JP2021000306A - Treatment system - Google Patents

Abstract

To perform sterilization from a main line to treatment devices, and to ensure the sterility of a treatment system.SOLUTION: A treatment system 10 comprises: an injection water production device 12 that supplies water to a looped main line 14; multiple branch lines 40, 100 which are connected to the main line 14; a liquid formulation preparation device 26 and a filling machine 28 which are connected to branch lines 40 and 100 and perform predetermined treatment using water; partition valves 42 and 102 which are installed in the branch lines 40 and 100; a steam generator 20 that supplies steam for sterilizing the liquid formulation preparation device 26 and the filling machine 28 to the main line 14; and drain discharge means 27 for the liquid formulation preparation device and drain drainage means 29 for the filling machine which are installed on the liquid formulation preparation device 26 and the filling machine 28 and discharge the steam having passed through and sterilized the main line 14, the branch lines 40 and 100, the liquid formulation preparation device 26, and the filling machine 28, and steam-condensed drain.SELECTED DRAWING: Figure 1

Description

The present invention relates to a treatment system that supplies and treats water to a point of use.

As a treatment system for supplying water to an aqueduct and treating it, for example, there is an injectable water supply device for supplying water for injection to an aqueduct and performing a predetermined treatment (see, for example, Patent Document 1).

Japanese Unexamined Patent Publication No. 2014-205092

The injection water supply device described in Patent Document 1 has a circulation line (loop-shaped main line) through which injection water circulates and a bypass line (branch) that branches from the circulation line and sends injection water to each use point (treatment device). Line) is equipped.

By circulating and holding high-temperature (for example, 80 ° C. or higher) water for injection in the circulation line, the growth of bacteria and microorganisms is prevented. In addition, the bypass line is provided with a heat exchanger for cooling the high-temperature injection water, so that the injection water flowing into the bypass line is cooled and supplied to the use point.

In the water supply device for injection, the supply of water for injection to the use point may be temporarily stopped, in which case the water for injection will be retained in the bypass line. The retention of water for injection leads to a decrease in the temperature of water for injection, which also leads to the growth of bacteria and microorganisms. Therefore, in order to suppress the temporary retention of the injection water, the injection water in the bypass line can be discharged to the outside through the blow means. Further, a steam sterilization means is connected to the bypass line, and after shutting off the circulation line and the bypass line with a bypass inlet valve and a bypass outlet valve, steam for sterilization is circulated through the bypass line to make the bypass line. It can be sterilized with steam.

In this water supply device for injection, since high temperature injection water circulates in the circulation line, the growth of bacteria and microorganisms in the circulation line is suppressed, and in the bypass line, the high temperature injection water flowing through the circulation line is used. It is possible to suppress the retention of water for injection by continuing the flow, and further, the bypass line can be sterilized by flowing steam at 121 ° C. or higher.

However, when sterilizing the bypass line, the supply valve provided in the middle of the supply line from the bypass line to the use point is closed, so that the steam uses the supply valve, the supply line on the downstream side of the supply valve, and the use point. Does not pass. In addition, after sterilization, clean air that has passed through the air supply line and the introduction line is supplied to the bypass line, and the steam inside does not pass through the supply valve, the supply line on the downstream side of the supply valve, and the use point. , It is discharged to the outside through the blow means connected to the bypass line.

Therefore, the supply valve through which steam does not pass, the supply line on the downstream side of the supply valve, and the point of use cannot be sterilized with steam.

Therefore, there is a concern that bacteria and microorganisms may be generated in the supply valve, the supply line on the downstream side of the supply valve, and the water for injection staying inside the use point.

In view of the above facts, an object of the present invention is to guarantee the sterility of the processing system as a piping configuration capable of sterilizing from the main line to the processing apparatus.

The treatment system according to claim 1 uses a water supply source for supplying water to a loop-shaped main line, a plurality of branch lines connected to the main line, and the water connected to the branch lines. A processing device that performs a predetermined treatment, a sluice valve provided in the branch line, a steam generating means for supplying steam for sterilizing the processing device to the main line, and each of the processing devices are provided. , The main line, the branch line, the steam sterilized through the processing apparatus, and a drain draining means for discharging the drain in which the steam is condensed.

