JP2021063068A - Cosmetic oil solution, and cosmetics or skin topical agents comprising the same - Google Patents
Cosmetic oil solution, and cosmetics or skin topical agents comprising the same Download PDFInfo
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- JP2021063068A JP2021063068A JP2020170590A JP2020170590A JP2021063068A JP 2021063068 A JP2021063068 A JP 2021063068A JP 2020170590 A JP2020170590 A JP 2020170590A JP 2020170590 A JP2020170590 A JP 2020170590A JP 2021063068 A JP2021063068 A JP 2021063068A
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- JP
- Japan
- Prior art keywords
- acid
- oil
- examples
- skin
- cosmetics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 29
- 239000003860 topical agent Substances 0.000 title 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 claims abstract description 63
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000004973 liquid crystal related substance Substances 0.000 claims abstract description 9
- 239000002253 acid Substances 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 11
- 229920000223 polyglycerol Polymers 0.000 abstract 2
- -1 setanol Chemical class 0.000 description 62
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 39
- 235000014113 dietary fatty acids Nutrition 0.000 description 34
- 229930195729 fatty acid Natural products 0.000 description 34
- 239000000194 fatty acid Substances 0.000 description 34
- 239000003921 oil Substances 0.000 description 24
- 235000019198 oils Nutrition 0.000 description 23
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 22
- 238000006243 chemical reaction Methods 0.000 description 22
- 239000006071 cream Substances 0.000 description 22
- 230000015572 biosynthetic process Effects 0.000 description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 17
- 235000019388 lanolin Nutrition 0.000 description 17
- 238000003786 synthesis reaction Methods 0.000 description 17
- 239000004166 Lanolin Substances 0.000 description 16
- 238000005886 esterification reaction Methods 0.000 description 16
- 229940039717 lanolin Drugs 0.000 description 16
- 235000002639 sodium chloride Nutrition 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- 230000032050 esterification Effects 0.000 description 15
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- 239000000843 powder Substances 0.000 description 14
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- 229910052757 nitrogen Inorganic materials 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 108090000765 processed proteins & peptides Proteins 0.000 description 10
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 229920001577 copolymer Polymers 0.000 description 9
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 238000009472 formulation Methods 0.000 description 7
- 210000004209 hair Anatomy 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 239000001993 wax Substances 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 6
- 239000002453 shampoo Substances 0.000 description 6
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- 238000011282 treatment Methods 0.000 description 6
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 5
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 5
- 235000011054 acetic acid Nutrition 0.000 description 5
- 150000001298 alcohols Chemical class 0.000 description 5
- 235000010323 ascorbic acid Nutrition 0.000 description 5
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- 239000011668 ascorbic acid Substances 0.000 description 5
- 235000015165 citric acid Nutrition 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
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- 235000014655 lactic acid Nutrition 0.000 description 5
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- 239000010466 nut oil Substances 0.000 description 5
- 239000000049 pigment Substances 0.000 description 5
- 238000006116 polymerization reaction Methods 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
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- 229920002125 Sokalan® Polymers 0.000 description 4
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- KVYGGMBOZFWZBQ-UHFFFAOYSA-N benzyl nicotinate Chemical compound C=1C=CN=CC=1C(=O)OCC1=CC=CC=C1 KVYGGMBOZFWZBQ-UHFFFAOYSA-N 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 229920000591 gum Polymers 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- 239000010445 mica Substances 0.000 description 4
- 229910052618 mica group Inorganic materials 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 3
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- 229920001353 Dextrin Polymers 0.000 description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
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- 235000019482 Palm oil Nutrition 0.000 description 3
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- 150000005215 alkyl ethers Chemical class 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
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Images
Abstract
Description
本発明は、化粧料用油剤、及びそれを含有する化粧料又は皮膚外用剤に関する。 The present invention relates to a cosmetic oil and a cosmetic or a skin external preparation containing the same.
従来、スキンケア用の美容液、クリーム、ローション等では肌への密着性や保湿性、口紅、リップクリーム、リップグロス、リップスティック等では唇への密着性や再付着防止効果、マスカラ、アイシャドー等では落ちにくさなど、剤型や用途に応じて様々な性能が求められている。 Conventionally, beauty essences, creams, lotions, etc. for skin care have adhesiveness and moisturizing properties to the skin, and lipsticks, lip balms, lip glosses, lipsticks, etc. have adhesiveness to the lips and anti-reattachment effect, mascara, eye shadow, etc. Then, various performances such as difficulty in falling off are required depending on the formulation and application.
特許文献1には、(スチレン−イソプレン)ジブロック共重合体を用いることで、糸曳きを生じず、滑らかな感触を持続できる油性口唇化粧料が提案されている。しかし、この化粧料は、高分子由来のつっぱり感が肌上に残ってしまうという問題点があり、密着性も十分満足できるものではなかった。 Patent Document 1 proposes an oil-based lip cosmetic that can maintain a smooth feel without causing stringing by using a (styrene-isoprene) diblock copolymer. However, this cosmetic has a problem that a feeling of tension derived from a polymer remains on the skin, and the adhesion is not sufficiently satisfactory.
特許文献2には、多価アルコール変性シリコーン、エステル油、着色剤、油剤、トリグリセリルを含有する油性化粧料が提案されている。この化粧料は塗布膜のつっぱり感がなく、色持ちの良さや色移りしにくい効果があるものの、肌や唇への密着性については未だ課題が残されていた。 Patent Document 2 proposes an oil-based cosmetic containing a polyhydric alcohol-modified silicone, an ester oil, a colorant, an oil agent, and triglyceryl. Although this cosmetic has the effect of not having a taut feeling of the coating film and having good color retention and resistance to color transfer, there are still problems with adhesion to the skin and lips.
本発明が解決しようとする課題は、肌や唇などの皮膚への密着性に優れる化粧料用油剤を提供することである。 An object to be solved by the present invention is to provide a cosmetic oil agent having excellent adhesion to skin such as skin and lips.
本発明者らは、上記問題を解決するため鋭意検討した結果、イソステアリン酸ポリグリセリル95質量%に水を5質量%添加し混合した際に異方性液晶構造をとるゲルを形成し、30℃におけるゲルの粘度が50000〜300000mPa・sであることを特徴とするイソステアリン酸ポリグリセリルが、上記課題を解決し得ることを見出し、本発明を完成するに至った。 As a result of diligent studies to solve the above problems, the present inventors formed a gel having an anisotropic liquid crystal structure when 5% by mass of water was added to 95% by mass of polyglyceryl isostearate and mixed, and at 30 ° C. It has been found that polyglyceryl isostearate, which is characterized by having a gel having a viscosity of 50,000 to 300,000 mPa · s, can solve the above-mentioned problems, and has completed the present invention.
本発明のイソステアリン酸ポリグリセリル、及びそれを含有する化粧料や皮膚外用剤は、皮膚への密着性に優れる。 The polyglyceryl isostearate of the present invention, and cosmetics and external preparations containing the same, have excellent adhesion to the skin.
以下に本発明を詳細に説明する。本発明の範囲はこの実施形態に限定されるものではなく、本発明の趣旨を損なわない範囲で変更等が加えられた形態も本発明に属する。なお、範囲を表す「〜」は上限と下限を含むものである。 The present invention will be described in detail below. The scope of the present invention is not limited to this embodiment, and embodiments modified to the extent that the gist of the present invention is not impaired also belong to the present invention. In addition, "~" indicating a range includes an upper limit and a lower limit.
本発明で使用するイソステアリン酸ポリグリセリルを構成するポリグリセリンは、グリセリンを脱水縮合されたものであり、その平均重合度は3〜20が好ましく、4〜20がより好ましく、8〜20が最も好ましい。ポリグリセリンの平均重合度が3〜20の範囲であれば、ハンドリング性が良好であり、かつ、化粧料や皮膚外用剤に用いた場合に皮膚への密着性に優れ、再付着防止効果も得られる。 The polyglycerin constituting the polyglyceryl isostearate used in the present invention is obtained by dehydrating and condensing glycerin, and the average degree of polymerization thereof is preferably 3 to 20, more preferably 4 to 20, and most preferably 8 to 20. When the average degree of polymerization of polyglycerin is in the range of 3 to 20, the handleability is good, and when used in cosmetics and external preparations for skin, the adhesion to the skin is excellent, and the effect of preventing reattachment is also obtained. Be done.
