JP2021500010A5 - - Google Patents
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- Publication number
- JP2021500010A5 JP2021500010A5 JP2020517556A JP2020517556A JP2021500010A5 JP 2021500010 A5 JP2021500010 A5 JP 2021500010A5 JP 2020517556 A JP2020517556 A JP 2020517556A JP 2020517556 A JP2020517556 A JP 2020517556A JP 2021500010 A5 JP2021500010 A5 JP 2021500010A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- amino acid
- amino acids
- polypeptide chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1940
- 150000001413 amino acids Chemical class 0.000 claims 1104
- 229920001184 polypeptide Polymers 0.000 claims 840
- 108090000765 processed proteins & peptides Proteins 0.000 claims 840
- 102000004196 processed proteins & peptides Human genes 0.000 claims 840
- 108091008874 T cell receptors Proteins 0.000 claims 16
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 238000003259 recombinant expression Methods 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 230000035772 mutation Effects 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023123893A JP7573075B2 (ja) | 2017-09-29 | 2023-07-28 | 変異型ｐ５３を認識するｔ細胞受容体 |
| JP2024178808A JP7814467B2 (ja) | 2017-09-29 | 2024-10-11 | 変異型ｐ５３を認識するｔ細胞受容体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762565383P | 2017-09-29 | 2017-09-29 | |
| US62/565,383 | 2017-09-29 | ||
| PCT/US2018/051285 WO2019067243A1 (en) | 2017-09-29 | 2018-09-17 | T CELL RECEPTORS RECOGNIZING P53 MUTE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023123893A Division JP7573075B2 (ja) | 2017-09-29 | 2023-07-28 | 変異型ｐ５３を認識するｔ細胞受容体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021500010A JP2021500010A (ja) | 2021-01-07 |
| JP2021500010A5 true JP2021500010A5 (https=) | 2021-11-11 |
| JP7324193B2 JP7324193B2 (ja) | 2023-08-09 |
Family
ID=63714167
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517556A Active JP7324193B2 (ja) | 2017-09-29 | 2018-09-17 | 変異型ｐ５３を認識するｔ細胞受容体 |
| JP2023123893A Active JP7573075B2 (ja) | 2017-09-29 | 2023-07-28 | 変異型ｐ５３を認識するｔ細胞受容体 |
| JP2024178808A Active JP7814467B2 (ja) | 2017-09-29 | 2024-10-11 | 変異型ｐ５３を認識するｔ細胞受容体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023123893A Active JP7573075B2 (ja) | 2017-09-29 | 2023-07-28 | 変異型ｐ５３を認識するｔ細胞受容体 |
| JP2024178808A Active JP7814467B2 (ja) | 2017-09-29 | 2024-10-11 | 変異型ｐ５３を認識するｔ細胞受容体 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11939365B2 (https=) |
| EP (2) | EP4647442A3 (https=) |
| JP (3) | JP7324193B2 (https=) |
| KR (2) | KR20250024096A (https=) |
| CN (2) | CN118955684A (https=) |
| AU (2) | AU2018342246B2 (https=) |
| BR (1) | BR112020006012A2 (https=) |
| CA (1) | CA3077024A1 (https=) |
| CR (4) | CR20200170A (https=) |
| DK (1) | DK3688027T3 (https=) |
| EA (1) | EA202090757A1 (https=) |
| ES (1) | ES3056082T3 (https=) |
| FI (1) | FI3688027T3 (https=) |
| IL (1) | IL273515B2 (https=) |
| MA (1) | MA50651A (https=) |
| MX (4) | MX421596B (https=) |
| PL (1) | PL3688027T3 (https=) |
| PT (1) | PT3688027T (https=) |
| SG (1) | SG11202002636PA (https=) |
| WO (1) | WO2019067243A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240007775A (ko) | 2016-12-08 | 2024-01-16 | 이매틱스 바이오테크놀로지스 게엠베하 | T 세포 수용체 및 이를 사용하는 면역 요법 |
