|
NL8200523A
(nl)
|
1982-02-11 |
1983-09-01 |
Univ Leiden |
Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna.
|
|
US4806476A
(en)
|
1983-09-08 |
1989-02-21 |
Lovelace Medical Foundation |
Efficient cell fusion process
|
|
US5071773A
(en)
|
1986-10-24 |
1991-12-10 |
The Salk Institute For Biological Studies |
Hormone receptor-related bioassays
|
|
AU623922B2
(en)
|
1988-08-04 |
1992-05-28 |
Amrad Operations Pty. Limited |
In vitro propagation of embryonic stem cells
|
|
US5240840A
(en)
|
1991-04-05 |
1993-08-31 |
Regents Of The University Of Michigan |
Dna superfragment cloning
|
|
US5637483A
(en)
|
1991-10-04 |
1997-06-10 |
Whitehead Institute For Biomedical Research |
Irradiated tumor cell vaccine engineered to express GM-CSF
|
|
JP3314241B2
(ja)
|
1992-04-06 |
2002-08-12 |
ヤマハ発動機株式会社 |
自動二輪車用エンジンの排気浄化装置
|
|
US5690926A
(en)
|
1992-10-08 |
1997-11-25 |
Vanderbilt University |
Pluripotential embryonic cells and methods of making same
|
|
US5453357A
(en)
|
1992-10-08 |
1995-09-26 |
Vanderbilt University |
Pluripotential embryonic stem cells and methods of making same
|
|
US5618829A
(en)
|
1993-01-28 |
1997-04-08 |
Mitsubishi Chemical Corporation |
Tyrosine kinase inhibitors and benzoylacrylamide derivatives
|
|
ATE361759T1
(de)
|
1993-07-15 |
2007-06-15 |
Cancer Res Campaign Tech |
Verbindungen die zur herstellung von protein- tyrosin-kinase-inhibitor-prodrogen verwendet werden können
|
|
US5804396A
(en)
|
1994-10-12 |
1998-09-08 |
Sugen, Inc. |
Assay for agents active in proliferative disorders
|
|
US5914268A
(en)
|
1994-11-21 |
1999-06-22 |
National Jewish Center For Immunology & Respiratory Medicine |
Embryonic cell populations and methods to isolate such populations
|
|
US5843780A
(en)
|
1995-01-20 |
1998-12-01 |
Wisconsin Alumni Research Foundation |
Primate embryonic stem cells
|
|
US5639757A
(en)
|
1995-05-23 |
1997-06-17 |
Pfizer Inc. |
4-aminopyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors
|
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US5855887A
(en)
|
1995-07-25 |
1999-01-05 |
The Regents Of The University Of California |
Blockade of lymphocyte down-regulation associated with CTLA-4 signaling
|
|
EA001595B1
(ru)
|
1996-04-12 |
2001-06-25 |
Варнер-Ламберт Компани |
Необратимые ингибиторы тирозинкиназ
|
|
US6207157B1
(en)
|
1996-04-23 |
2001-03-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Conjugate vaccine for nontypeable Haemophilus influenzae
|
|
US6331406B1
(en)
|
1997-03-31 |
2001-12-18 |
The John Hopkins University School Of Medicine |
Human enbryonic germ cell and methods of use
|
|
US6090622A
(en)
|
1997-03-31 |
2000-07-18 |
The Johns Hopkins School Of Medicine |
Human embryonic pluripotent germ cells
|
|
ZA986732B
(en)
|
1997-07-29 |
1999-02-02 |
Warner Lambert Co |
Irreversible inhibitiors of tyrosine kinases
|
|
US6100254A
(en)
|
1997-10-10 |
2000-08-08 |
Board Of Regents, The University Of Texas System |
Inhibitors of protein tyrosine kinases
|
|
CA2307807C
(en)
|
1997-10-23 |
2008-09-02 |
Andrea G. Bodnar |
Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
|
|
US6667176B1
(en)
|
2000-01-11 |
2003-12-23 |
Geron Corporation |
cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
|
|
US6682736B1
(en)
|
1998-12-23 |
2004-01-27 |
Abgenix, Inc. |
Human monoclonal antibodies to CTLA-4
|
|
US6740665B1
(en)
|
1999-02-10 |
2004-05-25 |
Ramachandran Murali |
Tyrosine kinase inhibitors and methods of using the same
|
|
US6245759B1
(en)
|
1999-03-11 |
2001-06-12 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
WO2001000213A1
(en)
|
1999-06-30 |
2001-01-04 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
EP1206260A4
(en)
|
1999-06-30 |
2002-10-30 |
Merck & Co Inc |
SRC-KINASE INHIBITING COMPOUNDS
|
|
EP1194152A4
(en)
|
1999-06-30 |
2002-11-06 |
Merck & Co Inc |
Links to SRC kinase inhibition
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
AU779908B2
(en)
|
1999-09-10 |
2005-02-17 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
AU778042B2
(en)
|
1999-10-19 |
2004-11-11 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US6794393B1
(en)
|
1999-10-19 |
2004-09-21 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
CA2387351C
(en)
|
1999-10-19 |
2009-09-08 |
Merck & Co., Inc. |
Indole derivatives as tyrosine kinase inhibitors
|
|
US6420382B2
(en)
|
2000-02-25 |
2002-07-16 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US6313138B1
(en)
|
2000-02-25 |
2001-11-06 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
NL1017973C2
(nl)
|
2000-05-10 |
2002-11-08 |
Tristem Trading Cyprus Ltd |
Inrichting.