In the treatment system according to claim 1, water can be supplied from a water supply source to a loop-shaped main line, thereby circulating water in the loop-shaped main line and suppressing the growth of bacteria and microorganisms. Can be done.

When the sluice valve provided on the branch line is opened, the water supplied to the main line is supplied to the treatment device via the branch line and is subjected to a predetermined treatment by the treatment device.

When sterilizing the main line, branch line, and treatment equipment, stop the supply of water from the water source to the main line, and drain the water inside the main line, branch line, and treatment equipment from the drain drainage means. After that, steam is supplied from the steam generating means to the main line.

Since the steam can pass through the main line, the branch line, and the treatment device in order and be discharged to the outside by the drain drainage means, the water passage path of the main line, the branch line, and the treatment device is heated by the heat of the steam. Can be sterilized. In addition, the drain generated by condensing steam inside the main line, the branch line, and the processing device can also be discharged to the outside from the drain drainage means.

In the treatment system according to claim 1, since the water passage path from the main line to the treatment device can be sterilized by heating with steam as described above, the sterility of the treatment system can be guaranteed. it can.

According to the second aspect of the present invention, in the processing system according to the first aspect, an air supply means for supplying cooling air is connected to the main line.

In the processing system according to claim 2, after sterilization with steam, cooling air is supplied to the main line from an air supply means to cool the steam inside the main line, the branch line, and the processing device. While replacing it with air, the drain generated inside can be discharged from the drain drainage means, and the path through which the steam has passed can be cooled.

In addition, by supplying cooling air to the main line from the air supply means, the passage path of water inside the main line, branch line, and treatment device is made positive pressure, and outside air etc. is sucked from the drain drainage means side or the like. You can avoid it.

The invention according to claim 3 has a direct connection line for directly supplying the steam generated by the steam generating means to the processing apparatus in the processing system according to claim 1 or 2.

In the processing system according to claim 3, when only the processing apparatus is sterilized, the steam generated by the steam generating means can be directly supplied to the processing apparatus via a direct connection line. Therefore, when only the processing apparatus is sterilized without sterilizing the main line and the branch line, it is not necessary to drain the water inside the main line and the branch line.

Since the processing system of the present invention has the above configuration, sterilization can be performed from the main line to the processing apparatus, and the sterility of the processing system can be guaranteed.

It is a piping diagram which shows the processing system which concerns on 1st Embodiment.

A processing system 10 according to an embodiment of the present invention will be described with reference to FIG. As shown in FIG. 1, the treatment system 10 of the present embodiment is, for example, an injection water producing apparatus 12 for producing injection water and an injection connected to the injection water producing apparatus 12 and supplied from the injection water producing apparatus 12. It is provided with a loop-shaped main line 14 for circulating irrigation water.

In the present embodiment, the water for injection 12 is installed on the floor 17 of the first machine room 16 provided inside the building, the main line 14 penetrates the ceiling 18, and substantially the entire surface thereof is the ceiling 18 of the clean room 24. It is piped to the upper level of. The water for injection production device 12 includes a control device 12C that controls various built-in devices.

In the first machine room 16, in addition to the water for injection production device 12, a steam generator 20 that supplies steam to the main line 14 is installed. The steam generator 20 and the main line 14 are connected by a pipe 22 penetrating the ceiling 18, and the steam generated by the steam generator 20 can be supplied to the main line 14 via the pipe 22. ..

The clean room 24 provided adjacent to the first machine room 16 is divided into two rooms, one room 24A is equipped with a liquid preparation facility 26, and the other room 24B has a filling machine 28. is set up. Further, in the clean room 24, equipment other than the liquid preparation equipment 26 and the filling machine 28 (which may use water for injection or may not use water for injection) may be installed. Often, the clean room 24 may be divided into three or more rooms. When the clean room 24 is divided into a plurality of rooms, the divided rooms (clean rooms) may not be adjacent to each other.
An air compressor 32 is installed in the second machine room 30 adjacent to the clean room 24. The first machine room 16 and the second machine room 30 may be separated from the clean room 24.

The air compressor 32 and the main line 14 are connected by a pipe 34, and the cooling air generated by the air compressor 32 can be supplied to the main line 14 via the pipe 34. The air compressor 32 produces sterile, dust-free compressed air from which foreign substances such as bacteria and microorganisms have been removed.