| SG11202002635RA (en) * | 2017-09-29 | 2020-04-29 | The United States Of America As Represented By The Secretary | Methods of isolating t cells having antigenic specificity for a p53 cancer-specific mutation |
| WO2020237368A1 (en) * | 2019-05-27 | 2020-12-03 | Provincial Health Services Authority | Immunotherapy constructs targeting kras antigens |
| TW202525841A (zh) * | 2019-06-27 | 2025-07-01 | 美國衛生與公眾服務部 | 識別p53中之r175h或y220c突變之t細胞受體 |
| CN113512124A (zh) * | 2020-04-10 | 2021-10-19 | 香雪生命科学技术（广东）有限公司 | 一种识别hpv16的高亲和力tcr |
| TWI900647B (zh) * | 2020-09-04 | 2025-10-11 | 美國衛生與公眾服務部 | 識別p53中r273c或y220c突變的t細胞受體 |
| WO2022183167A1 (en) | 2021-02-25 | 2022-09-01 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| JP2024517884A (ja) * | 2021-05-07 | 2024-04-23 | アメリカ合衆国 | ｐ５３におけるＣ１３５Ｙ、Ｒ１７５Ｈ又はＭ２３７Ｉ変異を認識するＴ細胞受容体 |
| WO2023050063A1 (zh) * | 2021-09-28 | 2023-04-06 | 溧阳瑅赛生物医药有限公司 | 一种识别hla-a*02:01/e629-38的tcr及其应用 |
| JP2024540197A (ja) * | 2021-10-29 | 2024-10-31 | ホウ，ヤフェイ | Ｐ５３におけるｒ１７５ｈ変異を認識するｔ細胞受容体およびその用途 |
| US20250145950A1 (en) | 2022-02-01 | 2025-05-08 | Alaunos Therapeutics, Inc. | Methods for Activation and Expansion of T Cells |
| US20240035027A1 (en) * | 2022-05-04 | 2024-02-01 | University Of Massachusetts | Oligonucleotides for pms2 modulation |
| CN116063577B (zh) * | 2022-11-18 | 2025-02-07 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
| WO2024206274A2 (en) | 2023-03-27 | 2024-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors targeting y220c or r175h mutation in p53 |
| WO2025024648A2 (en) * | 2023-07-25 | 2025-01-30 | Memorial Sloan-Kettering Cancer Center | T cell receptors targeting tp53 hotspot mutations and uses thereof |
| WO2025060149A1 (zh) * | 2023-09-22 | 2025-03-27 | 上海市第一人民医院 | 一种分离的tcr及其用途 |
| WO2025226769A1 (en) * | 2024-04-24 | 2025-10-30 | Bluesphere Bio, Inc. | T cell receptors targeting minor histocompatibility antigen lrh-1 |
| WO2025250587A1 (en) | 2024-05-29 | 2025-12-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Drug-regulatable, inducible cytokine expression |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6770749B2 (en) | 2000-02-22 | 2004-08-03 | City Of Hope | P53-specific T cell receptor for adoptive immunotherapy |
| CA2487779C (en) * | 2001-06-05 | 2012-10-02 | Altor Bioscience Corporation | P53 binding t cell receptor molecules and uses thereof |
| US8034334B2 (en) | 2002-09-06 | 2011-10-11 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after non-myeloablative lymphodepleting chemotherapy |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| US20120244133A1 (en) | 2011-03-22 | 2012-09-27 | The United States of America, as represented by the Secretary, Department of Health and | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| HUE049292T2 (hu) * | 2013-08-07 | 2020-09-28 | Yeda Res & Dev | A P53 mutánsok újraaktíválására képes peptidek |
| KR102375998B1 (ko) * | 2014-02-14 | 2022-03-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 키메라 항원 수용체 및 제조방법 |
