JP2021088550A - Liquid oral composition and intraoral bubble-discharging pump product - Google Patents

Abstract

To provide a liquid oral composition that can break bubbles in an oral cavity and quickly diffuse over the entire oral cavity without saliva or physical stimulus.SOLUTION: A liquid oral composition contains a surfactant, a thickener and water and is charged into a bubble discharging container. The discharged foam of the liquid oral composition has a diffusibility of 180% or more, and it is used in an oral cavity in a dry condition.SELECTED DRAWING: None

Description

The present invention relates to a liquid oral composition, and more particularly to a liquid oral composition for filling a foam discharge container. It also relates to an intraoral foam discharge pump product filled with the liquid oral composition.

Conventionally, as a toothpaste preparation containing an oral composition, dosage forms such as powder toothpaste, toothpaste, and liquid toothpaste have been mainly used.
In the case of toothpaste, the shape retention on the toothbrush is high, and it is excellent in that the preparation is carried into the oral cavity. On the other hand, when symptoms of dry mouth such as elderly people with low saliva secretion are observed, it takes time to spread the drug throughout the oral cavity, so the drug should be used within a short time of brushing the teeth. In some cases, it did not spread completely. Further, in the case of liquid toothpaste, the problems of toothpaste are solved, but when it is difficult to wash the mouth and spit out due to deterioration of oral function, there is a high risk of accidental ingestion and aspiration.

Therefore, in recent years, the development of oral compositions for formulations used in foam form has been widely studied. For example, in Patent Document 1, a liquid oral cavity containing a specific amount of anionic surfactant and amphoteric surfactant, a polysaccharide-based natural polymer or nonionic semisynthetic polymer having a specific viscosity, and water is contained in a foam discharge container. The composition for use is disclosed. Patent Document 2 discloses a foamy oral composition containing a surfactant and a binder in which a specific polymer compound is combined. Patent Document 3 discloses a foamy oral composition in which a foam discharge container is filled with 0.5 to 15% of a surfactant and an aldehyde compound having 7 or 8 carbon atoms.

Japanese Unexamined Patent Publication No. 2019-001741 Japanese Unexamined Patent Publication No. 9-295923 Japanese Unexamined Patent Publication No. 10-114637

All of the liquid oral compositions described in Patent Documents 1 and 2 are premised on the fact that the foam lasts even in the oral cavity and has a shape-retaining property, and that it can be foamed and brushed at the time of use. .. Further, the foamy oral composition described in Patent Document 3 improves flavoring, foaming stability over time, foam retention and foam texture.
As described above, in Patent Documents 1 to 3, various studies have been made on the foam quality of the oral composition, but no specific study has been made on the diffusibility in the oral cavity.

In a foamy liquid oral composition, the shape retention (foam quality) of the foam is one of the important factors, and if the foam breaks immediately, the liquid will drip when used on a toothbrush. It will occur. On the other hand, if the foamy state continues even in the oral cavity, there is a concern that the active ingredient has low diffusivity into the oral cavity. This is particularly noticeable for people with dry mouth, such as the elderly and those with dry mouth.

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a liquid oral composition that ruptures bubbles in the oral cavity and quickly diffuses throughout the oral cavity without saliva or physical irritation. ..

As a result of diligent research, the present inventor has found that the above problems can be solved by setting the diffusivity of the discharged foamy substance to a certain value or more, and has completed the present invention.
That is, the present invention is as follows.
(1) A liquid oral composition containing a surfactant, a thickener and water to be filled in a foam discharge container, in which the discharged foam has a diffusivity of 180% or more and is dried. A liquid oral composition characterized by being used in a state of the oral cavity.
(2) The liquid oral composition according to (1) above, wherein the discharged foamy substance has a liquefaction rate of 1 to 40%.
(3) A foam discharge type pump container including a nozzle body for discharging a foamy substance and a discharge flow path through which the mixed liquid and gas flow, and the nozzle body is a gas that mixes the liquid and the gas. A foam discharge pump container provided with a liquid mixing chamber and having a mesh structure for the discharge flow path was filled with a liquid oral composition containing a surfactant, a thickener and water as the liquid, and discharged. A foam discharge pump product for dry oral cavity, characterized in that the diffusivity of foam is 180% or more.