(Liquid preparation equipment)
The liquid preparation facility 26 is an apparatus for producing a chemical solution by mixing the water for injection produced by the water for injection production device 12 and a drug supplied from the outside. The liquid preparation equipment 26 includes a control device 26C that controls various built-in devices. The control device 26C of the liquid preparation facility 26 and the control device 12C of the water for injection production device 12 exchange data with each other via a network N such as CC-Link (Control & Communication Link: registered trademark), for example. It is possible.

The liquid preparation facility 26 includes a pipe 36 to which water for injection is supplied from the outside. A control valve 38 whose opening and closing is controlled by the control device 26C is provided in the middle of the pipe 36.

A first bent portion 14A penetrating the ceiling 18 of the clean room 24 is formed in a part of the main line 14, and one end of the branch pipe 40 is connected to the intermediate portion of the first bent portion 14A. The other end of 40 is connected to one end of the pipe 36 of the liquid preparation facility 26.

A sluice valve 42 as a control valve whose opening and closing is controlled by the control device 26C is provided in the middle portion of the branch pipe 40. Further, the first bent portion 14A of the main line 14 arranged in the clean room 24 is provided with ferrule joints 44 on both sides of the connecting portion with the branch pipe 40.

One end of the branch pipe 46 is connected to the intermediate portion of the pipe 22 connected to the steam generator 20 described above, and the other end of the branch pipe 46 is more partitioned than the control valve 38 in the pipe 36 of the liquid agent preparation facility 26. It is connected to the portion on the valve 42 side.

The branch pipe 46 arranged in the clean room 24 is provided with a manual on-off valve 50, and the branch pipe 46 arranged inside the liquid agent preparation facility 26 is provided with a control valve 52.

Further, one end of the branch pipe 54 is connected in the middle of the pipe 34 connected to the air compressor 32 described above. One end of the branch pipe 56 is connected in the middle of the branch pipe 54, and the other end of the branch pipe 56 is connected to a portion of the pipe 36 of the liquid agent preparation facility 26 on the sluice valve 42 side of the control valve 38.

The branch pipe 56 arranged in the clean room 24 is provided with a manual on-off valve 60, and the branch pipe 56 arranged inside the liquid agent preparation facility 26 is provided with a control valve 62.

Inside the liquid agent preparation facility 26, a preparation tank 64 is arranged below the pipe 36, and the pipe 36 and the preparation tank 64 are connected by the pipe 66. Further, a pipe 68 for supplying the medicine supplied from the outside into the preparation tank is connected to the preparation tank 64. In the preparation tank 64, a drug solution prepared by mixing a drug with the water for injection supplied from the water for injection production device 12 is stored. Further, one end of a pipe 70 for supplying the chemical solution to the filling machine 28 is connected to the lower part of the preparation tank 64.

One end of the pipe 72 constituting the drain drainage means 27 for the liquid preparation equipment is connected to the other end of the pipe 36. The other end of the pipe 72 extends toward the drainage facility 74 of a building such as a drainage box provided outside the clean room 24.

A control valve 76, a steam trap 78, and a control valve 80 are provided in this order in the middle of the pipe 72, and a temperature sensor 82 for measuring the temperature of the fluid in the pipe is provided between the control valve 76 and the steam trap 78. Is provided.

Further, a pipe 84 is connected to the pipe 72 so as to straddle the steam trap 78, and a control valve 86 is provided in the middle of the pipe 84.

Further, one end of a branch pipe 88 extending toward the drainage facility 74 is connected to the pipe 72 between the connection portion with the pipe 84 and the control valve 80. A control valve 90 and a control valve 92 are connected to the intermediate portion of the branch pipe 88.
Drain drainage means 27 for liquid preparation equipment by the pipe 72, control valve 76, steam trap 78, control valve 80, pipe 84, control valve 86, branch pipe 88, control valve 90, temperature sensor 82, and control valve 92 described above. Is configured.

(Filling machine)
The filling machine 28 is a device for filling the container 94 with the chemical solution produced by the liquid preparation facility 26. The container 94 is, for example, a vial, an ampoule, a prefilled syringe, a drip bag, or the like, but may have other forms. The filling machine 28 includes a control device 28C that controls various built-in devices. The control device 28C of the filling machine 28 and the control device 12C of the water injection water production device 12 can exchange data with each other via a network such as CC-Link.

