit |
| US20250145950A1 (en) | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| CN117264043B (zh) * | 2022-06-14 | 2024-05-10 | 上海镔铁生物科技有限责任公司 | 靶向kras g12v突变多肽的t细胞受体及其用途 |
| CN115850444B (zh) * | 2022-09-15 | 2025-01-28 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
| CN115960204B (zh) * | 2022-11-04 | 2023-08-25 | 新景智源生物科技(苏州)有限公司 | Kras_g12v突变抗原特异性tcr及其与cd8共表达重定向cd4 t细胞 |
| CN118852452A (zh) * | 2023-04-28 | 2024-10-29 | 北京鼎成肽源生物技术有限公司 | 靶向kras g12突变的tcr分子和细胞及其应用 |
| CN118909132A (zh) * | 2023-05-06 | 2024-11-08 | 北京鼎成肽源生物技术有限公司 | 靶向kras g12v突变的tcr分子和细胞及其应用 |
| WO2025056672A1 (en) * | 2023-09-15 | 2025-03-20 | Medigene Immunotherapies Gmbh | T-CELL RECEPTOR VARIANT AGAINST mKRAS7-16 G12V |
| WO2025056681A1 (en) * | 2023-09-15 | 2025-03-20 | Medigene Immunotherapies Gmbh | T-CELL RECEPTOR AGAINST mKRAS7-16 G12V AND G12C |
| WO2025125590A2 (en) * | 2023-12-15 | 2025-06-19 | Genovie Ab | Tcr recognizing g12v mutated ras and uses thereof |
| EP4570263A1 (en) * | 2023-12-15 | 2025-06-18 | Genovie AB | Tcrs recognizing g12v mutated ras and uses thereof |
| CN119350472B (zh) * | 2024-12-25 | 2025-04-04 | 北京可瑞生物科技有限公司 | 修饰的靶向kras g12v的t细胞受体或其片段以及用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1545204T3 (en) | 2002-09-06 | 2016-11-14 | The Government Of The Us Secretary Dept Of Health And Human Services | Immunotherapy with in vitro selected antigen-specific lymphocytes following non-myeloablative lymphodepletive chemotherapy |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| CN103124740B (zh) * | 2010-09-21 | 2015-09-02 | 美国卫生和人力服务部 | 抗-ssx-2t细胞受体和相关材料及使用方法 |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| PL3223850T3 (pl) * | 2014-11-26 | 2020-08-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Receptory limfocytów t przeciwko zmutowanemu kras |
| EP3901169A1 (en) * | 2015-09-15 | 2021-10-27 | The United States of America, as represented by the Secretary, Department of Health and Human Services | T cell receptors recognizing hla-cw8 restricted mutated kras |
| EP3394092A1 (en) * | 2015-12-23 | 2018-10-31 | Fred Hutchinson Cancer Research Center | High affinity t cell receptors and uses thereof |
| JP6697562B2 (ja) * | 2015-12-23 | 2020-05-20 | メディジーン イミュノテラピーズ ゲーエムベーハー | 樹状細胞組成物 |
| US12221627B2 (en) * | 2017-12-04 | 2025-02-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of enriching cell populations for cancer-specific T cells using in vitro stimulation of memory T cells |
-
2018
- 2018-12-03 CN CN201880087270.7A patent/CN111836638B/zh active Active
- 2018-12-03 CA CA3084246A patent/CA3084246A1/en active Pending
- 2018-12-03 EA EA202091335A patent/EA202091335A1/ru unknown
- 2018-12-03 WO PCT/US2018/063581 patent/WO2019112941A1/en not_active Ceased
- 2018-12-03 JP JP2020530325A patent/JP7385566B2/ja active Active
- 2018-12-03 KR KR1020207019185A patent/KR20200115484A/ko not_active Ceased
- 2018-12-03 CN CN202411410030.XA patent/CN119162251A/zh active Pending
- 2018-12-03 CR CR20200287A patent/CR20200287A/es unknown
- 2018-12-03 US US16/769,144 patent/US11466071B2/en active Active
- 2018-12-03 AU AU2018378200A patent/AU2018378200B2/en active Active
- 2018-12-03 MA MA051043A patent/MA51043A/fr unknown
- 2018-12-03 MA MA051042A patent/MA51042A/fr unknown
- 2018-12-03 SG SG11202005236QA patent/SG11202005236QA/en unknown
- 2018-12-03 EP EP18830062.8A patent/EP3720478A1/en active Pending
- 2018-12-03 BR BR112020011111-2A patent/BR112020011111A2/pt unknown
- 2018-12-03 MX MX2020005765A patent/MX2020005765A/es unknown
-
2020
- 2020-06-01 IL IL275031A patent/IL275031A/en unknown
-
2022
- 2022-09-12 US US17/931,391 patent/US20230026180A1/en active Pending
-
2023
- 2023-08-18 JP JP2023133670A patent/JP7620676B2/ja active Active
-
2025
- 2025-01-10 JP JP2025003895A patent/JP2025072378A/ja active Pending
- 2025-05-13 AU AU2025203455A patent/AU2025203455A1/en active Pending
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