JP2021502064A - プロバイオティクスを選択する方法 - Google Patents
プロバイオティクスを選択する方法 Download PDFInfo
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- JP2021502064A JP2021502064A JP2020524056A JP2020524056A JP2021502064A JP 2021502064 A JP2021502064 A JP 2021502064A JP 2020524056 A JP2020524056 A JP 2020524056A JP 2020524056 A JP2020524056 A JP 2020524056A JP 2021502064 A JP2021502064 A JP 2021502064A
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- Prior art keywords
- probiotic
- oleuropein
- probiotic strain
- composition
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Abstract
Description
したがって、本発明は、第1の態様において、プロバイオティクス菌株又はプロバイオティクス菌株混合物を選択する方法であって、
a.複数の菌株の、インシリコ分析によりβ−グルコシダーゼコード遺伝子を有するプロバイオティクス菌株を同定し及び/又はインビトロ分析によりβ−グルコシダーゼ活性を有するプロバイオティクス菌株を同定する工程と、
b.複数の菌株の、インシリコ分析によりエステラーゼコード遺伝子を有するプロバイオティクス菌株を同定し及び/又はインビトロ分析によりエステラーゼ活性を有するプロバイオティクス菌株を同定する工程と、
c.i)β−グルコシダーゼ活性を有するものとして工程aにおいて同定されたプロバイオティクス菌株、及びエステラーゼ活性を有するものとして工程bにおいて同定されたプロバイオティクス菌株の、細菌培養物、又はii)β−グルコシダーゼ活性及びエステラーゼ活性の両方を有するものとして工程a及びbにおいて同定されたプロバイオティクス菌株の細菌培養物を用いて、オレウロペインを発酵させる工程と、
d.工程cの発酵中に形成された代謝産物が、ヒドロキシチロソールアセテート、ヒドロキシチロソール、又はエレノール酸を含むかを同定する工程と、
e.工程cにおける発酵時間に比して残存するオレウロペインの割合を測定する工程と、
f.プロバイオティクス菌株又はプロバイオティクス菌株混合物を選択する工程であって、このプロバイオティクス菌株又はプロバイオティクス菌株混合物は、24未満の時間をかけて工程cにおいて少なくとも10重量%のオレウロペインを消費し、工程cの発酵中に形成された代謝産物は、ヒドロキシチロソールアセテート、ヒドロキシチロソール、及びエレノール酸からなる群から選択される分子を含む、選択する工程と、を含む、方法を提供する。
a.複数の菌株の、インシリコ分析によりβ−グルコシダーゼコード遺伝子を有するプロバイオティクス菌株を同定し及び/又はインビトロ分析によりβ−グルコシダーゼ活性を有するプロバイオティクス菌株を同定する工程と、
b.複数の菌株の、インシリコ分析によりエステラーゼコード遺伝子を有するプロバイオティクス菌株を同定し及び/又はインビトロ分析によりエステラーゼ活性を有するプロバイオティクス菌株を同定する工程と、
c.i)β−グルコシダーゼ活性を有するものとして工程aにおいて同定されたプロバイオティクス菌株、及びエステラーゼ活性を有するものとして工程bにおいて同定されたプロバイオティクス菌株の、細菌培養物、又はii)β−グルコシダーゼ活性及びエステラーゼ活性の両方を有するものとして工程a及びbにおいて同定されたプロバイオティクス菌株の細菌培養物を用いて、オレウロペインを発酵させる工程と、
d.工程cの発酵中に形成された代謝産物が、ヒドロキシチロソールアセテート、ヒドロキシチロソール、又はエレノール酸を含むかを同定する工程と、
e.工程cにおける発酵時間に比して残存するオレウロペインの割合を測定する工程と、
f.プロバイオティクス菌株又はプロバイオティクス菌株混合物を選択する工程であって、このプロバイオティクス菌株又はプロバイオティクス菌株混合物は、24未満の時間をかけて工程cにおいて少なくとも10重量%のオレウロペインを消費し、工程cの発酵中に形成された代謝産物は、ヒドロキシチロソールアセテート、ヒドロキシチロソール、及びエレノール酸からなる群から選択される分子を含む、選択する工程と、を含む。
定義
以下、いくつかの定義を示す。しかしながら定義が明細書の他の場所にある場合もあり、上記の見出し「定義」は、「実施形態」の項におけるそのような開示が定義ではないことを意味するものではない。
Claims (15)
- プロバイオティクス菌株又はプロバイオティクス菌株混合物を選択する方法であって、前記方法は、
a.複数の菌株の、インシリコ分析によりβ−グルコシダーゼコード遺伝子を有するプロバイオティクス菌株を同定し及び/又はインビトロ分析によりβ−グルコシダーゼ活性を有するプロバイオティクス菌株を同定する工程と、
b.複数の菌株の、インシリコ分析によりエステラーゼコード遺伝子を有するプロバイオティクス菌株を同定し及び/又はインビトロ分析によりエステラーゼ活性を有するプロバイオティクス菌株を同定する工程と、