ここで言うポリグリセリンの平均重合度(n)は、水酸基価から算出される値であり、下記式1及び下記式2から算出される。
(式1)分子量=74n+18
(式2)水酸基価=56110(n+2)/分子量
水酸基価とは、エステル化物中に含まれる水酸基数の大小の指数となる数値であり、1gのエステル化物に含まれる遊離のヒドロキシル基をアセチル化する為に必要な酢酸を中和するのに要する水酸化カリウムのミリグラム数を指し、社団法人日本油化学会編纂「日本油化学会制定、基準油脂分析試験法2013年度版」に準じて算出される。
The average degree of polymerization (n) of polyglycerin referred to here is a value calculated from the hydroxyl value, and is calculated from the following formula 1 and the following formula 2.
(Equation 1) Molecular weight = 74n + 18
(Equation 2) Hydroxyl value = 56110 (n + 2) / molecular weight The hydroxyl value is a numerical value that is an index of the number of hydroxyl groups contained in the esterified product, and acetylates the free hydroxyl group contained in 1 g of the esterified product. It refers to the number of milligrams of potassium hydroxide required to neutralize the acetic acid required for this purpose, and is calculated according to the "Standard Oil and Fat Analysis Test Method 2013 Edition established by the Japan Oil Chemists'Association" compiled by the Japan Oil Chemists' Society. To.
本発明で使用するポリグリセリンの水酸基価は、皮膚への密着性に優れる点で820〜880であることが好ましい。 The hydroxyl value of the polyglycerin used in the present invention is preferably 820 to 880 in terms of excellent adhesion to the skin.
本発明で使用するポリグリセリンは、重合度2以下のグリセリン重合物の含有量は、20%以下がよく、好ましくは15%以下がよく、更に好ましくは1%以下がよい。重合度2以下のグリセリン重合物の含有量が20%以下であれば、化粧料や皮膚外用剤に用いた際にべたつきがなく、優れた再付着防止効果が得られる。 The content of the glycerin polymer having a degree of polymerization of 2 or less is preferably 20% or less, preferably 15% or less, and more preferably 1% or less of the polyglycerin used in the present invention. When the content of the glycerin polymer having a degree of polymerization of 2 or less is 20% or less, there is no stickiness when used in cosmetics and external preparations for skin, and an excellent anti-reattachment effect can be obtained.
本発明で使用するイソステアリン酸ポリグリセリルのエステル化率は、優れた皮膚への密着性が得られる点で8〜23%が好ましい。 The esterification rate of polyglyceryl isostearate used in the present invention is preferably 8 to 23% in that excellent adhesion to the skin can be obtained.
ここで言うイソステアリン酸ポリグリセリルのエステル化率は、下記式3から算出される。
(式3)エステル化率={イソステアリン酸の付加モル数/(n+2)}×100
The esterification rate of polyglyceryl isostearate referred to here is calculated from the following formula 3.
(Equation 3) Esterification rate = {number of moles of isostearic acid added / (n + 2)} x 100
本発明のイソステアリン酸ポリグリセリルは、常法に従ってエステル化反応を行う方法で製造することができる。触媒としてパラトルエンスルホン酸、硫酸、塩酸、メタンスルホン酸、三フッ化硼素ジエチルエーテル錯体、水酸化ナトリウム、水酸化カリウム等を用いて、あるいは無触媒でもよく、溶媒の有無に関わらず、50〜260℃でエステル化を行うことができる。 The polyglyceryl isostearate of the present invention can be produced by a method of carrying out an esterification reaction according to a conventional method. Paratoluenesulfonic acid, sulfuric acid, hydrochloric acid, methanesulfonic acid, boron trifluoride diethyl ether complex, sodium hydroxide, potassium hydroxide, etc. may be used as a catalyst, or no catalyst may be used, and 50 to 50 to this may be used with or without a solvent. Esterification can be performed at 260 ° C.
本発明のイソステアリン酸ポリグリセリルは、イソステアリン酸ポリグリセリル95質量%に水を5質量%添加し混合した際に異方性液晶のゲルを形成し、30℃での粘度が50000〜300000mPa・s、好ましくは55000〜300000mPa・sであることを特徴とする。異方性液晶のゲル構造を取らない場合は、水分に接触した際に強固な水和膜を形成できず、化粧料や皮膚外用剤へ用いた際に皮膚への密着性が悪く、再付着防止効果を発現しない。異方性液晶構造を有するか否かは、例えば偏光顕微鏡による観察などにより確認することができる。 The polyglyceryl isostearate of the present invention forms an anisotropic liquid crystal gel when 5% by mass of water is added to 95% by mass of polyglyceryl isostearate and mixed, and the viscosity at 30 ° C. is 50,000 to 300,000 mPa · s, preferably. It is characterized by having a value of 55,000 to 300,000 mPa · s. If the gel structure of the anisotropic liquid crystal is not taken, a strong hydration film cannot be formed when it comes into contact with water, and when it is used for cosmetics or external preparations for skin, it has poor adhesion to the skin and reattaches. Does not exert a preventive effect. Whether or not it has an anisotropic liquid crystal structure can be confirmed by, for example, observation with a polarizing microscope.
30℃での粘度が50000mPa・s未満の場合は、化粧料や皮膚外用剤へ用いた際に皮膚への密着性が悪く、再付着防止効果を発現しない。300000mPa・sより高い場合は、化粧料や皮膚外用剤へ用いた際にべたつきが生じる。なお、ここで言う粘度とは、実施例にて示した測定条件にて得られた数値のことを示す。 When the viscosity at 30 ° C. is less than 50,000 mPa · s, the adhesion to the skin is poor when used in cosmetics and external preparations for skin, and the effect of preventing reattachment is not exhibited. If it is higher than 300,000 mPa · s, stickiness occurs when it is used for cosmetics or external preparations for skin. The viscosity referred to here means a numerical value obtained under the measurement conditions shown in the examples.
本発明に係る化粧料用油剤の用途としては、毛髪用化粧料、基礎化粧料、メーキャップ化粧料、皮膚外用剤等が挙げられる。本発明の化粧料や皮膚外用剤は、通常の方法に従って製造することができる。 Examples of the use of the cosmetic oil agent according to the present invention include hair cosmetics, basic cosmetics, makeup cosmetics, skin external preparations and the like. The cosmetic or external preparation for skin of the present invention can be produced according to a usual method.
本発明に係る化粧料用油剤の用途を更に詳細に説明すると、毛髪用化粧料としては、オイルシャンプー、クリームシャンプー、コンディショニングシャンプー、ふけ用シャンプー、ヘアカラー用シャンプー、リンス一体型シャンプー、リンス、トリートメント、ヘアパック、ヘアフォーム、ヘアムース、ヘアワックス、ヘアジェル、ヘアクリーム、ヘアカラープレトリートメント、ヘアカラーアフタートリートメント、パーマプレトリートメント、パーマアフタートリートメント等が好ましいものとして挙げられる。 The use of the cosmetic oil agent according to the present invention will be described in more detail. Examples of hair cosmetics include oil shampoo, cream shampoo, conditioning shampoo, indulgence shampoo, hair coloring shampoo, rinse-integrated shampoo, rinse, and treatment. , Hair packs, hair foams, hair mousses, hair waxes, hair gels, hair creams, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments and the like are preferable.
基礎化粧料としては、エモリエントクリーム、栄養クリーム、ナリシングクリーム、バニシングクリーム、モイスチャークリーム、ナイトクリーム、マッサージクリーム、クレンジングクリーム、メーキャップクリーム、ベースクリーム、プレメーキャップクリーム、サンスクリーンクリーム、サンタンクリーム、除毛クリーム、デオドラントクリーム、シェービングクリーム、角質軟化クリーム等が好ましいものとして挙げられる。 Basic cosmetics include emollient cream, nutritional cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, and hair removal. Creams, deodorant creams, shaving creams, keratin softening creams and the like are preferred.
メーキャップ化粧料としては、白粉・打粉類、ファンデーション類、口紅類、リップグロス、頬紅類、アイライナー、マスカラ、アイシャドー、眉墨、アイブロー、ネイルエナメル、エナメルリムーバー、ネイルトリートメント等が好ましいものとして挙げられる。 Preferred makeup cosmetics include white powder / dusting powder, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, and nail treatment. ..
皮膚外用剤としては、軟膏、液剤、エアゾール剤、貼付剤、パップ剤、リニメント剤等が挙げられる。 Examples of external preparations for skin include ointments, liquids, aerosols, patches, poultices, liniments and the like.
