JP2021136867A5 - - Google Patents

Info

Publication number

JP2021136867A5

JP2021136867A5 JP2020034548A JP2020034548A JP2021136867A5 JP 2021136867 A5 JP2021136867 A5 JP 2021136867A5 JP 2020034548 A JP2020034548 A JP 2020034548A JP 2020034548 A JP2020034548 A JP 2020034548A JP 2021136867 A5 JP2021136867 A5 JP 2021136867A5

Authority

JP

Japan

Prior art keywords

amino acid

acid sequence

seq

activity

gene

Prior art date

2020-02-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 88
• 238000006467 substitution reaction Methods 0.000 claims 34
• 108090000623 proteins and genes Proteins 0.000 claims 32
• 238000001514 detection method Methods 0.000 claims 31
• 230000000694 effects Effects 0.000 claims 28
• 102000004190 Enzymes Human genes 0.000 claims 25
• 108090000790 Enzymes Proteins 0.000 claims 25
• 102200012546 rs111033636 Human genes 0.000 claims 17
• 108090000765 processed proteins & peptides Proteins 0.000 claims 14
• 150000001413 amino acids Chemical class 0.000 claims 12
• OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 12
• 229920001184 polypeptide Polymers 0.000 claims 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims 12
• 238000013518 transcription Methods 0.000 claims 11
• 230000035897 transcription Effects 0.000 claims 11
• 102220505661 Mitochondrial amidoxime reducing component 2_C245W_mutation Human genes 0.000 claims 10
• 230000002708 enhancing effect Effects 0.000 claims 10
• 102200045855 rs72554624 Human genes 0.000 claims 10
• 102220487776 4-hydroxybenzoate polyprenyltransferase, mitochondrial_S57T_mutation Human genes 0.000 claims 9
• 102200106455 rs2072799 Human genes 0.000 claims 9
• 239000002773 nucleotide Substances 0.000 claims 8
• 125000003729 nucleotide group Chemical group 0.000 claims 8
• 102220229301 rs769666619 Human genes 0.000 claims 8
• 238000000034 method Methods 0.000 claims 7
• AJPADPZSRRUGHI-RFZPGFLSSA-N 1-deoxy-D-xylulose 5-phosphate Chemical compound CC(=O)[C@@H](O)[C@H](O)COP(O)(O)=O AJPADPZSRRUGHI-RFZPGFLSSA-N 0.000 claims 6
• OFNXOACBUMGOPC-HZYVHMACSA-N 5'-hydroxystreptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](CO)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O OFNXOACBUMGOPC-HZYVHMACSA-N 0.000 claims 6
• 108010081750 Reticulin Proteins 0.000 claims 6
• 229960004126 codeine Drugs 0.000 claims 6
• OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 6
• OFNXOACBUMGOPC-UHFFFAOYSA-N hydroxystreptomycin Natural products CNC1C(O)C(O)C(CO)OC1OC1C(C=O)(O)C(CO)OC1OC1C(N=C(N)N)C(O)C(N=C(N)N)C(O)C1O OFNXOACBUMGOPC-UHFFFAOYSA-N 0.000 claims 6
• OKPOKMCPHKVCPP-UHFFFAOYSA-N isoorientaline Natural products C1=C(O)C(OC)=CC(CC2C3=CC(OC)=C(O)C=C3CCN2C)=C1 OKPOKMCPHKVCPP-UHFFFAOYSA-N 0.000 claims 6
• JTQHYPFKHZLTSH-UHFFFAOYSA-N reticulin Natural products COC1CC(OC2C(CO)OC(OC3C(O)CC(OC4C(C)OC(CC4OC)OC5CCC6(C)C7CCC8(C)C(CCC8(O)C7CC=C6C5)C(C)O)OC3C)C(O)C2OC)OC(C)C1O JTQHYPFKHZLTSH-UHFFFAOYSA-N 0.000 claims 6
• 230000035945 sensitivity Effects 0.000 claims 6
• KJTLQQUUPVSXIM-ZCFIWIBFSA-N (R)-mevalonic acid Chemical compound OCC[C@](O)(C)CC(O)=O KJTLQQUUPVSXIM-ZCFIWIBFSA-N 0.000 claims 5
• KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 claims 5
• 230000001419 dependent effect Effects 0.000 claims 4
• NUHSROFQTUXZQQ-UHFFFAOYSA-N isopentenyl diphosphate Chemical compound CC(=C)CCO[P@](O)(=O)OP(O)(O)=O NUHSROFQTUXZQQ-UHFFFAOYSA-N 0.000 claims 4
• 230000035772 mutation Effects 0.000 claims 4
• 238000001243 protein synthesis Methods 0.000 claims 4
• 102200067184 rs121913655 Human genes 0.000 claims 4
• 102220199908 rs150665982 Human genes 0.000 claims 4
• 102220259759 rs1553901266 Human genes 0.000 claims 4
• 102220008316 rs199476304 Human genes 0.000 claims 4
• 102220014743 rs397517240 Human genes 0.000 claims 4
• 102220292103 rs750764857 Human genes 0.000 claims 4
• 238000012216 screening Methods 0.000 claims 4
• 230000014616 translation Effects 0.000 claims 4
• 230000002255 enzymatic effect Effects 0.000 claims 3
• MGYSTOQOSMRLQF-JZUJSFITSA-N 2-hydroxy-1-[(3s,9r,10s,13s,14r,17s)-3-hydroxy-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]ethanone Chemical compound C1[C@@H](O)CC[C@@]2(C)[C@@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4C3=CC=C21 MGYSTOQOSMRLQF-JZUJSFITSA-N 0.000 claims 2
• 101100009643 Papaver somniferum CODM gene Proteins 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000000758 substrate Substances 0.000 claims 2
• 102220481291 Podocan_V66A_mutation Human genes 0.000 claims 1
• JSJFLHPWPFCJTN-UHFFFAOYSA-N dimethyl phosphono phosphate Chemical compound COP(=O)(OC)OP(O)(O)=O JSJFLHPWPFCJTN-UHFFFAOYSA-N 0.000 claims 1
• 102200146364 rs141090506 Human genes 0.000 claims 1
• 102220334721 rs1554659236 Human genes 0.000 claims 1
• 230000002103 transcriptional effect Effects 0.000 claims 1