The filling machine 28 includes a pipe 96 to which water for injection is supplied from the outside. A control valve 98 whose opening and closing is controlled by the control device 28C is provided in the middle of the pipe 96.

A second bent portion 14B penetrating the ceiling 18 of the clean room 24 is formed in a part of the main line 14, and one end of the branch pipe 100 is connected to the intermediate portion of the second bent portion 14B to form a branch pipe. The other end of 100 is connected to one end of the pipe 96 of the filling machine 28.

A sluice valve 102 as a control valve whose opening and closing is controlled by the control device 28C is provided in the middle portion of the branch pipe 100. Further, the second bent portion 14B of the main line 14 arranged in the clean room 24 is provided with ferrule joints 104 on both sides of the connecting portion with the branch pipe 100.

One end of the branch pipe 106 is connected to the middle portion of the branch pipe 46 branched from the pipe 22 connected to the steam generator 20 described above, and the other end of the branch pipe 106 is a control valve in the pipe 96 of the filling machine 28. It is connected to the portion on the sluice valve 102 side of 98.

The branch pipe 106 arranged in the clean room 24 is provided with a manual on-off valve 110, and the branch pipe 106 arranged inside the filling machine 28 is provided with a control valve 112.

Further, the other end of the branch pipe 54 connected in the middle of the pipe 34 connected to the air compressor 32 described above is connected to a portion of the filling machine 28 pipe 96 closer to the sluice valve 102 than the control valve 98. There is.

The branch pipe 54 arranged in the clean room 24 is provided with a manual on-off valve 116, and the branch pipe 54 arranged inside the filling machine 28 is provided with a control valve 118.

Inside the filling machine 28, a filling portion 120 is provided below the pipe 96. A branch pipe 122 extending from the pipe 96 and a pipe 70 extending from the liquid preparation equipment 26 are connected to the filling part 120, and the filling part 120 is configured to fill the container 94 with the chemical solution.

One end of the pipe 124 constituting the drain drainage means 29 for the filling machine is connected to the other end of the pipe 96. The other end of the pipe 124 extends toward the drainage facility 126 of a building such as a drainage box provided outside the clean room 24.

A control valve 128, a steam trap 130, and a control valve 132 are provided in this order in the middle of the pipe 124, and a temperature sensor 133 that measures the temperature of the fluid in the pipe is provided between the control valve 128 and the steam trap 130. Is provided.

Further, a pipe 134 is connected to the pipe 124 so as to straddle the steam trap 130, and a control valve 136 is provided in the middle of the pipe 134.

Further, one end of a branch pipe 138 extending toward the drainage facility 126 is connected to the pipe 124 between the connection portion with the pipe 134 and the control valve 132. A control valve 140 and a control valve 142 are connected to the intermediate portion of the branch pipe 138.
The drain drain means 29 for the filling machine is provided by the pipe 124, the control valve 128, the steam trap 130, the control valve 132, the pipe 134, the control valve 136, the branch pipe 138, the control valve 140, the temperature sensor 133, and the control valve 142 described above. It is configured.

(Action, effect)
Next, the operation and effect of the processing system 10 of the present embodiment will be described.

(Process using water for injection and its pre-process)
In the treatment system 10 of the present embodiment, first, before operating the liquid preparation equipment 26 and the filling machine 28, the sluice valve 42 and the sluice valve 102 are closed, and water for injection is always supplied at a constant speed or higher. It is circulated inside the main line 14. As a result, the retention of water for injection inside the main line 14 is suppressed, and the generation of bacteria and microorganisms is suppressed inside the main line 14.

When water for injection is used in the liquid preparation equipment 26, the control device 26C of the liquid preparation equipment 26 opens the sluice valve 42. As a result, the water for injection in the main line 14 passes through the branch pipe 40 and the sluice valve 42 and is supplied to the liquid preparation facility 26. In the liquid preparation facility 26, the chemical solution prepared by mixing the drug with the water for injection is stored in the preparation tank 64. The chemical solution stored in the preparation tank 64 is supplied to the filling machine 28 via the pipe 70 as needed.

