JP2021001177A5 - - Google Patents

Download PDF

Info

Publication number
JP2021001177A5
JP2021001177A5 JP2020143429A JP2020143429A JP2021001177A5 JP 2021001177 A5 JP2021001177 A5 JP 2021001177A5 JP 2020143429 A JP2020143429 A JP 2020143429A JP 2020143429 A JP2020143429 A JP 2020143429A JP 2021001177 A5 JP2021001177 A5 JP 2021001177A5
Authority
JP
Japan
Prior art keywords
pkc
inhibitor
lsd
csc
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2020143429A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021001177A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2021001177A publication Critical patent/JP2021001177A/ja
Publication of JP2021001177A5 publication Critical patent/JP2021001177A5/ja
Pending legal-status Critical Current

Links

JP2020143429A 2014-08-25 2020-08-27 がん幹細胞を調節するための組成物およびその使用 Pending JP2021001177A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2014903345 2014-08-25
AU2014903345A AU2014903345A0 (en) 2014-08-25 Compositions for Modulating Cancer Stem Cells and Uses Therefor

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2017511233A Division JP2017528452A (ja) 2014-08-25 2015-08-25 がん幹細胞を調節するための組成物およびその使用

Publications (2)

Publication Number Publication Date
JP2021001177A JP2021001177A (ja) 2021-01-07
JP2021001177A5 true JP2021001177A5 (enExample) 2021-02-18

Family

ID=55398499

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017511233A Pending JP2017528452A (ja) 2014-08-25 2015-08-25 がん幹細胞を調節するための組成物およびその使用
JP2020143429A Pending JP2021001177A (ja) 2014-08-25 2020-08-27 がん幹細胞を調節するための組成物およびその使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2017511233A Pending JP2017528452A (ja) 2014-08-25 2015-08-25 がん幹細胞を調節するための組成物およびその使用

Country Status (8)

Country Link
US (2) US10485772B2 (enExample)
EP (1) EP3185858A4 (enExample)
JP (2) JP2017528452A (enExample)
CN (1) CN107106517A (enExample)
AU (1) AU2015309686B2 (enExample)
CA (1) CA2958704A1 (enExample)
SG (1) SG11201701237QA (enExample)
WO (1) WO2016029262A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3381896T3 (fi) 2015-11-27 2023-04-21 Taiho Pharmaceutical Co Ltd Bifenyyliyhdiste tai sen suola
JP7341451B2 (ja) * 2016-02-01 2023-09-11 エピアクシス セラピューティクス プロプライアタリー リミティド タンパク質性化合物とその利用
SG11201901624RA (en) * 2016-09-07 2019-03-28 Univ Canberra Lysine specific histone demethylase-1 inhibitors and uses therefor
WO2018059549A1 (en) * 2016-09-30 2018-04-05 Novartis Ag Immune effector cell therapies with enhanced efficacy
WO2018216795A1 (ja) * 2017-05-26 2018-11-29 大鵬薬品工業株式会社 新規なビフェニル化合物を用いた抗腫瘍効果増強剤
RU2765152C2 (ru) 2017-05-26 2022-01-26 Тайхо Фармасьютикал Ко., Лтд. Новое соединение бифенила или его соль
AU2018276611B2 (en) 2017-05-31 2022-01-06 Taiho Pharmaceutical Co., Ltd. Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1
CN111587120A (zh) * 2017-11-08 2020-08-25 艾比克斯治疗私人有限公司 免疫原性组合物及其用途
AU2018377852B2 (en) * 2017-11-29 2022-03-24 Epiaxis Therapeutics Pty Ltd Enhancing T-cell function and treating a T-cell dysfunctional disorder with a combination of an LSD inhibitor and a PD1 binding antagonist
KR102125960B1 (ko) * 2018-10-15 2020-06-25 한국생명공학연구원 세포 리프로그래밍 조성물 및 이를 이용한 유도만능줄기세포의 제조방법
MX2022005811A (es) 2019-11-13 2022-06-08 Taiho Pharmaceutical Co Ltd Sal novedosa de compuesto de terfenilo.