The liquid oral composition according to the present invention quickly ruptures bubbles even when used in a slightly dry oral cavity, and diffuses well into the oral cavity without saliva or physical irritation.
When brushing teeth, it is not necessary to add water such as moistening the toothbrush with water, so it is easy to use when others brush their teeth such as nursing care, and it is also a detergent, bactericide, anti-inflammatory agent. It is also possible to prevent various components such as inflammatory agents from being excessively diluted to diminish the effect.

[Liquid oral composition]
The liquid oral composition according to the present invention contains a surfactant, a thickener and water, and is intended to be filled in a foam discharge container, and the diffusivity of the discharged foam is 180% or more. It is characterized by being used in the oral cavity in a dry state.

Here, the dry oral cavity means the oral cavity of a person who secretes a small amount of saliva, such as an elderly person or a dry mouth person. Specifically, it is possible to determine whether or not the oral cavity is in a dry state by a gum test or a Saxon test.
In the gum test, chew gum and the amount of saliva that comes out is 10 mL or less in 10 minutes. In the Saxon test, chew gauze and the weight of saliva contained in the gauze is 2 g in 2 minutes. When the following, it can be determined that the oral cavity is in a dry state.

Further, the dry oral foam discharge pump product according to the present invention is obtained by filling the foam discharge pump container with the liquid oral composition, but the dry oral foam product is in the dry state. It is synonymous with being used in a certain oral cavity.

<Surfactant>
Surfactants are components mainly used as detergents and foaming agents. Specifically, one or more surfactants selected from the group consisting of nonionic surfactants, anionic surfactants, amphoteric surfactants, and cationic surfactants can be used. In the present specification, polyoxyethylene may be referred to as POE, and polyoxypropylene may be referred to as POP.

Examples of the nonionic surfactant include POE-hardened castor oil; POE alkyl ethers such as POE lauryl ether, POE cetyl ether and POE stearyl ether; POE fatty acid esters; POE sorbitan coconut oil fatty acid esters (also referred to as POE coconut oil fatty acid sorbitan). .) Etc. POE sorbitan fatty acid ester; POE higher alcohol ether; POE alkylphenyl ether; POE phytosterol; POE / POP alkyl ether such as POE / POP cetyl ether; POE / POP block polymer; POE / POP fatty acid ester; alkyl glycoside; Examples thereof include propylene glycol fatty acid esters; glycerin fatty acid esters such as polyglyceryl monolaurate; polyethylene glycol fatty acid esters such as polyethylene glycol monostearate; and sorbitan fatty acid esters. These can be used alone or in combination of two or more.
Among them, POE-hardened castor oil, POE alkyl ether, POE sorbitan fatty acid ester, and alkyl glycoside are preferable because the preparation is stable when used in combination with a cationic bactericide, and POE-hardened castor oil, POE lauryl ether, and POE coconut oil are preferable. Fatty acid sorbitan and alkyl glycoside are more preferable.

Examples of the anionic surfactant include POE alkyl ether phosphate such as POE lauryl ether phosphate and sodium POE lauryl ether phosphate or POE alkyl ether phosphate; POE alkyl ether sulfate; and POE sodium lauryl ether acetate. Alkyl ether carboxylate; N-acyl amino acid salts such as sodium lauroyl sarcosin and sodium myristyl sarcosin; N-acyl taurine salts such as sodium lauroyl methyl taurine; alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate; di sulfosuccinate (di (sulfosuccinate) 2-Ethylhexyl) Sulfates such as sodium; alkyl phosphates and the like can be mentioned. These can be used alone or in combination of two or more.
Among them, N-acylamino acid salt, alkyl sulfate and N-acyl taurine salt are preferable from the viewpoint of excellent foaming power, and sodium lauroyl sarcosine, sodium lauryl sulfate and sodium lauroyl methyl taurine are more preferable.

As the amphoteric surfactant, either a betaine type or a glycine type can be used. Of these, alkyl betaine type or glycine type is preferable, and for example, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, coconut oil fatty acid amide propyl betaine, lauryl diaminoethyl glycine sodium, lauryl dimethyl amino acetate betaine and the like are preferable. Can be mentioned. These can be used alone or in combination of two or more.

