JP2021503480A5 - - Google Patents
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- JP2021503480A5 JP2021503480A5 JP2020527780A JP2020527780A JP2021503480A5 JP 2021503480 A5 JP2021503480 A5 JP 2021503480A5 JP 2020527780 A JP2020527780 A JP 2020527780A JP 2020527780 A JP2020527780 A JP 2020527780A JP 2021503480 A5 JP2021503480 A5 JP 2021503480A5
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- JP
- Japan
- Prior art keywords
- day
- tradipitant
- pharmaceutical composition
- amount
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CAVRKWRKTNINFF-UHFFFAOYSA-N [2-[1-[[3,5-bis(trifluoromethyl)phenyl]methyl]-5-pyridin-4-yltriazol-4-yl]pyridin-3-yl]-(2-chlorophenyl)methanone Chemical compound FC(F)(F)C1=CC(C(F)(F)F)=CC(CN2C(=C(N=N2)C=2C(=CC=CN=2)C(=O)C=2C(=CC=CC=2)Cl)C=2C=CN=CC=2)=C1 CAVRKWRKTNINFF-UHFFFAOYSA-N 0.000 claims 18
- 229950011232 tradipitant Drugs 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 17
- 208000024891 symptom Diseases 0.000 claims 8
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 6
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 6
- 230000002496 gastric effect Effects 0.000 claims 6
- 206010000060 Abdominal distension Diseases 0.000 claims 4
- 208000031649 Postoperative Nausea and Vomiting Diseases 0.000 claims 4
- 201000006549 dyspepsia Diseases 0.000 claims 4
- 208000010643 digestive system disease Diseases 0.000 claims 3
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 3
- 208000004998 Abdominal Pain Diseases 0.000 claims 2
- 206010059186 Early satiety Diseases 0.000 claims 2
- 206010028813 Nausea Diseases 0.000 claims 2
- 206010028817 Nausea and vomiting symptoms Diseases 0.000 claims 2
- 206010047700 Vomiting Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 208000024330 bloating Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 230000030135 gastric motility Effects 0.000 claims 2
- 208000001288 gastroparesis Diseases 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 230000000291 postprandial effect Effects 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762587681P | 2017-11-17 | 2017-11-17 | |
| US62/587,681 | 2017-11-17 | ||
| PCT/US2018/061593 WO2019099883A1 (en) | 2017-11-17 | 2018-11-16 | Method of treatment of gastrointestinal diseases with tradipitant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021503480A JP2021503480A (ja) | 2021-02-12 |
| JP2021503480A5 true JP2021503480A5 (enExample) | 2021-12-23 |
| JP7306614B2 JP7306614B2 (ja) | 2023-07-11 |
Family
ID=64734107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020527780A Active JP7306614B2 (ja) | 2017-11-17 | 2018-11-16 | トラジピタントを用いた胃腸疾患の治療方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20200030307A1 (enExample) |
| EP (1) | EP3710000B1 (enExample) |
| JP (1) | JP7306614B2 (enExample) |
| KR (2) | KR102864285B1 (enExample) |
| CN (2) | CN119074729A (enExample) |
| AU (1) | AU2018367623B2 (enExample) |
| BR (1) | BR112020009520A2 (enExample) |
| CA (1) | CA3081582A1 (enExample) |
| CL (1) | CL2020001290A1 (enExample) |
| DK (1) | DK3710000T3 (enExample) |
| ES (1) | ES3032138T3 (enExample) |
| FI (1) | FI3710000T3 (enExample) |
| HR (1) | HRP20250615T1 (enExample) |
| HU (1) | HUE071527T2 (enExample) |
| IL (1) | IL274541B2 (enExample) |
| MX (1) | MX2020005167A (enExample) |
| PT (1) | PT3710000T (enExample) |
| SI (1) | SI3710000T1 (enExample) |
| WO (1) | WO2019099883A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016141341A1 (en) * | 2015-03-04 | 2016-09-09 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| US20210228555A1 (en) * | 2018-06-08 | 2021-07-29 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| US10821099B2 (en) | 2018-09-28 | 2020-11-03 | Vanda Pharmaceuticals Inc. | Use of tradipitant in motion sickness |