On the other hand, when the filling machine 28 uses water for injection, the control device 28C of the filling machine 28 opens the control valve 102. As a result, the water for injection in the main line 14 passes through the branch pipe 100 and the sluice valve 102 and is supplied to the filling machine 28. In the filling machine 28, the chemical solution supplied from the liquid preparation equipment 26 is filled in the container 94 by the filling unit 120. In the filling machine 28, after the container 94 is completely filled with the chemical solution and the container 94 is removed, injection water is used to clean and rinse the inside of the piping of the filling machine 28.

As described above, in the treatment system 10, the water for injection is always circulated inside the main line 14 at a constant speed or higher before the liquid preparation equipment 26 and the filling machine 28 are operated. Therefore, the liquid preparation equipment 26 When the water for injection is used in the filling machine 28, the water for injection free of bacteria and microorganisms can be supplied from the main line 14 to the liquid preparation equipment 26 and the filling machine 28.

(Sterilization process)
Next, a sterilization step of sterilizing the path through which the water for injection passes will be described.
When the operator presses a steam sterilization start button (not shown), the sterilization step of the processing system 10 described below is started. When water for injection is used in the liquid preparation equipment 26, the filling machine 28, etc., control is performed so that steam is not supplied from the steam generator 20 to the main line 14 even if the steam sterilization start button is pressed. Is done.

(1) When the steam sterilization start button is pressed, a signal is first sent to each device to drain water, the drive of the injection water production device 12 is stopped (the supply of injection water to the main line 14 is stopped), and the water is drained. The control valve 76, control valve 86, control valve 90, and control valve 92 of the pipe 72 connected to the liquid preparation facility 26 are opened, and the control valve 128, control valve 136, control valve 140 of the pipe 124 connected to the filling machine 28 are opened. And the control valve 142 is opened, and the water for injection staying inside the main line 14, the inside of the branch pipe 40, the inside of the liquid preparation equipment 26, the inside of the branch pipe 100, and the inside of the filling machine 28 is taken into the branch pipe. The water is drained to the drainage facilities 74 and 126 via 88 and 138.

(2) Next, the control valve 80 of the drain drainage means 27 for the liquid preparation equipment 26 on the liquid preparation equipment 26 side is opened, the control valve 90 and the control valve 92 are closed, and the drain drainage for the filling machine on the filling machine 28 side is closed. The control valve 132 of the means 29 is opened, and the control valve 140 and the control valve 142 are closed. After that, the steam generator 20 is driven, and the steam generator 20 generates high-temperature steam (for example, 121 ° C. or higher), and the steam is supplied to the main line 14 via the pipe 22. The steam supplied to the main line 14 passes through the inside of the branch pipe 40, the inside of the liquid preparation equipment 26, and the drain drainage means 27 for the liquid preparation equipment, and is discharged to the drainage facility 74, and the inside of the branch pipe 100. , The inside of the filling machine 28, and the drain draining means 29 for the filling machine are discharged to the drainage facility 126, and the passage path of the injection water is heated by the heat of steam.

When the sterilization process was started, the control device 12C of the water for injection 12 was connected to the thermometer side data of the temperature sensor 82 provided in the pipe 72 connected to the liquid preparation equipment 26 and the pipe 124 connected to the filling machine 28. Monitoring of the thermometer side data of the provided temperature sensor 133 is started.

In the present embodiment, as an example, steam drain is discharged to the drainage facilities 74 and 126 until the temperature measured by the temperature sensor 82 and the temperature sensor 133 exceeds a predetermined temperature (for example, 121 ° C.), the control valve 86, and the control valve 86, and The control valve 136 is closed, steam is retained in the system to raise the temperature repeatedly, and when the temperature measured by the temperature sensor 82 and the temperature sensor 133 exceeds 121 ° C., the control valve 86 and the control valve 136 are closed. , Steam is supplied from there for a certain period of time, and the path is maintained at a temperature exceeding, for example, 121 ° C. for a certain period of time.

During this period, the steam drain (water in which steam is condensed) in the path on the liquid preparation facility 26 side is discharged from the steam trap 78 to the drainage facility 74 via the pipe 72 and the control valve 80, and the steam in the path. Is suppressed from being discharged to the outside by the action of the steam trap 78. On the other hand, the steam drain in the path on the filling machine 28 side is discharged from the steam trap 130 to the drainage facility 126 via the pipe 124 and the control valve 132, but the steam in the path is the action of the steam trap 130. The discharge to the outside is suppressed.