c.i)β−グルコシダーゼ活性を有するものとして工程aにおいて同定されたプロバイオティクス菌株、及びエステラーゼ活性を有するものとして工程bにおいて同定されたプロバイオティクス菌株の、細菌培養物、又はii)β−グルコシダーゼ活性及びエステラーゼ活性の両方を有するものとして工程a及びbにおいて同定されたプロバイオティクス菌株の細菌培養物を用いて、オレウロペインを発酵させる工程と、
d.工程cの前記発酵中に形成された代謝産物が、ヒドロキシチロソールアセテート、ヒドロキシチロソール、又はエレノール酸を含むかを同定する工程と、
e.工程cにおける発酵時間に比して残存するオレウロペインの割合を測定する工程と、
f.プロバイオティクス菌株又はプロバイオティクス菌株混合物を選択する工程であって、前記プロバイオティクス菌株又はプロバイオティクス菌株混合物は、24時間未満の時間をかけて工程cにおいて少なくとも10重量%のオレウロペインを消費し、工程cの前記発酵中に形成された前記代謝産物は、ヒドロキシチロソールアセテート、ヒドロキシチロソール、及びエレノール酸からなる群から選択される分子を含む、選択する工程と、を含む、方法。 - インシリコ分析による工程aにおけるプロバイオティクス菌株の同定が、前記プロバイオティクス菌株のゲノムを準備し、前記プロバイオティクス菌株の前記ゲノム中のβ−グルコシダーゼ酵素をコードする遺伝子の配列類似性検索を行うことによって行われ、インシリコ分析による工程bにおけるプロバイオティクス菌株の同定が、前記プロバイオティクス菌株のゲノムを準備し、前記プロバイオティクス菌株の前記ゲノム中のエステラーゼ酵素をコードする遺伝子の配列類似性検索を行うことによって行われる、請求項1に記載の方法。
- インビトロ分析による工程a及びbにおけるプロバイオティクス菌株の同定が、表現型スクリーニングにより行われる、請求項1又は2に記載の方法。
- オリーブポリフェノールの有効性を増加させる、請求項1〜3のいずれか一項にしたがって選択されたプロバイオティクス菌株又はプロバイオティクス菌株混合物の使用。
- 前記プロバイオティクス菌株又はプロバイオティクス菌株混合物が、オリーブポリフェノールを更に含む食品又は飲料組成物内に含まれる、請求項4に記載の使用。
- 個体におけるオレウロペインの治療効果及び/又は予防効果の相乗作用に使用する、請求項1〜3のいずれか一項にしたがって選択されたプロバイオティクス菌株又はプロバイオティクス菌株混合物を含む組成物。
- 前記プロバイオティクス菌株又はプロバイオティクス菌株混合物が、オレウロペインアグリコン、ヒドロキシチロソールアセテート、ヒドロキシチロソール、及びこれらの混合物からなる群から選択されるオレウロペイン代謝産物を形成する、請求項6に記載の組成物。
- オリーブポリフェノール(例えば、オレウロペイン)を更に含む、請求項6又は7に記載の組成物。
- 前記治療効果及び/又は予防効果が、高齢者における運動障害の処置又は予防;骨形成と骨吸収との間の不均衡を含む状態を有する個体における骨形成の刺激及び/又は骨吸収の阻害;滑膜炎の処置又は予防;滑膜炎を有する若しくは滑膜炎から回復中の個体における滑膜炎に続く関節軟骨の分解の処置又は予防;並びに軟骨の破壊の処置又は予防からなる群から選択される、請求項6〜8のいずれか一項に記載の組成物。
- 前記治療効果及び/又は予防効果が、前記高齢者における運動障害の処置又は予防であり、前記高齢者が、フレイル、プレフレイル、サルコペニア、サルコペニアから回復中である、骨粗鬆症、骨関節炎、栄養不良、栄養不良のリスクがある、リハビリテーションを受けている、来年中にリハビリテーションを受ける予定である、及びこれらの組み合わせからなる群から選択される状態を有する、請求項9に記載の組成物。
- 前記治療効果及び/又は予防効果が、前記骨形成と骨吸収との間の不均衡を含む状態を有する個体における骨形成の刺激及び/又は骨吸収の阻害であり、前記状態が、骨粗鬆症、ページェット病、プロテーゼに隣接する骨溶解、転移性骨疾患、甲状腺機能亢進症、癌による高カルシウム血症、多発性骨髄腫、歯周病、骨関節炎、骨減少症、骨折に起因する骨欠損、骨折治癒、及びこれらの組み合わせからなる群から選択される、請求項9に記載の組成物。
- 前記治療効果及び/又は予防効果が、前記滑膜炎の処置又は予防であり、前記滑膜炎が、狼瘡、痛風、関節リウマチ、骨関節炎、骨軟骨炎、変形性関節症、及びこれらの組み合わせからなる群から選択される状態に関連する、請求項9に記載の組成物。
- 前記組成物が、経口投与用の組成物である、請求項6〜12のいずれか一項に記載の組成物。
- 前記組成物が、食品製品又は飲料製品である、請求項13に記載の組成物。
- 前記組成物が、タンパク質、炭水化物、脂肪、及びこれらの組み合わせからなる群から選択される構成成分を含む、請求項14に記載の組成物。
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US11452308B2 (en) | 2022-09-27 |
ES2955922T3 (es) | 2023-12-11 |
WO2019092066A1 (en) | 2019-05-16 |
CA3078194A1 (en) | 2019-05-16 |
JP2024012359A (ja) | 2024-01-30 |
EP3706760A1 (en) | 2020-09-16 |
US20200345050A1 (en) | 2020-11-05 |
EP3706760B1 (en) | 2023-08-02 |
CN111246853A (zh) | 2020-06-05 |
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