本発明の化粧料には必要に応じて水及び通常化粧料に配合される添加成分、例えば油性基剤、界面活性剤、アルコール類、保湿剤、高分子・増粘・ゲル化剤、酸化防止剤、防腐剤、殺菌剤、キレート剤、pH調整剤・酸・アルカリ、紫外線吸収剤、溶剤、角質剥離・溶解剤、制汗剤、還元剤・酸化剤、高分子粉体、α−ヒドロキシ酸類及びその誘導体類、ビタミン類及びその誘導体類、糖類及びその誘導体類、酵素類、核酸類、無機粉体類、香料、色素等を配合することができる。 The cosmetics of the present invention include additive components that are added to water and ordinary cosmetics as needed, such as oily bases, surfactants, alcohols, moisturizers, polymers / thickening / gelling agents, and antioxidants. Agents, preservatives, bactericides, chelating agents, pH adjusters / acids / alkalis, UV absorbers, solvents, keratin stripping / dissolving agents, antiperspirants, reducing agents / oxidizing agents, polymer powders, α-hydroxy acids And its derivatives, vitamins and their derivatives, sugars and their derivatives, enzymes, nucleic acids, inorganic powders, fragrances, pigments and the like can be blended.
これらの添加成分を例示すると、油性基剤としては、例えば高級アルコール類としてセタノール、ミリスチルアルコール、オレイルアルコール、ラウリルアルコール、セトステアリルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール、ホホバアルコール、キミルアルコール、バチルアルコール、ヘキシルデカノール、イソステアリルアルコール、2−オクチルドデカノール、ダイマージオール等が挙げられる。また、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、ベヘン酸、ウンデシレン酸、12−ヒドロキシステアリン酸、パルミトオレイン酸、オレイン酸、リノール酸、リノレイン酸、エルカ酸、ドコサヘキサエン酸、エイコサペンタエン酸、イソヘキサデカン酸、アンテイソヘンイコサン酸、長鎖分岐脂肪酸、ダイマー酸、水素添加ダイマー酸等の脂肪酸類及びそのアルミニウム塩、カルシウム塩、マグネシウム塩、亜鉛塩、カリウム塩等の金属石けん類、及びアミド等の含窒素誘導体類;流動パラフィン、重質流動イソパラフィン、α−オレフィンオリゴマー、ポリイソブテン、水添ポリイソブテン、ポリブテン、スクワラン、スクワレン、ワセリン、固形パラフィン等の炭化水素類;キャンデリラワックス、カルナウバワックス、ライスワックス、もくろう、みつろう、モンタンワックス、オゾケライト、セレシン、パラフィンワックス、マイクロクリスタリンワックス、ペトロラタム、フィッシャートロプシュワックス、ポリエチレンワックス、エチレン・プロピレンコポリマー等のワックス類;ヤシ油、パーム油、パーム核油、サフラワー油、オリーブ油、ヒマシ油、アボカド油、ゴマ油、茶油、月見草油、小麦胚芽油、マカデミアナッツ油、ヘーゼルナッツ油、ククイナッツ油、ローズヒップ油、メドウフォーム油、パーシック油、ティーツリー油、ハッカ油、トウモロコシ油、ナタネ油、ヒマワリ油、アマニ油、綿実油、大豆油、落花生油、コメヌカ油、カカオ脂、シア脂、水素添加ヤシ油、水素添加ヒマシ油、ホホバ油、水素添加ホホバ油等の植物油脂類;牛脂、乳脂、馬脂、卵黄油、ミンク油、タートル油等の動物性油脂類;鯨ロウ、ラノリン、オレンジラッフィー油等の動物性ロウ類;液状ラノリン、還元ラノリン、吸着精製ラノリン、酢酸ラノリン、酢酸液状ラノリン、ヒドロキシラノリン、ポリオキシエチレンラノリン、ラノリン脂肪酸、硬質ラノリン脂肪酸、ラノリンアルコール、酢酸ラノリンアルコール、酢酸(セチル・ラノリル)エステル等のラノリン類;ホスファチジルコリン、ホスファチジルエタノールアミン、ホスファチジルイノシトール、スフィンゴミエリン、ホスファチジン酸、リゾレシチン等のリン脂質類;水素添加大豆リン脂質、水素添加卵黄リン脂質等のリン脂質誘導体類;コレステロール、ジヒドロコレステロール、ラノステロール、ジヒドロラノステロール、フィトステロール等のステロール類;酢酸コレステリル、ノナン酸コレステリル、ステアリン酸コレステリル、イソステアリン酸コレステリル、オレイン酸コレステリル、N−ラウロイル−L−グルタミン酸ジ(コレステリル/ベヘニル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(コレステリル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(フィトステリル/ベヘニル/オクチルドデシル)、N−ラウロイル−L−グルタミン酸ジ(フィトステリル/オクチルドデシル)、12−ヒドロキシステアリン酸コレステリル、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、イソステアリン酸フィトステリル、軟質ラノリン脂肪酸コレステリル、硬質ラノリン脂肪酸コレステリル、長鎖分岐脂肪酸コレステリル、長鎖α−ヒドロキシ脂肪酸コレステリル等のステロールエステル類;オレイン酸エチル、アボカド油脂肪酸エチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、パルミチン酸オクチル、イソステアリン酸イソプロピル、ラノリン脂肪酸イソプロピル、セバシン酸ジエチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、アジピン酸ジイソプロピル、コハク酸ジオクチル等の低級アルコール脂肪酸エステル類;ミリスチン酸オクチルドデシル、ミリスチン酸ヘキシルデシル、イソステアリン酸オクチルドデシル、パルミチン酸オクチルドデシル、オクタン酸セチル、オクタン酸ヘキシルデシル、イソノナン酸イソトリデシル、イソノナン酸イソノニル、イソノナン酸オクチル、イソノナン酸イソトリデシル、ネオペンタン酸イソデシル、ネオペンタン酸イソトリデシル、ネオペンタン酸イソステアリル、ネオデカン酸オクチルドデシル、オレイン酸オレイル、オレイン酸オクチルドデシル、リシノレイン酸オクチルドデシル、ラノリン脂肪酸オクチルドデシル、ジメチルオクタン酸ヘキシルデシル、エルカ酸オクチルドデシル、イソステアリン酸硬化ヒマシ油等の高級アルコール脂肪酸エステル類;乳酸セチル、リンゴ酸ジイソステアリル、モノイソステアリン酸水添ヒマシ油等のオキシ酸エステル類;トリオクタン酸グリセリル、トリオレイン酸グリセリル、トリイソステアリン酸グリセリル、トリ(カプリル酸/カプリン酸)グリセリル、トリ(カプリル酸/カプリン酸/ミリスチン酸/ステアリン酸)グリセリル、水素添加ロジングリセリル(水素添加エステルガム)、ジオクタン酸ネオペンチルグリコール、ジオクタン酸2−ブチル−2−エチル−1,3−プロパンジオール、ジオレイン酸プロピレングリコール、テトラオクタン酸ペンタエリスリチル、水素添加ロジンペンタエリスリチル、(ヒドロキシステアリン酸/ステアリン酸/ロジン酸)ジペンタエリスリチル、ジイソステアリン酸ジグリセリル、テトライソステアリン酸ポリグリセリル、ノナイソステアリン酸ポリグリセリル−10、デカ(エルカ酸/イソステアリン酸/リシノレイン酸)ポリグリセリル−8等の多価アルコール脂肪酸エステル類;ダイマージリノール酸ジイソプロピル、ダイマージリノール酸ジイソステアリル、ダイマージリノール酸ジ(イソステアリル/フィトステリル)、ダイマージリノール酸(フィトステリル/ベヘニル)、ダイマージリノール酸(フィトステリル/イソステアリル/セチル/ステアリル/ベヘニル)、ダイマージリノール酸ダイマージリノレイル、ジイソステアリン酸ダイマージリノレイル、ダイマージリノレイル水添ロジン縮合物、ダイマージリノール酸硬化ヒマシ油、ヒドロキシアルキルダイマージリノレイルエーテル等のダイマー酸若しくはダイマージオールの誘導体;ヤシ油脂肪酸モノエタノールアミド、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、ラウリン酸ジエタノールアミド、パルミチン酸モノエタノールアミド、パルミチン酸ジエタノールアミド等の脂肪酸アルカノールアミド類等;低粘度ジメチルポリシロキサン、高粘度ジメチルポリシロキサン、環状ジメチルシロキサン(デカメチルシクロペンタシロキサン)、メチルフェニルポリシロキサン、ジフェニルポリシロキサン、シリコーン樹脂、シリコーンゴム、アミノプロピルジメチコン及びアモジメチコン等のアミノ変性ポリシロキサン、カチオン変性ポリシロキサン、ポリエーテル変性ポリシロキサン、ポリグリセリン変性ポリシロキサン、糖変性ポリシロキサン、アルキル変性ポリシロキサン、脂肪酸変性ポリシロキサン、フッ素変性ポリシロキサン等のシリコーン類;パーフルオロデカン、パーフルオロオクタン、パーフルオロポリエーテル等のフッ素系油剤類等が挙げられる。 Examples of these additive components include, for example, higher alcohols such as setanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, araquil alcohol, behenyl alcohol, jojoba alcohol, and chimil alcohol. Examples thereof include batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, dimerdiol and the like. In addition, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, d. Fatty acids such as icosapentaenoic acid, isohexadecanoic acid, anteisohen icosanoic acid, long-chain branched fatty acids, dimer acid, hydrogenated dimer acid and metal soaps such as aluminum salt, calcium salt, magnesium salt, zinc salt and potassium salt. , And nitrogen-containing derivatives such as amide; hydrocarbons such as liquid paraffin, heavy liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, squalane, vaseline, solid paraffin; candelilla wax, Carnauba wax, rice wax, mokuro, mitsuro, montan wax, ozokerite, selecin, paraffin wax, microcrystallin wax, petrolatum, Fishertropch wax, polyethylene wax, ethylene / propylene copolymer and other waxes; palm oil, palm oil, Palm kernel oil, saflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rose hip oil, meadowfoam oil, persic oil, tea tree Oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, flaxseed oil, cotton seed oil, soybean oil, peanut oil, rice bran oil, cacao fat, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba Vegetable fats and oils such as oils; animal fats and oils such as beef fat, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as