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365458A (en) 1964-06-23 1968-01-23 Aldrich Chem Co Inc N-aryl-n'-cyclopropyl-ethylene diamine derivatives
US3532749A (en) 1965-05-11 1970-10-06 Aldrich Chem Co Inc N'-propargyl-n**2-cyclopropyl-ethylenediamines and the salts thereof
US3471522A (en) 1967-09-29 1969-10-07 Aldrich Chem Co Inc N-cyclopropyl-n'-furfuryl-n'-methyl ethylene diamines
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
US5804604A (en) 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
ATE318832T1 (de) 1990-06-11 2006-03-15 Gilead Sciences Inc Verfahren zur vervendung von nukleinsäureliganden
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
ATE237694T1 (de) 1991-08-20 2003-05-15 Us Gov Health & Human Serv Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
EP0673431A1 (en) 1992-12-03 1995-09-27 Genzyme Corporation Gene therapy for cystic fibrosis
EP0705344B8 (en) 1993-06-24 2006-05-10 Advec Inc. Adenovirus vectors for gene therapy
DE69435223D1 (de) 1993-10-25 2009-09-03 Canji Inc Rekombinanter Adenoviren-Vektor und Verfahren zur Verwendung
US5783405A (en) 1994-02-01 1998-07-21 Terrapin Technologies, Inc. Rapid screening method for effectors of signal transduction
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US20030073640A1 (en) 1997-07-23 2003-04-17 Ribozyme Pharmaceuticals, Inc. Novel compositions for the delivery of negatively charged molecules
CA2326823A1 (en) 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
US20050020525A1 (en) 2002-02-20 2005-01-27 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US8202979B2 (en) 2002-02-20 2012-06-19 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
KR20080023768A (ko) 2000-03-30 2008-03-14 화이트헤드 인스티튜트 포 바이오메디칼 리서치 Rna 간섭의 rna 서열 특이적인 매개체
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
KR20030014425A (ko) 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
EE200300015A (et) 2000-07-07 2004-10-15 Angiogene Pharmaceuticals Limited Kolhinooli derivaadid kui angiogeneesi inhibiitorid
ATE506372T1 (de) 2000-09-01 2011-05-15 Ribozyme Pharm Inc Verfahren zur herstellung von nukleosidderivate
US20020150936A1 (en) 2000-09-01 2002-10-17 Leonid Beigelman Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
CN100523215C (zh) 2000-12-01 2009-08-05 马普科技促进协会 介导rna干涉的小rna分子
US20050282188A1 (en) 2001-05-18 2005-12-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050239731A1 (en) 2001-05-18 2005-10-27 Sirna Therapeutics, Inc. RNA interference mediated inhibition of MAP kinase gene expression using short interfering nucleic acid (siNA)
JP2005523326A (ja) 2002-04-22 2005-08-04 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ プロテインキナーゼcのペプチドインヒビター
WO2003106451A1 (en) 2002-06-14 2003-12-24 Altana Pharma Ag Substituted diaminopyrimidines
EP1590334B1 (en) 2003-01-30 2009-08-19 Boehringer Ingelheim Pharmaceuticals Inc. 2,4-diaminopyrimidine derivatives useful as inhibitors of pkc-theta
JP2007509185A (ja) 2003-10-27 2007-04-12 ノバルティス アクチエンゲゼルシャフト βアミロイド産生および/または凝集と関係がある神経障害および血管障害の処置のためのインドリル−ピロールジオン誘導体
US20050187156A1 (en) 2003-12-11 2005-08-25 Daria Mochly-Rosen Isozyme-specific antagonists of protein kinase C
TW200533357A (en) 2004-01-08 2005-10-16 Millennium Pharm Inc 2-(amino-substituted)-4-aryl pyrimidines and related compounds useful for treating inflammatory diseases
ATE432260T1 (de) 2005-03-28 2009-06-15 Boehringer Ingelheim Int Pyridinderivate als pkc-theta-hemmer
EP1940773B1 (en) 2005-08-10 2015-03-18 Johns Hopkins University Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
AU2007309167A1 (en) * 2006-10-20 2008-05-02 N.V. Organon Purines as PKC-theta inhibitors
MX2011000837A (es) 2008-07-23 2011-04-05 Vertex Pharma Inhibidores de pirazolpiridina cinasa triciclica.
MX2011001319A (es) 2008-08-06 2011-04-05 Vertex Pharma Inhibidores de aminopiridina cinasa.
US8436025B2 (en) 2008-09-19 2013-05-07 CompleGen Partners, Inc. Compounds and methods for PKC theta inhibition
WO2010043721A1 (en) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Oxidase inhibitors and their use
CN102292333B (zh) 2009-01-15 2015-05-13 里格尔药品股份有限公司 蛋白激酶c抑制剂及其用途
US8993808B2 (en) 2009-01-21 2015-03-31 Oryzon Genomics, S.A. Phenylcyclopropylamine derivatives and their medical use
EP3361368B1 (en) 2009-06-10 2021-02-17 Hexagon Technology Center GmbH Ontological filtering using spatial boundary of 3d objects
EP2528917B1 (en) * 2010-01-27 2016-10-19 Vertex Pharmaceuticals Incorporated Pyrazolopyridines useful for the treatment of autoimmune, inflammatory or (hyper)proliferative diseases
MX2012008642A (es) 2010-01-27 2012-11-23 Vertex Pharma Inhibidores de cinasas de pirazolopiridinas.
RS55348B1 (sr) 2010-04-19 2017-03-31 Oryzon Gnomics S A Inhibitori lizin specifične demetilaze-1 i njihova upotreba
WO2012009475A1 (en) * 2010-07-14 2012-01-19 Oregon Health & Science University Methods of treating cancer with inhibition of lysine-specific demethylase 1
DK2598482T3 (en) 2010-07-29 2018-06-14 Oryzon Genomics Sa ARYLCYCLOPROPYLAMINE-BASED DEMETHYLASE INHIBITORS OF LSD1 AND THEIR MEDICAL USE
EP2598480B1 (en) 2010-07-29 2019-04-24 Oryzon Genomics, S.A. Cyclopropylamine derivatives useful as lsd1 inhibitors
WO2012034116A2 (en) 2010-09-10 2012-03-15 The Johns Hopkins University Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
BR112014002939A2 (pt) 2011-08-09 2017-03-01 Takeda Pharmaceuticals Co composto, medicamento, método para profilaxia ou tratamento de doença, a doença sendo esquizofrenia, alzheimer, parkinson ou huntington, uso do composto, e, método para inibir o lsd1
US9266838B2 (en) 2011-08-15 2016-02-23 University Of Utah Research Foundation Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
US9289415B2 (en) 2011-09-01 2016-03-22 The Brigham And Women's Hospital, Inc. Treatment of cancer
WO2014084298A1 (ja) * 2012-11-28 2014-06-05 京都府公立大学法人 リシン構造を有するlsd1選択的阻害薬
US9144555B2 (en) 2012-11-30 2015-09-29 Darlene E. McCord Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition
SG11201510369WA (en) 2013-06-25 2016-01-28 Univ Canberra Methods and compositions for modulating cancer stem cells
CA2923765C (en) 2013-09-18 2021-06-29 University Of Canberra Stem cell modulation ii

