JP2021118728A5 - - Google Patents
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- Publication number
- JP2021118728A5 JP2021118728A5 JP2021076105A JP2021076105A JP2021118728A5 JP 2021118728 A5 JP2021118728 A5 JP 2021118728A5 JP 2021076105 A JP2021076105 A JP 2021076105A JP 2021076105 A JP2021076105 A JP 2021076105A JP 2021118728 A5 JP2021118728 A5 JP 2021118728A5
- Authority
- JP
- Japan
- Prior art keywords
- positive
- fibroblasts
- csf
- adult heart
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002950 fibroblast Anatomy 0.000 claims 14
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 7
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 4
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000001054 cardiac fibroblast Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018160898 | 2018-08-29 | ||
| JP2018160898 | 2018-08-29 | ||
| JP2020539572A JP6883904B2 (ja) | 2018-08-29 | 2019-08-29 | 線維芽細胞の製造方法及びｇ−ｃｓｆ陽性線維芽細胞集団 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539572A Division JP6883904B2 (ja) | 2018-08-29 | 2019-08-29 | 線維芽細胞の製造方法及びｇ−ｃｓｆ陽性線維芽細胞集団 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021118728A JP2021118728A (ja) | 2021-08-12 |
| JP2021118728A5 true JP2021118728A5 (https=) | 2022-09-06 |
| JP7428389B2 JP7428389B2 (ja) | 2024-02-06 |
Family
ID=69642802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539572A Active JP6883904B2 (ja) | 2018-08-29 | 2019-08-29 | 線維芽細胞の製造方法及びｇ−ｃｓｆ陽性線維芽細胞集団 |
| JP2021076105A Active JP7428389B2 (ja) | 2018-08-29 | 2021-04-28 | 線維芽細胞の製造方法及びｇ－ｃｓｆ陽性線維芽細胞集団 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020539572A Active JP6883904B2 (ja) | 2018-08-29 | 2019-08-29 | 線維芽細胞の製造方法及びｇ−ｃｓｆ陽性線維芽細胞集団 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210254009A1 (https=) |
| EP (1) | EP3845635A4 (https=) |
| JP (2) | JP6883904B2 (https=) |
| KR (1) | KR102883773B1 (https=) |
| CN (1) | CN112639082A (https=) |
| AU (1) | AU2019332400B2 (https=) |
| CA (1) | CA3110831A1 (https=) |
| IL (1) | IL281081B (https=) |
| SG (1) | SG11202102028SA (https=) |
| WO (1) | WO2020045547A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3845635A4 (en) * | 2018-08-29 | 2022-06-15 | Metcela Inc. | PROCEDURE FOR PREPARING FIBROBLAST AND G-CSF-POSITIVE FIBROBLAST MASS |
| WO2021177387A1 (ja) * | 2020-03-04 | 2021-09-10 | 株式会社メトセラ | エリスロポエチン産生能が亢進された線維芽細胞 |
| CA3211113A1 (en) | 2021-03-04 | 2022-09-09 | Metcela Inc. | Lymphangiogenesis promoting factor-expressing fibroblast, and pharmaceutical composition containing same |
| US20240316113A1 (en) | 2021-09-08 | 2024-09-26 | Metcela Inc. | Fibroblast-containing pharmaceutical composition for treating kidney disease |
| CN119685401A (zh) * | 2024-06-03 | 2025-03-25 | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 一种改造成纤维细胞的方法及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1886150B (zh) * | 2003-10-27 | 2010-05-26 | 学校法人庆应义塾 | 含有g-csf的成纤维细胞动员剂及创伤治疗剂 |
| US9987310B2 (en) * | 2013-11-27 | 2018-06-05 | University Of Louisville Research Foundation, Inc. | Cardiac progenitor cells and methods of use therefor |
| CN106661552B (zh) * | 2014-07-11 | 2020-07-07 | 玛土撤拉有限公司 | 心脏细胞培养材料 |
| CN107881145A (zh) * | 2016-09-26 | 2018-04-06 | 新乡医学院 | 一种分选大鼠心成纤维细胞cd90+亚群的方法及其应用 |
| KR102407387B1 (ko) * | 2017-02-24 | 2022-06-10 | 가부시키가이샤 메토세라 | 섬유아세포를 포함하고, 심장 질환들의 치료를 위하여 사용될 수 있는 주사용 조성물, 및 치료 용도를 위하여 섬유아세포를 생산하는 방법 |
| EP3845635A4 (en) * | 2018-08-29 | 2022-06-15 | Metcela Inc. | PROCEDURE FOR PREPARING FIBROBLAST AND G-CSF-POSITIVE FIBROBLAST MASS |
-
2019
- 2019-08-29 EP EP19856084.9A patent/EP3845635A4/en active Pending
- 2019-08-29 CN CN201980056534.7A patent/CN112639082A/zh active Pending
- 2019-08-29 AU AU2019332400A patent/AU2019332400B2/en active Active
- 2019-08-29 CA CA3110831A patent/CA3110831A1/en active Pending
- 2019-08-29 JP JP2020539572A patent/JP6883904B2/ja active Active
- 2019-08-29 IL IL281081A patent/IL281081B/en unknown
- 2019-08-29 WO PCT/JP2019/033835 patent/WO2020045547A1/ja not_active Ceased
- 2019-08-29 SG SG11202102028SA patent/SG11202102028SA/en unknown
- 2019-08-29 KR KR1020217009135A patent/KR102883773B1/ko active Active
-
2021
- 2021-02-26 US US17/187,459 patent/US20210254009A1/en active Pending
- 2021-04-28 JP JP2021076105A patent/JP7428389B2/ja active Active
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