In this way, in the processing system 10 of the present embodiment, the passage path of the water for injection from the temperature sensor 82 and the temperature sensor 133 to the steam generator 20 on the upstream side is heated to a temperature exceeding 121 ° C. for a certain period of time. Main line 14, branch pipe 40 connecting the main line 14 and the liquid preparation equipment 26, a sluice valve 42 provided in the branch pipe 40 to separate the main line 14 from the liquid preparation equipment 26, liquid preparation equipment 26, main line 14 The branch pipe 100 that connects the filling machine 28 and the filling machine 28, the sluice valve 102 that is provided in the branch pipe 100 and separates the main line 14 from the filling machine 28, and the filling machine 28 can be reliably sterilized.

(3) After the sterilization is completed after a certain period of time, the drive of the steam generator 20 is stopped, the supply of steam to the main line 14 is stopped, and the control valve 86 and the control valve 136 are opened. , Steam in the path is discharged to the external drainage facility 74 and the drainage facility 126.

(4) Immediately after the control valve 86 and the control valve 136 are opened, the air compressor 32 is driven to supply compressed air for cooling to the main line 14, and the compressed air passes through a path heated by steam. The air is discharged to the drainage facility 74 and the drainage facility 126, and the temperature of the path is lowered. At this time, the inside of the path is maintained at a positive pressure (the pressure in the installation environment of the processing system 10, that is, higher than the atmospheric pressure), and the aseptic state is maintained.
By supplying the compressed air for cooling to the main line 14 in this way, the temperature of the path through which the steam has passed can be quickly lowered.

(5) When the temperature measured by the temperature sensor 82 and the temperature sensor 133 becomes equal to or lower than the preset temperature, the control valve 76 and the sluice valve 42 on the liquid preparation equipment 26 side are closed and the filling machine 28 side. Although the control valve 128 and the control valve 102 are closed and not shown, compressed air is supplied from the air compressor 32 so that the pressure becomes positive according to the pressure inside the pipes of the liquid preparation equipment 26 and the filling machine 28. Will be done. Then, the operation of the air compressor 32 is stopped. As a result, the pressure in the passage path of the injection water of the liquid preparation facility 26 and the filling machine 28 is maintained at a positive pressure until the next filling step is restarted, and the invasion of bacteria and microorganisms from the outside is suppressed.
When the temperature measured by the temperature sensor 82 and the temperature sensor 133 becomes equal to or lower than the preset temperature, the control of the sterilization process ends.

(6) When the temperatures of the temperature sensor (not shown), the temperature sensor 82, and the temperature sensor 133 in the water for injection 12 are equal to or lower than the preset temperature, the water for injection 12 is set to the water for injection in the treatment system 10. Water for injection circulates inside the main line 14 as described above.
In the present embodiment, the liquid preparation equipment 26 and the filling machine 28 are connected to the main line 14, but the liquid preparation equipment 26 and the equipment using water for injection other than the filling machine 28 are connected to the main line 14. The liquid preparation equipment 26 and the equipment that uses water for injection other than the filling machine 28 can also be sterilized in the same manner as the liquid preparation equipment 26 and the filling machine 28.

(Sterilization process only for liquid preparation equipment)
In the above-mentioned sterilization step, the main line 14, the liquid preparation equipment 26, and the filling machine 28 were sterilized at the same time, but in the processing system 10 of the present embodiment, the liquid preparation equipment 26 or the filling machine 28 is as follows. Can also be sterilized individually.
Hereinafter, as a representative, a sterilization step of sterilizing only the liquid preparation equipment 26 alone will be described.
(1) In this sterilization step, first, the sluice valve 42 of the branch pipe 40 connected to the liquid preparation equipment 26 is closed, and then the control valve 76, the control valve 86, the control valve 90 of the pipe 72 connected to the liquid preparation equipment 26, The control valve 92 is opened, and the water for injection staying inside the liquid preparation facility 26 is drained to the drainage facility 74 via the branch pipe 88.