whale wax, lanolin, orange raffy oil; liquid lanolin, reduced lanolin , Adsorption-purified lanolin, lanolin acetate, liquid acetate lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, lanolins such as acetic acid (cetyl lanolyl) ester; phosphatidylcholine, phosphatidylethanol Phosphorids such as amine, phosphatidylinositol, sphingomyelin, phosphatidic acid, lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanosterol, dihydro Sterols such as loranosterol and phytosterol; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L Di-glutamate (cholesteryl / octyldodecyl), N-lauroyl-L-di-glutamate (phytosteryl / behenyl / octyldodecyl), di-lauroyl-L-glutamate (phytosteryl / octyldodecyl), cholesteryl 12-hydroxystearate, macadamia nuts Sterol esters such as oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, isostearate phytosteryl, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; ethyl oleate, avocado oil fatty acid ethyl , Isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dioctyl succinate and other lower alcohol fatty acid esters; myristic acid Octyldodecyl, hexyldecyl myristate, octyldodecyl isostearate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridesyl isononanoate, isononyl isononanoate, octyl isononanoate, isotolideyl neopentanoate, isodecyl neopentanoate , Isostearyl neopentate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hardened castoric acid isostearate, etc. Fatty acid esters; oxyacid esters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, tri (caprylic acid / caprylic acid) glyceryl , Tri (caprylic acid / capric acid / myristic acid / stearic acid ) Glyceryl, hydrogenated rosingliceryl (hydrogenated ester gum), neopentyl glycol dioctanoate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogen Additions rosinpentaerythricyl, (hydroxystearic acid / stearic acid / logonic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8 Polyvalent alcohol fatty acid esters such as: Diisopropyl dimergylinolate, diisostearyl dimergilinolate, dimergilinol acid di (isostearyl / phytosteryl), dimergilinol acid (phytosteryl / behenyl), dimergilinoleic acid ( Phytosteryl / Isostearyl / Cetyl / Stearyl / Behenyl), Dimariginolate Dimarizinoleil, Diomalystearate Dimergylinoleil, Dimergylinoleyl Hydrogenated Rossine Condensate, Dimergylinol Acid Hardened Himasi Oil, Hydroxyalkyl Dimerge Dimeric acid or derivative of dimerdiol such as linoleyl ether; fatty acids such as coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, lauric acid diethanolamide, palmitic acid monoethanolamide, and palmitate diethanolamide. Alkanolamides, etc .; low-viscosity dimethylpolysiloxane, high-viscosity dimethylpolysiloxane, cyclic dimethylsiloxane (decamethylcyclopentasiloxane), methylphenylpolysiloxane, diphenylpolysiloxane, silicone resin, silicone rubber, aminopropyldimethicone, amodimethicone, etc. Amino-modified polysiloxane, cation-modified polysiloxane, polyether-modified polysiloxane, polyglycerin-modified polysiloxane, sugar-modified polysiloxane, alkyl-modified polysiloxane, fatty acid-modified polysiloxane, fluorine-modified polysiloxane, and other silicones; , Perfluorooctane, fluorine-based oils such as perfluoropolyether, and the like.
界面活性剤としては、脂肪酸塩、アルキル硫酸エステル塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキル硫酸塩、ポリオキシエチレン脂肪酸アミン硫酸塩、アシルN−メチルタウリン塩、アルキルリン酸エステル塩、アルキルエーテルリン酸エステル塩、N−アシルアミノ酸塩等の陰イオン性界面活性剤;ポリオキシエチレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンアルキルエーテルソルビタン脂肪酸部分エステル、ポリオキシエチレン硬化ヒマシ油、多価アルコール脂肪酸部分エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレン脂肪酸エステル、アルキルジメチルアミンオキサイド、アルキルポリグリコシド、アルキルグルコシド等の非イオン界面活性剤;アルキルトリメチルアンモニウムクロリド、アルキルトリメチルアンモニウムブロミド、ジアルキルジメチルアンモニウムクロリド、エチル硫酸長鎖分岐脂肪酸(12〜31)アミノプロピルエチルジメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム、短鎖ポリオキシエチレンアルキルアミン及びその塩又は四級塩、塩化ベンザルコニウム等の陽イオン性界面活性剤;脂肪酸アミドアミン及びその塩;アルキルジメチルアミノ酢酸ベタイン、アルキルアミドジメチルアミノ酢酸ベタイン、2−アルキル−N−カルボキシ−N−ヒドロキシイミダゾリニウムベタイン等の両性界面活性剤;ポリビニルアルコール、アルギン酸ナトリウム、デンプン誘導体、トラガントガム、アクリル酸・メタアクリル酸アルキル共重合体等の高分子界面活性剤等を例示することができる。 Surfactants include fatty acid salts, alkyl sulfate ester salts, alkylbenzene sulfonates, polyoxyethylene alkyl sulfates, polyoxyethylene fatty acid amine sulfates, acyl N-methyltaurine salts, alkyl phosphate ester salts, alkyl ether phosphorus. Anionic surfactants such as acid ester salts and N-acylamino acid salts; polyoxyethylene alkyl ethers, polyoxyethylene alkyl phenyl ethers, polyoxyethylene alkyl ether sorbitan fatty acid partial esters, polyoxyethylene hydrogenated castor oil, polyvalent Nonionic surfactants such as alcohol fatty acid partial ester, polyglycerin fatty acid ester, polyoxyethylene fatty acid ester, alkyldimethylamine oxide, alkylpolyglycoside, alkylglucoside; alkyltrimethylammonium chloride, alkyltrimethylammonium bromide, dialkyldimethylammonium chloride, Ethylsulfate long-chain branched fatty acids (12-31) aminopropyl ethyldimethylammonium, ethyl sulfate lanolin fatty acids aminopropylethyldimethylammonium, short-chain polyoxyethylene alkylamines and salts thereof or quaternary salts, cations such as benzalconium chloride. Sexual surfactants; fatty acid amide amines and salts thereof; amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, alkylamide dimethylaminoacetic acid betaine, 2-alkyl-N-carboxy-N-hydroxyimidazolinium betaine; polyvinyl alcohol, alginic acid Examples thereof include high-molecular-weight surfactants such as sodium, starch derivatives, traganth gum, and alkyl acrylate / methacrylic acid copolymers.
アルコール類としては、メタノール、エタノール、n−プロピルアルコール、イソプロピルアルコール、n−ブチルアルコール、イソブチルアルコール、ペンチルアルコール等を例示することができる。 Examples of alcohols include methanol, ethanol, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, pentyl alcohol and the like.