|
|
US6921632B2
(en)
|
2000-08-30 |
2005-07-26 |
Maria Biotech Co., Ltd. |
Human embryonic stem cells derived from frozen-thawed embryo
|
|
JP4183614B2
(ja)
|
2001-05-31 |
2008-11-19 |
伸弥 山中 |
Es細胞特異的発現遺伝子
|
|
CA2450562A1
(en)
|
2001-06-22 |
2003-01-03 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US6958340B2
(en)
|
2001-08-01 |
2005-10-25 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
US6927293B2
(en)
|
2001-08-30 |
2005-08-09 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
|
CA2466279A1
(en)
|
2001-11-13 |
2003-05-22 |
Dana-Farber Cancer Institute, Inc. |
Agents that modulate immune cell activation and methods of use thereof
|
|
CN101899114A
(zh)
|
2002-12-23 |
2010-12-01 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
WO2005047524A2
(en)
|
2003-11-10 |
2005-05-26 |
The Scripps Research Institute |
Compositions and methods for inducing cell dedifferentiation
|
|
DK2439273T3
(da)
|
2005-05-09 |
2019-06-03 |
Ono Pharmaceutical Co |
Humane monoklonale antistoffer til programmeret død-1(pd-1) og fremgangsmåder til behandling af cancer ved anvendelse af anti-pd-1- antistoffer alene eller i kombination med andre immunterapeutika
|
|
PT1907424E
(pt)
|
2005-07-01 |
2015-10-09 |
Squibb & Sons Llc |
Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
|
|
US8278104B2
(en)
|
2005-12-13 |
2012-10-02 |
Kyoto University |
Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
|
|
US8129187B2
(en)
|
2005-12-13 |
2012-03-06 |
Kyoto University |
Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
|
|
WO2007109571A2
(en)
|
2006-03-17 |
2007-09-27 |
Prometheus Laboratories, Inc. |
Methods of predicting and monitoring tyrosine kinase inhibitor therapy
|
|
BR122017025062B8
(pt)
|
2007-06-18 |
2021-07-27 |
Merck Sharp & Dohme |
anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
|
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
|
US20100279404A1
(en)
|
2008-05-02 |
2010-11-04 |
Shinya Yamanaka |
Method of nuclear reprogramming
|
|
US8552154B2
(en)
|
2008-09-26 |
2013-10-08 |
Emory University |
Anti-PD-L1 antibodies and uses therefor
|
|
EP3255060A1
(en)
|
2008-12-09 |
2017-12-13 |
F. Hoffmann-La Roche AG |
Anti-pd-l1 antibodies and their use to enhance t-cell function
|
|
JP5844159B2
(ja)
|
2009-02-09 |
2016-01-13 |
ユニヴェルシテ デクス−マルセイユUniversite D’Aix−Marseille |
Pd−1抗体およびpd−l1抗体ならびにその使用
|
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
|
WO2011082400A2
(en)
|
2010-01-04 |
2011-07-07 |
President And Fellows Of Harvard College |
Modulators of immunoinhibitory receptor pd-1, and methods of use thereof
|
|
CN102906249A
(zh)
*
|
2010-05-25 |
2013-01-30 |
独立行政法人国立癌症研究中心 |
能够在体外自我复制的诱导性前癌干细胞或诱导性恶性干细胞,这些细胞的制备方法,及这些细胞的应用
|
|
WO2011159877A2
(en)
|
2010-06-18 |
2011-12-22 |
The Brigham And Women's Hospital, Inc. |
Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
JP5888753B2
(ja)
|
2010-11-04 |
2016-03-22 |
国立大学法人京都大学 |
効率的な人工多能性幹細胞の樹立方法
|
|
JP6309274B2
(ja)
|
2011-03-11 |
2018-04-11 |
ターンストーン・リミテッド・パートナーシップ |
ヒストンデアセチラーゼ阻害剤を含むワクチン接種法
|
|
US20130136722A1
(en)
|
2011-11-11 |
2013-05-30 |
The Board Of Trustees Of The University Of Illinois |
Methods of Ex Vivo Expansion of Blood Progenitor Cells, and Generation of Composite Grafts
|
|
KR101467631B1
(ko)
*
|
2012-05-22 |
2014-12-05 |
가톨릭대학교 산학협력단 |
자살 유전자 치료법에서의 발프로산의 기능
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
AU2015335607B2
(en)
|
2014-10-24 |
2020-04-23 |
Calidi Biotherapeutics (Nevada), Inc. |
Combination immunotherapy approach for treatment of cancer
|
|
AU2014277667B2
(en)
|
2014-12-15 |
2022-07-14 |
The University Of Queensland |
Differentiation of pluripotent stem cells to form renal organoids
|
|
CN108135996B
(zh)
|
2015-08-11 |
2022-06-21 |
卡利迪生物治疗有限公司 |
用以癌症治疗的天花疫苗
|
|
CN116376812A
(zh)
|
2016-05-25 |
2023-07-04 |
国家医疗保健研究所 |
治疗癌症的方法和组合物
|
|
US20180296850A1
(en)
|
2017-04-14 |
2018-10-18 |
Tianxin Wang |
Reagents and methods for cancer treatment using Magnetic particle
|