Examples of the cationic surfactant include cetylpyridinium chloride, benzalconium chloride, benzethonium chloride, alkyltrimethylammonium chloride, dialkyldimethylammonium chloride, POE alkylamine / fatty acid amide and the like. These can be used alone or in combination of two or more.

Surfactants are considered to be components that contribute to the liquefaction rate of liquid oral compositions. That is, it contributes to the shape retention when the liquid oral composition is discharged in the form of bubbles. By lowering the liquefaction rate, the shape-retaining property of the foamy substance is enhanced, and it is possible to suppress the liquid dripping when the foamy substance is discharged to the toothbrush.
From the above viewpoint, the surfactant preferably contains a nonionic surfactant, and specifically, at least one selected from the group consisting of POE-hardened castor oil, POE lauryl ether, POE coconut oil fatty acid sorbitan, and alkyl glycoside. It is more preferable to use seeds or more. The total content of the surfactant is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, preferably 10% by mass or less, more preferably 5% by mass or less, and 4% by mass. % Or less is more preferable.

<Thickener>
Thickeners are also considered to be components that contribute to the liquefaction rate of liquid oral compositions. Examples of the thickener include carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, xanthan gum, guar gum, carrageenan, gellan gum, pectin, locust bean gum, starch, dextrin and the like. It is preferable to use at least one selected from the above. Of these, hydroxyethyl cellulose and xanthan gum are more preferable, and hydroxyethyl cellulose is even more preferable.
The total content thereof is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, preferably 1% by mass or less, and more preferably 0.5% by mass or less.

<Other ingredients>
In addition to water as a solvent, the liquid oral composition according to the present invention may contain various other components as long as the effects of the present invention are not impaired.
For example, alcohols such as ethanol; wetting agents such as glycerin, propylene glycol, sorbitol, polyethylene glycol; sweeteners such as stebioside, xylitol, erythritol, sorbitol, sclorose, trehalose, sodium saccharin, stevia; azulene, azulene sulfonate, β- Anti-inflammatory agents such as glycyrrhetinic acid, glycyrrhizinic acid and salts, dihydrocholesterol, epidihydrocholesterin, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, ε-aminocaproic acid, tranexamic acid; lysoteam chloride, dextranase , Mutanase, protease and other enzymes; fluorine ion sources such as sodium fluoride, stannous fluoride, fluorophosphate and fluoroborate; phosphate ion sources such as calcium phosphate and hydroxyapatite; Toothstone preventives such as coalesced salt, zinc chloride, zinc organic acid; astringents such as hinokithiol, allantin, allantinchlorohydroxyaluminum, allantindihydroxyaluminum, sodium chloride; preservatives such as parahydroxybenzoic acid ester, sodium benzoate; ethylenediamine Hydroxyethyl triacetate, edetonic acid and its salts, gluconodeltalactone, gluconic acid, hydroxyethylethylenediamine triacetate, pyrophosphate, polyphosphate, metaphosphate, alanine, citric acid and its salts, or tartrate and Chelating agents such as salts; pH adjusters such as sodium monohydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate; peppermint oil, peppermint oil, menthol, carbachlor, eucalyptus oil, eugenol, anetol, cineole , Hinokithiol, Timor, Pinen, Peppermint Oil, Cinnamon Oil, Clove Oil, Eugenol, Lemon Oil, Vanillin, Cineol, Eucalyptus Oil, etc. Coloring agents such as No. 4, Yellow No. 202 (1), Red No. 102, Green No. 3, Green No. 201, and sodium copper chlorophyllin; bactericides such as isopropylmethylphenol and triclosan can be mentioned.

<Diffusiveness>
The diffusivity of the foamy substance discharged from the liquid oral composition according to the present invention is preferably 180% or more, more preferably 280% or more. The foamy substance in the present specification means a foamy substance discharged from the foam discharge type pump container.
The foam discharge type pump container includes a nozzle body for discharging foam and a discharge flow path through which mixed liquids and gases flow. The nozzle body includes a gas-liquid mixing chamber that mixes a liquid and a gas, and the discharge flow path includes a network structure.

