JP2021072930A - 拡散スペックルコントラスト解析を用いた深部組織流量測定 - Google Patents
拡散スペックルコントラスト解析を用いた深部組織流量測定 Download PDFInfo
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- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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Abstract
Description
Claims (23)
- 患者において血流量を決定するための方法であって、
前記患者の組織の第1の位置にコヒーレント光を向ける工程;
前記患者の組織の第2の位置を画像化する工程であって、前記コヒーレント光の一部が、前記患者の組織の下の血流によって散乱され、その結果、その散乱光が前記第2の位置で少なくとも部分的に検出可能である、工程;および
前記第2の位置の画像に基づいて血流量を計算する工程
を含む、方法。 - 前記計算が、スペックルコントラストを計算することを含む、請求項1に記載の方法。
- 前記スペックルコントラストの計算が、強度の標準偏差を前記第2の位置の画像の平均強度で割ることを含む、請求項2に記載の方法。
- 前記血流が、前記患者の皮膚の表面から少なくとも5mm下にある、請求項1に記載の方法。
- 前記第1の位置および前記第2の位置が、患者の体肢上にある、請求項1に記載の方法
。 - 前記第1の位置および前記第2の位置が、患者の足上にある、請求項1に記載の方法。
- 前記第2の位置の画像化が、CCDカメラで画像を撮影することを含む、請求項1に記載の方法。
- 前記コヒーレント光が、レーザーからの光を含んでなる、請求項1に記載の方法。
- 前記第1の位置および前記第2の位置が、少なくとも10mm離れている、請求項1に記載の方法。
- オペレーターに前記血流量を信号通信することをさらに含む、請求項1に記載の方法。
- 患者において血流量を決定するための方法であって、
前記患者の皮膚の第1の位置にコヒーレント光を向ける工程;
前記患者の皮膚の第2の位置での光強度の時系列測定値を得る工程であって、前記コヒーレント光の一部が、前記患者の皮膚の下の血流によって散乱され、その結果、その散乱光が前記第2の位置で少なくとも部分的に検出可能である、工程;および
前記時系列測定値に基づいて血流量を計算する工程
を含む、方法。 - 前記計算が、時間的スペックルコントラストを計算することを含む、請求項11に記載の方法。
- 前記時間的スペックルコントラストの計算が、強度の時間標準偏差を前記第2の位置での時間平均強度で割ることを含む、請求項12に記載の方法。
- 前記血流が、前記患者の皮膚の表面から少なくとも5mm下にある、請求項11に記載の方法。
- 前記第1の位置および前記第2の位置が、患者の足上にある、請求項11に記載の方法。
- 前記第1の位置および前記第2の位置が、少なくとも10mm離れている、請求項11に記載の方法。
- オペレーターに前記血流量を信号通信することをさらに含む、請求項11に記載の方法。
- 前記信号通信が、血流の聴覚的、視覚的、または触覚的特徴を提供することを含む、請求項11に記載の方法。
- 組織における血流の評価のためのシステムであって、
前記組織に光を照射するように構成されたコヒーレント光源と;
前記組織を通って透過した少なくともある量の光を含む光情報を捕捉するように構成されたマルチピクセルイメージセンサーであって、前記光が、前記血流によって、少なくとも部分的に、散乱される、マルチピクセルイメージセンサーと;
前記光情報を解析して、前記組織における血流量を決定するように構成されたアナライザーと;
前記アナライザーによって決定された血流量を示す信号を提供するように構成されたフィードバックデバイスと
を含んでなる、システム。 - 前記マルチピクセルイメージセンサーが、CCDカメラを含んでなる、請求項19に記載のシステム。
- 前記アナライザーが、強度の空間標準偏差を強度の空間平均値で割ることによって空間的スペックルコントラストを計算するように構成された、請求項19に記載のシステム。
- 実質的にリアルタイムで前記血流量を示す信号を提供するように構成された、請求項19に記載のシステム。
- 前記アナライザーが、強度の時間標準偏差を強度の時間平均値で割ることによって時間的スペックルコントラストを計算するように構成された、請求項19に記載のシステム。
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EP (2) | EP3957238A1 (ja) |
JP (4) | JP2016509509A (ja) |
KR (2) | KR20150135241A (ja) |
CN (1) | CN105188523B (ja) |
AU (3) | AU2014209741B2 (ja) |
BR (1) | BR112015017456A2 (ja) |
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CN105188523A (zh) | 2015-12-23 |
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CN105188523B (zh) | 2022-01-25 |
MX369421B (es) | 2019-10-28 |
EP3957238A1 (en) | 2022-02-23 |
JP2019217352A (ja) | 2019-12-26 |
SG11201505620YA (en) | 2015-08-28 |
AU2018260946A1 (en) | 2018-11-29 |
RU2015133309A (ru) | 2017-03-03 |
HK1218849A1 (zh) | 2017-03-17 |
JP2016509509A (ja) | 2016-03-31 |
EP2948052A1 (en) | 2015-12-02 |
ES2891558T3 (es) | 2022-01-28 |
JP2023082712A (ja) | 2023-06-14 |
US11206990B2 (en) | 2021-12-28 |
PT2948052T (pt) | 2021-09-29 |
WO2014116483A1 (en) | 2014-07-31 |
BR112015017456A2 (pt) | 2017-07-11 |
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