JP2021075579A5 - - Google Patents
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- JP2021075579A5 JP2021075579A5 JP2021025180A JP2021025180A JP2021075579A5 JP 2021075579 A5 JP2021075579 A5 JP 2021075579A5 JP 2021025180 A JP2021025180 A JP 2021025180A JP 2021025180 A JP2021025180 A JP 2021025180A JP 2021075579 A5 JP2021075579 A5 JP 2021075579A5
- Authority
- JP
- Japan
- Prior art keywords
- nanoparticle
- composition according
- lyophilized
- complex
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002105 nanoparticle Substances 0.000 claims 30
- 239000000203 mixture Substances 0.000 claims 26
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 102000009027 Albumins Human genes 0.000 claims 6
- 108010088751 Albumins Proteins 0.000 claims 6
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 238000001727 in vivo Methods 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066452A JP2022087255A (ja) | 2015-08-18 | 2022-04-13 | キャリア結合剤組成物およびそれを作製および使用する方法 |
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562206771P | 2015-08-18 | 2015-08-18 | |
| US201562206770P | 2015-08-18 | 2015-08-18 | |
| US201562206772P | 2015-08-18 | 2015-08-18 | |
| US62/206,772 | 2015-08-18 | ||
| US62/206,770 | 2015-08-18 | ||
| US62/206,771 | 2015-08-18 | ||
| USPCT/US2015/054295 | 2015-10-06 | ||
| PCT/US2015/054295 WO2016057554A1 (en) | 2014-10-06 | 2015-10-06 | Carrier-antibody compositions and methods of making and using the same |
| PCT/US2016/026270 WO2017176265A1 (en) | 2016-04-06 | 2016-04-06 | Carrier-binding agent compositions and methods of making and using the same |
| USPCT/US2016/026270 | 2016-04-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506415A Division JP6921802B2 (ja) | 2015-08-18 | 2016-08-18 | キャリア結合剤組成物およびそれを作製および使用する方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066452A Division JP2022087255A (ja) | 2015-08-18 | 2022-04-13 | キャリア結合剤組成物およびそれを作製および使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021075579A JP2021075579A (ja) | 2021-05-20 |
| JP2021075579A5 true JP2021075579A5 (https=) | 2022-01-04 |
| JP7133050B2 JP7133050B2 (ja) | 2022-09-07 |
Family
ID=58051595
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506415A Active JP6921802B2 (ja) | 2015-08-18 | 2016-08-18 | キャリア結合剤組成物およびそれを作製および使用する方法 |
| JP2021025180A Active JP7133050B2 (ja) | 2015-08-18 | 2021-02-19 | キャリア結合剤組成物およびそれを作製および使用する方法 |
| JP2022066452A Withdrawn JP2022087255A (ja) | 2015-08-18 | 2022-04-13 | キャリア結合剤組成物およびそれを作製および使用する方法 |
| JP2022140647A Withdrawn JP2022164916A (ja) | 2015-08-18 | 2022-09-05 | キャリア結合剤組成物およびそれを作製および使用する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506415A Active JP6921802B2 (ja) | 2015-08-18 | 2016-08-18 | キャリア結合剤組成物およびそれを作製および使用する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066452A Withdrawn JP2022087255A (ja) | 2015-08-18 | 2022-04-13 | キャリア結合剤組成物およびそれを作製および使用する方法 |
| JP2022140647A Withdrawn JP2022164916A (ja) | 2015-08-18 | 2022-09-05 | キャリア結合剤組成物およびそれを作製および使用する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250170067A1 (https=) |
| EP (1) | EP3337823A4 (https=) |
| JP (4) | JP6921802B2 (https=) |
| CN (2) | CN114796130B (https=) |
| AU (1) | AU2016308337B2 (https=) |
| CA (1) | CA2995384A1 (https=) |
| IL (1) | IL256621A (https=) |
| WO (1) | WO2017031368A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012253571A1 (en) | 2011-05-09 | 2014-01-09 | Mayo Foundation For Medical Education And Research | Cancer treatments |
| US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
| EP3154586B1 (en) | 2014-06-13 | 2020-05-27 | Mayo Foundation for Medical Education and Research | Treating lymphomas |
| KR20170020371A (ko) | 2014-06-16 | 2017-02-22 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | 골수종의 치료 |
| US9446148B2 (en) | 2014-10-06 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Carrier-antibody compositions and methods of making and using the same |
| JP6921802B2 (ja) * | 2015-08-18 | 2021-08-18 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ | キャリア結合剤組成物およびそれを作製および使用する方法 |
| TW201707725A (zh) | 2015-08-18 | 2017-03-01 | 美國馬友醫藥教育研究基金會 | 載體－抗體組合物及其製造及使用方法 |
| TW201713360A (en) | 2015-10-06 | 2017-04-16 | Mayo Foundation | Methods of treating cancer using compositions of antibodies and carrier proteins |