The diffusivity of the foam can also be adjusted by the foam discharge type pump container used, for example, by a mesh structure.
The mesh of the network structure is preferably 380 mesh or less, more preferably 300 mesh or less, from the viewpoint of obtaining high diffusivity of foamy substances. On the other hand, from the viewpoint of liquefaction rate, the mesh is preferably 70 mesh or more, and more preferably 100 mesh or more. The mesh is the number of warp threads or weft threads per inch (about 25.4 mm), and the number of warp threads and weft threads is the same.

The opening of the network structure is preferably 40 μm or more, more preferably 50 μm or more, from the viewpoint of obtaining high diffusivity of the foamy substance. On the other hand, from the viewpoint of the liquefaction rate of the foam, 200 μm or less is preferable, and 150 μm or less is more preferable. The opening means the distance between the warp threads or the weft threads.

Further, the foam discharge type pump container may have a plurality of mesh structures. For example, when a mesh structure is used at two places immediately before the foam is discharged, the upper part and the lower part, the liquid preparation is circulated through the mesh and the fine bubbles are discharged. Here, the upper mesh structure means a structure located on the foam discharge port side, and the lower mesh structure means a structure located on the container body side. Therefore, the liquid formulation passes through the lower network structure and the upper network structure in this order, and is discharged as bubbles from the discharge port. In the present specification, when foamy substances are discharged using a foam discharge type pump container having a mesh of the upper mesh structure of 250 mesh and a mesh of the lower mesh structure of 200 mesh, "mesh size # 250". Notated as "/ 200".
In addition, although the case where there are two mesh structures is described above, the mesh structure may be used in three or more places.

As described above, a foam discharge type pump container provided with a plurality of mesh structures may be used, and the same mesh and openings may be used in combination or different ones may be used in combination. By arranging the network structure with a desired gap, it is possible to adjust the diffusivity and liquefaction rate of the foamy substance composed of the liquid oral composition.

Due to the diffusivity of the foamy substance discharged from the liquid oral composition, the foam can be rapidly ruptured even in the dry oral cavity without saliva or physical irritation. The liquid oral composition diffuses throughout the oral cavity.
Further, when brushing teeth, it is not necessary to add water such as moistening the toothbrush with water. As a result, it is easy for those who need assistance or care such as infants and the elderly to brush their teeth by others, and it is possible to prevent aspiration and minimize rinsing. Therefore, it is preferable. Furthermore, it is possible to prevent various components such as detergents, bactericides, and anti-inflammatory agents from being diluted to dilute the effect.

On the other hand, if the diffusivity is high and the liquefaction rate is too high, the shape-retaining property of the discharged foam is low, and the foam discharged on the toothbrush may drip before being carried into the oral cavity. .. Therefore, although there is a preferable upper limit to the diffusivity of the discharged foam, the diffusivity value actually reaches a plateau. Therefore, as an index related to liquid dripping, the liquefaction rate described later can be used instead of the upper limit of the diffusibility.

As described above, the diffusibility can be adjusted by, for example, the type and content of the thickener. It can also be adjusted with an alcohol such as ethanol and a wetting agent such as polyethylene glycol.

Diffusibility can be confirmed from a test using a pig tongue by the following procedure.
First, the tongue of the pig (the muscle of the tongue is cut if necessary and processed so that the surface of the tongue is parallel to the test table) is lightly washed with running water, and then the water on the surface of the tongue is removed. The dry mouth state is reproduced by removing the water, but the amount of water on the surface of the pig tongue after the water is removed is 15 or more and less than 25 when measured with the oral moisture meter Mucus (manufactured by Life Co., Ltd., trade name). Remove water until.
A columnar cylinder is placed on the surface of the pig tongue, and the liquid oral composition is discharged into the foam. Since the contact area between the foam and the pig tongue is fixed by the columnar cylinder, this is defined as the initial foam property, and the contact area is defined as the initial contact area.
Next, the foamy substance is discharged, and after 2 minutes have passed since the cylinder was removed, the contact area between the foamy substance and the pig tongue is measured and used as the contact area after 2 minutes have passed. From the initial contact area and the contact area after 2 minutes, the diffusibility (%) is calculated by the following formula.
Diffusibility (%) = (contact area after 2 minutes / initial contact area) x 100