保湿剤としては、プロピレングリコール、グリセリン、ジグリセリン、ポリグリセリン、DPG、1,2−アルカンジオール、1,3−ブタンジオール、3−メチル−1,3−ブタンジオール等の多価アルコール類、ヒアルロン酸ナトリウム、クエン酸塩、尿素、乳酸菌培養液、酵母抽出液、卵殻膜タンパク、牛顎下腺ムチン、ヒポタウリン、ゴマリグナン配糖体、ベタイン、コンドロイチン硫酸、グルタチオン、ポリエチレングリコール、ソルビトール、カルビトール、乳酸ナトリウム、2−ピロリドン−5−カルボン酸ナトリウム、アルブミン、トリメチルグリシン;コラーゲン、ゼラチン、エラスチン、コラーゲン分解ペプチド、エラスチン分解ペプチド、ケラチン分解ペプチド、コンキオリン分解ペプチド、シルク蛋白分解ペプチド、大豆蛋白分解ペプチド、小麦蛋白分解ペプチド、カゼイン分解ペプチド、アシル化ペプチド等の蛋白ペプチド類及びその誘導体;アルギニン、セリン、グリシン、スレオニン、グルタミン酸、システイン、メチオニン、ロイシン、トリプトファン等のアミノ酸類;胎盤抽出液、エアラスチン、コラーゲン、アロエ抽出物、ハマメリス水、ヘチマ水、カモミラエキス、カンゾウエキス、コンフリーエキス等の動物・植物抽出成分、天然型セラミド(タイプ1、2、3、4、5、6)、ヒドロキシセラミド、疑似セラミド、スフィンゴ糖脂質等のセラミド類を例示することができる。 Moisturizers include polyhydric alcohols such as propylene glycol, glycerin, diglycerin, polyglycerin, DPG, 1,2-alkanediol, 1,3-butanediol, 3-methyl-1,3-butanediol, and hyalurone. Sodium acid, citrate, urea, lactic acid bacterium culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland mutin, hypotaurine, sesame lignan glycoside, betaine, chondroitin sulfate, glutathione, polyethylene glycol, sorbitol, carbitol, lactic acid Sodium, 2-pyrrolidone-5-carboxylate, albumin, trimethylglycine; collagen, gelatin, elastin, collagen-degrading peptide, elastin-degrading peptide, keratin-degrading peptide, conchiolin-degrading peptide, silk proteolytic peptide, soybean proteolytic peptide, wheat Protein peptides such as proteolytic peptides, casein-degrading peptides, acylated peptides and their derivatives; amino acids such as arginine, serine, glycine, threonine, glutamate, cysteine, methionine, leucine, tryptophan; Animal / plant extracts such as aloe extract, Hamamelis water, Hechima water, chamomile extract, kanzo extract, and comfree extract, natural ceramides (types 1, 2, 3, 4, 5, 6), hydroxyceramides, pseudo-ceramides. , Sphingo glycolipides and other ceramides can be exemplified.
高分子・増粘剤・ゲル化剤としては、グアーガム、ローカストビーンガム、クィーンスシード、カラギーナン、ガラクタン、アラビアガム、タラガム、タマリンド、ファーセレラン、カラヤガム、トロロアオイ、キャラガム、トラガントガム、ペクチン、アルギン酸及びその塩、マンナン、デンプン、キサンタンガム、デキストラン、サクシノグルカン、カードラン、ヒアルロン酸及びその塩、ザンサンガム、プルラン、ジェランガム、キチン、キトサン、寒天、コンドロイチン硫酸塩、カゼイン、ゼラチン、アルブミン、メチルセルロース、エチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロース及びその塩、メチルヒドロキシプロピルセルロース、カチオン化セルロース、可溶性デンプン、カルボキシメチルデンプン、メチルデンプン、アルギン酸プロピレングリコールエステル、ポリビニルアルコール、ポリビニルピロリドン、ポリオキシエチレン-ポリオキシプロピレン共重合体、ポリ酢酸ビニル部分けん化物、マレイン酸共重合体、ポリアクリル酸エステル共重合体、カルボキシビニルポリマー、ポリアクリル酸及びその塩、アクリル酸・メタクリル酸エステル共重合体、両性メタクリル酸エステル共重合体、アクリル酸・メタクリル酸アルキル共重合体、ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・ジアリルジメチルアンモニウムクロリド・アクリルアミド共重合体、アクリル酸・カチオン化メタアクリル酸エステル共重合体、アクリル酸・カチオン化メタクリル酸アミド共重合体、塩化メタクリル酸コリンエステル重合体、カチオン化グアーガム、ニトロセルロース;12−ヒドロキシステアリン酸及びその塩、デキストリン脂肪酸エステル、無水ケイ酸、金属石鹸、有機変性粘土鉱物、ショ糖脂肪酸エステル、フラクトオリゴ糖脂肪酸エステル等を例示することができる。 Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, farseleran, karaya gum, trolley aoi, cara gum, tragant gum, pectin, alginic acid and salts thereof. , Mannan, starch, xanthan gum, dextran, succinoglucan, curdran, hyaluronic acid and its salts, zansan gum, purulan, gellan gum, chitin, chitosan, agar, chondroitin sulfate, casein, gelatin, albumin, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose , Hydroxypropyl cellulose, carboxymethyl cellulose and its salts, methyl hydroxypropyl cellulose, cationized cellulose, soluble starch, carboxymethyl starch, methyl starch, propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, polyoxyethylene-polyoxypropylene co-weight Combined, polyvinyl acetate partially saponified product, maleic acid copolymer, polyacrylic acid ester copolymer, carboxyvinyl polymer, polyacrylic acid and its salt, acrylic acid / methacrylic acid ester copolymer, amphoteric methacrylic acid ester copolymer weight Combined, acrylic acid / alkyl methacrylate copolymer, diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized metaacrylic acid ester copolymer, acrylic acid -Cated methacrylic acid amide copolymer, choline chloride ester polymer, cationized guar gum, nitrocellulose; 12-hydroxystearic acid and its salts, dextrin fatty acid ester, silicic anhydride, metal soap, organically modified clay minerals, Examples thereof include sucrose fatty acid esters and fructo-oligosaccharide fatty acid esters.
酸化防止剤としては、BHT、BHA、没食子酸プロピル、ビタミンE(トコフェロール)及び/又はその誘導体、ビタミンC(アスコルビン酸)及び/又はその誘導体、亜硫酸塩、亜硫酸水素塩等を例示することができる。防腐剤としては、フェノール類、フェノキシエタノール、ヒドロキシ安息香酸及びその塩類、1,2−ペンタンジオール、1,2−ヘキサンジオール、ハロゲン化ビスフェノール類、酸アミド類、四級アンモニウム塩類等を例示することができる。殺菌剤としては、トリクロロカルバニド、ジンクピリチオン、塩化ベンザルコニウム、塩化ベンゼトニウム、クロルヘキシジン、ハロカルバン、ヒノキチオール、フェノール、イソプロピルフェノール、感光素類等を例示することができる。キレート剤としては、エデト酸塩、フィチン酸、ホスホン酸類、シュウ酸ナトリウム、ポリアミノ酸類等を例示することができる。pH調整剤・酸・アルカリとしては、クエン酸、乳酸、グリコール酸、コハク酸、酢酸、塩酸、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、イソプロパノールアミン、アルギニン、水酸化ナトリウム、水酸化カリウム、アンモニア水、炭酸グアニジン等を例示することができる。 Examples of the antioxidant include BHT, BHA, propyl gallate, vitamin E (tocopherol) and / or a derivative thereof, vitamin C (ascorbic acid) and / or a derivative thereof, sulfite, hydrogen sulfite and the like. .. Examples of preservatives include phenols, phenoxyethanol, hydroxybenzoic acid and salts thereof, 1,2-pentanediol, 1,2-hexanediol, bisphenol halides, acid amides, quaternary ammonium salts and the like. it can. Examples of the bactericide include trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine, halocarban, hinokitiol, phenol, isopropylphenol, and photosensitizers. Examples of the chelating agent include edetates, phytic acids, phosphonic acids, sodium oxalate, polyamino acids and the like. Acids / alkalis include citric acid, lactic acid, glycolic acid, succinic acid, acetic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, arginine, sodium hydroxide, potassium hydroxide, and aqueous ammonia. , Guanidin carbonate and the like can be exemplified.
防腐剤としては、イソブチルパラベン、イソプロピルパラベン、エチルパラベン、メチルパラベン、ブチルパラベン、フェノキシエタノール、ベンジルアルコール等を例示することができる。 Examples of the preservative include isobutylparaben, isopropylparaben, ethylparaben, methylparaben, butylparaben, phenoxyethanol, benzyl alcohol and the like.