(2) Next, the steam generator 20 is driven, and the control valve 52 provided in the branch pipe 46 connected to the intermediate portion of the pipe 22 connected to the steam generator 20 is opened. The manual on-off valve 50 provided in the branch pipe 46 is normally open.

The steam generated by the steam generator 20 is supplied to the pipe 36 of the liquid preparation equipment 26 via the branch pipe 46, passes through the inside of the liquid preparation equipment 26 and the drain drainage means 27 for the liquid preparation equipment, and drains the drainage equipment. It is discharged to 74, and the passage path of water for injection in the liquid preparation facility 26 is heated by the heat of steam.

During the sterilization process, the thermometer-side data of the temperature sensor 82 provided in the pipe 72 connected to the liquid preparation facility 26 is monitored.

The control valve 86 is opened to discharge the steam drain to the drainage facility 74 until the temperature measured by the temperature sensor 82 exceeds a predetermined temperature (for example, 121 ° C.), and the control valve 86 is closed to allow steam to stay in the system. When the temperature measured by the temperature sensor 82 exceeds a predetermined temperature (for example, 121 ° C.), the control valve 86 is closed, steam is supplied from there for a certain period of time, and the path is set to a predetermined temperature (for example, 121 ° C.). Hold for a certain period of time at a temperature exceeding (° C).
During this period, the steam drain (water in which steam is condensed) in the path on the liquid preparation facility 26 side is discharged from the steam trap 78 to the drainage facility 74 via the pipe 72 and the control valve 80, and is discharged in the path. The steam is suppressed from being discharged to the outside by the action of the steam trap 78.

In this way, even when only the liquid preparation equipment 26 is sterilized independently, the upstream side from the temperature sensor 82 is similar to the case where the main line 14, the liquid preparation equipment 26, and the filling machine 28 are sterilized at the same time. Since the path of the water for injection to the steam generator 20 is heated to a temperature exceeding 121 ° C. for a certain period of time, the liquid preparation equipment 26 can be reliably sterilized.

(3) After a certain period of time has passed and sterilization is completed, the operation of the steam generator 20 is stopped, the supply of steam to the main line 14 is stopped, the control valve 86 is opened, and the steam in the path is opened. Is discharged to the external drainage facility 74.

(4) After that, the air compressor 32 is driven, and the control valve 62 of the branch pipe 54 provided in the middle of the pipe 34 connected to the air compressor 32 is opened, and the compressed air for cooling is prepared as a liquid agent. The compressed air is supplied to the pipe 36 of the equipment 26, passes through a path heated by steam, and is discharged to the drainage facility 74, and the temperature of the path is rapidly lowered. The inside of the path is maintained at a positive pressure (higher pressure than the atmosphere) to maintain an aseptic state. The manual on-off valve 60 provided in the branch pipe 56 is normally open.

(5) When the temperature measured by the temperature sensor 82 becomes equal to or lower than the preset temperature, the control valve 76 is closed, and although not shown, the pressure becomes positive according to the pressure inside the pipe of the liquid preparation equipment 26. Compressed air is supplied from the air compressor 32. Then, the operation of the air compressor 32 is stopped.
As a result, the pressure in the passage path of the injection water of the liquid preparation facility 26 is maintained at a positive pressure until the next filling step is restarted, and the invasion of bacteria and microorganisms from the outside is suppressed.
When the temperature measured by the temperature sensor 82 becomes equal to or lower than the preset temperature, the control of the sterilization process ends.

When the filling machine 28 is sterilized alone, the sterilization can be performed in the same manner as when the liquid preparation equipment 26 is sterilized alone.
Further, when the liquid preparation equipment 26 and the equipment using water for injection other than the filling machine 28 are connected to the main line 14, each equipment is independently used as in the liquid preparation equipment 26 and the filling machine 28. Can be sterilized.

[Other Embodiments]
Although the embodiments of the present invention have been described above, the present invention is not limited to these embodiments, and it goes without saying that the present invention can be implemented in various modes without departing from the gist of the present invention.

In the above embodiment, two processing devices of the liquid preparation equipment 26 and the filling machine 28 are connected to the main line 14, but the main line 14 is used as a processing device other than the liquid preparation equipment 26 and the filling machine 28. For example, other types of processing devices such as a rubber stopper cleaning and sterilizing machine may be connected, and the number of processing devices connected to the main line 14 may be three or more.