<Liquefaction rate>
The liquefaction rate of the foamy substance discharged from the liquid oral composition according to the present invention is preferably 1% or more, more preferably 2% or more. The liquefaction rate is preferably 40% or less, more preferably 20% or less, and further preferably 15% or less. When the liquefaction rate is 40% or less, the shape-retaining property of the foam outside the oral cavity is improved, and the occurrence of liquid dripping can be further suppressed before the discharged foamy substance is carried into the oral cavity. Further, by setting the liquefaction rate to 1% or more, bubbles can be ruptured in the oral cavity and the diffusibility can be improved.

As described above, the liquefaction rate can be adjusted, for example, by the type and content of the surfactant. It can also be adjusted with alcohols such as ethanol, wetting agents such as polyethylene glycol, salts and the like.

The liquefaction rate can be confirmed by the following procedure.
About 4 g of the liquid oral composition is discharged into a 50 mL conical liquid meter in the form of bubbles. The weight at this time is taken as the total discharge composition weight. Then, after allowing to stand for 30 seconds, the liquefied composition is collected with a Pasteur pipette, and the weight thereof is measured as the weight of the liquefied composition. The liquefaction rate (%) is calculated from the total weight of the discharged composition and the weight of the liquefied composition by the following formula.
Liquefaction rate (%) = (weight of liquefied composition / weight of total discharge composition) x 100

When the above liquid oral composition is used, it is filled in a foam discharge container as a liquid preparation for toothpaste, and the foam is discharged onto a toothbrush.
Since the liquid oral composition in the form of foam is excellent in diffusivity in the oral cavity, it is preferably used for elderly people, dry mouths, and other persons who have little saliva and have a dry oral cavity. Be done. However, it does not exclude the use for those who have a sufficient amount of saliva.

Further, when brushing teeth, it is not necessary to add water such as moistening the toothbrush with water, so that aspiration can be prevented and the minimum rinsing can be performed. Therefore, it is also effective for those who need assistance or long-term care, such as infants and the elderly, to have others brush their teeth.
Further, since it is not necessary to add water at the time of use, it is possible to prevent various components such as a cleaning agent, a bactericide, and an anti-inflammatory agent contained in the liquid oral composition from being diluted to dilute the effect.

[Foam discharge pump product for oral cavity]
The present invention also relates to an intraoral foam discharge pump product filled with the above liquid oral composition, preferably a dry oral foam discharge pump product. Specifically, the foam discharge type pump container is filled with a liquid oral composition containing a surfactant, a thickener and water, and the discharged foam has a diffusivity of 180% or more. And.
The foam discharge type pump container includes a nozzle body that discharges a foamy substance, and a discharge flow path through which a mixed liquid oral composition and a gas flow. The nozzle body includes a gas-liquid mixing chamber that mixes a liquid oral composition and a gas, and the discharge flow path includes a network structure.
One aspect of the foam discharge type pump container is shown below, but the configuration is not limited to this, and a conventionally known foam discharge type pump container can be used.

The foam discharge type pump container is a nozzle body that is detachably attached to a container body having an upper opening and an opening of the container body, and discharges a liquid oral composition filled in the container body as a foam. Consists of.

In the nozzle body, the air delivered from the air cylinder and the liquid oral composition delivered from the liquid cylinder are merged and mixed in the gas-liquid mixing chamber. After that, the mixed liquid and gas flow through the discharge flow path in the nozzle head, and a network structure is provided in the discharge flow path.

The meshes and openings of the network structure are as described above, but the network structure may be provided in the flow path where the liquid oral composition and air are mixed and circulated, and the place and number of the network structures may be arranged. It is optional.

Hereinafter, the present invention will be further described with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

<Examples 1 to 9 and Comparative Example 1>
Various components were mixed according to the formulation shown in Table 1 to prepare liquid oral compositions according to Examples 1 to 9 and Comparative Example 1, respectively. In addition, the numerical value which shows the compounding prescription in Table 1 is a mass part display.
Specifically, first, the components other than the aqueous hydroxyethyl cellulose solution, concentrated glycerin, and purified water were mixed in a state of being heated to 50 ° C. Then, after returning to room temperature, a liquid oral composition was obtained by appropriately adding a fragrance and mixing the aqueous hydroxyethyl cellulose solution, concentrated glycerin, and purified water.