殺菌剤としては、安息香酸、デヒドロ酢酸などの有機酸類;フェニルエタノール、フェノキシイソプロピルアルコールなどのアルコール類;p−クロロフェノール、クロルフェネシン、クロルヘキシジン、セトリモニウムクロリド、ベンザルコニウムクロリド、酸化亜鉛等を例示することができる。 Examples of the fungicide include organic acids such as benzoic acid and dehydroacetic acid; alcohols such as phenylethanol and phenoxyisopropyl alcohol; p-chlorophenol, chlorphenesin, chlorhexidine, cetrimonium chloride, benzalkonium chloride, zinc oxide and the like. It can be exemplified.
キレート剤としては、EDTA、EDTA−2Na、カプリルヒドロキサム酸、クエン酸、クエン酸Na、グルコノラクトン、シクロデキストリン、ヒドロキシプロピルシクロデキストリン、フィチン酸等を例示することができる。 Examples of the chelating agent include EDTA, EDTA-2Na, caprylhydroxamic acid, citric acid, Na citrate, gluconolactone, cyclodextrin, hydroxypropylcyclodextrin, phytic acid and the like.
pH調整剤・酸・アルカリとしては、蟻酸、酢酸、乳酸、酒石酸、リンゴ酸、クエン酸、グリコール酸等の有機酸や無機酸又はその塩、トリエタノールアミンなどのアルカリを例示することができる。 Examples of the pH adjuster / acid / alkali include organic acids such as formic acid, acetic acid, lactic acid, tartaric acid, malic acid, citric acid and glycolic acid, inorganic acids or salts thereof, and alkalis such as triethanolamine.
紫外線吸収剤としては、オキシベンゾン等のベンゾフェノン誘導体、パラアミノ安息香酸誘導体、パラメトキシケイヒ酸誘導体、サリチル酸誘導体、フェルラ酸及びその誘導体、ウロカニン酸及びウロカニン酸エチル等の誘導体、ブチルメトキシベンゾイルメタン、オクチルトリアゾン、2−(2’−ヒドロキシ−5’−メチルフェニル)ベンゾトリアゾール、アントラニル酸メチル、ルチン及びその誘導体等を例示することができる。美白剤としては、アルブチン、アスコルビン酸、アスコルビン酸グルコシド、アスコルビン酸リン酸エステル塩、アスコルビン酸分岐脂肪酸エステル、アスコルビン酸アルキルエーテル等のアスコルビン酸誘導体、コウジ酸、グルタチオン、エラグ酸、プラセンタエキス、オリザノール、ブチルレゾルシノール、カモミラエキス等植物エキスを例示することができる。 Examples of the ultraviolet absorber include benzophenone derivatives such as oxybenzone, paraaminobenzoic acid derivatives, paramethoxysilicate derivatives, salicylic acid derivatives, ferulic acid and its derivatives, derivatives such as urocanic acid and ethyl urocanate, butylmethoxybenzoylmethane, and octylriazone. , 2- (2'-Hydroxy-5'-methylphenyl) benzotriazole, methyl anthranilate, rutin and its derivatives can be exemplified. Examples of whitening agents include ascorbic acid derivatives such as arbutine, ascorbic acid, ascorbic acid glucoside, ascorbic acid phosphate ester salt, ascorbic acid branched fatty acid ester, and alkyl ether ascorbic acid, kodiic acid, glutathione, ellagic acid, placenta extract, oryzanol, and so on. Plant extracts such as butylresorsinol and chamomile extract can be exemplified.
溶剤類としては、エタノール、2−プロパノール等の低級アルコール類;アセトン、酢酸エチル、エチレングリコールモノエチルエーテル、トルエン等を例示することができる。 Examples of the solvent include lower alcohols such as ethanol and 2-propanol; acetone, ethyl acetate, ethylene glycol monoethyl ether, toluene and the like.
角質剥離・溶解剤としては、サリチル酸、イオウ、レゾルシン、硫化セレン、ピリドキシン等を例示することができる。鎮痒剤としては、塩酸ジフェンヒドラミン、マレイン酸クロルフェニラミン、カンファー等を例示することができる。消炎剤としては、グリチルリチン酸及びその誘導体、グアイアズレン、酢酸ヒドロコルチゾン、プレドニゾロン等を例示することができる。制汗剤としては、クロルヒドロキシアルミニウム、塩化アルミニウム、酸化亜鉛、パラフェノールスルホン酸亜鉛等を例示することができる。清涼剤としては、メントール、サリチル酸メチル等を例示することができる。抗ヒスタミン剤としては、塩酸ジフェヒドラミン、マレイン酸クロルフェニラミン、グリチルレチン酸誘導体等を例示することができる。収れん剤としては、クエン酸、酒石酸、乳酸、硫酸アルミニウム・カリウム、タンニン酸等を例示することができる。刺激剤としては、カンタリスチンキ、ショウキョウチンキ、トウガラシチンキ、ニコチン酸ベンジル等を例示することができる。育毛用薬剤・血行促進剤としては、センブリエキス、トウガラシチンキ、ショウキョウチンキ、カンタリスチンキ等の植物エキス・チンキ類;セファランチン、ビタミンE及びその誘導体、γ−オリザノール、ニコチン酸及びニコチン酸ベンジルエステル等の誘導体、アラントイン、感光素301、感光素401、ペンタデカン酸モノグリセリド、フラバノノール誘導体、ミノキシジル等を例示することができる。 Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antipruritic agent include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor and the like. Examples of the anti-inflammatory agent include glycyrrhizic acid and its derivatives, guaiazulene, hydrocortisone acetate, prednisolone and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenol sulfonate and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the antihistamine include difehydramine hydrochloride, chlorpheniramine maleate, and glycyrrhetinic acid derivatives. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid and the like. Examples of the stimulant include cantalis tincture, ginger tincture, ginger tincture, benzyl nicotinate and the like. Hair-growth agents and blood circulation promoters include plant extracts and tinctures such as senburi extract, capsicum tincture, ginger tincture, and cantalis tincture; cepharanthin, vitamin E and its derivatives, γ-oryzanol, nicotinic acid, and nicotinic acid benzyl ester. Derivatives such as, allantin, photosensitizer 301, photosensitizer 401, pentadecanoic acid monoglyceride, flavanonol derivative, minoxidil and the like can be exemplified.
制汗剤としては、(アジピン酸/ネオペンチルグリコール)クロスポリマー、クロルヒドロキシAl、ホップ球果エキス等を例示することができる。 Examples of the antiperspirant include (adipic acid / neopentyl glycol) crosspolymer, chlorohydroxyAl, hop cone extract and the like.
還元剤としては、チオグリコール酸、システイン、システアミン等を例示することができる。酸化剤としては、過酸化水素水、過硫酸アンモニウム、臭素酸ナトリウム等を例示できる。 Examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Examples of the oxidizing agent include hydrogen peroxide solution, ammonium persulfate, sodium bromate and the like.
高分子粉体としては、デンプン、ナイロンパウダー、ポリエチレン末、ポリメタクリル酸メチル、ポリエチレンテレフタレート・ポリメチルメタクリレート積層末、ポリエチレンテレフタレート・アルミニウム・エポキシ積層末等、及び、これらの表明処理粉体を例示することができる。 Examples of the polymer powder include starch, nylon powder, polyethylene powder, polymethyl methacrylate, polyethylene terephthalate / polymethylmethacrylate laminated powder, polyethylene terephthalate / aluminum / epoxy laminated powder, and the like, and these expression-treated powders. be able to.
α−ヒドロキシ酸類及びその誘導体類としては、乳酸、グリコール酸、フルーツ酸、ヒドロキシカプリン酸、長鎖α−ヒドロキシ脂肪酸、長鎖α−ヒドロキシ脂肪酸コレステリル等を例示することができる。 Examples of α-hydroxy acids and derivatives thereof include lactic acid, glycolic acid, fruit acid, hydroxycapric acid, long-chain α-hydroxy fatty acid, long-chain α-hydroxy fatty acid cholesteryl and the like.
ビタミン類及びその誘導体類としては、ビタミンA、ビタミンB群、ビタミンD、ビタミンE、パントテン酸、ビオチン等のビタミン類;ステアリン酸アスコルビル、パルミチン酸アスコルビル、ジパルミチン酸アスコルビル、リン酸アスコルビルマグネシウム、アスコルビン酸ナトリウム、ニコチン酸トコフェロール、酢酸トコフェロール、リノール酸トコフェロール、フェルラ酸トコフェロール等のビタミン誘導体類を例示することができる。 Vitamins and their derivatives include vitamins such as vitamin A, vitamin B group, vitamin D, vitamin E, pantothenic acid, and biotin; ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl magnesium phosphate, ascorbyl. Vitamin derivatives such as sodium acid, tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, and tocopherol ferlate can be exemplified.