The drain drainage means 27 for the liquid preparation equipment and the drain drainage means 29 for the filling machine provided in the treatment system 10 are not limited to the above configurations, and it is sufficient that the water for injection, the steam, and the drain can be drained. It can take various forms as long as it does not deviate from the gist.

In the processing system 10, for example, in the liquid preparation equipment 26, steam for sterilization can be supplied to the preparation tank 64 to sterilize the preparation tank 64 and the pipe 70. Further, in the filling machine 28, it is also possible to supply steam for sterilization to the branch pipe 122 to sterilize the branch pipe 122.

In the treatment system 10 of the present embodiment, the drain inside the main line 14 can be discharged to the outside of the treatment system 10 via the liquid preparation facility 26 or the filling machine 28, so that the drain drainage means (liquid agent) dedicated to the main line 14 can be discharged. It is not necessary to install the drainage directly from the main line 14 to the outside of the system without going through the preparation facility 26 and the filling machine 28) inside the clean room 24. Therefore, the volume of the clean room 24 can be reduced as compared with the case where the drain drainage means dedicated to the main line 14 is provided, and the number of parts and the number of control points of the parts related to the drain drainage means can be reduced. Can be done. Further, by reducing the volume of the clean room 24, for example, the air conditioning of the clean room 24 can be saved.

Further, when there is an existing treatment device in which the drain drainage means dedicated to the main line is installed inside the clean room, the drain drainage means dedicated to the main line is removed, and the branch line and the sluice valve which are the configurations of the present invention are removed from the main line. By connecting a processing device such as a liquid preparation facility or a filling machine via the above, the configuration of the processing system of the present invention can be modified. As a result, the space from which the drain drainage means dedicated to the main line has been removed can be effectively used for other purposes.

The processing system 10 of the above embodiment has a configuration in which the liquid preparation equipment 26 and the filling machine 28 can be sterilized individually, but it is necessary to sterilize the liquid preparation equipment 26 and the filling machine 28 individually. If not, the branch pipe 46 for directly supplying the steam to the liquid preparation equipment 26, the manual on-off valve 50 provided in the branch pipe 46, the control valve 52, and the steam are directly supplied to the filling machine 28. The branch pipe 106, the manual on-off valve 110 provided in the branch pipe 106, and the control valve 112 may not be provided. Further, a branch pipe 54 that directly supplies compressed air to the filling machine 28, a manual on-off valve 116 provided in the branch pipe 54, a control valve 118, and a branch for directly supplying compressed air to the liquid preparation equipment 26. The pipe 56, the manual on-off valve 60 provided on the branch pipe 56, and the control valve 62 may not be provided.

In the processing system 10 of the above embodiment, an air compressor 32 for supplying compressed air to the main line 14 is provided in order to quickly cool the passage path of the steam after sterilization, but the steam after sterilization is provided. If it is not necessary to cool the passage path quickly, the air compressor 32 may not be provided.

10 ... Treatment system, 12 ... Water production equipment for injection (water supply source), 14 ... Main line, 20 ... Steam generator (steam generator), 22 ... Piping (direct connection line), 26 ... Liquid preparation equipment (treatment equipment) , 27 ... Drain drainage means for liquid preparation equipment (drain discharge means), 28 ... Filler (treatment device), 29 ... Drain drainage means for filling machine (drain discharge means), 32 ... Air compressor (air supply means), 40 ... branch line, 42 ... sluice valve, 46 ... branch pipe (direct connection line), 100 ... branch line, 102 ... sluice valve, 106 ... branch pipe (direct connection line)

Claims (3)

A water source that supplies water to the looped main line,
A plurality of branch lines connected to the main line and
A processing device that is connected to each of the branch lines and performs a predetermined treatment using the water.
A sluice valve provided on the branch line
A steam generating means for supplying steam for sterilizing the processing apparatus to the main line, and
A drain drainage means provided in each of the treatment devices, which discharges the steam sterilized through the main line, the branch line, and the treatment device, and the drain in which the steam is condensed.
Processing system with. The processing system according to claim 1, wherein an air supply means for supplying cooling air is connected to the main line. The processing system according to claim 1 or 2, further comprising a direct connection line for directly supplying the steam generated by the steam generating means to the processing apparatus.