<Diffusiveness>
The diffusivity of the liquid oral composition was evaluated by the following procedure.
After lightly washing the pig tongue (the tongue muscle is cut if necessary and processed so that the surface of the pig tongue is parallel to the test table) with running water, the water on the surface of the pig tongue is removed from Kim Towel (manufactured by Nippon Paper Crecia Co., Ltd.). Removed with (trade name). The dry mouth state is reproduced by removing such water, but the amount of water on the surface of the pig tongue after removing the water is 15 or more and less than 20 when measured with an oral moisture meter Mucus (manufactured by Life Co., Ltd., trade name). From this, it was confirmed that the water could be sufficiently removed.
A columnar cylinder was placed on the surface of the pig tongue, and the liquid oral composition was discharged into the liquid oral composition by 2 pushes (about 0.8 g) in the form of bubbles using mesh size # 255/200. The contact area between the foam and the pig tongue ^{was fixed at 4.86 cm 2} by the columnar cylinder, which was defined as the initial foam property, and the initial contact area was 4.86 cm ² .
Next, after 2 minutes have passed since the foamy substance was discharged and the cylinder was removed, the contact area between the foamy substance and the pig tongue (contact area after 2 minutes passed) was determined using Image J, which is image processing software. It was measured from the captured image. Then, the diffusivity (%) was calculated from the initial contact area and the contact area after 2 minutes by the following formula.
Diffusibility (%) = (contact area after 2 minutes) / initial contact area) x 100
The results are summarized in Table 1, and the criteria are as follows. If ○ or Δ, the result is acceptable.
◯: Diffusibility is 280% or more, which is very good.
Δ: The diffusibility is 180% or more and less than 280%, which is good.
X: Diffusibility is less than 180%, which is insufficient.

<Liquefaction rate>
The liquefaction rate of the liquid oral composition was evaluated by the following procedure.
The liquid oral composition was dispensed into a 50 mL conical liquid meter using 10 pushes (about 4 g) in the form of bubbles using mesh size # 255/200. The weight at this time is taken as the total discharge composition weight. Then, after allowing to stand for 30 seconds, the liquefied composition was collected with a Pasteur pipette, and the weight thereof was measured as the weight of the liquefied composition. The liquefaction rate (%) was calculated from the total weight of the discharged composition and the weight of the liquefied composition by the following formula.
Liquefaction rate (%) = (weight of liquefied composition / weight of total discharge composition) x 100
The results are summarized in Table 1, and the criteria are as follows, preferably ◯ or Δ.
◯: The liquefaction rate is 20% or less, and the shape retention of the foam is good.
Δ: The liquefaction rate is more than 20% and 40% or less, and the shape retention of the foamy substance reaches the usage level.
X: The liquefaction rate is more than 40%, and the shape retention of the foam does not reach the usage level.

Based on the above, by setting the diffusivity of the liquid oral composition to 180% or more, even when the oral cavity is in a dry state, after introducing the liquid oral composition as a foam, the moisture content is reduced. It was shown that the components can be quickly diffused throughout the oral cavity without addition, saliva, physical irritation, etc. Moreover, it was shown that the above effect can be obtained regardless of the type of surfactant.

Claims (3)

A liquid oral composition that contains a surfactant, a thickener and water and is to be filled in a foam discharge container.
The diffusivity of the discharged foam is 180% or more,
A liquid oral composition characterized by being used in a dry oral cavity. The liquid oral composition according to claim 1, wherein the discharged foamy substance has a liquefaction rate of 1 to 40%. A foam discharge type pump container including a nozzle body for discharging foam and a discharge flow path through which mixed liquid and gas flow, and a gas-liquid mixing chamber in which the nozzle body mixes liquid and gas. In a foam discharge type pump container in which the discharge flow path is provided with a mesh structure.
As the liquid, a liquid oral composition containing a surfactant, a thickener and water is filled.
A foam discharge pump product for dry oral cavity, characterized in that the diffusivity of the discharged foam is 180% or more.