Similar Documents

Publication Publication Date Title
CO2024009571A2 (es) Inhibidores de parp1
CL2023000525A1 (es) Inhibidores de sarm1
CL2007002686A1 (es) Compuestos derivados de 2h-isoquinolin-1-ona y 3h-quinazolin-4-ona, inhibidores de cinasa rho; y composicion farmaceutica, util para el tratamiento de una enfermedad o afeccion cardiovascular.
JOP20210050B1 (ar) معدلات تعبير pnpla3
CL2007003138A1 (es) Compuestos derivados de anilinopiperazina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
WO2007042465A3 (en) Combinati0n of nilotinib with farnesyl transferase inhibitors
CL2007003495A1 (es) Compuestos derivados de heterociclos condensados sustituidos, inhibidores de la actividad de la akt; composicion farmaceutica; y uso para el tratamiento o prevencion del cancer.
NO20072179L (no) Kombinasjon av en SRC kinase inhibitor og en. BCR-ABL inhibitor for behandling av proleferative sykdommer
PH12020551995A1 (en) Modulator of apol1 expression
WO2018017368A9 (en) COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING A SYMPTOM ASSOCIATED WITH GUT OR HYPERURICEMIA
CL2007002431A1 (es) Compuestos derivados de azabenzotiofenil; composicion farmaceutica; y uso para la inhibicion del crecimiento celular anomalo o de tratamiento de un trastorno hiperproliferativo.
WO2023064282A8 (en) Combinations of wee 1 inhibitors and anti-cd47 antibodies.
MX2022007626A (es) Combinaciones.
CL2007002385A1 (es) Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento y/o profilaxis de enfermedades seleccionadas de infeccion por helicobacter pylori, pterigion, endometriosis, sindrome de hiperestimulacion ovarica y enfermedad del rinon poliquistico.
CL2008000409A1 (es) Compuestos derivados de 2-(4 amino-pirrolo-piridin) furan-3,4 diol; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento y/o prevencion de infecciones virales.
CL2007002479A1 (es) Compuestos derivados de pirazol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos tromboembolicos.
MX2021003598A (es) Microorganismos para la inhibicion de patogenos vegetales.
MX2022007628A (es) Combinaciones.
EP3964512A4 (en) CASEIN KINASE INHIBITOR 1epsilon, PHARMACEUTICAL COMPOSITION AND USE THEREOF
JOP20210108A1 (ar) معدِّلات تعبير irf5
BRPI0812421A2 (pt) Polinucleotídeo isolado, cassete de expressão, planta, métodos para aumentar o nível de um polipeptídeo em uma planta e para aumentar o rendimento em uma planta, e, polipeptídeo isolado.
IL288864A (en) Treatment that includes sglt inhibitors, for example sglt 1/2 inhibitors
BRPI0812302A2 (pt) Compostos, proceso para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de sst do bubtipo 5 e uso destes compostos.
CL2007003847A1 (es) Compuestos derivados de pirimidinas 2,4,5 tri-sustituidas; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento del cancer.
CL2008000093A1 (es) Compuestos derivados de piridina, inhibidores de p2y12; composicion farmaceutica que comprende a dichos compuestos; y su uso para el tratamiento de un desorden de agregacion plaquetaria.