| CA2945388A1 (en) * | 2014-04-23 | 2015-10-29 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) for use in therapy and methods for making the same |
| MX375379B (es) | 2014-05-29 | 2025-03-06 | Us Health | Receptores de celulas t anti - papilomavirus 16 e7 humano. |
| JP6599450B2 (ja) | 2014-10-02 | 2019-10-30 | アメリカ合衆国 | がん特異的突然変異に対し抗原特異性を有するｔ細胞を単離する方法 |
| AU2014407539B2 (en) * | 2014-10-02 | 2020-10-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation |
| EP3265079A4 (en) | 2015-03-03 | 2019-01-02 | Caris MPI, Inc. | Molecular profiling for cancer |
| WO2016179006A1 (en) * | 2015-05-01 | 2016-11-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating t cells and t cell receptors having antigenic specificity for a cancer-specific mutation from peripheral blood |
| IL294183B2 (en) | 2015-05-20 | 2023-10-01 | Dana Farber Cancer Inst Inc | shared neoantigens |
| US11047011B2 (en) * | 2015-09-29 | 2021-06-29 | iRepertoire, Inc. | Immunorepertoire normality assessment method and its use |
-
2018
- 2018-09-17 WO PCT/US2018/051285 patent/WO2019067243A1/en not_active Ceased
- 2018-09-17 IL IL273515A patent/IL273515B2/en unknown
- 2018-09-17 US US16/651,242 patent/US11939365B2/en active Active
- 2018-09-17 AU AU2018342246A patent/AU2018342246B2/en active Active
- 2018-09-17 CA CA3077024A patent/CA3077024A1/en active Pending
- 2018-09-17 CR CR20200170A patent/CR20200170A/es unknown
- 2018-09-17 EP EP25200391.8A patent/EP4647442A3/en active Pending
- 2018-09-17 EA EA202090757A patent/EA202090757A1/ru unknown
- 2018-09-17 KR KR1020257002917A patent/KR20250024096A/ko active Pending
- 2018-09-17 JP JP2020517556A patent/JP7324193B2/ja active Active
- 2018-09-17 ES ES18780006T patent/ES3056082T3/es active Active
- 2018-09-17 EP EP18780006.5A patent/EP3688027B1/en active Active
- 2018-09-17 CN CN202411117183.5A patent/CN118955684A/zh active Pending
- 2018-09-17 BR BR112020006012-7A patent/BR112020006012A2/pt unknown
- 2018-09-17 FI FIEP18780006.5T patent/FI3688027T3/fi active
- 2018-09-17 CN CN201880074539.8A patent/CN111386282B/zh active Active
- 2018-09-17 CR CR20250153A patent/CR20250153A/es unknown
- 2018-09-17 PT PT187800065T patent/PT3688027T/pt unknown
- 2018-09-17 MA MA050651A patent/MA50651A/fr unknown
- 2018-09-17 CR CR20240303A patent/CR20240303A/es unknown
- 2018-09-17 PL PL18780006.5T patent/PL3688027T3/pl unknown
- 2018-09-17 KR KR1020207012344A patent/KR102762272B1/ko active Active
- 2018-09-17 MX MX2020003504A patent/MX421596B/es unknown
- 2018-09-17 SG SG11202002636PA patent/SG11202002636PA/en unknown
- 2018-09-17 DK DK18780006.5T patent/DK3688027T3/da active
- 2018-09-17 CR CR20240302A patent/CR20240302A/es unknown
-
2020
- 2020-07-13 MX MX2024005677A patent/MX2024005677A/es unknown
- 2020-07-13 MX MX2024005676A patent/MX2024005676A/es unknown
- 2020-07-13 MX MX2024005678A patent/MX2024005678A/es unknown
-
2023
- 2023-07-28 JP JP2023123893A patent/JP7573075B2/ja active Active
-
2024
- 2024-02-21 US US18/583,139 patent/US20240270814A1/en active Pending
- 2024-10-11 JP JP2024178808A patent/JP7814467B2/ja active Active
- 2024-10-28 AU AU2024227695A patent/AU2024227695A1/en active Pending
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