糖類及びその誘導体類としては、シクロデキストリン、β−グルカン、キチン、キトサン、グルコース、トレハロース、ペクチン、アラビノガラクタン、デキストリン、デキストラン、メタクリル酸グルコシルエチル重合物若しくは共重合物等を例示することができる。有機酸類としては、酢酸、プロピオン酸、クエン酸、アビエチン酸、酒石酸等を例示することができる。 Examples of saccharides and derivatives thereof include cyclodextrin, β-glucan, chitin, chitosan, glucose, trehalose, pectin, arabinogalactan, dextrin, dextran, glucosylethyl methacrylate polymer or copolymer. .. Examples of organic acids include acetic acid, propionic acid, citric acid, abietic acid, tartaric acid and the like.
酵素類としては、塩化リゾチーム、パパイン、パンクレアチン、プロテアーゼ等を例示することができる。核酸類としては、アデノシン三リン酸二ナトリウム等を例示することができる。ホルモン類としては、エストラジオール、エストロン、エチニルエストラジオール、コルチゾン、ヒドロコルチゾン、プレドニゾロン等を例示することができる。 Examples of enzymes include lysozyme chloride, papain, pancreatin, protease and the like. Examples of nucleic acids include disodium adenosine triphosphate and the like. Examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisolone and the like.
無機粉体類としては、マイカ、タルク、カオリン、モンモリロナイト、セリサイト、カオリナイト、炭酸カルシウム、ベンガラ、黄酸化鉄、黒酸化鉄、群青、紺青、カーボンブラック、二酸化チタン、酸化亜鉛、アルミナ、シリカ、煙霧状シリカ(超微粒子無水ケイ酸)、雲母チタン、魚鱗箔、窒化ホウ素、ホトクロミック顔料、合成フッ素金雲母、微粒子複合粉体、金、アルミニウム等の無機粉体及びこれらを表面処理により疎水化した粉体等を例示することができる。 Inorganic powders include mica, talc, kaolin, montmorillonite, cericite, kaolinite, calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine blue, dark blue, carbon black, titanium dioxide, zinc oxide, alumina, silica. , Smoke-like silica (ultrafine particulate silicic acid), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine gold mica, fine particle composite powder, inorganic powders such as gold and aluminum, and hydrophobic by surface treatment. Examples thereof include carbonized powder and the like.
香料としては、リモネン、リナノール、シトラール、β−イオノン、ベンジルベンゾエート、インドール、オイゲノール、オーランチオール、ゲラニオール、リラール、ダマスコン、ベンジルアセテート、ジャスミンラクトン、ガラクソリッド、精油等が例示することができる。 Examples of the fragrance include limonene, linalool, citral, β-ionone, benzylbenzoate, indol, eugenol, aurantiol, geraniol, linalool, damascon, benzylacetate, jasmine lactone, galactosolid, essential oil and the like.
色素としては、β−カロチン、カルサミン、ルチン、コチニール、クロロフィル等の天然色素;法定色素、塩基染料、レーキ等の有機顔料;p−フェニレンジアミン、トルエン−2,5−ジアミン、m−フェニレンジアミン、o−,m−,若しくはp−アミノフェノール、レゾルシン等の酸化染料中間体等を例示することができる。 As dyes, natural pigments such as β-carotene, calsamine, rutin, cochineal and chlorophyll; organic pigments such as legal dyes, basic dyes and lakes; p-phenylenediamine, toluene-2,5-diamine, m-phenylenediamine, Examples thereof include oxidation dye intermediates such as o-, m-, p-aminophenol, and resorcin.
その他公知の化粧料、医薬品、食品等に使用される成分を本発明の効果を損なわない範囲において、適宜配合することができる。 Other known ingredients used in cosmetics, pharmaceuticals, foods, etc. can be appropriately blended as long as the effects of the present invention are not impaired.
以下、実施例及び比較例により本発明をより具体的に説明するが、本発明の範囲はこれらの実施例により限定されるものではない。 Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the scope of the present invention is not limited to these Examples.
<合成例1>
イソステアリン酸224.5gとポリグリセリン(10%加水物、水酸基価845)655.3gを反応容器に入れ、0.8gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率8.9%のイソステアリン酸ポリグリセリル793.1gを得た。
<Synthesis example 1>
224.5 g of isostearic acid and 655.3 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.8 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 793.1 g of polyglyceryl isostearate having an esterification rate of 8.9%.
<合成例2>
イソステアリン酸239.0gとポリグリセリン(10%加水物、水酸基価845)640.1gを反応容器に入れ、0.8gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率9.7%のイソステアリン酸ポリグリセリル790.5gを得た。
<Synthesis example 2>
239.0 g of isostearic acid and 640.1 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.8 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 790.5 g of polyglyceryl isostearate having an esterification rate of 9.7%.
<合成例3>
イソステアリン酸348.4gとポリグリセリン(10%加水物、水酸基価845)526.3gを反応容器に入れ、0.4gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率17.2%のイソステアリン酸ポリグリセリル797.2gを得た。
<Synthesis example 3>
348.4 g of isostearic acid and 526.3 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) were placed in a reaction vessel, 0.4 g of sodium hydroxide was added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 797.2 g of polyglyceryl isostearate having an esterification rate of 17.2%.
<合成例4>
イソステアリン酸363.6gとポリグリセリン(10%加水物、水酸基価845)510.5gを反応容器に入れ、0.4gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率18.5%のイソステアリン酸ポリグリセリル791.7gを得た。
<Synthesis example 4>
363.6 g of isostearic acid and 510.5 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.4 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 791.7 g of polyglyceryl isostearate having an esterification rate of 18.5%.
<合成例5>
イソステアリン酸379.9gとポリグリセリン(10%加水物、水酸基価845)493.5gを反応容器に入れ、0.4gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率20.0%のイソステアリン酸ポリグリセリル791.4gを得た。
<Synthesis example 5>
379.9 g of isostearic acid and 493.5 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.4 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 791.4 g of polyglyceryl isostearate having an esterification rate of 20.0%.
<合成例6>
イソステアリン酸406.8gとポリグリセリン(10%加水物、水酸基価845)465.5gを反応容器に入れ、0.4gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率22.7%のイソステアリン酸ポリグリセリル791.2gを得た。
<Synthesis example 6>
406.8 g of isostearic acid and 465.5 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.4 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 791.2 g of polyglyceryl isostearate having an esterification rate of 22.7%.
<合成例7>
イソステアリン酸180.7gとポリグリセリン(10%加水物、水酸基価845)700.8gを反応容器に入れ、0.8gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率6.7%のイソステアリン酸ポリグリセリル791.8gを得た。
<Synthesis example 7>
180.7 g of isostearic acid and 700.8 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.8 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 791.8 g of polyglyceryl isostearate having an esterification rate of 6.7%.
<合成例8>
イソステアリン酸249.8gとポリグリセリン(10%加水物、水酸基価890)629.0gを反応容器に入れ、0.8gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率9.8%のイソステアリン酸ポリグリセリル792.8gを得た。
<Synthesis Example 8>
249.8 g of isostearic acid and 629.0 g of polyglycerin (10% hydrolyzate, hydroxyl value 890) were placed in a reaction vessel, 0.8 g of sodium hydroxide was added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 792.8 g of polyglyceryl isostearate having an esterification rate of 9.8%.
<合成例9>
イソステアリン酸344.1gとポリグリセリン(10%加水物、水酸基価890)530.8gを反応容器に入れ、0.8gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率16.0%のイソステアリン酸ポリグリセリル792.5gを得た。
<Synthesis example 9>
344.1 g of isostearic acid and 530.8 g of polyglycerin (10% hydrolyzate, hydroxyl value 890) were placed in a reaction vessel, 0.8 g of sodium hydroxide was added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 792.5 g of polyglyceryl isostearate having an esterification rate of 16.0%.
<合成例10>
イソステアリン酸459.8gとポリグリセリン(10%加水物、水酸基価845)410.4gを反応容器に入れ、0.4gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率29.1%のイソステアリン酸ポリグリセリル776.4gを得た。
<Synthesis Example 10>
459.8 g of isostearic acid and 410.4 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.4 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 776.4 g of polyglyceryl isostearate having an esterification rate of 29.1%.