| WO2017120501A1 (en) | 2016-01-07 | 2017-07-13 | Mayo Foundation For Medical Education And Research | Methods of treating cancer with interferon |
| WO2017139698A1 (en) | 2016-02-12 | 2017-08-17 | Mayo Foundation For Medical Education And Research | Hematologic cancer treatments |
| EP3432926A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | METHOD FOR REDUCING THE TOXICITY OF CHEMOTHERAPEUTICS |
| EP3432928A4 (en) | 2016-03-21 | 2019-11-20 | Mayo Foundation for Medical Education and Research | PROCESS FOR IMPROVING THE THERAPEUTIC INDEX FOR CHEMOTHERAPEUTIC |
| US10618969B2 (en) | 2016-04-06 | 2020-04-14 | Mayo Foundation For Medical Education And Research | Carrier-binding agent compositions and methods of making and using the same |
| JP2019526579A (ja) | 2016-09-01 | 2019-09-19 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ | Ｔ細胞癌を標的とする為の方法及び組成物 |
| WO2018045239A1 (en) | 2016-09-01 | 2018-03-08 | Mayo Foundation For Medical Education And Research | Carrier-pd-l1 binding agent compositions for treating cancers |
| EP3509635A1 (en) | 2016-09-06 | 2019-07-17 | Vavotar Life Sciences LLC | Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins |
| RU2021128415A (ru) | 2016-09-06 | 2021-11-08 | Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч | Композиции с паклитакселом, альбумином и связывающим средством и способы их применения и получения |
| KR20230011473A (ko) | 2016-09-06 | 2023-01-20 | 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 | Ｐｄ－ｌ１ 발현 암의 치료 방법 |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| MX2022011248A (es) * | 2020-03-11 | 2022-12-15 | Selecta Biosciences Inc | Metodos y composiciones relacionados con nanoportadores sinteticos. |
| EP4208204A1 (en) | 2020-09-02 | 2023-07-12 | Mayo Foundation for Medical Education and Research | Antibody-nanoparticle complexes and methods for making and using the same |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60146833A (ja) * | 1984-01-10 | 1985-08-02 | Green Cross Corp:The | モノクロ−ナル抗体製剤 |
| JPS6178731A (ja) * | 1985-05-20 | 1986-04-22 | Green Cross Corp:The | 加熱処理免疫グロブリン製剤 |
| WO1990011091A1 (en) * | 1989-03-27 | 1990-10-04 | Centocor, Inc. | FORMULATIONS FOR STABILIZING OF IgM ANTIBODIES |
| US20070166388A1 (en) * | 2005-02-18 | 2007-07-19 | Desai Neil P | Combinations and modes of administration of therapeutic agents and combination therapy |
| US20100112077A1 (en) * | 2006-11-06 | 2010-05-06 | Abraxis Bioscience, Llc | Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer |
| EP2131821B1 (en) * | 2007-03-07 | 2018-05-09 | Abraxis BioScience, LLC | Nanoparticle comprising rapamycin and albumin as anticancer agent |
| MX2010011145A (es) * | 2008-04-11 | 2011-04-11 | Merrimack Pharmaceuticals Inc | Enlazadores de la albumina de suero humana y conjugados de la misma. |
| US10413606B2 (en) * | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
| KR102148551B1 (ko) * | 2013-02-11 | 2020-08-26 | 아브락시스 바이오사이언스, 엘엘씨 | 흑색종을 치료하는 방법 |
| CR20170031A (es) * | 2014-10-06 | 2017-05-22 | Mayo Found For Medical Educaction And Res | Composiciones de portador-anticuerpo y métodos para realizarlas y utilizarlas |
| JP6921802B2 (ja) | 2015-08-18 | 2021-08-18 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ | キャリア結合剤組成物およびそれを作製および使用する方法 |
-
2016
- 2016-08-18 JP JP2018506415A patent/JP6921802B2/ja active Active
- 2016-08-18 EP EP16837869.3A patent/EP3337823A4/en active Pending
- 2016-08-18 CA CA2995384A patent/CA2995384A1/en active Pending
- 2016-08-18 AU AU2016308337A patent/AU2016308337B2/en not_active Ceased
- 2016-08-18 CN CN202210483706.2A patent/CN114796130B/zh active Active
- 2016-08-18 WO PCT/US2016/047641 patent/WO2017031368A1/en not_active Ceased
- 2016-08-18 CN CN201680047942.2A patent/CN108290944B/zh active Active
-
2017
- 2017-12-27 IL IL256621A patent/IL256621A/en unknown
-
2021
- 2021-02-19 JP JP2021025180A patent/JP7133050B2/ja active Active
-
2022
- 2022-04-13 JP JP2022066452A patent/JP2022087255A/ja not_active Withdrawn
- 2022-09-05 JP JP2022140647A patent/JP2022164916A/ja not_active Withdrawn
-
2024
- 2024-07-26 US US18/785,952 patent/US20250170067A1/en active Pending
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