JP2021503292A5 - - Google Patents

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JP2021503292A5
JP2021503292A5 JP2020527909A JP2020527909A JP2021503292A5 JP 2021503292 A5 JP2021503292 A5 JP 2021503292A5 JP 2020527909 A JP2020527909 A JP 2020527909A JP 2020527909 A JP2020527909 A JP 2020527909A JP 2021503292 A5 JP2021503292 A5 JP 2021503292A5
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Japan
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library
members
sub
cdr3
composition
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JP2020527909A
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Japanese (ja)
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JP7291700B2 (ja
JP2021503292A (ja
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Priority claimed from PCT/US2018/061592 external-priority patent/WO2019099882A2/en
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Priority to JP2023084817A priority Critical patent/JP7628153B2/ja
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JP2020527909A 2017-11-20 2018-11-16 mRNAディスプレイ抗体ライブラリー及び方法 Active JP7291700B2 (ja)

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Application Number Priority Date Filing Date Title
JP2023084817A JP7628153B2 (ja) 2017-11-20 2023-05-23 mRNAディスプレイ抗体ライブラリー及び方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762588914P 2017-11-20 2017-11-20
US62/588,914 2017-11-20
PCT/US2018/061592 WO2019099882A2 (en) 2017-11-20 2018-11-16 mRNA DISPLAY ANTIBODY LIBRARY AND METHODS

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JP2023084817A Division JP7628153B2 (ja) 2017-11-20 2023-05-23 mRNAディスプレイ抗体ライブラリー及び方法

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JP2021503292A JP2021503292A (ja) 2021-02-12
JP2021503292A5 true JP2021503292A5 (https=) 2021-08-12
JP7291700B2 JP7291700B2 (ja) 2023-06-15

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JP2020527909A Active JP7291700B2 (ja) 2017-11-20 2018-11-16 mRNAディスプレイ抗体ライブラリー及び方法
JP2023084817A Active JP7628153B2 (ja) 2017-11-20 2023-05-23 mRNAディスプレイ抗体ライブラリー及び方法

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US (3) US11015188B2 (https=)
EP (3) EP4644544A3 (https=)
JP (2) JP7291700B2 (https=)
KR (2) KR102615744B1 (https=)
CN (2) CN111511768B (https=)
AU (1) AU2018367622B2 (https=)
CA (1) CA3082172C (https=)
ES (1) ES2969081T3 (https=)
IL (2) IL316884A (https=)
TW (4) TWI877823B (https=)
WO (1) WO2019099882A2 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11034951B2 (en) 2017-11-20 2021-06-15 Nantbio, Inc. mRNA display antibody library and methods
US11015188B2 (en) 2017-11-20 2021-05-25 NantBio Inc. MRNA display antibody library and methods
KR102736548B1 (ko) * 2019-01-31 2024-12-02 난트바이오 인코포레이티드 Mrna 디스플레이 항체 라이브러리 및 방법
JP2022548783A (ja) * 2019-09-23 2022-11-21 ツイスト バイオサイエンス コーポレーション 単一ドメイン抗体のバリアント核酸ライブラリー
EP4314075A4 (en) 2021-03-24 2025-04-09 Twist Bioscience Corporation VARIANT NUCLEIC ACID BANKS FOR CD3

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7667004B2 (en) * 2001-04-17 2010-02-23 Abmaxis, Inc. Humanized antibodies against vascular endothelial growth factor
WO2003099999A2 (en) * 2002-05-20 2003-12-04 Abmaxis, Inc. Generation and selection of protein library in silico
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
ES2563491T3 (es) * 2004-07-06 2016-03-15 Bioren, LLC Bibliotecas universales de anticuerpos
GB0500099D0 (en) 2005-01-05 2005-02-09 Cambridge Antibody Tech Methods and means relating to protein variants
KR20080073293A (ko) 2005-10-14 2008-08-08 메디뮨 엘엘씨 항체 라이브러리의 세포 디스플레이
US8716195B2 (en) * 2005-11-14 2014-05-06 Bioren, Inc. Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening
EP2069558B1 (en) * 2006-10-02 2013-05-01 Sea Lane Biotechnologies,llc. Design and construction of diverse synthetic peptide and polypeptide libraries
CN101720368A (zh) * 2007-03-09 2010-06-02 中国抗体制药有限公司 储备多样性最大化的功能性人化抗体文库之构建及应用
AU2008343589A1 (en) * 2007-12-19 2009-07-09 Centocor Ortho Biotech Inc. Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods
KR100961392B1 (ko) 2008-04-15 2010-06-07 이화여자대학교 산학협력단 항체 파지 표면제시 라이브러리 제조방법, 상기 방법에의해 제조된 항체 파지 표면제시 라이브러리, 상기 항체파지 표면제시 라이브러리 유전자를 포함한 파지미드 벡터
NZ591543A (en) * 2008-09-30 2012-11-30 Abbott Lab Improved antibody libraries
KR20110076906A (ko) * 2008-09-30 2011-07-06 아보트 러보러터리즈 개선된 rna 디스플레이 방법
CA2742969A1 (en) 2008-11-07 2010-05-14 Fabrus Llc Anti-dll4 antibodies and uses thereof
ES2551871T3 (es) 2010-01-29 2015-11-24 Morphosys Ag Genotecas combinatorias de anticuerpos de roedor
KR101694832B1 (ko) * 2014-12-31 2017-01-12 앱클론(주) 항체 라이브러리 및 그의 제작방법
EP3246434A1 (en) * 2015-01-13 2017-11-22 Ewha University-Industry Collaboration Foundation Method for preparing novel antibody library and library prepared thereby
EP3448427A1 (en) * 2016-04-29 2019-03-06 CureVac AG Rna encoding an antibody
US11034951B2 (en) 2017-11-20 2021-06-15 Nantbio, Inc. mRNA display antibody library and methods
US11015188B2 (en) 2017-11-20 2021-05-25 NantBio Inc. MRNA display antibody library and methods
KR102736548B1 (ko) 2019-01-31 2024-12-02 난트바이오 인코포레이티드 Mrna 디스플레이 항체 라이브러리 및 방법

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