<合成例11>
イソステアリン酸502.1gとポリグリセリン(10%加水物、水酸基価845)366.4gを反応容器に入れ、0.4gの水酸化ナトリウムを加えた後、窒素気流下において200〜240℃、3時間反応を行い、エステル化率35.6%のイソステアリン酸ポリグリセリル788.2gを得た。
<Synthesis Example 11>
502.1 g of isostearic acid and 366.4 g of polyglycerin (10% hydrolyzate, hydroxyl value 845) are placed in a reaction vessel, 0.4 g of sodium hydroxide is added, and then 200 to 240 ° C. for 3 hours under a nitrogen stream. The reaction was carried out to obtain 788.2 g of polyglyceryl isostearate having an esterification rate of 35.6%.
<実施例1>
合成例1のイソステアリン酸ポリグリセリル95質量%に水を5質量%添加し水和ゲルを形成させた。水和ゲルの液晶構造については、直交ニコル下での偏光顕微鏡による観察により等方性/異方性のいずれを示すかを判定した。粘度については、動的粘弾性測定装置(TA Instruments製、Rheometer HR−2)にて測定治具として直径40mmのパラレルプレートを用い、測定温度を30℃、プレートギャップを500μm、プレートの回転速度を0.3rad/sとしたときの測定開始20秒後の値を用いた。また、合成例1のイソステアリン酸ポリグリセリルを用いて皮膚への密着性を評価した。結果を表1に示した。
<実施例2〜6、比較例1〜5>
合成例2〜11のイソステアリン酸ポリグリセリルを用いたこと以外は、実施例1と同様に行った。
<Example 1>
5% by mass of water was added to 95% by mass of polyglyceryl isostearate of Synthesis Example 1 to form a hydrated gel. Regarding the liquid crystal structure of the hydrated gel, it was determined whether it was isotropic or anisotropic by observing with a polarizing microscope under orthogonal Nicol. Regarding the viscosity, a parallel plate with a diameter of 40 mm was used as a measuring jig with a dynamic viscoelasticity measuring device (manufactured by TA Instruments, Rheometer HR-2), the measuring temperature was 30 ° C., the plate gap was 500 μm, and the rotation speed of the plate was adjusted. The value 20 seconds after the start of measurement at 0.3 rad / s was used. In addition, the adhesion to the skin was evaluated using polyglyceryl isostearate of Synthesis Example 1. The results are shown in Table 1.
<Examples 2 to 6 and Comparative Examples 1 to 5>
The procedure was the same as in Example 1 except that polyglyceryl isostearate of Synthesis Examples 2 to 11 was used.
[肌への密着性]
20名のパネラーにより、官能評価を行った。各イソステアリン酸ポリグリセリル10質量%に水を90質量%添加した水溶液を肌に塗布した際の肌への密着性を5点満点として評価した。20名の平均点を算出し、以下の基準により評価した。点数が高いほど肌への密着性は良好である。その結果を表1に示す。
○:4.0点以上
△:3.0点以上、4.0点未満
×:3.0点未満
[Adhesion to the skin]
Sensory evaluation was performed by 20 panelists. The adhesion to the skin when an aqueous solution obtained by adding 90% by mass of water to 10% by mass of each polyglyceryl isostearate was applied to the skin was evaluated on a scale of 5 points. The average score of 20 people was calculated and evaluated according to the following criteria. The higher the score, the better the adhesion to the skin. The results are shown in Table 1.
◯: 4.0 points or more Δ: 3.0 points or more and less than 4.0 points ×: less than 3.0 points
本発明のイソステアリン酸ポリグリセリルを用いた実施例1〜6は、いずれも肌への密着性に優れるものであった。一方、異方性液晶構造を取るものの、30℃での粘度が50000mPa・s未満となる水和ゲルを形成するイソステアリン酸ポリグリセリルを用いた比較例1、2や、等方性液晶構造を取る水和ゲルを形成するイソステアリン酸ポリグリセリルを用いた比較例3〜5は、肌への密着性に劣るものであった。 Examples 1 to 6 using the polyglyceryl isostearate of the present invention were all excellent in adhesion to the skin. On the other hand, Comparative Examples 1 and 2 using polyglyceryl isostearate, which forms a hydrated gel having an anisotropic liquid crystal structure but having a viscosity at 30 ° C. of less than 50,000 mPa · s, and water having an isotropic liquid crystal structure. Comparative Examples 3 to 5 using polyglyceryl isostearate forming a Japanese gel were inferior in adhesion to the skin.
配合実施例1 モイスチャーゲル
グリセリン 10.00
ジグリセリン 7.00
BG 5.00
10%−水酸化K(85%) 3.00
カルボマー 0.45
(アクリレーツ/アクリル酸アルキル(C10−30))クロスポリマー 0.30
合成例5のイソステアリン酸ポリグリセリル 0.10
精製水 74.15
Formulation Example 1 Moisture Gel Glycerin 10.00
Diglycerin 7.00
BG 5.00
10% -K hydroxide (85%) 3.00
Carbomer 0.45
(Acrylate / Alkyl Acrylate (C10-30)) Cross Polymer 0.30
Polyglyceryl isostearate of Synthesis Example 5 0.10
Purified water 74.15
全成分を80℃にて加温して均一溶解した。 All components were heated at 80 ° C. to uniformly dissolve.
配合実施例1で得られたモイスチャーゲルは、べたつきやぬるつきがなく、肌への密着性が良好であった。 The moisture gel obtained in Formulation Example 1 was not sticky or slimy, and had good adhesion to the skin.
配合実施例2 クリームファンデーション
A相
マカデミアナッツ油ポリグリセリル−6エステルズベヘネート 1.00
ポリリシノレイン酸ポリグリセリル−6 1.40
合成例5のイソステアリン酸ポリグリセリル 0.50
シクロペンタシロキサン 10.90
イソノナン酸イソトリデシル 9.00
ジステアルジモニウムヘクトライト 2.00
B相
顔料(シリコーン処理) 8.30
C相
ジグリセリン 3.00
BG 8.00
塩化Na 0.50
精製水 55.40
Formulation Example 2 Cream Foundation Phase A Macademia Nut Oil Polyglyceryl-6 Esters Behenate 1.00
Polyglyceryl polyricinoleate-6 1.40
Polyglyceryl isostearate of Synthesis Example 5 0.50
Cyclopentasiloxane 10.90
Isotridecyl isononanoate 9.00
Disteardimonium Hectorite 2.00
Phase B pigment (silicone treatment) 8.30
Phase C diglycerin 3.00
BG 8.00
Na chloride 0.50
Purified water 55.40
A相を60℃に加温し、均一溶解した。その後B相をA相に添加し分散させ、60℃に加温し均一化させたC相を添加し、乳化した。 Phase A was heated to 60 ° C. and uniformly dissolved. Then, the B phase was added to the A phase to disperse it, and the C phase heated to 60 ° C. and homogenized was added and emulsified.
配合実施例2で得られたクリームファンデーションは、べたつきがなく、みずみずしい使用感を有し、かつ、肌への密着性が良好であった。 The cream foundation obtained in Formulation Example 2 was not sticky, had a fresh feeling of use, and had good adhesion to the skin.
配合実施例3 リキッドルージュ
水添ポリイソブテン 16.70
マカデミアナッツ油ポリグリセリル−6エステルズベヘネート 8.00
リンゴ酸ジイソステアリル 25.00
マイクロクリスタリンワックス 17.00
スクワラン 15.00
合成例5のイソステアリン酸ポリグリセリル 10.00
パルミチン酸デキストリン 5.00
顔料(シリコーン処理) 1.60
酸化チタン マイカ 1.70
Formulation Example 3 Liquid Rouge Hydrogenated Polyisobutene 16.70
Macademia Nut Oil Polyglyceryl-6 Esters Behenate 8.00
Diisostearyl malate 25.00
Microcrystalline wax 17.00
Squalan 15.00
Polyglyceryl isostearate of Synthesis Example 5 10.00
Dextrin palmitate 5.00
Pigment (silicone treatment) 1.60
Titanium oxide mica 1.70
全成分を加温し、均一に溶解した。 All ingredients were warmed and dissolved uniformly.
配合実施例3で得られたリキッドルージュは、唇への密着性や再付着防止効果に優れ、伸びが良い使用感であった。 The liquid rouge obtained in Formulation Example 3 was excellent in adhesion to the lips and the effect of preventing reattachment, and had a good feeling of use.
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