| CN111918701B (zh) * | 2018-09-28 | 2024-08-02 | 万达制药公司 | 曲地匹坦在晕动病中的用途 |
| WO2020117811A1 (en) | 2018-12-03 | 2020-06-11 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| JP7791832B2 (ja) | 2020-03-26 | 2025-12-24 | バンダ・ファーマシューティカルズ・インコーポレイテッド | トラジピタントによる下気道感染症の治療 |
| WO2023019084A1 (en) | 2021-08-12 | 2023-02-16 | Vanda Pharmaceuticals Inc. | Treatment of gastric accommodation with tradipitant |
| US20240350469A1 (en) | 2021-08-31 | 2024-10-24 | Vanda Pharmaceuticals Inc. | Treatment of lower respiratory tract infection with tradipitant |
| JP2025542424A (ja) | 2022-12-21 | 2025-12-25 | バンダ・ファーマシューティカルズ・インコーポレイテッド | トラジピタントによる処置の方法 |
| EP4599831A1 (en) | 2024-02-09 | 2025-08-13 | Vanda Pharmaceuticals Inc. | Treatment of gastroparesis with tradipitant |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003230829B8 (en) | 2002-04-26 | 2008-12-11 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
| KR100848407B1 (ko) * | 2003-10-24 | 2008-07-28 | 일라이 릴리 앤드 캄파니 | ｛2-[1-(3,5-비스-트리플루오로메틸벤질)-5-피리딘-4-일-1ｈ-[1,2,3]트리아졸-4-일]-피리딘-3-일｝-(2-클로로페닐)-메탄온의 신규 결정질 형태 |
| WO2008079600A1 (en) * | 2006-12-20 | 2008-07-03 | Eli Lilly And Company | Novel intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone |
| HRP20140759T1 (hr) * | 2009-11-18 | 2014-10-24 | Helsinn Healthcare S.A. | Kompozicije za lijeäśenje središnje posredovane muäśnine i povraä†anja |
| WO2016141341A1 (en) * | 2015-03-04 | 2016-09-09 | Vanda Pharmaceuticals Inc. | Method of treatment with tradipitant |
| CA3009325A1 (en) | 2015-12-22 | 2017-06-29 | Takeda Pharmaceutical Company Limited | Tripartite modulators of endosomal g protein-coupled receptors |
-
2018
- 2018-11-16 HR HRP20250615TT patent/HRP20250615T1/hr unknown
- 2018-11-16 KR KR1020207014967A patent/KR102864285B1/ko active Active
- 2018-11-16 EP EP18821773.1A patent/EP3710000B1/en active Active
- 2018-11-16 PT PT188217731T patent/PT3710000T/pt unknown
- 2018-11-16 MX MX2020005167A patent/MX2020005167A/es unknown
- 2018-11-16 WO PCT/US2018/061593 patent/WO2019099883A1/en not_active Ceased
- 2018-11-16 FI FIEP18821773.1T patent/FI3710000T3/fi active
- 2018-11-16 CN CN202411421827.XA patent/CN119074729A/zh active Pending
- 2018-11-16 SI SI201831236T patent/SI3710000T1/sl unknown
- 2018-11-16 CN CN201880073477.9A patent/CN111343981A/zh active Pending
- 2018-11-16 KR KR1020257031352A patent/KR20250140655A/ko active Pending
- 2018-11-16 AU AU2018367623A patent/AU2018367623B2/en active Active
- 2018-11-16 JP JP2020527780A patent/JP7306614B2/ja active Active
- 2018-11-16 BR BR112020009520-6A patent/BR112020009520A2/pt not_active Application Discontinuation
- 2018-11-16 DK DK18821773.1T patent/DK3710000T3/da active
- 2018-11-16 CA CA3081582A patent/CA3081582A1/en active Pending
- 2018-11-16 ES ES18821773T patent/ES3032138T3/es active Active
- 2018-11-16 HU HUE18821773A patent/HUE071527T2/hu unknown
- 2018-11-16 IL IL274541A patent/IL274541B2/en unknown
-
2019
- 2019-10-01 US US16/590,048 patent/US20200030307A1/en not_active Abandoned
-
2020
- 2020-05-15 CL CL2020001290A patent/CL2020001290A1/es unknown
- 2020-12-11 US US17/119,349 patent/US20210093621A1/en not_active Abandoned
-
2021
- 2021-07-08 US US17/370,211 patent/US20210330656A1/en not_active Abandoned
-
2023
- 2023-08-16 US US18/450,564 patent/US20230390269A1/en active Pending
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